CLUSTAL X (1.8) multiple sequence alignment Streptomyces ----------------------------MNGGLLVAGTTSDAGKSVVTAGICRWLVRQGV Mycobacterium ----------------------------MSG-LLVAGTTSDAGKSAVTAGLCRALARRGV Rhodobacter -----------------------------MTALMIQGAGSNVGKSMLVAGLCRAARRRGL Methylbacterium ------------------------------------------------------------ Pseudomonas ----------------------------MTRRIMLQGTGSDVGKSVLVAGLCRLAANQGL Deinococcus ---------------MTGGSSALSRRFSMGKAIMVQGCTSNAGKSYLCAALCRMLSDEGL Methanobacterium -----------------MALSTGSGEAMSAKCIMVQGTSSSAGKSVMVAALCRIFSRRGY Methanococcus -------------------------MMKMAEFIMVVGTSSNSGKTTITAGLCRILANKGY Pyrococcus ----------------------------MGKALMVQGTMSGAGKSLLVAALCRIFTNLGY Salmonella ----------------------------MTQAVMLQGTASDVGKSVLAAGLCRIFYQDGL Archaeoglobus -----------------------------MPSLMVGGTTSSAGKSLLAAAFCRILARRGY Synechocystis MEPYSHRMECPRSFVFLADSSIQSKQNLTMKAIMVVGTTSHAGKSFLTTGLCRLLRRRGD Acinetobacter -----------------------------MRHISIFGTSSDAGKSTLTFVIAKILQRAGI Streptomyces KVAPFKAQNMSLNSFVTR-----DGAEIGRAQAMQAQACRVEPTAHMNPVLLKPGGERSS Mycobacterium RVAPFKAQNMSNNSMVCRG-PDGTGVEIGRAQWVQALAARTTPEAAMNPVLLKPASDHRS Rhodobacter TVAPFKPQNMSNNAAVTA-----DGGEIGRAQALQALACGLEPVTDMNPILLKPESDVGA Methylbacterium ---------------------------------LQARAAGVPPSVHMNPVLLKPQSEVGS Pseudomonas KVRPFKPQNMSNNAAVSD-----DGGEIGRAQWLQALAARVPSSVHMNPVLLKPQSDVGS Deinococcus RVAPFKAQNMSNNAGVTPPESSAPGLEMGRAQLVQARAARVVPDVRMNPVLLKPEADTSS Methanobacterium RVAPFKSQNMSLNSFTTA-----ENREIAVAQVLQAEAAGIEPSHHMNPVLLKPKEDFTS Methanococcus KVAPFKSQNMSLNSRVAK-----EDGEIAIAQYTQSLACRVEPSVHFNPILLKPKGNFIS Pyrococcus DVVPFKSQNMSLNSAPSI-----EGGEISRAQYLQALACRKKPSVKFNPILLKPEGNMRS Salmonella RTAPFKSQNMALNSGITP-----DGKEMGRAQIFQAEAAGITPDVRMNPVLLKPTSDRQA Archaeoglobus DVAPFKAQNMSLNSFVTS-----KGKEIAIAQAYQAFAAGIEPDERMNPVLLKPKGNFVS Synechocystis RVTPFKGQNMALNAFVTI-----DGGEMGHAQAVQAWAAGTVPRVAMNPILLKPQGDMTS Acinetobacter RVAPFKAQNVSNNARVCD-----DGSEIAIAQSFQAEVLAIPTSYHLNPILLKSGINGQA *: . . :**:***. : : Streptomyces QVVLLGRPVGEMSARGYHGGRQERLLGTVLDSLAELRGTYDAVICEGAGSPAEINLRRTD Mycobacterium HVVLMGKPWGEVASSSWCAGRR-ALAEAACRAFDALAARYDVVVAEGAGSPAEINLRAGD Rhodobacter QVVVQGKRLTTTRARDYATLKP-QLMGAVLESFNRLKATHDLVIVEGAGSPAEVNLRAGD Methylbacterium QVVVQGRMVGPAKARDYQGWKP-RLLTSVLESFAHLRAEADLVVVEGAGSASEVNLRAGD Pseudomonas QIVVQGKVAGQARGREYQALKP-KLLGAVMESFEQISAGADLVVVEGAGSPAEINLRPGD Deinococcus QVVLLGRAAPELTALPWRERKP-RLWPFVKGALHSLLDEFDVVVIEGAGSPAEVNLRPSD Methanobacterium QVIVHGRPAGNMNFQDYQTEFRDTALEAIRESLEYLKSRYELIVIEGAGSPAEINMRDRD Methanococcus QVIVHGRPYKDMNYNEYR-KNKDFFLKKIKESLEILDREYDYVIMEGAGSCCEINLLKDD Pyrococcus QVVFMGRPIGSVSARDYMLSKKAELFEKAIEVLKELMREHDLVIIEGAGSPVEINLKDYD Salmonella QVVLMGKVATNMDAVSYH-DYKPRLREQILAVYNSLAQEYDVIVLEGAGSPAEINLRDRD Archaeoglobus QLVVMGEAVGDVDSRKYYGVKVEWLKRVVEEAYLSLAEEYDFVVIEGAGGMAEINLYERD Synechocystis QVIMLGQAVGTTRAQEYYQNYFDRGWQAIANSLETLAQDFDVVVCEGAGSPAEINLKHRD Acinetobacter SVIVEGQVISQQDVLEYYRDLD-TLKPAVQRCFETLAKMYDCIVAEGAGSPVELNLMDKD ::. *. : : : :: ****. *:*: * Streptomyces IVNMGIARGAGLPVLVVGDIDRGGVFASFFGTVALLAPEDQALVAGFLVNKFRGDVSLLE Mycobacterium YVNMGLARHAGLPTIVVGDIDRGGVFAAFLGTVALLAAEDQALVAGFVVNKFRGDSDLLA Rhodobacter IANMGFARAADVPVVLVGDIDRGGVIAQIVGTQAVLDPADAEMISGFLINKFRGDVTLFD Methylbacterium SANMGFARATDTPVILLGDIDRGGVIASLVGTKAVLDPADAAMVRGFLVNRFRGDPSLFA Pseudomonas IANMGFATRANVPVVLVGDIDRGGVIASLVGTHAILPEEDRRMVTGYLINKFRGDVTLFD Deinococcus IVNMRVAREARAAVLLAADIDRGGAFAHLLGTWHCLMPEERALMRGFILNRFRGDASLLA Methanobacterium LANMEIAHLADADVILVADIDRGGVFASIAGTLMLLDERDRSRIKGVVINKFRGNIDILM Methanococcus IANLRIAELVNAKAILVADIDRGGVFASIYGTIKLLPENWRKLIKGIIINKFRGNVEVLK Pyrococcus IANMRVAKAVNAPVILVADIDRGGSFAQIVGTMELLSEEERELVMGFIFNKFRGDASLLK Salmonella IVNMGMAEMAQCPVILVADIDRGGVFAAIYGTLALLHKQERDRVKGVIINKFRGDVALLY Archaeoglobus LPNIHIARFARPDILIVGDIDRGGVFASLYGTYALLPDDVKPLVKGFVINRLRGREDVLE Synechocystis LTNMRVATHLQAATILIADIDRGGVFAHVVGTLQLLEPEERKLIKGIVINKFRGQRSLLD Acinetobacter LSNIFIAKHYQTKIILVADIEKGGVFASVWGTYNLLPADLRSNVIGVIINKFRGDLSLFD *: .* :: .**::** :* . ** * : * :.*::** :: Streptomyces PGLDMLHGLTGRRTYGVLPFRHGLG-IDEEDGLRVSLRGTVRESVVAPPVGED--VLRVA Mycobacterium PGLRDLERVTGRRVYGTLPWHPDLW-LDSEDALDLQGR--------R-AAGTG--ARRVA Rhodobacter DGYRLIGARTGWRGFGTLPWFPLAHKLPAEDALDIASG-----------PATG--GTVIA Methylbacterium DGMRIIAERTGWESLGLVPHFADAARLPAEDVLGLRGSE----------AGPG--ARVVA Pseudomonas DGIAAVNRYTGWPCFGVVPWLKAAARLPAEDSVVLEKLT----------RGEGR-ALKVA Deinococcus PAPEWLEEQTGVPTLGVVPWLNVA--LPEEDGVAVEAPAAIIP-----SPSTG----FVA Methanobacterium PGIERIEEITGVPVLGVLPYDEGLK-LPEEDSASLSQRK---------YRG--RGDIRVG Methanococcus EGIEKIEELTGIPVLGIVPYDENLV-LPEEDSQVLQSMR---------SFGNAKSGVEIN Pyrococcus PGFEFLEKRCGKPVLGVVPYIEHR--LPEEDS-LAEFPK---------VRG----DLHIQ Salmonella SGIEQIESLTGVPVLGVMPWLDVD--LEDEDGVALQNDK---------YRGNAPRDITIA Archaeoglobus SGIRELERLTGIRVLGVLPYLDYN--FPSEDSLNIEEWG-----------AEG----TVG Synechocystis SGITWLEEYTGIPVLGVIPYGQNL--FSAEDSLDILERS----------GRPSKEDIRIV Acinetobacter EGIRIIEQAFKIPVLGVLPYMPFN--LGFEDNASLQNFVQ--------QPRQK--KLKIG . : * :* : ** : Streptomyces VCAVPLMSNFTDVDALAAEPGVVVRFVDRPEEL-ADADLVIVPGTRGTVRALEWLRERGL Mycobacterium VVRLPRISNFTDVDALGLEPDLDVVFASDPRAL-DDADLIVLPGTRATIADLAWLRARDL Rhodobacter CLTLSRIANFDDLDPLAAEPGVRMVMVQPGQPIPAEARLVILPGSKSTRGDLAFLREQGW Methylbacterium VPVLSRIANFDDLDPLRAEPGIAVVLVRPGEAIPGNADLVLLPGSKTTIDDLADLRAQGW Pseudomonas VPVLSRIANFDDLDPLAAEPEIDLVFVRPGSPIPVDAGLVVIPGSKSTIGDLIDFRAQGW Deinococcus IPRLPRVSNLDEFAPLG----ELARWVTSPQEL-AGARAVILPGSKSTAADLAWLRATGL Methanobacterium VMRLPRISNFTDIDPLEYEEDVAVRLIETGDSL-DDLDAIIIPGTRNTISDLIHLEENGF Methanococcus VVRFSKISNFTDLDPLRY--DAFIKFIDFDDDI-TG-DILIFPGTRSSTKEAYYLKQHNF Pyrococcus IIKLPHISNFTDFEPLHW--ANGVDYVTRAEEI-KG-DLIIVPGSKNTVEDLLWMRENGI Salmonella IVQLPHISNFTDFNALAAQPDVRIRYIRRPEAL-TDVDLVILPGSKNTLSDLAWLRESGM Archaeoglobus IVRLPRVSNFTDFEPLR----EHARFLSLNSSL-NGCEVVIIPGSKDTIADLKALKSSKL Synechocystis VLRLPRIANFTDFEPLEAESGVYVDYLPLEKQL-GNPDAVIIPGSKTTIADLQALQNSGM Acinetobacter VIAYPYMSNYNDFEPLIADDEVLLEFINSPISL-EHFDGVILPGSKLVIEDLHWLKTNGL . ::* :. .* : ::.**:: :. Streptomyces ADAIARRAAERRPVLGICGGYQLLGEHIED--EVESRAG----HVDGLGLLPVRVRFDRE Mycobacterium DRALLVHVAAGKPLLGICGGFQMLGRVIRDPYGIEGPGGQVT-EVEGLGLLDVETAFSPH Rhodobacter DIDLAAHVRRGGHVLGICGGYQMLGRSVADPEGIEGPAG----TTPGLGLLDVETVMTPD Methylbacterium DVDIRAHLRRGGRVLGLCGGYQMLGRRISDPHGIEGEAR----SVPGLGLLDVETVMTPL Pseudomonas DRDLERHVRRGGRVIGICGGYQMLGRRVTDPLGIEGGER----AVEGLGLLEVETEMAPE Deinococcus AGAVTRLAVQGVPVLGICGGLQMLGQTLSDPQGVEGGSAASGGKVYGLGLLDLHTAFAAD Methanobacterium ADEIRDLSR-EIPVFGICGGFQMLGKRILDDARQESSEG----SVDGLGLLDCETHFTGE Methanococcus DEKVLEFLKDGGIVIGICGGYQVLGKELIDKEKKESDVG----DIEGLKIFDAKTYFGND Pyrococcus EDAIIEAHREGSFVVGICGGFQMLGKEIID--EVESKRG----RVEGIGLLPAKTVFTGE Salmonella ADAVLQTHRQGVPVMGICGGYQMLGDTIVD--EVESGLG----TQPGLGLLNTITRFAQD Archaeoglobus GEEIVRKAG-EIPVIGICGGYQIMCRELVD-MGVEHGRI----RAKGLGLLDAVTEFREY Synechocystis AQQIMDYAQAGGTVMGICGGYQMLGQTIADPENIEGNVS----NCQGLGLLPLTTVINQE Acinetobacter FEQLQQRRK---PIFAICGGYEMLFEQLHDPERIENLEP---TTATGLGLIDDEIYFAKN : :..:*** ::: : * * *: :: : Streptomyces KTLTRAVG----EA-------LGEPVEGYEIHHG-VAE------VTGGAPFL--D----- Mycobacterium KVLRLPRG----EG-------LGVPASGYEIHHGRITR------GDTAEEFL--G----- Rhodobacter KRLTRVRVRATHAG-------SGLAVEGYEIHIGRTEG------ADRARPFA-IVEGQNE Methylbacterium KRLEAVTG--ESLS-------DAVPFAGYEMHIGDTAG------PDAARPLLRLADGRTD Pseudomonas KTVRNSRA--WSLE-------HDVVLEGYEIHLGKTQG------ADCGRPSV-RIDNRAD Deinococcus KTTRLSEVR--DPE-------TGLRLQGYEIHHGQTRS------GPGVQTLVP------- Methanobacterium GKIISQSQGRVLGN-GIFSGMRGETVEGYELHEGTTVLGDVKPLLRVDRGFGNTRSGGFD Methanococcus KVVKNSCGFLEIDN-KTFN------VKGYEIHEGFTYS-KEKPLIKIERGFGNCGNG-FD Pyrococcus KRTNHLKAEVLWEP-ARVMW-----VEGYEIRMGRSTS--EKPFSVITSINGARAFE-PE Salmonella KTTTQVNATMSGELPGWLAAAAGLPVRGYEIHMGETVL-QEGCCTAMTLQKNGCSVA--D Archaeoglobus RKRTVQVEKRVNGNAVILDRIRGEKVWGYEIHKGITRA--------SNPIFE---D---D Synechocystis KITRQCQTITHAPP-------SGLTVTGYEIHQGLSRR------SEHSQDFLPMFDQEEL Acinetobacter KILNKAEYPIFGLN-----------IAGFEMHHGISQK--------YPLYFQ-------- *:*:: * Streptomyces GCR----VGRTWGTHWHGSLESDGFRRAFLREVAAAAGRRFVPAPDTSFAALREEQLDRL Mycobacterium GAR----DGPVFGTMWHGSLEGDALREAFLRETLGLAP------SGSCFLAARERRLDLL Rhodobacter GAMS--ADGRVIGSYLHGLFGADAFRAAFLRGLGIRAS-------GQSHAAGVEAALDAL Methylbacterium GAVS--ADGRVAGTYVHGLFADDRQRAAWLARLGAAAS-------GAAYEAGIEAVLDGL Pseudomonas GALS--ADGRVMGTYLHGLFTSDAYRGALLKSFGIEGG-------ANNYRQSVDAALDDV Deinococcus GLLW--RSGNVRGTYLHGLLENSAYLEHFLRWADLPVP---------ACLDSLDARLDAI Methanobacterium GAV----DGNVAGTYFHGIFHNFRFRRYFTNLLRERKGIEPLEYLDDNFSASRRFSIDRL Methanococcus GSIKKFGDGLAIGTYFHGIFENYEFRNYIINLIRKRKGLD--EIYGDSYKDSIEKSLNYF Pyrococcus GAIG----KRAFGTYLHGIFHNFAFTERFLNMLRAEKGLEP--------VKVEEWSIEEE Salmonella GAVT--ADGLAFGTYLHGLFDSDAFTRAVVNGLRARKGLAPWET-TFCYADHKARQFDLL Archaeoglobus GCAS--EDGMCWGTYLHGLFWNENVLRALGGYLGIKFR-------------QKEDWADLI Synechocystis GMVN--AQQNLWGCYLHGLFDNGAWRRCWLNNLRQRRGLDPLPTSIGNYQEQREGMLDSL Acinetobacter -------KDNIQGTFIHQVFDHNAFRTQYLRAICAQYQG-------FDFQLYKTEQINNF * * : : Streptomyces GDLIEHHADTDALWRLIESGAPQGLPFIPPGAPA Mycobacterium GDLVERHLDVDALLNLARHGCPPTLPFLAPGAP- Rhodobacter ADHLETHLDVTGILALAR---------------- Methylbacterium ARHIEAHVDCDRLLALAG---------------- Pseudomonas ANELEAVLDRRWLDELLRH--------------- Deinococcus AAQVQAGLSWDRVRALL----------------- Methanobacterium AEIVEENMDLSIIEEILEG--------------- Methanococcus AEVVERSVNLKPLGI------------------- Pyrococcus IREVYPGCEGER---------------------- Salmonella AEAMRQHIDIDKIYTIMQQHQEPV---------- Archaeoglobus ADEVEGRLDLGVLGL------------------- Synechocystis ADFVETHVNLEPILQSLPEENETP---------- Acinetobacter IEACRKRLNVKLILEAIQDQ-------------- .