CLUSTAL X (1.64b) multiple sequence alignment Pyrococcus -------MIKE------PEFRDYTPGKLEEKIEEFWKEN-NIYQKIKELRKNGP-KYYFL Pyrococcus2 ------------------------------------------------------------ Methanococcus --------MKK------VEPVNFR--ELDKKIKKFWEEN-DIYQKVKKKNERNK-EFYFV METHANOBACTERIUM ------MMPIQ------EAEKSYKPHVIEEKVQSFWEER-DIYERVKELREEGP-RYSFL Methanobacterium2 -------MPIQ------EAEKSYKPHVIEEKVQSFWEER-DIYERVKELREEGP-RYSFL Methanobacterium3 -------MPIQ------EAEKSYRPHRIEEKVQSFWEER-DIYERVKELREDRP-RYSFL Archaeoglobus -----------------MLPAKYSPKDVESEIFKFWEDN-DIYRKVKEK--GGR-KFYFV Sulfolobus ------------------------------------------------------------ Arabidopsis --MEEVCEGKE-------FS----FPRQEEDVLSFWTEI-DAFKTQLKRTENLP-EYIFY Tetrahymena --MASKTTFKD-------LQEIPDFPKEEENILKFWDEI-NAFKQQLEKTKDCP-PFTFY Homosapiens -------MLQQ-------VPENINFPAEEEKILEFWTEF-NCFQECLKQSKHKP-KFTFY Homosapiens2 ---MSNKMLQQ-------VPENINFPAEEEKILEFWTEF-NCFQECLKQSKHKP-KFTFY Celegans -----MSGLST-------VPDNINFAREEDKVAQKWQDE-NTFQRSVELSKDRP-HFTFY Saccharomyces --------MSE-------SNAHFSFPKEEEKVLSLWDEI-DAFHTSLELTKDKP-EFSFF Saccharomyces2 --------MSE-------SNAHFSFPKEEEKVLSLWDEI-DAFHTSLELTKDKP-EFSFF Schizosaccharomyces --------MS------------FNVPKEEEKIVEFWREI-DAFHTQLKLSQGRP-TYTFF Nosema ------------------------------------------------------------ Chlamydia ---------MD-------NEDKISISAKEEKILSFWKEQ-DIFQKTLDNREGCP-TFSFY Chlamydophila -------MTAD-------EVGKNSFAKKEEQVLKFWKDN-QIFEKSLQNRQGKT-LYSFY Borrelia -------MFKK-------VENKANFPKIEEKILKFWNDN-KIFEKSIKQREGCE-EFTFY Treponema -------MYTP-------VDPKVDFVAQERRILAFWRER-RVFEQSVAQRAQGK-SYVFF Mycobacterium ---MTDNAYPK------LAGGAPDLPALELEVLDYWSRD-DTFRASIARRDGAP-EYVFY Mycobacterium2 ---MTNSAYPRTDLGADQRGGSPNFPALEAQVLDYWSND-DTFRASIARCDDAP-EYVFY Rickettsia ---MTNTKYYP------DVSANVDFAAIEQEILKFWQNN-NIFQKSIDYRNGES-EFIFY Staphylococcus ---MTKKYLN-----------------TQNEISAFWNTQ-KIFKKSIDNRKGQE-SFVFY Thermus ---MFKEVGEP------------NFPKLEEEVLAFWKRE-KIFQKSVENRKGGP-RYTVY Helicobacter ----MEEYKDTLNLNTTTFSMKGNLSVNEPKTYAKWQEQ-QAFKRMQ-ARKDNHGDFTLH Helicobacter2 ----MKEYKDTLNLNETTFSMKGNLSVNEPKTYAKWQEQ-QAFKRMQ-NRKDNHGDFTLH Campylobacter -----MDYKETLLLPSTTFAMRANLAELEPQRFKKWFEQNYAYEKMKENRKNAKKSFTLH Haemophilus ---MTVDYKNTLNLPETSFPMRGDLAKREPDKXKNWYEK-NLYQKIRKASKGKK-SFILH Ecoli ---MS-DYKSTLNLPETGFPMRGDLAKREPGMLARWTDD-DLYGIIRAAKKGKK-TFILH Pseudomonas ---MT-DYKATLNLPDTAFPMKAGLPQREPQILQRWNSI-GLYGKLREIGKDRP-KFVLH Streptococcus -----MKLKDTLNLGKTEFPMRAGLPTKEPVWQKEWEDA-KLYQRRQELNQGKP-HFTLH Bacillus -----MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEE-DIYRLVQERTKDRP-KFVLH Fervidobacterium --------------------MKANLVNKEPEMLKFWEEK-EIYKKTLETRANAP-TYLLH Thermotoga -----MEYKNTLNLPKTSFPMKANLVNKEKVFLEEWEKM-DLYNYVLEQRKGKP-LFVLH Aquifex MEEKKVDLKDTLNLPRTEFPMKANLPQREPQILEKWKG---LYEKIQKERKGRE-VFVLH Ciona ------------------------------------------------------------ Synechocystis -MTEAKSYKDTVNLPQTRFDMRANANKREPEIQQYWQEK-GIYADLADNNPKDL--FVLH Mycoplasma -----MNLKKTLLMPQTAFEMQGKLTTKEQQFQAFWQSK-RIYQKLHRQNKDKP-QKILH Deinococcus ------------------------------------------------------------ Pyrococcus DGPPYVSGAIHLGTAWNKIIKDMIIRFRTMQGYNVWRQPGFDMHGLPIEVKVEQALG--L Pyrococcus2 -----------------------------------------DTHGLPIEVKVEQALG--L Methanococcus DGPPYCSGAIHLGTAWNKIIKDTYLRFKRMQGYNVLDKAGWDMHGLPIEVKVENEFG--I METHANOBACTERIUM DGPPYCSGRIHLGTAWNKIMKDSYLRFKSMRGFNVRRQPGWDTHGLPIEHKVEGILG--V Methanobacterium2 DGPPYCSGRIHLGTAWNKIMKDSYLRFKSMRGFNVRRQPGWDTHGLPIEHKVEGILG--V Methanobacterium3 DGPPYCSGRIHLGTAWNKIMKDTYLRFKSMKGFNVRRQPGWDTHGLPIEHKVEGLLG--V Archaeoglobus DGPPYTTGRIHLGTAWNKVLKDTILRYKRMMGFAPTDTPGWDMHGLPIEVKVEQELG--F Sulfolobus -----------------------------------------DTHGLPIEVETEKRLG--I Arabidopsis DGPPFATGLPHYGHILAGTIKDIVTRYQTMTGHHVTRRFGWDCHGLPVENEIDRKLN--I Tetrahymena DGPPFATGLPHYGNLLAGTIKDVVCRYASQNGKYVERRFGWDCHGLPVEYEIDKKLG--I Homosapiens DGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLG--I Homosapiens2 DGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLG--I Celegans DGPPFATGLPHYGHMLTSTIKDVVGRWAHQNGHYVERRFGWDTHGLPVEYEIDKTLG--I Saccharomyces DGPPFATGTPHYGHILASTIKDIVPRYATMTGHHVERRFGWDTHGVPIEHIIDKKLG--I Saccharomyces2 DGPPFATGTPHYGHILASTIKDIVPRYATMTGHHVERRFGWDTHGVPIEHIIDKKLG--I Schizosaccharomyces DGPPFATGRPHHGHLLASTIKDSVTRYACLKGYHVERRFGWDTHGLPVEHEIDKKLG--I Nosema ----------------------------------------WDRHGVPVEYEIDKALG--I Chlamydia DGPPFATGLPHYGHLLAGTIKDVVCRYASMDGHYVPRRFGWDCHGVPVEYEVEKSLG--L Chlamydophila DGPPFATGLPHYGHLLASTIKDVVGRYATMDGYYVPRRFGWDCHGVPVEYEVEKSLS--L Borrelia DGPPFATGLPHFGHFVPNTIKDIIPRYQTMQGKYVKRNFGWDTHGLPVEYEVEKKLG--I Treponema DGPPFATGLPHFGHFVPSTIKDIIPRYQTMRGAYVPRRFGWDCHGLPIEHLIEQELN--L Mycobacterium DGPPFANGLPHYGHLLTGYVKDIVPRYRTMRGYKVERRFGWDTHGLPAELEVERQLG--I Mycobacterium2 DGPPFANGLPHYGHLLTGYVKDIVPRYRTMCGYKVERRFGWDTHGLPAELEVERQLG--I Rickettsia DGPPFANGLPHYGHLLTGFIKDVYARYKTIKGKKVERRFGWDCHGLPAEMQSEKELG--I Staphylococcus DGPPTANGLPHAGHVLGRVIKDLVARLKTMQGFYVERKAGWDTHGLPVELEVEKKIG--I Thermus EGPPTANGLPHVGHAQARSYKDLFPRYKTMRGYYAPRRAGWDTHGLPVELEVEKKLG--L Helicobacter DGPPYANGHLHLGHALNKILKDIVVKREYFKGKKIYYTPGWDCHGLPIEQQILERLE--- Helicobacter2 DGPPYANGHLHLGHALNKILKDIVIKREYFKGKKIYYTPGWDCHGLPIEQQILEQLE--- Campylobacter DGPPYANGHIHIGHALNKILKETIIKTHYFKGESVRFTPGWDCHGLPIEQQVEVKLG--- Haemophilus DGPPYANGNIHIGHAVNKILKDIIIKSKTALGFDSPYIPGWDCHGLPIELKVEGLVG--- Ecoli DGPPYANGSIHIGHSVNKILKDIIVKSKGLSGYDSPYVPGWDCHGLPIELKVEQEYG--- Pseudomonas DGPPYANGTIHIGHALNKILKDMILRSKTLSGFDAPYVPGWDCHGLPIEHKVEVTYG--- Streptococcus DGPPYANGNIHVGHAMNKISKDIIVRSKSMSGFYAPFIPGWDTHGLPIEQVLSK-QG--- Bacillus DGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIETALTKNKK--- Fervidobacterium DGPPYANGDIHLGTAMNKILKDFVTRYKTMRGYRVPFVPGWDTHGLPIEHRVTTSLG-EE Thermotoga DGPPYANGHIHIGTALNKILKDIVVKYKTMRGYRAPYVPGWDTHGLPIEHRVSQELG-EK Aquifex DGPPYANGHIHVGHALNKILKDVINKYNLLIGKNVNFIPGWDCHGLPIERAVEKELSKKK Ciona ------------------------------------------------------------ Synechocystis DGPPYANGALHMGHALNKVLKDIINKYKLLQGHKVHYVPGWDCHGLPIELKVLQSLK--S Mycoplasma DGPPYANGNIHVGHALNKILKDFVLRSWNLQGFGTVFIPGWDCHGLPIEHAVSKKDP--- Deinococcus ------------------------------------------------------------ Pyrococcus KTKKEIEEKIGVENFIKKCKEFALNNLKIMTEQFKMLGIWMDWDDPYMTIKNE-YIESAW Pyrococcus2 KTKKEIEEKIGVENFVQKCKEFALNNLRIMTEQFKMLGVWMDWDNPYMTIKNE-YIESAW Methanococcus KNKKEIETKIGVKQFIEKCKEFALKHKEIMEKQFKNLGVWLDWENAYMPITKE-YMEIGW METHANOBACTERIUM RSKKDIEDKIGIEEFVRKCREFAMENKAVMTSQFQRLGVWMDWDDPYVTFDPA-YMESCW Methanobacterium2 RSKKDIEDKIGIEEFVRKCREFAMENKAVMTSQFQRLGVWMDWDDPYVTFDPA-YMESCW Methanobacterium3 RSKKDIEDKIGIEEFVNKCREFAVENKAVMTGQFQRLGVWMDWDDPYVTFDPA-YMESCW Archaeoglobus RTKRDIES-FGIDKFIERCMNYALANKDAMTEQFKSLAVWMDWENPYMTIKAE-YMNAAW Sulfolobus KSKAEIIEKVGVDNFISKCKEFAVNNSKSLTQNFRNLGIFMDWENPYFTFNND-YISNSW Arabidopsis KRRDEVIK-MGIDKYNEECRSIVTRYVAEWEKVITRCGRWIDFKNDYKTMDLP-FMESVW Tetrahymena TNRQEVLK-MGVDKYNAECRSIVMRYAQEWRSIVNRFGRWVDFDNDYKTLDLK-FMESVW Homosapiens RGPEDVAK-MGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQ-FMESVW Homosapiens2 RGPEDVAK-MGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQ-FMESVW Celegans SGPQDVMK-MGIANYNNECRKIVMRYSGEWEKTMGRLGRWVDFKHDYKTLYPW-FMESVW Saccharomyces TGKDDVFK-YGLENYNNECRSIVMTYASDWRKTIGRLGRWIDFDNDYKTMYPS-FMESTW Saccharomyces2 TGKDDVFK-YGLENYNNECRSIVMTYASDWRKTIGRLGRWIDFDNDYKTMYPS-FMESTW Schizosaccharomyces TGSDDVMA-MGIDKYNAECRKIVMTYASEWRATVERLGRWIDFDNDYKTLYPS-FMESVW Nosema TGVKDIHD-MGIRKYNKECRKIVLRYTKEWEAVVKRMGRWIDFRNGYRTMDRS-FMESIW Chlamydia TEPGAIER-FGVANFNEECRKIVFRYADEWKYFVDRIGRWVDFSATWRTMDLS-FMESVW Chlamydophila TAPGAIED-FGIASFNEECRKIVFRYVHEWEYYINRIGRWVDFSSTWKTMDAS-FMESVW Borrelia SGKYEIEN-YGIENFNKECRKIVLRYTEEWKNIILRLGRWVDFEKGYKTMDIS-FMESVW Treponema NSKSDVES-YGVSAFNAACRSSVLRYVKEWQRTLTRLGRWVDFDNDYKTMDVC-YMESVW Mycobacterium TDKSQIEA-MGIAAFNDACRASVLRYTDEWQAYVTRQARWVDFDNDYKTLDLA-YMESVI Mycobacterium2 TDKSQIDA-MGIAAFNEACRKSVLRYTEEWQAYVTRQARWVDFDNDYKTLDLS-YMESVI Rickettsia SGRIAITN-FGIEKFNNHCRASVMQYASEWEQYVTRQARWVAFKNAYKTMDKN-FMESVL Staphylococcus KGKQDIEK-YGIENFINECKKSVFNYEKEWRDFSKDLGYWVDMDSPYITLENN-YIESVW Thermus KSKREIEA-YGIERFNQACRESVFTYEKEWEAFTERIAYWVDLEDAYATLEPT-YIESIW Helicobacter KEKTSLEN---PTLFREKCRDHAKKFLEIQKNEFLQLGVLGDFEDPYKTMDFK-FEASIY Helicobacter2 KEKTSLEN---PTLFREKCRDHAKKFLEIQKNEFLQLGVLGDFEDPYKTMDFK-FEASIY Campylobacter EKKKSLSK----KEIREFCRQHASEFVDIQREEFKNLGIIADWDKPYLTMKFE-FEAAIY Haemophilus KPNEKISA----AEFRQKCREYAAEQVEGQKKDFIRLGVLGDWDNPYLTMNFD-TEANII Ecoli KPGEKFTA----AEFRAKCREYAATQVDGQRKDFIRLGVLGDWSHPYLTMGLQNWKANII Pseudomonas KN---LGA----DKTRELCRAYATEQIEGQKSEFIRLGVLGEWDNPYKTMNFK-NEAGEI Streptococcus VKRKEMDL----VEYLKLCREYALSQVDKQREDFKRLGVSGDWENPYVTLTPD-YEAAQI Bacillus VNRKEMSV----AEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPE-YEAQQI Fervidobacterium AKKKSP------AEIRKLCKEFALKYVDIQREEFKRLGVKGDWEHPYITLDPD-YEYHIL Thermotoga IKEMSP------AEIRKKCEEFALRFVDIQREEFKRLGVRGDWENPYITLKPD-YEVKIL Aquifex IKKESLPK----TEFRELCREYAKKYVNIQREDFVRLGVLGDWEHPYLTMDPK-YEAQEI Ciona ------------------------------------------------------------ Synechocystis SERAELTP----LTLRHKARDFALKAQQEQAVGFQRYGIWGDWKKPYLTLTPE-YEAAQI Mycoplasma QHYASLS----LSEKRDLCKQFALSQIAIQKAQFQRLGLLNDFSKYYKTIDES-FQQNEL Deinococcus ------------------------------------------------------------ Pyrococcus FTLKKAWEKGLLEKDKRVLHWCPRCETALAEHEVRG---EYKLRKD-PSIYVK------- Pyrococcus2 FTLKWAWEKGLLEKDKRVLHWCPRCETALAEHEVRG---EYKLRKD-PSIYVK------- Methanococcus WTLKVAHEKGLLTRDLRVVYWCPRCETALAEHEVRG---EYKEVYD-PSVYVK------- METHANOBACTERIUM WTLKRAHEKDLLLRDLRVITWCPRCETALALAEI-----DYHEKED-PSIYVK------- Methanobacterium2 WTLKRAHEKDLLLRDLRVITWCPRCETALALAEI-----DYHEKED-PSIYVK------- Methanobacterium3 WTLKRAHEKDLLVRDLRVITWCPRCETALALAEI-----DYHDKED-PSIYVK------- Archaeoglobus FAIKRAHERGLLERKKMVVNWCHRCETALADAEV-----EYWDEED-PSIYVK------- Sulfolobus AVIK-SIRRGLLYKGVHVLHWCSRCETTLADYEVS----EYRDLED-PSIYVK------- Arabidopsis WVFSQLWEKNLVYRGFKVMPYSTGCKTPLSNFEAGQN---YKEVPD-PEIMVT------- Tetrahymena WVFKQMFDKGLVYRGCKVMPYSNGCATVLSNFETQQN---YKEVDD-PSLFIA------- Homosapiens WVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFESHQN---YKDVQD-PSVFVT------- Homosapiens2 WVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFESHQN---YKDVQD-PSVFVT------- Celegans WAFSELHKKGLVYKGVKVMPFSTACSTPLSNFEAGQN---YKDVVD-PAVFVG------- Saccharomyces WAFKQLHEKGQVYRGFKVMPYSTGLTTPLSNFEAQQN---YKDVND-PAVTIG------- Saccharomyces2 WAFKQLHEKGQVYRGFKVMPYSTGLTTPLSNFEAQQN---YKDVND-PAVTIG------- Schizosaccharomyces WVFKELHTKGKVYRGYRVMPYSTACTTPLSNFEAQQN---YKEVPD-PAIVVA------- Nosema HIFKMLYEKGSVYRGHRVMPYSTACSTPLSNFEANQN---YKDVSD-PSILVA------- Chlamydia WVFRSLYDQGLVYEGTKVVPFSTKLGTPLSNFEAGQN---YKEVDD-PSVVVK------- Chlamydophila WVFQSLYNQGLVYEGTKVVPFSTALGTPLSNFEASQN---YKEVDD-PSLVVR------- Borrelia WVFKNLYEKGLIYESYYVLPYSPKLATPLSNFEVNLGE--YKEVND-PSLTIK------- Treponema WVVAQLWQRKLLYEGYKILPYCPRCATALSNHELNLGG--YQDVSD-PAITVR------- Mycobacterium WAFKQLWDKGLAYEGYRVLPYCWRDETPLSNHELRMDDDVYQSRQD-PAVTVG------- Mycobacterium2 WAFKQLWDKGLAYESYRVLPYCWRDETPLSNHELRMDDDVYQSRQD-PAVTLG------- Rickettsia WAFKELYNKDLLYESMRVMPYSWACETPLSNFETRLDN-AYRERTD-KAITVSFVLNE-- Staphylococcus NILSTFHKKGLLYKGHKVTPYCTHDQTALSSHEVAQG---YKNVKD-LSAVVK------- Thermus WSLKNLFDRGLLYRDHKVVPYCPRCGTPLSSHEVALG---YKEIQD-PSVYVR------- Helicobacter RALVEVAKKGLLKERHKPIYWSYACESALAEAEV-----EYKMKKS-PSIFVAFGLK--- Helicobacter2 RALVGVAKKGLLKERHKPIYWSYACESALAEAEV-----EYKMKKS-PSIFVAFDLK--- Campylobacter RTLCEIAKKGLLCERSKPVFWSWAAKSALAEAEV-----EYQDKED-YSIFVAFDLD--- Haemophilus RTLGKVIENGHLYKGSKPVHWCLDCGSSLAEAEV-----EYEDKVS-PSIYVRFPAESAD Ecoli RALGKIIGNGHLHKGAKPVHWCVDCRSALAKRKL-----SITTKLLRPSTLLSR-AVDQD Pseudomonas RALAEIVKGGFVFKGLKPVNWCFDCGSALAEAEV-----EYEDKKS-STIDVAFPIADDA Streptococcus RVFGEMANKGYIYRGAKPVYWSWSSESALAEAEI-----EYHDLVS-TSLYYAN------ Bacillus RVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEI-----EYQDKRS-ASIYVAF------ Fervidobacterium DVFKTLVENGNVYRGNKPVYWCPTCRTALAEAEI-----EYHDHES-PSIYVKFQMV--- Thermotoga DVFKTLVEQGNVYRSLKPIYWCPRCRTALAEAEI-----EYHDHKS-PSIYVKFRSK--- Aquifex RELGKFFERGLAYRSKKPVYWCIYDKTAEAEAEV-----EYYEKED-PSIYVKFPLKS-- Ciona ------------------------------------------------------------ Synechocystis GVFGAMALKGYIYRGLKPVHWSPSSRTALAEAEL-----EYPEGHTSRSIYVSFPITQAG Mycoplasma DLFLQAVKKDLIFQALKPTYWSPVSRTSLAEAEI-----EYKEVKT-IGLYLT------- Deinococcus ------------------------------------------------------------ Pyrococcus -----FPIEGKE----------------------NEYLLIWTTTPWTLPANLAVSAHPEY Pyrococcus2 -----FPVEGKE----------------------NEYLLIWTTTPWTLPANLAVSALPDY Methanococcus -----FRLANEE----------------------NTYIVIWTTTPWTLVANLAVTVHPDY METHANOBACTERIUM -----FPVSG------------------------DTYILVWTTTPWTLPANMAVAVHPDF Methanobacterium2 -----FPVSG------------------------DTYILVWTTTPWTLPANMAVAVHPDF Methanobacterium3 -----FPVSG------------------------DTHILVWTTTPWTLPANMAVAVHPDF Archaeoglobus -----FPVKGEK----------------------DTYIVIWTTTPWTLPANMAVAVHPSL Sulfolobus -----FRVKGEP----------------------NRYLVIWTTTPWTLPANVFVMINKDF Arabidopsis -----FPVIGDQDN---------------------AAFVAWTTTPWTLPSNLALCVNAKF Tetrahymena -----FKTAEDPK----------------------TKFIAWTTTPWTLPSNLALVINKDF Homosapiens -----FPLEEDET----------------------VSLVAWTTTPWTLPSNLAVCVNPEM Homosapiens2 -----FPLEEDET----------------------VSLVAWTTTPWTLPSNLAVCVNPEM Celegans -----FKLLDCPN----------------------RQLVAWTTTPWTLPSNLALVVHPDM Saccharomyces -----FNVIGQEK----------------------TQLVAWTTTPWTLPSNLSLCVNADF Saccharomyces2 -----FNVIGQEK----------------------TQLVAWTTTPWTLPSNLSLCVNADF Schizosaccharomyces -----FQSISDPE----------------------VSFLAWTTTPWTLPSNLALAVHPDL Nosema -----FPLRKPFKGY-------------------SLSLVAWTTTPWTLPSHMAILVNQSF Chlamydia -----FALQDNQG-----------------------FLLAWTTTPWTLVSNMALAVHPEL Chlamydophila -----MPLQNDSA-----------------------SLLVWTTTPWTLPSNMAIAVGETL Borrelia -----FKIK-----------------------DKNEYLLVWTTTPWTLPSNLGIAVGQEI Treponema -----FECTSVVPGSPAAREFCAAASWGSASLPAHTCFLAWTTTPWTLPCNAALALGPQI Mycobacterium -----FKVVGGQP----------------DNGLDGAYLLVWTTTPWTLPSNLAVAVSPDI Mycobacterium2 -----FKVLGGD-----------------DEDLVGAYLLVWTTTPWTLPSNLAVAVHPDV Rickettsia -----VTLINGIISQ---KSDMK--E---GDNFKEYRILAWTTTPWTLPANLALAVGSDI Staphylococcus -----FQLTNSK----------------------DTYFLSWTTTPWTLPANVALAINKDL Thermus -----FPLKEPKKLG-----------------LEKASLLIWTTTPWTLPGNVAAAVHPEY Helicobacter ----KESLEKLKV--------------------KKASLVIWTTTPWTLYANVAIALKKDA Helicobacter2 ----KEGLEKLKV--------------------KKASLVIWTTTPWTLYANVAIALKKDA Campylobacter ----VKACKKLGV--------------------SKASAVIWTTTPWTLVANQAIALNPNE Haemophilus EIEAKFSAQGRGQ--------------------GKLSAIIWTTTPWTMPSNRAIAVNADL Ecoli ALKAKFAVSNVN---------------------GPISLVIWTTTPWTLPANRAISIAPDF Pseudomonas KLAEAFGLASLA---------------------KPAAIVIWTTTPWTIPANQALNVHPEF Streptococcus KVKDGKGVLDTD-----------------------TYIVVWTTTPFTITASRGLTVGADI Bacillus GVKDGKGVLENG-----------------------ERIIIWTTTPWTIPANLGISVHPDL Fervidobacterium --------DKPD-----------------------TYIVIWTTTPWTIPANVAIALHPDY Thermotoga --------EDPN-----------------------FFIVIWTTTPWTLPANVGIALHPDY Aquifex --GEKFGIKDKK-----------------------VFAIIWTTTPWTLPANLGIMVKEDA Ciona ------------------------------------------------------------ Synechocystis --EKAAEILAPYI--------------------DDLAVAIWTTTPWTLPGNLAVALNPEL Mycoplasma -----FTVVQSAVLN------------------SGTKLLVWTTTPWTLPTNQAIAVHPQF Deinococcus ------------------------------------------------------------ Pyrococcus DYVKVKVE-FNGKEEYWILAKALVDKVLGEIG---------------------------V Pyrococcus2 DYVKVGVD-LNGREEYWILAKALVEKVLGDIG---------------------------V Methanococcus DYAYVEVE-FDDKKEVWIIAEKLVEEVINKAKK-------FHN----------------I METHANOBACTERIUM DYAHTR---LDG--ETYIMAEALVEKVLG------------------------------- Methanobacterium2 DYAHTR---LDG--ETYIMAEALVEKVLG------------------------------- Methanobacterium3 EYAYAR---LDG--ETYIMAEALVEKVLG------------------------------- Archaeoglobus EYAKFRAV-KDGKVEYLILAKELADSVLGKGD---------------------------Y Sulfolobus EYADVR----VG-DEILVIAKDRVKELMKEAR---------------------------I Arabidopsis VYVKVRNK-NTG--KVYIVAESRLSALPTDKPKAKLSNGPAGDTKKANPKAKGAKPESAA Tetrahymena DYVKVLDA-KTQ--EHYILAECRLPEL--YK------------------KDK-------- Homosapiens QYVKIKDV-ARG--RLLILMEARLSALYK----------------------L-------E Homosapiens2 QYVKIKDV-ARG--RLLILMEARLSALYK----------------------L-------E Celegans LYVVTKDK-TTG--IEYVVLEERLGELK-------------------------------N Saccharomyces EYVKIYDE-TRD--RYFILLESLIKTLYKKP--------------------K-------N Saccharomyces2 EYVKIYDE-TRD--RYFILLESLIKTLYKKP--------------------K-------N Schizosaccharomyces QYIKILDK-DSN--KKYILMESCLGILYKNP--------------------K-------K Nosema IYAIFRLK-S----AFFIMQRDRVNVYFK------------------------------- Chlamydia TYVRIKDK-ESG--DEYILGQESLPRWFPDR----------------------------- Chlamydophila VYVRIQDK-KSG--EQWILSQGCVSRWFSNP----------------------------- Borrelia EYSKIFDK-TKE--EILILGSKKLNSYYDDE----------------------------- Treponema LY--VLIE-AND--EHYILARSRLEFYYPDS----------------------------- Mycobacterium TYVQVQAG-D----RRFVLAEARLAAYARELG---------------------------E Mycobacterium2 TYVDVRAG-D----RRFVLAQARLTAYARELG---------------------------D Rickettsia DYAFVDKN-E----VCYIIAASSVAKYAKELG---------------------------L Staphylococcus NYSKIRVE-N----EYYILATDLINSIIT------------------------------- Thermus TYAAFQVG-D----EALILEEGLGRKLLG------------------------------- Helicobacter VYALTQ-------KG-YLVAKALHEKLA----------------------------ALGV Helicobacter2 VYALTQ-------KG-YLVAKALHEKLA----------------------------ALGV Campylobacter NYVITK-------EG-LIFASALLKSMV----------------------------EKGL Haemophilus EYNLVQ----LGDER-VILAAELVESVAK---------------------------AVGI Ecoli DYALVQ----IDGQA-VILAKDLVESVMQ---------------------------RIGV Pseudomonas TYALVD----VGDRL-LVLAEEMVESCLA---------------------------RYEL Streptococcus DYVLVQP---VGEARKFVVAAELLTSLSE---------------------------KFGW Bacillus EYSVIA----VGEDR-FVVASALVENVAS---------------------------ACGF Fervidobacterium TYVKIK----VDEEY-WIVAEGLLQKFAA---------------------------DVGI Thermotoga EYSVVK----VGEEK-WVIATDLLDAFSK---------------------------ETGI Aquifex DYVLVE----VEDEV-WIVAKELMDKFFE---------------------------TVNR Ciona ------------------------------------------------------------ Synechocystis TYAVVETESHIFHRSYLIVALDLVEKLSE---------------------------TFGV Mycoplasma EYLLFTYN-----NEQYVVLASLFESLKTKFG---------------------------W Deinococcus ------------------------------------------------------------ Pyrococcus KG-EVIEEFKGRELEGLRYIHVLMDEYPRQKEFREK----YEWAHRIILADFVTLEEGTG Pyrococcus2 KG-EVVEEFKGKELEGLRYVHILMDEYPRQKEFREK----YEWVHRVILADFVTLEEGTG Methanococcus KNYKIIKKVKGKELEGIKYIHPLLEENERQKEFAE-----LENAHTVILGEHVTLEGGTG METHANOBACTERIUM EEAEIIKTVRGSELEGLTYRHPLDEEVPCHRDMEH----------RVILGDHVTLTEGTG Methanobacterium2 EEAEIIKTVRGSELEGLTYRHPLDEEVPCHRDMEH----------RVILGDHVTLTEGTG Methanobacterium3 EEAEILKRVKGTELEGLTYRHPLDDEVPLHREIEH----------RVILGDHVTLTEGTG Archaeoglobus DSWEVVETYLGEDLEGLEYEHPLADEVPLQKNWKH----------QVFFADFVT-AENTG Sulfolobus KEYKILRVYKGEELLGLEYEHPLADIVSAQSKINN-------HHKVLDGGEAVTLQEGTG Arabidopsis DSYEVLEKFNGASLVGKKYEPLFDY--FSDFSS---------EAFRVVADDYVTDDSGTG Tetrahymena DGYKILEKFKGSELVGREYEPLFPY--FLSRKQD--------GCFRILAGDFVTADAGTG Homosapiens SDYEILERFPGAYLKGKKYRPLFDY--FLKCKEN--------GAFTVLVDNYVKEEEGTG Homosapiens2 SDYEILERFPGAYLKGKKYRPLFDY--FLKCKEN--------GAFTVLVDNYVKEEEGTG Celegans DNLEVIEKLAGSQLKDLRYEPLFPY--FAYMREER-------NAFRVLNDTFVTSDSGTG Saccharomyces EKYKIVEKIKGSDLVGLKYEPLFPY--FAEQFHE--------TAFRVISDDYVTSDSGTG Saccharomyces2 EKYKIVEKIKGSDLVGLKYEPLFPY--FAEQFHE--------TAFRVISDDYVTSDSGTG Schizosaccharomyces ANFEILERFQGKALDGQKYEPLFPY--FKSTFGE--------RAFKLYSADYVEEGSGTG Nosema -DAVVISEVKGHELLHLEHDQPFMY--YNHYREK--------GFFRVYHADFVSEIDGTG Chlamydia ESYEWIGQLSGKSLVGQSYEPLFPY--FQDKKEL--------EAFRILPADFIEESEGTG Chlamydophila EEFVILESFSGKDLVGRTYEPPFTF--FQSKREE--------GAFRVIAASFVEESEGTG Borrelia NSYTIIEKFKGSKLEGIEYEPIFNY--FLEQKD--------KGAFKVHTADYVTTDDGTG Treponema SAYRVVWEKRGEHLAGIRYRPLFSYPVFGQGPDPSVQGDSEEGLFCTRVADFVSTEDGTG Mycobacterium E-PVVLGTYRGAELLGTRYLPPFAY--FMDWP----------NAFQVLAGDFVTTDDGTG Mycobacterium2 E-PEVLATYRGADLLGRHYLPPFQY--FYESAR---------NAFQVLPGDFVTTDDGTG Rickettsia SGKENFEIIKGLKLQGLSYKPLFNY--FENHP----------NSFKIFASDFVVEGDGTG Staphylococcus EKYEIIDTFSGSNLINLKYIPPFES-----DGLVN--------AYYVVDGEFVTNSEGTG Thermus EGTQVLKTFPGKALEGLPYTPPYP------QALEK--------GYFVVLADYVSQEDGTG Helicobacter VDNEITHEFNSNDLEYLVATNPLN-----------------QRDSLVALGEHVGLEDGTG Helicobacter2 VDNAITHEFNSNDLEYLVATNPLN-----------------QRDSLVVLGDHVSLEDGTG Campylobacter TSGEIQKELNAKEFEKLEAINPLN-----------------GRKSVLIMGEHVLMDGGSG Haemophilus EHIEILGSVKGDDLELSRFHHPFY-----------------DFTVPVILGDHVTTDGGTG Ecoli TDSR-HGKRCG--AGAAAFTHPFM-----------------GFDVPAILGDHVTLDAGTG Pseudomonas QGSV-IATATGSALELINFRHPFY-----------------DRLSPVYLADYVELGSGTG Streptococcus ADVQVLETYRGQELNHIVTEHPWDT----------------AVEELVILGDHVTTDSGTG Bacillus DQYEVTRTVKGKDLENIIAEHPLY-----------------GRDSLVMLGEHVTTDAGTG Fervidobacterium DFE-VVEKFVGKELEGKLTKHPLYD-----------------RTSVVVLADYVTLEDGTG Thermotoga DCSNVVEKIKGKDLEGKEFVHPIFDD----------------RTSRVILADYVSLETGTG Aquifex PEGLVLETVKGKDLVGLEYTHPFVEKEKLKGHLSEETL---KNMWKIYPSEFVSLDTGTG Ciona ---------------GMICRHPIYL----------------ERTVRMIGSDIANTSKGTG Synechocystis KLT-VKVTLQGESLENTCYQHPLFD----------------RVSPIVIGGDYVTTESGTG Mycoplasma TDAIQVQTISGSQLQNTTYKHCLYD-----------------KVNPVLLGNHVLCNEGTG Deinococcus ------------------------------------------------------------ Pyrococcus LVHTAPGHGEEDFEVG-KKYGLPIY-----SPVDDQG-RYVE-------------GKWKG Pyrococcus2 LVHTAPGHGEEDFEVG-QKYGLPVY-----SPVDDQG-KYVE-------------GKWKG Methanococcus LVHTAPGHGEEDFEVG-KKYNLPIY-----SPIDDEG-KYVE-------------GKWKG METHANOBACTERIUM CVHTAPGHGPEDFEIG-KEYGLPVF-----CPVDEAG-VFTEDA-----------GKYRG Methanobacterium2 CVHTAPGHGPEDFEIG-KEYGLPVF-----CPVDEAG-VFTEDA-----------GKYRG Methanobacterium3 CVHTAPGHGPEDFEIG-KKYGLEVI-----CPVDEAG-IFTEEA-----------GKYSG Archaeoglobus CVHIAPGHGVEDYELG-VEKGLEVF-----NPVDDRG-VYTEEA-----------GKYAG Sulfolobus LVHSAPGHGDVDFEIG-KKYDMPVV-----MLVNDKG-EFTQDS-----------GKYAG Arabidopsis IVHCAPAFGEDDYRVC-LLNKIIKKGENLVVAVDDDG-LFTERI-----------THFSG Tetrahymena IVHCAPGFGDDDYKVS-VANNIIKP-DDPPVPVDENG-HFTNVV-----------SDFAG Homosapiens VVHQAPYFGAEDYRVC-MDFNIIRKDSLPVCPVDASG-CFTTEV-----------TDFAG Homosapiens2 VVHQAPYFGAEDYRVC-MDFNIIRKDSLPVCPVDASG-CFTTEV-----------TDFAG Celegans VVHQAPYFGEIDFQVC-VANGVIAKDQKMICPVDESG-KYTSEV-----------PDYQG Saccharomyces IVHNAPAFGEEDNAAC-LKNGVISEDSVLPNAIDDLG-RFTKDV-----------PDFEG Saccharomyces2 IVHNAPAFGEEDNAAC-LKNGVISEDSVLPNAIDDLG-RFTKDV-----------PDFEG Schizosaccharomyces IVHQAPAFGEADYDAA-WAAGIIDADHQPPCPVDEQG-LLTSEI-----------TDFAG Nosema VVHCSPGFGEDDYKAM-TMPGLIKENELLPSPLDENG-RFNEEV-----------PEYKG Chlamydia IVHMAPAFGEADFFAC-QEHNVPLV-----CPVDNQG-CYTAEV-----------KDFVG Chlamydophila VVHMAPAFGEGDFLVC-KENHVPLV-----CPVDAHG-SFTEEI-----------PQYQG Borrelia IVHIAP-FGEEDYRIL-KKHTNVDIID----PLDAEC-KFTNQV-----------KDFKG Treponema VVHVAPAFGEDDYEVF-KDAG-ISIQC----PLDAEC-RFTAEV-----------ADYQG Mycobacterium IVHMAPAYGEDDMVVA-EAVGIAPV-----TPVDSKG-RFDVTV-----------ADYQG Mycobacterium2 IVHIAPAYGEDDMATA-DKVGIVPV-----TPVDSNG-CFDATV-----------PDYQG Rickettsia IVHMAPGFGEDDQILC-ESKGIELV-----CPVDNSG-KFTKEI-----------PDLEG Staphylococcus IVHIAPAHGEDDYQLV-LERDLDFL-----NVITREG-VYNDRF-----------PELVG Thermus IVHQAPAFGAEDLETA-RVYGLPLL-----KTVDEEGKLLVEPF-----------KGLYF Helicobacter AVHTAPGHGEEDYYLG-LRYNLE-----VLMSVDEKG-CYDEGIIHNQLLD----ESYLG Helicobacter2 AVHTAPGHGEEDYYLG-LKYHLE-----VLMSVDEKG-CYDEGIIHNQLLD----KSYLG Campylobacter LVHTAPGHGEDDYYAC-LKYGIE-----VLMPVDDSG-CYDETLRAKRLLPSHLLEEFIG Haemophilus LVHTAPDHGLDDFIVG-KQYDLP-----MAGLVSNDG-KFIS-------TT----EFFAG Ecoli AVHTAPGHGPDDYVIG-QKYGLE-----TANPVGPDG-TYLPG------TY----PTLDG Pseudomonas IVHCSPAYGVDDFVIC-KKYGMVND--DIINPVQSNG-VYVP-------SL----EFFGG Streptococcus IVHTAPGFGEDDYNVG-IANNLE-----VAVTVDERG-IMMKN------AG----PEFEG Bacillus CVHTAPGHGEDDFIIG-QKYGLD-----VLCPVDEKG-VMTSE------A-----PGFEG Fervidobacterium CVHTAPGHGEEDYQTG-LKYNLP-----VLSPVDDEG-RFTKE------AG----KYEG- Thermotoga CVHIAPGHGEEDYIYGHVQYGLP-----IVSPVDEEG-RFTEE------AG----KYKG- Aquifex LVHMAPGHGQEDYVVG-QRYGLE-----PYAPVSDEG-RFVEP------AP----EFLIN Ciona VVHIAPAHGMDDFGIG-QKHNLS-----TESSVNSDG-EFMANIAP---------NLEGK Synechocystis LVHTAPGHGQEDYVVG-QRYGLP-----ILSPVDAAG--NLTEEAG---------KFAGL Mycoplasma LVHTSPAYGLDDFYLC-KQNKLNEA----LVSLDEKG-VFNDTLN---------DPVLTG Deinococcus ------------------------------------------------------------ Pyrococcus IYVKEADPQIIEHLKEK-GY-------LVKAGEIEHKYPHCWRCKTP--LIFRATDQWFL Pyrococcus2 VYVKEADPQIIEHLKEK-GY-------LVKAGEIEHKYPHCWRCKTP--LIFRATDQWFL Methanococcus VFVKDADAEIIETLKNK-GL-------LVYAGKIKHSYPHCWRCKTP--LLFRATEQWFL METHANOBACTERIUM LFVKDADSDIIDDLRSK-NL-------LLRAETISHRYGFCWRCKTP--IIYLATEQWFL Methanobacterium2 LFVKDADSDIIDDLRSK-NL-------LLRAETISHRYGFCWRCKTP--IIYLATEQWFL Methanobacterium3 RFVKDADEDIIADLRSK-GL-------LLKAGTISHRYGFCWRCKTP--IIYLATEQWFL Archaeoglobus KHVKEANDDIIDDLYRK-DL-------LLAEERIVHRYGHCWRCKTP--IIYRATEQWFI Sulfolobus KYVRSASEEIISDLKQR-SA-------LLHASKIVHRYPVCWRCKTP--LILRAIEQWFI Arabidopsis RYVKDADKDIIEAVKAK-GR-------LVKTGSFTHSYPFCWRSDTP--LIYRAVPSWFV Tetrahymena VYIKEADKLIRKNLKER-GL-------LLVDSSFKHNYPFCWRSDTP--LIYKAVHCWFI Homosapiens QYVKDADKSIIRTLKEQ-GR-------LLVATTFTHSYPFCWRSDTP--LIYKAVPSWFV Homosapiens2 QYVKDADKSIIRTLKEQ-GR-------LLVATTFTHSYPFCWRSDTP--LIYKAVPSWFV Celegans VYVKDADKLIIKRLKEM-GN-------LVRQAEVKHSYPFCWRSDTP--LLYKAVPSWFI Saccharomyces VYVKDADKLIIKYLTNT-GN-------LLLASQIRHSYPFCWRSDTP--LLYRSVPAWFV Saccharomyces2 VYVKDADKLIIKYLTNT-GN-------LLLASQIRHSYPFCWRSDTP--LLYRSVPAWFV Schizosaccharomyces QYVKDADKEIIRSLKAS-GH-------LVKHSQIFHSYPFCWRSDTP--LIYRAVPSWFV Nosema MHVKDADQSIIKDLGKK----------ILYEGKVYHRYPFCWRSDTP--LIYKLVPNWFV Chlamydia EYIKSADKGIARRLKNE-NK-------LFYQGTVRHRYPFCWRTDSP--LIYKAVNSWFV Chlamydophila QYIKHADKEIIKFLKKE-GR-------IFYHGTVKHRYPFCWRTDTP--LIYKAVNSWFV Borrelia LFVKDADKKIIENLKLR-NF-------LFKRENYLHRYPFCYRTNCP--IIYRPISSWFV Treponema LFVKAADKAIIARVQKQ-GA-------LFRREQISHAYPHCWRCASP--LIYRAVHSWFV Mycobacterium QHVFDANAQIVRDLKTQSGPAAVNGPVLIRHETYEHPYPHCWRCRNP--LIYRSVSSWFV Mycobacterium2 QHVFEANAQIIRDLKNQSGSAAVNGAVLLRHETYEHPYPHCWRCRNP--LIYRAVSSWFV Rickettsia VQVFDANDKIIIKLKEQ-GN-------WIKTEQYIHNYPHCWRTDTP--LIYKAVPSWYV Staphylococcus NKAKNSDIEIIKLLSKK-QL-------LYKKQKYEHNYPHCWRCGNP--LIYYAMEGWFI Thermus REANR---AILRDLRGR-GL-------LFKEESYLHSYPHCWRCSTP--LMYYATESWFI Helicobacter EHVFKAQKRIIEQLG----------DSLLLEQEIEHSYPHCWRTHKP--VIYRATTQWFI Helicobacter2 EHIFKAQKRIIEQLG----------DSLLLEREIEHSYPHCWRTHKP--VIYRATTQWFI Campylobacter LHIFKANEKILELLG----------EKLLHSSKFIHSYPFCWRTHKP--VIYRATKQWFI Haemophilus KGVFEANPLVIEKLQEV--------GNLLKVEKIKHSYPHCWRHKTP--IIFRATPQWFI Ecoli VNVFKANDIVAALLQEK--------GALLHVEKMQHSYPCCWRHKTP--IIFRATPQWFV Pseudomonas QFIFKADQPIIEKLREV--------GALMQTAAIQHSYMHCWRHKTP--LIYRATAQWFI Streptococcus QFYEKVVPTVIEKLG----------NLLLAQEEISHSYPFDWRTKKP--IIWRAVPQWFA Bacillus MFYDDANKAITQQLDEK--------GALVKLEFITHSYPHDWRTKKP--TIFRATAQWFA Fervidobacterium LKIWDANKVIVEDLKNN--------GSLIKAGKISHSYPHCWRCKGP--VMFRATPQWFI Thermotoga MFIEDANEVIIEDLKRK--------GILVHASSITHSYPHCWRCKGP--VIFRATEQWFI Aquifex VRVFDANHLIVGVLKEK--------GFLVHEEKIRHSYPHCWRCKNP--VIFRATPQWFI Ciona FIFTSGNEAVVEMLKEE--------MNLFHEHDYKHSYPYDWRTKQP--IFVHTSNQWFV Synechocystis NVLNDANEAIINALQDQ--------KVLLKEEAYEHKYPYDWRTKKP--TIFRATEQWFA Mycoplasma LFYLKANDVIIERLKQHHN--------FVFSESFLHREPHDWRSKTP--VIYRASKQLFI Deinococcus -----------------------------NTAIPSTTAPATPSSTSPRRAGTSARRRWRA * Pyrococcus KVS----------KVKDRIIKENDEKVTWYPDWV-KIRFDNGVRDSGDWVISRQRYWGIP Pyrococcus2 KVS----------KVKEKIIKENDEKVTWYPEWV-KIRFDNGVRDSGDWVISRQRYWGIP Methanococcus EIS----------KIKDNII-EHAKTVQWIPHWV-ETRYINGVKFVGDWNISRQRYWGIP METHANOBACTERIUM KIT----------EIKDKML-SELDRVQWIPSWAGESRFRNWIENARDWTISRQRYWGIP Methanobacterium2 KIT----------EIKDKML-SELDRVQWIPSWAGESRFRNWIENARDWTISRQRYWGIP Methanobacterium3 KIT----------EIKDKML-RELDRVQWVPSWAGESRFRNWIENARDWTISRQRYWGIP Archaeoglobus KIS----------ELKDEML-EEIDKVMWIPEWAGSARFKDWVSNAKDWCISRQRYWGIP Sulfolobus AVS----------KLKDHLM-GEIDRVRWIPDWG-KTRIGNMVKEVRDWVISRQRFWGTP Arabidopsis RVE----------QLKEKLL-KSNEQTEWVPGYVKDKRFHNWLENARDWAISRSRFWGTP Tetrahymena KVT----------ALKDDLL-ANNKKAYWVPKFAQEGRFNNWLQNVSDWCFSRSRFWGNP Homosapiens RVE----------NMVDQLL-RNNDLCYWVPELVREKRFGNWLKDARDWTISRNRYWGTP Homosapiens2 RVE----------NMVDQLL-RNNDLCYWVPELVREKRFGNWLKDARDWTISRNRYWGTP Celegans NVE----------TLIPRLL-ANNDETYWVPAFVKEKRFANWLRDARDWAVSRNRFWGTP Saccharomyces RVK----------NIVPQML-DSVMKSHWVPNTIKEKRFANWIANARDWNVSRNRYWGTP Saccharomyces2 RVK----------NIVPQML-DSVMKSHWVPNTIKEKRFANWIANARDWNVSRNRYWGTP Schizosaccharomyces RVK----------EITNEMV-ENVMSTHWVPQNIRDKRFANWLKNARDWNISRNRYWGTP Nosema RVK----------REIPRLL-ESNSTINWIPESIGEHKFKNWLSEARDWSISRNRFWGTP Chlamydia AVE----------KVKSKML-KANESIHWTPEHIKQGRFGKWLEGARDWAISRNRYWGTP Chlamydophila AVE----------KIKDKML-RANSSIHWVPEHIQEGRFGKWLEGARDWAISRNRYWGTP Borrelia NVE----------KIKTKLL-EVNEKINWMPAHLKKGRFGKWLENAKDWAISRNRFWGNP Treponema AVE----------KIKDKML-AANASICWQPSHIRDGRFGKWLVCARDWAISRDRYWGNP Mycobacterium RVT----------DFRDRMV-ELNQQITWYPEHVKDGQFGKWLQGARDWSISRNRYWGTP Mycobacterium2 AVT----------EFRDRMV-ELNQQITWYPEHVKDGQFGKWLQGARDWSISRNRYWGTP Rickettsia RVT----------KFKDRMV-ELNQQINWIPHNVKDNLFGKWLENARDWSISRNRFWGTP Staphylococcus KTT----------NFKNEII-NNNNNIEWFPSHIKEGRMGNFLENMVDWNIGRNRYWGTP Thermus KNT----------LFKDELI-RNNQEIHWVPPHIKEGRYGEWLKNLVDWALSRNRYWGTP Helicobacter LMDEPFIQNDGSQKTLREVALDAIEKVEFVPSSG-KNRLKTMIENRPDWCLSRQRKWGVP Helicobacter2 LMDEPFIQNDGSQKTLREVALDAIEKVEFVPSSG-KNRLKTMIENRPDWCLSRQRKWGVP Campylobacter LMDEPKLQG----KTLRECAKEQLLKTTFYPQSG-VKRIGSMVENRPDWCISRQRDWGTP Haemophilus GMETQ---------GLRQQALGEIKQVRWIPDWG-QARIEKMVENRPDWCISRQRTWGVP Ecoli SMDQK---------GLRAQSLKEIKGVQWIPDWG-QARIESMVANRPDWCISRQRTWGVP Pseudomonas GMDKEPTSG----DTLRVRSLKAIEDTKFVPSWG-QARLHSMIANRPDWCISRQRNWGVP Streptococcus SVSKF----------R-QEILDEIEKVKFHSEWG-KVRLYNMIRDRGDWVISRQRTWGVP Bacillus SIKDF----------R-SDLLDAIKETKWVPEWG-EQRLHNMVRDRGDWCISRQRAWGVP Fervidobacterium SVD-----K----NNLRGKVLEEIKKVKWYPAWG-ETRITAMVQERPDWTISRQRVWGVP Thermotoga SVD-----H----NNLRQKVLEEIDKVKWIPEWG-RNRIRSMVEERPDWCISRQRVWGTP Aquifex GMDIE-FFG----KTLRQRALEEIEKVKWIPEYG-KNRIKSMVENRPDWCISRQRFWGVP Ciona DTAM-----------LANKAEAAISGITTYPDNG-ISSMLNRLQLRSYWCISRQRAWGLP Synechocystis SVEG-----------FRDQALKAIKEVTWIPTQG-ENRITPMVGDRSDWCISRQRAWGVP Mycoplasma KTK-----------SIQSKLKRQIKRVKFVNNKN-KERLQEMLLQRAEWCISRQRVWGLP Deinococcus RCWR-----------RTKRS-TGCRATSSTGASATGWRATWTGPSPANATGARRCPSGSP .* * * Pyrococcus LPIWQSED---GEIY-VVGSWRELVELAVAIEVNGERIDLPESYEEKLKVIEEKLGPEDL Pyrococcus2 LPIWQSED---GEIY-VVGSWKELVELTVAIEVNSERIDLPESYEEKLKVIEEKLGPEDL Methanococcus IPVWVCEKC--GKYI-VVGSVEEL--------------------EEKMINKDEVGEINDL METHANOBACTERIUM IPIWVCEDC--DSIH-VVGSIGEL------------------R----ELAVEGQLEGDFI Methanobacterium2 IPIWVCEDC--DSIH-VVGSIGEL------------------R----ELAVEGQLEGDFI Methanobacterium3 IPIWICEEC--DSIH-VVGSIDEL------------------R----ELAVEGELEGDFI Archaeoglobus IPVWICEKC--GEMK-VVGSIN-------------------------EIEWENDLD---L Sulfolobus LPIWVCSNC--QNII-VVGGVDELG------------------------KIPINQVPQDL Arabidopsis LPIWISDDG--EEVV-IMDSVEKLE----------------------KLSG-VK--VFDL Tetrahymena IPIWVSEDF--EEVV-CIGSVEELK----------------------KLTGATE--ITDL Homosapiens IPLWVSDDF--EEVV-CIGSVAELE----------------------ELSGAK---ISDL Homosapiens2 IPLWVSDDF--EEVV-CIGSVAELE----------------------ELSGAK---ISDL Celegans INLWVSEDG--EEVV-CVGSIAELE----------------------ELSGQK---ITDL Saccharomyces IPLWVSDDF--EEVV-CVGSIKELE----------------------ELTGVRN--ITDL Saccharomyces2 IPLWVSDDF--EEVV-CVGSIKELE----------------------ELTGVRN--ITDL Schizosaccharomyces IPLWVSDDY--EEVV-CIGSIKELE----------------------ELSGVSN--ITDI Nosema IPLWHCDG----KYI-CIGSIEELS----------------------RLSGRK---IDDI Chlamydia IPIWRSDDG---ELL-VIGSIQELE----------------------ALSGQK---IVDL Chlamydophila IPIWKSADG---EIL-VVGSIRELE----------------------ELTGTQ---ITDI Borrelia IPIWICSKT--GKKI-CIGSKKELE----------------------NLSGQK---IEDL Treponema LPIWRCVHC--GATD-CIGSRTQLY----------------------ERSGML---LEDL Mycobacterium IPVWKSDDPAYPRID-VYGSLDELE----------------------RDFGVR---PANL Mycobacterium2 IPVWKSDDPDYPRID-VYGSLDELE----------------------RDFGVR---PTNL Rickettsia LPVWKSDDPKYPRID-VYGSIEEIE----------------------KDFGVK---INDL Staphylococcus LNVWICNDCN--HEY-APSSIKDLQ----------------------NNSINKIDEDIEL Thermus LPIWVCQACG--KEE-AIGSFQELK----------------------ARATKPLPEPFDP Helicobacter LAFFIDKRTNKPCF--ESEVLEHVANLFE-------------------KKGCD----VWW Helicobacter2 LAFFIDKRTNKPCF--ESEVLEHVANLFE-------------------EKGCD----VWW Campylobacter IAFFRDKNTKEVIF--DDELFDFVAAIFE-------------------KHGAD----AWW Haemophilus MTLFVHKETEELHPR-TLDLLEEVAKRVE-------------------RAGIQ----AWW Ecoli MSLFVHKDTEELHPR-TLELMEEVAKRVE-------------------VDGIQ----AWW Pseudomonas IPFFLNKESGELHPR-TVELMEVVAQRVE-------------------QQGIE----AWF Streptococcus LPIFYAEDGTAIM---VAETIEHVAQLFE-------------------KHGSS----IWW Bacillus IPVFYAENGEPVI---TDETIEHVSELFR-------------------QHGSN----IWF Fervidobacterium IPAVKCKDCGEVTL--EPKVIEHFANIVK-------------------EKGTD----AWF Thermotoga IPAVKCKECGEVVL--DPKVIEHFMKIVE-------------------KEGTN----AWF Aquifex ITVFYCENCGEIIK--DREVFERVAQLVEN-----S------------EKGSD----VWF Ciona IPVFYHKESGELLL--NESTIQHLVSLVL-------------------KHGAD----IWW Synechocystis IPVFYDEETSEPLL--TEETINHVQQIIA-------------------EKGSD----AWW Mycoplasma IPLIYADNQPLLDVTTIKYTIQQLK-----------------------KYGID----SWF Deinococcus RAAXLRVIG-------SVAELSELAG----------------------RDLSD----LDL Pyrococcus HRPYVDAFIIKV-N-G---KEMRRVKDVVDVWFDSGIASWASLGYPRN--KELFEK---- Pyrococcus2 HRPYVDAFIIKV-N-G---KEMRRVKDVVDVWFDSGIASWASLGYPRN--KELFEK---- Methanococcus HKPTVDKIKLRC-ECG---GEMKRVPDVLDVWFDSGLAPYASIG---------VKE---- METHANOBACTERIUM HRPHVDRIILECGRCG---GRMKRTPDVLDVWIDSGVAGWAALHYPRE--KELFSE---- Methanobacterium2 HRPHVDRIILECGRCG---GRMKRTPDVLDVWIDSGVAGWAALHYPRE--KELFSE---- Methanobacterium3 HRPHVDRIVLECGECG---GRMKRTPDVLDVWIDSGVAGWAALHYPSE--TELFRE---- Archaeoglobus HRPKIDAVTFSC-QCG---GVMRRVPDVFDVWFDSGVASWGSIAYPLR--KDKFEE---- Sulfolobus HRPWIDSVVLDVKNVE---GQARRISDVADVWFDSGVAFFASLGQDWR--KR-WSE---- Arabidopsis HRHHIDHITIPSSRGDE-FGVLRRVEDVFDCWFESGSMPYAYIHYPFE-NKELFEK---- Tetrahymena HKDFIDHLTIPSQKGK---GVLRRIDEVFDCWFESGSMPYGQQHYPFSMNEEEFSK---- Homosapiens HRESVDHLTIPSRCGK---GSLHRISEVFDCWFESGSMPYAQVHYPFE-NKREFED---- Homosapiens2 HRESVDHLTIPSRCGK---GSLHRISEVFDCWFESGSMPYAQVHYPFE-NKREFED---- Celegans HRESVDDVTIPSRSGR---GVLKRVSEVFDCWFESGSMPYAQNHYPFE-NRKIFED---- Saccharomyces HRDVIDKLTIPSKQGK---GDLKRIEEVFDCWFESGSMPYASQHYPFE-NTEKFDE---- Saccharomyces2 HRDVIDKLTIPSKQGK---GDLKRIEEVFDCWFESGSMPYASQHYPFE-NTEKFEE---- Schizosaccharomyces HRDSIDHITIPSKKGK---GTLHRVSEVFDCWFESGSMPYASRHYPFE-RIEEFKH---- Nosema HRENVDDVVICKDGEK-----YRRIEEVFDCWFESGCMPYAQRHWPFE----CDNL---- Chlamydia HRHFIDEIEINQNGKS-----FRRIPYVFDCWFDSGAMPYAQNHYPFE-RAEETEA---- Chlamydophila HRHFIDDLNIVKDGKP-----FHRIPYVFDCWFDSGAMPYAQNHYPFE-NQKETEE---- Borrelia HKDQIDKITWPSKDGG----KFIRTSEVLDCWFESGAMPYASNHYPFT-NEINFKN---- Treponema HKHVVDMVTIPCACGS----VMRRVPEVLDCWFESGAMPYAQQHYPFE-HATDFER---- Mycobacterium HRPYIDELTRPNPDDPTGRSTMRRIPDVLDVWFDSGSMPYAQVHYPFE-NLDWFQG---- Mycobacterium2 HRPYIDELTRPNPDDPTGLSTMRRIPDVFDVWFDSGSMPYAQVHYPFE-NDDWFDGFDSA Rickettsia HRPFIDELTRTNPDDPTGKSTMRRIDDVFDCWFESGSMPYGQVHYPFE-NKKWFVE---- Staphylococcus HRPYVDNITLSCPKCN---GKMSRVEEVIDVWFDSGSMPFAQHHYPFD-NQKIFNQ---- Thermus HRPYVDQVELAC-ACG---GTMRRVPYVIDVWYDSGAMPFASLHYPFE-HEEVFRE---- Helicobacter EYSVKDLLPPS---YQEDAKHYEKIMHILDVWFDSGSTFKAVLED-----YHGEK----- Helicobacter2 EYNIKDLLPPS---YQDNAKHYEKVMHILDVWFDSGSTFKAVLED-----YHGEK----- Campylobacter EFEIKDLIPTN---SKYNAENLEKVYDILDVWFDSGSTFNAVLNS-----GLYDA----- Haemophilus DLDEKELL-------GADAETYRKVPDTLDVWFDSGSTYSSVVAN-----RLEFN----- Ecoli DLDAKEIL-------GDEADQYVKVPDTLDVWFDSGSTHSSVVDV-----RPEFA----- Pseudomonas KLDAAELL-------GDEAPLYDKISDTLDVWFDSGTTHWHVLRG-----SHPMGHE--- Streptococcus ERDAKDLLPEGFTHPGSPNGEFKKETDIMDVWFDSGSSWNGVVVN-----RPELT----- Bacillus EKEAKDLLPEGFTHPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEE-----RDDLV----- Fervidobacterium ELDVNELIPADFKCPACGSKNFEKTHDTLDVWMDSGCSWEAVIRS-----KGER------ Thermotoga EKEVEELIPEDFVCPKCGKRSFEKMLDTLDVWIDSGASFEYITTK-----REDHP----- Aquifex ELTSSQLLPEGYKCPKCGGDSFTKEEDILDVWFDSGCSHAAVIRP-----LGFQ------ Ciona EG--TELLPTQY-----NADEYERGRDILDIWFDSGVSWDCVLRD-----SKNR------ Synechocystis ELTVEELLPEAYR--N-NGRTYRKGEDTMDVWFDSGSSWAAVAN------AKNRP----- Mycoplasma EKDINFFLNPKKIQPG---VEYKKETDTLEVWFDSGSTYNVLISN-------KLN----- Deinococcus HRPYIDDITFTLDGEE-----YRRVPEVLDVWFDSGSMPYAQWGLLLNEQGEAVRG---- . . : : * :** Pyrococcus --------LWPADFIVEGEDQVTKWFYSQQAASVIAFDTVPYRR-VAMHGYVLDEKGDKM Pyrococcus2 --------LWPADFIVEGEDQVTKWFYSQQAASVIAFDTVPYRA-VAMHGYVLDEKGDKM Methanococcus --------LKKADFITEGHDQVTKWFYSQHALSAIVFNDIPYKK-CLMHGFTLDEHGDKM METHANOBACTERIUM --------WFPYDFITEGHDQTRGWFYSQLGCGVIALDETPYRR-VLMHGFTLDEEGRKM Methanobacterium2 --------WFPYDFITEGHDQTRGWFYSQLGCGVIALDETPYRR-VLMHGFTLDEEGRKM Methanobacterium3 --------WFPYDFITEGHDQTRGWFYSQLGCGVIALDEVPYRR-VLMHGFTLDEEGRKM Archaeoglobus --------LWPADFITEGHDQTRGWFYSQLGTSVVCFDKAPYKA-VLMHGFTLDEQGRKM Sulfolobus --------LGPVDLVLEGHDQLRGWFFSLLRTGVILMDKAPYEA-VLVHGFMLDEQGREM Arabidopsis --------NFPGDFVAEGLDQTRGWFYTLMVLSTALFEKPAFKN-LICNGLVLAEDGKKM Tetrahymena --------RFPADFIGEGIDQTRGWFYTLNVISTALRNSNPYKN-LIVNGIVLAADGKKM Homosapiens --------AFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKN-VIVNGLVLASDGQKM Homosapiens2 --------AFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKN-VIVNGLVLASDGQKM Celegans --------NFPADFIAEGIDQTRGWFYTLLVLSTALFNKPPFKN-LICNGLVLASDGAKM Saccharomyces --------RVPANFISEGLDQTRGWFYTLAVLGTHLFGSVPYKN-VIVSGIVLAADGRKM Saccharomyces2 --------RVPANFISEGLDQTRGWFYTLAVLGTHLFGSVPYKKSVIVSGIVLAADGRKM Schizosaccharomyces --------GFPADFISEGVDQTRGWFYTLTVLGTLLFDKAPYKN-VIVSGLVMAEDGKKM Nosema --------CLPADFVAEGVDQTRGWFYTMHVISTVLLAKPRFRN-CIVNGIVLASDKKKM Chlamydia --------CFPADFIAEGLDQTRGWFYTLTVIAAALFDQPAFKN-VIVNGIILAEDGNKM Chlamydophila --------AFPADFIAEGLDQTRGWFYTLTVISAILFDRPAFRN-AIVNGIILAEDGNKM Borrelia --------IFPADFIAEGLDQTRGWFYTLTILGTALFENTAFKN-VIVNGLVLSSDGRKM Treponema --------YFPAHFISEGLDQTRGWFYTLTILAVALFERPAFEN-CIVTGLVLASDGKKM Mycobacterium --------HYPGDFIVEYIGQTRGWFYTLHVLATALFDRPAFKT-CVAHGIVLGFDGQKM Mycobacterium2 DSDKQVDAHYPGDFIVEYIGQARGWFYTLHVLATALFDRPAFKT-CIAHGVVLGSNGQKM Rickettsia --------HFPADFIVEYSSQTRGWFYTLMVLSTALFDRPPFLN-CICHGVILDATGQKL Staphylococcus --------HFPADFIAEGVDQTRGWFYSLLVISTILKGKSSYKR-ALSLGHILDSNGKKM Thermus --------SFPADFIAEGIDQTRGWFNSLHQLGVMLFGSIAFKN-VICHGLILDEKGQKM Helicobacter -------GQSPSDVILEGSDQHRGWFQSSLLIGCVLNNQAPFKK-VITHGFIVDEKGEKM Helicobacter2 -------GQSPSDVVLEGSDQHRGWFQSSLLIGCVLNNQAPFKK-VITHGFIVDEKGEKM Campylobacter -------GEKRASMYLEGSDQHRGWFQSSLLVGTAINESTPYES-ILTHGFTTDEKGQKM Haemophilus --------GQDIDMYLEGSDQHRGWFMSSLMLSTATDSKAPYKQ-VLTHGFTVDGQGRKM Ecoli --------GHAADMYLEGSDQHRGWFMSSLMISTAMKGKAPYRQ-VLTHGFTVDGQGRKM Pseudomonas -------TGPRADLYLEGSDQHRGWFHSSLLTGCAIDNHAPYRE-LLTHGFTVDETGRKM Streptococcus ---------YPADLYLEGSDQYRGWFNSSLITSVANHGVAPYKQ-ILSQGFALDGKGEKM Bacillus ---------RPADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKG-VLSHGFALDGEGRKM Fervidobacterium ---------FPVDLYLEGDDQHRGWFQSSIFLSTAKAGTAPFKA-VVTHGFIKDEQGRKM Thermotoga ---------FPLDMYLEGSDQHRGWFHSSIFLAVAKRGSAPYKE-VLTHGFIKDEQGRKM Aquifex ----------KADLYLEGSDQHRGWFQASLLESVGSYLEAPYKA-VLTHGFIVDEKGRKM Ciona --------TTQADFYIEGKDQYGGWFQSSLLTSVGLQGVAPYKN-LMVHGFVLDEKGQKM Synechocystis -------LKYPVDMYLEGSDQHRGWFQSSLLTSVAVNGIAPYKT-VLTHGFVLDEKGHKM Mycoplasma ---------FPADLYLEGSDQYRGWFNSSASCGIIQTDQLPFKS-LISHGFTLDEHGNKM Deinococcus --AEQFAKHYPADYICEAIDQTRGWFYSLHAISTMLYDQPAYKN-VICLGHIVDEKGLKM * .* ** : . : * :: Pyrococcus SKSLGNIIRPEEVVE---------KAGRDTFRFYMLWATNPWENLKFSWKGV--EQVRRM Pyrococcus2 SKSLGN------------------------------------------------------ Methanococcus SKSLGNVVNPDDVVE---------KYGADLLRFYLLSANKVWEDLRFVWSEM--DDVLSL METHANOBACTERIUM SKSLGNVVEPEDVIE---------KYGADVLRFYLLWANKPWEDLKFVWDEL--KNVNKM Methanobacterium2 SKSLGNVVEPEDVIE---------KYGADVLRFYLLWANKPWEDLKFVWDEL--KNVNKM Methanobacterium3 SKSLGNVVEPEDVIE---------KYGADVLRFYLLWENKPWEDLKFVWDEL--RNVNKM Archaeoglobus SKSLGNVVEPEEVVG---------QIGVDGFRLYVLYS-APWEDLRFSWEEA--RNINRM Sulfolobus HKSSGNYVEPSQVVS---------KYGQRYVKIMVTLEIPHGKMSKSHGN---------- Arabidopsis AKKLRNYPPPLEVID---------EYGADAVRLYLINSPVVRAEPLRFKKEG--VLGVVK Tetrahymena SKSKKNYDDPLLIAS---------KYSVDAIRLYMINSPLVRAEEMSFKSEG--VFAVKK Homosapiens SKRKKNYPDPVSIIQ---------KYGADALRLYLINSPVVRAENLRFKEEG--VRDVLK Homosapiens2 SKRKKNYPDPVSIIQ---------KYGADALRLYLINSPVVRAENLRFKEEG--VRDVLK Celegans SKSKKNYPDPMLIVN---------KYGADALRLYLINSPVVRGENLRFREEG--VRDLLK Saccharomyces SKSLKNYPDPSIVLN---------KYGADALRLYLINSPVLKAESLKFKEEG--VKEVVS Saccharomyces2 SKSLKNYPDPSIVLN---------KYGADALRLYLINSPVLKAESLKFKEEG--VKEVVS Schizosaccharomyces SKRLKNYPEPNLIIE---------KYGSDALRLYLINSPVVRAEILKFKEDG--VREVVT Nosema SKRLKNYPDPMDVIN---------RYSADSLRLYLISSPVVMAENMCFSEEG--VGEVLK Chlamydia SKRLNNYPSPKMIMD---------AYGADALRLYLLNSVVVKAEDLRFSDKG--VESVLK Chlamydophila SKRLNNYPSPKYVLD---------TYGADALRLYLLHSVVVKAEDLRFSDKG--IEGVLK Borrelia SKSFKNYTDPMQVIN---------TFGADALRLYLIMSPVVKADDLKYSDNG--VRDVLK Treponema SKALRNYADPNEVMD---------RYGADALRLFLVRSAVVRADDLKYSDEG--VKDILK Mycobacterium SKSLRNYPDVTEVFD---------RDGSDAMRWFLMASPILRGGNLIVTEQG--IRDGVR Mycobacterium2 SKSLRNYPDVTEIFD---------RDGSDAMRWFLMASPILRGGNLIITEPG--IREGMR Rickettsia SKRLNNYADPLELFD---------KYGSDALRVTMLSSNVVKGQELLIDKDGKMVFDTLR Staphylococcus SKSKGNVINPTELIN---------KYGADSLRWALISDSAPWN-NKRFSENI--VAQTKS Thermus SKSKGNVVDPWDIIR---------KFGADALRWYIYVSAPPEA-DRRFGPNL--VRETVR Helicobacter SKSKGNVVSLDKLLK---------THGSDVVRLWVAFN--DYQNDLRVSQTF---FTQTE Helicobacter2 SKSKGNVVSLDNLLK---------KHGSDVVRLWVAFN--DYQNDLRVSQTF---FIQTE Campylobacter SKSKGNVIAPEYVAK---------TYGVEILRLWILLS--DYSSDLKISDNI---LKQVG Haemophilus SKSIGNIVTPQEVMD---------KFGGDILRLWVAST--DYTGEMTVSDEI---LKRAA Ecoli SKSIGNTVSPQDVMN---------KLGADILRLWVAST--DYTGEMAVSDEI---LKRAA Pseudomonas SKSLKNVIEPKKIND---------TLGADIMRLWVAST--DYSGEIAVSDQI---LARSA Streptococcus SKSLGNTIAPSDVEK---------QFGAEILRLWVTSV--DSSNDVRISMDI---LSQVS Bacillus SKSIGNVVVPAKVMK---------QLGADILRLWVSSV--DYQADVRVSDAI---LKQVA Fervidobacterium SKSLGNVIDPMEIVN---------KYGADILRLWVAST--DFFDNIRVGKNI---IEQQV Thermotoga SKSLGNVVDPMEVVE---------KYGAEILRLWLASS--DYFNDIKISMRI---VEQQT Aquifex SKSLGNVISPQEVVK---------EFGADILRLWVVSE--DYTEDVKLGKNL---LKKIA Ciona SKSIGNVVDPMVLTNGGKNPQRDPAYGADALRWWVAES--NVHQDVHISTTI---IKSAA Synechocystis SKSLGNVVDPYQIINGGKNQKQEPAYGADVLRLWVASV--DYANDVPIGQGI---LKQLV Mycoplasma SKSLGNVVDPLKLCD---------QYGADILRLWVTNV--DWQVDNRIGDNI---IKQIV Deinococcus SKSKGNVVAPLPLFD---------QYGADSVRWYMFMAS-DPGDQKRFSER--------- * * Pyrococcus LNIL---WNVYVLSATYMSLDNFDPRNVKVEELAF-----------REEDKWILSRVNSL Pyrococcus2 ------------------------------------------------------------ Methanococcus FNTL---WNAYMFAVNYMVLDNFKPDEKYFEYLK-------------DEDRWIVSRINSV METHANOBACTERIUM FNIL---WNVYVFATTYMSLDRFQPGDHELEDLHF-----------RDEDRWIISRVNSV Methanobacterium2 FNIL---WNVYVFATTYMSLDRFQPGDHELEDLHF-----------RDEDRWIISRVNSV Methanobacterium3 FNIL---WNVYVFATTYMSLDRFQPGDHSAEDLSF-----------RDEDRWILSRINSV Archaeoglobus LNVV---WNAVRFAHTYMSLDNYSFG----EKGEL-----------KIEDRWILSRLESF Sulfolobus ------------------------------------------------------------ Arabidopsis DVFLPW-YNAYRFLVQNAKRLETEGGVPFVPTDL---ATIQS---ANILDQWIHSATQSL Tetrahymena DIFLPW-YNAYKFLIQSITRWELATGKDYMFNEQ---LSVDTTKLTNPTDRWIIISCQNL Homosapiens DVLLPW-YNAYRFLIQNVLRLQKEEEIEFLYNEN---TVRES---PNITDRWILSFMQSL Homosapiens2 DVLLPW-YNAYRFLIQNVLRLQKEEEIEFLYNEN---TVRES---PNITDRWILSFMQSL Celegans DVFLPW-FNAYRFFVQNVQAY--EHETGNVFDMN---VHVAS---ENVMDRWIESFTNSL Saccharomyces KVLLPW-WNSFKFLDGQIALLKKMSNIDFQYDDS---VK--S---DNVMDRWILASMQSL Saccharomyces2 KVLLPW-WNSFKFLDGQIALLKKMSNIDFQYDDS---VK--S---DNVMAEMILASMQSL Schizosaccharomyces RVLIPW-WNSYKFFEAQAALYKKVTGKDFVFDDA---ATL-S---SNVMDRWILARCQSL Nosema TLLIPW-YNCIYFYSECPNAG--D-------QEQ---TR---------MDDWILNTLNTF Chlamydia QVLLPL-SNALAFYKTYAELY----GFDPKETDN---IELA------EIDRWILSSLYSL Chlamydophila QILLPL-TNVLSFFNTYAELY----GFDPKSQD----IEPAY----TEIDQWILSNLYSV Borrelia NIIIPI-WNAYSFFTTYAIIDKFKPP------------KNLSLAKNNNLDKWIISELESL Treponema TVIIPL-WNSYSFYVTYANIDGIDPPVCAKVDGMGQAVTRLATHLNNPLDRWILSLTEKL Mycobacterium QVLLPL-WNTYSFLALYA------PKVGTWRVDS-----------VHVLDRYILAKLAVL Mycobacterium2 QVLLPL-WNAYSFLALYA------PKIGTWHTDV-----------SHVLDRYILAKLAVL Rickettsia LFIKPI-WNAYHFFTIYANAD---SLKGTLNFAS-----------QNVLDVYILSKLKIA Staphylococcus KFIDTL-DNIYKFYNMYNKIDHYNPNNE-ITKSR------------NTLDNWALSRLNTL Thermus DYFLTL-WNVYSFFVTYANLDRPDLKNPPPPEKR------------PEMDRWLLARMQDL Helicobacter QHYKKF-RNTLKFLLANFSD--MDLKNLERPH------------NFSPLDHFMLETLETI Helicobacter2 QHYKKF-RNTLKFLLANFSD--MDLKNLERPH------------DFSPLDHFILEALETI Campylobacter EQYRKI-RNTIRFLLANTN----DLKDLEVK-------------EFSFIDKWILSRASKV Haemophilus DSYRRI-RNTARFLLANLNG--FDPKRDLVKPE-----------KMISLDRWAVACALDA Ecoli DTYRRI-RNTARFLLANLNG--FDPAKDMVKRR-----------EMVVLDRWAVVVR-KR Pseudomonas DAYRRI-RNTARFMLSNLTG--FNPASDLLPAE-----------DMLALDRWAVDRTLLL Streptococcus ETYRKI-RNTLRFLIANTSD--FNPAQDTVAYD-----------ELRSVDKYMTIRFNQL Bacillus EVYRKI-RNTFRFLHGNLFD--FDPKTNAVAVE-----------DLREVDQYMLIKLNKL Fervidobacterium EVYRKL-RNTLRYLLSNLYD--FT-EADLLPYE-----------KLLPLDKWALGRLQKF Thermotoga EVYRKI-RNTFRFLLGNLED--FDPELDRVPHE-----------KLLTIDRWALGRLQEI Aquifex DDYRKI-RNTLRFIIGNLYD--FNPRTNALPFE-----------KLHHFDRWIISELQNL Ciona ESVQKI-RNSVRFMLGNLNE--FD-KMKIVPTP-----------AMLILD------LRYR Synechocystis DIRNKI-RNTARFLLGNLHD--FNPETDAVAYE-----------DLPELDRYMLHRMTEV Mycoplasma EQYRRIRNSLLRFILGNLNHFNFG-EMKDYR--------------FALEDKIVIHKTNAL Deinococcus ------------------------------------------------------------ Pyrococcus IREVENGIETFYLTK-ATRALYNFVVEDLSRWYVRLIRKRLWVEGDDP-DKLAAYYTLWK Pyrococcus2 ------------------------------------------------------------ Methanococcus AKIAIENLEVPYFHT-YTWTLKDFILNDLSRWYIRLIRDRTWKEKDDA-DKLAAYQTLYY METHANOBACTERIUM ALKVTEALDNLHFHR-ATREIHDFIVEDLSRWYIRLIRSRTWIERDDP-DKLAAYHSLYT Methanobacterium2 ALKVTEALDNLHFHR-ATREIHDFIVEDLSRWYIRLIRSRTWIERDDP-DKLAAYHSLYT Methanobacterium3 ALKVTEAIENLHFHR-ATREIHDFIVEDLSRWYIRLIRSRTWIERDDP-DKLAAYHTLYT Archaeoglobus IKEANEAMEGYQVHR-VVRAFFDFFVEDFSRWYIQIIRPRVWEERDSP-SKLAAYYTMFR Sulfolobus ------------------------------------------------------------ Arabidopsis VRFVREEMDAYRLYT-VVPRLLKFL-DNLTNIYVRFNRKRLKGRTGED-DCHTALSTLFN Tetrahymena INYVRIEMEKYHLYN-VVPRLIHFL-ENLTNWYIRLNRNRLKGDYGLE-EQETSLNVLFN Homosapiens IGFFETEMAAYRLYT-VVPRLVKFV-DILTNWYVRMNRRRLKGENGME-DCVMALETLFS Homosapiens2 IGFFETEMAAYRLYT-VVPRLVKFV-DILTNWYVRMNRRRLKGENGME-DCVMALETLFS Celegans VAFVRKEMDSYRLYA-VVGPLTKFF-DTLTNIYIRLNRKRVKGDNGLH-EQHHALAALGR Saccharomyces VQFIHEEMGQYKLYT-VVPKLLNFI-DELTNWYIRFNRRRLKGENGVE-DCLKALNSLFD Saccharomyces2 VQVIHEEMGQYKLYT-VVPKLLNFI-DELTNWYIRFNRRRLKGENVVE-DCLKALNSLFD Schizosaccharomyces IGFVDEEMKQYRLYT-VVPQLLGLI-EEMTNWYIRFNRRRLKGEDGEI-ETINALNVLFE Nosema GNKVKRDMSKYMLQG-VMGYATSFV-NDLSNWYIRLN----------------------- Chlamydia VGKTRESMSQYDLHA-AVNPFVDFI-EDLTNWYIRRSRRRFWDAEDSA-DRRAAFSTLYE Chlamydophila VGKVRESMSQYHLNF-AVEPFVTFI-DDLTNWYIRRCRRRFWEAEDTP-DRRAAFSTLYE Borrelia KKILNTEIDKYNLTK-SIESLLEFI-DKLNNWYIRRSRRRFWKSENDK-DKNDAYETLYY Treponema VQDIACALDAYDVSK-VADPIVSYV-DQLNNWYIRRSRRRFWKSINDE-DKRCAYNTLYC Mycobacterium RDDLSESMEVYDIPG-ACEHLRQFT-EALTNWYVRRSRSRFWAEDAD------AIDTLHT Mycobacterium2 RDDLSQAMEVCDISG-ACEQLRQFT-EPLTNWYLRRSRARFWDEDVD------AIDTLHT Rickettsia VNKIEESLDNFDTQT-AYHAVSEFF-EVLNNWYIRRSRARFWKNEKDT-DKQNAYNTLYS Staphylococcus IKESNIYVNNYDFTS-AARLINEYT-NTISNWYIGDSRGRFWEQGISN-DKKDAYNTLYE Thermus IQRVTEALEAYDPTT-SARALRDFVVEDLSQWYVRRNRRRFWKNEDAL-DREAAYATLYE Helicobacter SAGVNSAFEEHDFVK-GLNILMAFVTNELSGIYLDACKDSLYCDSKNNEKRQAIQMVLLA Helicobacter2 SAGVNSAFEEHDLVK-GLNILMAFVTNELSGIYLDACKDSLYCDSKNNEKRQAIQMVLLA Campylobacter FKASKEAFFAYEFAK-GFSLLLNFLSADLSGIYLDISKDRLYCDSENAQRRKSAQVAMAL Haemophilus QNEIKDAYDNYQFHT-VVQRLMRFCSVEMGSFYLDIIKDRQYTTKADSLARRSCQTALWH Ecoli HRKTSSRRTKHTISTKWYKRLMRFCSVEMGSFYLDIIKDRQYYAKGHSVARRSCQTALYH Pseudomonas QRELQEHYGEYRFWN-VYSKIHNFCVQELGGFYLDIIKDRQYTTGANSKARRSAQTALYH Streptococcus VKTIRDAYADFEFLT-IYKALVNFINVDLSAFYLDFAKDVVYIEGAKSLERRQMQTVFYD Bacillus IDKVKKAYDEYEFAV-VYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSMQTVSYE Fervidobacterium IEQITQYYEGFEYSK-VYNATVKYCTTELSAVYLDILKDRLYVEAKDSIYRRSAQTALHY Thermotoga IKRATEYYDSYEFSK-VYNLVVKYCTTELSSLYLDVVKDRLYVEAKDSIYRRSAQTVMHE Aquifex LKKVHENYEKFLFYR-VHNHIKNFVITTLSAIYLDVLKDRLYVYAPASWERRSAQTALWH Ciona FEDKKLWYVTSMNYP-LNLSV--------------------------------------- Synechocystis FTEVTEAYESFQFFK-FFQTVQNFCVVDLSNFYLDIAKDRLYISAPNAPRRRSCQTILQL Mycoplasma VQELHQWLKQYNFLN-CLKAINKFV-LWLSGWYFEIIKDTLYCDAKTNPNRVAKQAVLNY Deinococcus ------------------------------------------------------------ Pyrococcus VFDVLLRLMAPFTPYITEEIYQNLMRPF-----------------------IGIESVHML Pyrococcus2 ------------------------------------------------------------ Methanococcus VLLKLATILAPVAPHTAEAIYQNLKT-------------------------EDMEESIFM METHANOBACTERIUM ALKTLIVTLSPIAPHVCEDIYQNLVRGAEP---------------------DSPESIHML Methanobacterium2 ALKTLIVTLSPIAPHVCEDIYQNLVRGAEP---------------------DSPESIHML Methanobacterium3 VLKTLIVTLSPMAPHVCEDIYQNLVRGAEP---------------------DSPESIHML Archaeoglobus VIDRSLRAIAPFAPLIAEWFYQHVVKEFR----------------------EGEESIFME Sulfolobus ------------------------------------------------------------ Arabidopsis VLLTSCKVMAPFTPFFTETLYQNLRKAC-------------------KGS---EESVHYC Tetrahymena VILNSTILMSPLVPFITESFYQNLRKVIP------------------KGSSYLEESIHFL Homosapiens VLLSLCRLIAPYTPFLTELMYQNLKVLIDP----------------VSVQDKDTLSIHYL Homosapiens2 VLLSLCRLMAPYTPFLTELMYQNLKVLIDP----------------VSVQDKDTLSIHYL Celegans VLILIVRLMAPFTPFFCEYIWLNLKKVIG----------------------STEESVHFL Saccharomyces ALFTFVRAMAPFTPFLSESIYLRLKEYIPEAV--------------LAKYGKDGRSVHFL Saccharomyces2 ALFTFVRAMAPFTPFLSESIYLRLKEYIPEAV--------------LAKYGKDGRSVHFL Schizosaccharomyces VLFTLVRIMGPFTPFITENIYQHLRNYMP-----------------IDKNEISLRSVHFL Nosema ------------------------------------------------------------ Chlamydia VLVVFSKVIAPFIPFIAEDMYQQLRGETD------------------------PESVHLC Chlamydophila VLTVFCKVIAPFVPFLAEDIYQKLKLEKE------------------------PESVHLC Borrelia AIKTLMILLAPFIPFITEEIYQNLKTDED------------------------KQSIHLN Treponema VLKRCVLAIAPVVPFITESIWQNIRAADD------------------------VQSVHLA Mycobacterium VLEVTTRLAAPLLPLITEIIWRGLTR---------------------------ERSVHLT Mycobacterium2 VLEVTARLAAPLLPLITEIIWRSVTG---------------------------GRSVHLT Rickettsia CLKIMTIAMSALIPMISETIYQGLHNTAITQLNCLLSEGKHIVQNPMSDTQDYNTSVHLC Staphylococcus ILTTLSRLVAPFVPFISEKIHYNLTG----------------------------KSVHLQ Thermus ALVLVATLAAPFTPFLAEVLWQNLVRSVRL---------------------EAKESVHLA Helicobacter TASKLCYFLAPILTHTIEEVLEHSQALRIF---------------------LQAKDVFDL Helicobacter2 VASQLCYFLAPILTHTIEEVLEHSQVLRAF---------------------LQAKDVFDL Campylobacter IAKELLNLLASNLSYSVDEALEHANVL-IK---------------------GDAKDVFDL Haemophilus IAEALVRWMAPILSFTADEIWQHLPQT-ES---------------------ARAEFVFTE Ecoli IAEALVRWMAPILSFTADEVWGYLP----G---------------------EREKYVFTG Pseudomonas ISEALVRWIAPILAFTADELWEYLP----G---------------------ERNESVMLN Streptococcus ILVKITKLLTPILPHTAEEIWSYLE----F---------------------ETEDFVQLS Bacillus TLLALVKLSAPILPHTADELWSHLT----F---------------------VEEQSVQLT Fervidobacterium ILEALIKILAPIIPFTAEEAYQESHLK-------------------------RYESVHLE Thermotoga ILISLMKILAPIMTFTMEEVYSHLHEK-D----------------------RKYKTVQAE Aquifex LLIALTTSTAPYLSFTAEELWEHVGKL-DP---------------------SLPESVFLY Ciona ------------------------------------------------------------ Synechocystis ALENLTKAIAPVLCHLAEDIWQFLP---YE---------------------KPTESVFQS Mycoplasma IFTQLIGFLNIFIPHTAEDAWQNYLLP------------------------KKPVSVNLF Deinococcus ------------------------------------------------------------ Pyrococcus DWPKVDESAVDEDLEKEMEFIRRIVEAGSAARQKARIKLRYPVRKIIIETQDETVKKAVE Pyrococcus2 ------------------------------------------------------------ Methanococcus NKIEVDEEFIDEELERDMAIVRDVVDAIYRGRDRIKYTLRYPLKEITIAGGEE-VKKAVE METHANOBACTERIUM DWMVSE-DAVDGKLEAEMDIVREIIEACARARDTARYKLRWPVREIVVVSEDDKVLEAAE Methanobacterium2 DWMVSE-DAVDGKLEAEMDIVREIIEACARARDTARYKLRWPVREIVVVSEDDKVLEAAE Methanobacterium3 DWILDE-GAVDSQLEADMDIVREIIEACARARDTARYKLRWPVREMVVVSEDEGVLKAAE Archaeoglobus EYSTAEVEMIDGELEAAMKVAKEIVEAAANARNKAKRKLRWPLRELVIESGSEKVRKAVE Sulfolobus ------------------------------------------------------------ Arabidopsis SIP-PREGMEGERIELSVTRMMKIIDLARNIRERNKLPLKTPLKEMIVVHPDADFLNDIT Tetrahymena RIPTPKQELLDEKIERNFERMQNIINFARTLREKRKVSLKQPIMSLTVINQDQEFHDSLK Homosapiens MLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALKDIK Homosapiens2 MLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALKDIK Celegans MLPKPDESLIDETVERRVEVMRNVIDLVRLVRDREGLAVKYPLKEMIVINRDSQFLEDVK Saccharomyces SYPVVKKEYFDEAIETAVSRMQSVIDLGRNIREKKTISLKTPLKTLVILHSDESYLKDVE Saccharomyces2 SYPVVKKEYFDEAIETAVSRMQSVIDLGRNIREKKTISLKTPLKTLVILHSDESYLKDVE Schizosaccharomyces PFPTYKSELDDETVLRRVKRMQTIIELARYVREQNNISLKTPLKTLIVILTNEEYLEDAK Nosema ------------------------------------------------------------ Chlamydia DFPHVVLEKILPDLERKMQDIREIVALGHSLRKEHKLKVRQPLQNVYIVGSK-ERKEALA Chlamydophila DFPQVEMDKILPDLEKRMHDIREIVGLGHSLRKEHKLKVRQPLANFYVVGSK-DRLSLLK Borrelia DYPKANENFINKTIEEKINLARKITSMARSLRSLHNIKIRMPISTIYIVTKNQNEQNMLM Treponema DYPVCTPMVRDDALEFKMETVQRVVSMARAIRAQCNLKVRQPLKAMQVITRNPMERSALL Mycobacterium DWPAPDLLPSDADLVAAMDQVRDVCSAASSLRKAKKLRVRLPLPKLIVAVEN---PQLLR Mycobacterium2 DWPQANQLPADPDLVAVMDQVRQVCSAASSLRKAKKLRVRLPLPKLVVAVYN---SQRLK Rickettsia NYPTLSDFEINYELVSTMDNVLDICSNSLFIRSTENIRVRQPLACITIISKH---NNNLK Staphylococcus DYPQYKESFINQALEDEMHTVIKIVELSRQARKNADLKIKQPLSKMVIKPNSQLNLSFLP Thermus DWPEADPALADEALVAQMRAVLKVVDLARAARAKSGV----------------------- Helicobacter KDISVSEKLHLKEFKKPEN-----FEAVLALRSAFNEELDRLKKEG-VIKNSLECAIEVK Helicobacter2 KGISVLEKLHLKEFKKPEN-----FEAVLALRSAFNEELDRLKKEG-VVKNSLECAIEVK Campylobacter ---SLTQDFDY-DFGIDDT-----F--LMSVREKFFEQIDILKKDK-IIKSTLELNLNIS Haemophilus EFYQGLFGLGEDEKLDDAY-----WQQLIKVRSEVNRVLEISRNNK-EIGGGLEAEVTVY Ecoli EWYEGLFGLADSEAMNDAF-----WDELLKVRGEVNKVIEQARADK-KVGGSLEAAVTLY Pseudomonas TWYEGLTELPADFELGREY-----WEGVMAVKVAVNKELEVQRAAK-AVGGNLQAEVTLF Streptococcus ELPEVQT-FANQEEILDT------WAAFMDFRGQAQKALEEARNAK-VIGKSLEAHLTVY Bacillus DMPETIT-VPNSEATEEK------FDRFMALRDDVLKALETARNEK-IIGKSLEANLKLY Fervidobacterium YWPEVRKEFIDEALLEEF-------DHLLLIRDDVLKALENARASD-IIGHSLDAHVIIE Thermotoga YWPEYREEFIDRKLMEDF-------EKLLSIREDVLKALEEKRQQD-VIGHSLDAEVVLV Aquifex EMPKPDENLKDEEVLKDY-------EILLKVRDEVMRALEVARKEKGIIKHPYEAKVYIR Ciona ------------------------------------------------------------ Synechocystis GWVNLDAQWQQPQLAQKW-------VSLRQLRDGINQLLEQARRDK-VIGSSLEAKLIIV Mycoplasma AGPAMFKVANVKGLDRLH-------ESFSAIKDRAYAAIEQARQNG-VITKNNQVVLTLG Deinococcus ------------------------------------------------------------ Pyrococcus RLN-YILRDQLNAK-EVVIGKVER---ELTVKPNFAKVGPEFKGDSRLVAKWINEHGLEL Pyrococcus2 ------------------------------------------------------------ Methanococcus RFE-YIIKEQGNVK-NIKFGEVEGS--KYIIKPNYRELGKRYRSEVPKVVEALNKADAKE METHANOBACTERIUM SLK-GVIAEQANAKSIRTSTEFPDM--RIIAKPNPATLGPKLRQDMPPVMRKLEEADGAE Methanobacterium2 SLK-GVIAEQANAKSIRTSTEFPDM--RIIAKPNPATLGPKLRQDMPPVMRKLEEADGAE Methanobacterium3 SLK-NVIAEQANAKSIKTSTEFPDM--KIIARPNPATLGPRLRQDIPLVMRELEGADGSA Archaeoglobus MLE-ETILSQCNVKQVRVVDSF-EK--EIEIKPNYKYIGPLLKEKAGEFAKYVASLK--E Sulfolobus ------------------------------------------------------------ Arabidopsis GVLREYVLEELNVRSLVPCNDTLKY-ASLKAEPDFSVLGKRLGKSMGLVAKEVK-EMSQK Tetrahymena DYI-QYIEDEINTPSILHEINTANY-VDLKAIPNHKLLGQKLGKEYNKDLKAAAGNLSAK Homosapiens SLE-KYIIEELNVRKVTLSTDKNKYGIRLRAEPDHMVLGKRLKGAFKAVMTSIK-QLSSE Homosapiens2 SLE-KYIIEELNVRKVTLSTDKNKYGIRLRAEPDHMVLGKRLKGAFKAVMTSIK-QLSSE Celegans SLE-SYILLELNVRKLTVSQDKQKYGITLKAEPNFKILGARLKGEQKKVADYLKNQITES Saccharomyces ALK-NYIIEELNVRDVVITSDEAKYGVEYKAVADWPVLGKKLKKDAKKVKDALP-SVTSE Saccharomyces2 ALK-NYIIEELNVRDVVITSDEAKYGVEYKAVADWPVLGKKLKKDAKKVKDALP-SVTSE Schizosaccharomyces LLE-RYIAEELNVREVVFTSNEEKYGVVYSVQADWPVLGKKLRKDMARVKKALP-NVTSE Nosema ------------------------------------------------------------ Chlamydia QVG-SLIGEELNVKDVHFCSETPEY-VTTLIKPNFRTLGKKVGNRLPEIQRALA-GLPQE Chlamydophila TFE-GLIAEELNVKNVIFYEEAPSF-IYTTVKPNFRMLGKKVGSKMKEVQKALS-ELPNN Borrelia EMQ-EIILDEINAKEMKIKANEEEL-ITYKAKANFKELGKKLGKDMKAVSTEIS-KLKNE Treponema EME-EDVLDELNVKELVFHEKEDEI-VEYRAKANFRVLGKELGSKTKRAALSIE-RLSSA Mycobacterium PFV-DLIGDELNVKQVELTDAIDTY-GRFELTVNARVAGPRLGKDVQAAIKAVK------ Mycobacterium2 PYI-DLIGDELNVKQIELTDAIDTY-GRFEFTVNARVAGPRLGRDVQAAIKVVK------ Rickettsia DFE-DLIKDEINVKTVIYRDDLENY-ARKKLSLNFAILGKRLPHKMKAIIDAAK------ Staphylococcus NYY-SIIKDELNIKNIELTDNINDY-ITYELKLNFSSVGPKLGNKTKNIQTLID-SLSEY Thermus ------------------------------------------------------------ Helicobacter E--------------------------------KALD-ENLVEELLMVSFVG-------I Helicobacter2 E--------------------------------KALC-ENLVEELLMVSFVG-------V Campylobacter F--------------------------------NKFP-NEELADWFMVSQISNE-NEE-I Haemophilus A--------------------------NDEYRALLAQLGNELRFVLITSKVDVK-SLSEK Ecoli A--------------------------EPELSAKLTALGDELRFVLLTSGATVA-DYNDA Pseudomonas A--------------------------EDGLTADLAKLSNELRFVLITSTASLA-PFTQA Streptococcus P--------------------------NEVVKTLLEAVNSNVAQLLIVSELTIA-EEP-A Bacillus P--------------------------NKENKELLASIKENLSQLFIVSELTIS-EENEA Fervidobacterium AK-------------------------NEELKNLLRKYESLLEEFFIVSKVTLS-EN--- Thermotoga PK-------------------------NDTIKALLEKYRDILEELFIVSKVSLS-DA--- Aquifex G--------------------------DESVESLLKKYEDYLNFFFTVSQVELR-EGG-- Ciona ------------------------------------------------------------ Synechocystis DPRTAESGTDEKQGENFVHWFYGWLENFNEPTFDPNDRKISLRNIFLTSQVEFI-KSAEI Mycoplasma VDS------------------------TSAIDPTSCKTFSSLAKRKPGKYNEWPQRN--- Deinococcus ------------------------------------------------------------ Pyrococcus YEKGEVDVE---IEGKKFH-LT--REHIIVEEKLP---------------------DFLV Pyrococcus2 ------------------------------------------------------------ Methanococcus LMERLKEGA---VILDGYE-IK--PEYVEIRLEIP---------------------EHIA METHANOBACTERIUM VKAALESEGSFRVDLDGRI-IVLEPDDIIFETELP---------------------ENIV Methanobacterium2 VKAALESEGSFRVDLDGRI-IVLEPDDIIFETELP---------------------ENIV Methanobacterium3 VKAALDSDGEFTVETDGKK-FKLTSEDIVFETELP---------------------ENIV Archaeoglobus IPEKLVFDG---VELDPK-------QAIVVDYRLP---------------------EGYE Sulfolobus ------------------------------------------------------------ Arabidopsis DILAFEEAGEVTIAN-----HLLKETDIKVSHAMMFSCEIALRIVRVFKRPDDLKENEID Tetrahymena DIETLKTTGSIDLVG-----KKLLLEDFTITQN--------------YKK--EYSSGDLE Homosapiens ELEQFQKTGTIVVEG-----HELHDEDIRLMYTFDQ---------------ATGGTAQFE Homosapiens2 ELEQFQKTGTIVVEG-----HELHDEDIRLMYTFDQ---------------ATGGTAQFE Celegans ELEKFLLEGKLTVLG-----HELSSEEVAVSYAAGS---------------DQG--HGYK Saccharomyces QVREYLESGKLEVAG-----IELVKGDLNAIRGLP----------------ESAVQAGQE Saccharomyces2 QVREYLESGKLEVAG-----IELVKGDLNAIRGLP----------------ESAVQAGQE Schizosaccharomyces EVKEFQKNKKMVLDG-----IELVEGDLQIIRSV------------------EVKNEFLK Nosema ------------------------------------------------------------ Chlamydia QIQAFMHKGQMVVSLGEET-ISLDKEDITVSWAS------------------AEG---FV Chlamydophila AIDKLIQEETWVLTIDDRE-IALDGDDVVICRHT------------------DPG---YI Borrelia DIIKIINGTSYEIKVANAK-HYLSLNDIILERE------------------EKEN---LK Treponema EIQEILEGTTLYLDVDGDR-LELTEEKILVQRI------------------ERES---LK Mycobacterium AGDGVINPDGTLLAGP----AVLTPDEYNSRLVAAD-------------------PESTA Mycobacterium2 AGEGVANPDGTLTAGP----VVLQPDEYSSRLVAAN-------------------PEFTA Rickettsia KGEWEATTLGLAICG-----EILNSDEYTLILEPYSH------------------IKGTA Staphylococcus DKKSLIESNNFKSLSS--D-AELTKDDFIIKTLP---------------------KDSYQ Thermus ------------------------------------------------------------ Helicobacter AKEKLSET-----------------PAFTLFKAP-------------------------- Helicobacter2 AKEKLSET-----------------PAFTLFKAP-------------------------- Campylobacter LAEFEVEN-----------------EKFKITKAS-------------------------- Haemophilus PADLADSE-LEG-------------IAVSVTRSN-------------------------- Ecoli PADAQQSEVLKG-------------LKVALSKAE-------------------------- Pseudomonas PADAVATE-VPG-------------LKLKVVKSA-------------------------- Streptococcus PEAALSFE--D--------------VAFTVERAA-------------------------- Bacillus PNDAQSFA--T--------------GKIAVEKAE-------------------------- Fervidobacterium ISGLNGQ----F-------------ANVLVQRAE-------------------------- Thermotoga SGELKGE----L-------------VEVTVKHAE-------------------------- Aquifex EVQIEGEE--LP-------------VKVGVNKAE-------------------------- Ciona ------------------------------------------------------------ Synechocystis EPSFTYEETVVINLERHDNNIRTKPIKIIVTKAD-------------------------- Mycoplasma ------------------------------------------------------------ Deinococcus ------------------------------------------------------------ Pyrococcus AEDFEGGRVYVDKTLTRELLAEGLAREFVRRIQEMRKRLDLDVNDRIVVTIETTDDN--- Pyrococcus2 ------------------------------------------------------------ Methanococcus GVEFSKGTVFINTEITDDLIKEGLMREVIRRIQAMRKDMDLDIEEKIKIKVEG--ID--- METHANOBACTERIUM NAQFEGGSVFVDTELTPEIMSEAMARELVRRIQDMRKDLDLDVEARIEVSVKCSPEF--- Methanobacterium2 NAQFEGGSVFVDTELTPEIMSEAMARELVRRIQDMRKDLDLDVEARIEVSVKCSPEF--- Methanobacterium3 SAQFDGGSVFIDTELTPEIMSEAMARELVRRIQDMRKDLDLDVEASIEVSVKCSEEF--- Archaeoglobus YAEFSGGVVYIYKELDDELVREAFAREVIRRIQEMRKELDLDVEEFIETTVEMD------ Sulfolobus ------------------------------------------------------------ Arabidopsis SAGDGDVLVILDLRADDSLVEAGFAREIVNRIQKLRKKSGLEPTDFVEVYFQSLDEDE-- Tetrahymena LGGEGEVILLLNLAQDEKLKSKGLVREFTSNVQKTKKKTGLKVDDNIVIYYDVTKAPK-- Homosapiens AHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYKAKSEGT-- Homosapiens2 AHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYKAKSEGT-- Celegans THSDAKTIVMIDTTEDESLIEEGLCREVTNRVQRLRKQAKLVSTDTAHVHIVVSPADS-- Saccharomyces TRTDQDVLIIMDTNIYSELKSEGLARELVNRIQKLRKKCGLEATDDVLVEYELVKDTI-- Saccharomyces2 TRTDQDVLIIMDTNIYSELKSEGLARELVNRIQKLRKKCGLEATDDVLVEYELVKDTI-- Schizosaccharomyces SNTDGICIVLLDIEIDAQLQAEGLAREVINRVQRLRKKSNLQVTDDVRMTYKIKNDTI-- Nosema ------------------------------------------------------------ Chlamydia ARSSASFVAVLDCQLTEPLIMEGIARELVNKINTMRRNRKLHVSDRIAIRLHAPVIVQ-- Chlamydophila ARSSALFSVILDCQLREPLIVEGIARELVNKINTMRRNQQLHVSDRIALRIKTTEAVH-- Borrelia VINEESITIGIDSLITKELYLEGLTREFVRQIQNLRKEKNFDVSDRINLYIENNE----T Treponema AINEGTLTVALDTTLTEDLLLEGAIRDLVRGVQNLRKERGFSLVDRICLRVFSSDQDIVC Mycobacterium ALPDGAGLVVLDGTVTAELEAEGWAKDRIRELQELRKSTGLDVSDRIRVVMSVPAE---- Mycobacterium2 ELPDGSGLVVLDDTVTPELEAEGWAKDRIRELQELRKLIGLDVSDRIRVLMSVPAE---- Rickettsia NFDNNSSLLILNLELTSELIEEGYARDIVRFIQYARKEADFSITDRILIEIISEFD---- Staphylococcus LSEDNDCVILLDKNLSPELIREGHARELIRLIQQLRKKKNLPINQRIDIYIGVTGE---- Thermus ------------------------------------------------------------ Helicobacter -FYKCPRCWRFK----SELENTP-CKRCEQVLKER------------------------- Helicobacter2 -FYKCPRCWRFK----SELENTP-CKRCEEVLKER------------------------- Campylobacter -LCKCPRCWKLQ----SKDEETP-CLRCEEVLKGIQC----------------------- Haemophilus -AEKCPRCWHYSDEIGVSPEHPTLCARCVENVVGNGEVRYFA------------------ Ecoli -GEKCPRCWHYTQDVGKVAEHAEICGRCVSNVAGDGEKRKFA------------------ Pseudomonas -FPKCARCWHCREDVGVNPEHPEICGRCVDNISGEGEVRHYA------------------ Streptococcus -GEVCDRCRRIDPTTAERSYQAVICDHCASIVEENFADAVAEGFEEK------------- Bacillus -GEMCERSRVISKDVGANPKYPTLSLRNAEIVEKYYQK---------------------- Fervidobacterium -GQKCQRCWKYHPDTGKDLEHPETCPRCSAVLRGERK----------------------- Thermotoga -GEKCQRCWKYTTEISASEDFPGVCPRCLAVLKGERK----------------------- Aquifex -GEKCPRCWIYY---QKEEFVGCVCKRCAKALSEMGIELNAVC----------------- Ciona ------------------------------------------------------------ Synechocystis -GHKCERCWNYSTQVGSFSDDPTICERCNEALQGNF------------------------ Mycoplasma ------------------------------------------------------------ Deinococcus ------------------------------------------------------------ Pyrococcus ---RELLQENLDYIMRETRAIEVRFEEAKGYVVEWP---EVQAKIGIEKVE--------- Pyrococcus2 ------------------------------------------------------------ Methanococcus ---LDEFKEIIEREVRGQFVDEIKADYEKDWEIKTPNGEKYNVKIAIERINK-------- METHANOBACTERIUM ---RELTEPQREFVENEVRASHLSFDYTELEYTKEWKISDENLIISIKPSDKV------- Methanobacterium2 ---RELTEPQREFVENEVRASHLSFDYTELEYTKEWKISDENLIISIKPSDKV------- Methanobacterium3 ---RELTEPQREFIENEVRASTLSFDYSELEYTKEWKISDENLIISIKPAKV-------- Archaeoglobus ---AELVKGWEDYIKSETRSQKLVFGKAEG-YVREWNIEGKKVKIGIKRLRG-------- Sulfolobus ------------------------------------------------------------ Arabidopsis -SVSKQVLVSQEQNIKDSIGSTLLLSSLMPSHAVIIADET-FTPKETSDESVKKVPKLSY Tetrahymena ---LNAAIQSDLEAVQKVLKKPLVPLSEK-NAALKIVENS-LLTFQVDEESV------TI Homosapiens -Y-LNSVIESHTEFIFTTIKAPLKP-YPVSPSDKVLIQEKTQLKGSELEITLTR-GSSLP Homosapiens2 -Y-LNSVIESHTEFIFTTIKAPLKP-YPVSPSDKVLIQEKTQLKGSELEITLTR-GSSLP Celegans -Q-LAKVVAAKLNDIVSATGTPIKLGSPPAAAKAPTATSKSAIKDSEVELWLFAEGDSFD Saccharomyces -D-FEAIVKEHFDMLSKTCRSDIAKYDGS-KTDPIGDEEQ-SINDTIFKLKVFKL----- Saccharomyces2 -D-FEAIVKEHFDMLSKTCRSDIAKYDGS-KTDPIGDEEQ-SINDTIFKLKVFKL----- Schizosaccharomyces -G-LESAVDSNEALFSKVLRRPIEKETGADESNIIASEEQ-DVQGATFLLSLLRL----- Nosema ------------------------------------------------------------ Chlamydia ---E-AFALHKEYICEETLTTSVSVIDYK--EGEEWDINGHA--VSFVLERVER------ Chlamydophila ---R-AFLDYENYICEETLIIAYDFTQDSDFQGENWDINGHATQIEITVSSIDS------ Borrelia L--KEMLNKFEKYIKTETLALNIILNKSK--LEKKINLADDIFTLIGIEKC--------- Treponema A--RKAYDLHRSYIVGETLAAHVQWARVRDGASAVYVKSDAVLWEVSIDKA--------- Mycobacterium ---REDWARTHRDLIAGEIL---ATDFEFADLADGVAIGDG-VRVSIEKT---------- Mycobacterium2 ---RADWARVHRDFIAREIL---ATSFEFGEPADSVAIGDG-VRVSLLKV---------- Rickettsia ---LSKIIDHYGDFIKEQTLGEFAKNFTP-DYVSKVALENNQIQLKVKRL---------- Staphylococcus ---LLESIKTNKNMFKENFVIKNIHLNVIDEYENTIHFNNKEIKISLLY----------- Thermus ------------------------------------------------------------ Helicobacter ------------------------------------------------------------ Helicobacter2 ------------------------------------------------------------ Campylobacter ------------------------------------------------------------ Haemophilus ------------------------------------------------------------ Ecoli ------------------------------------------------------------ Pseudomonas ------------------------------------------------------------ Streptococcus ------------------------------------------------------------ Bacillus ------------------------------------------------------------ Fervidobacterium ------------------------------------------------------------ Thermotoga ------------------------------------------------------------ Aquifex ------------------------------------------------------------ Ciona ------------------------------------------------------------ Synechocystis ------------------------------------------------------------ Mycoplasma ------------------------------------------------------------ Deinococcus ------------------------------------------------------------ Pyrococcus ------------------------------------------------------------ Pyrococcus2 ------------------------------------------------------------ Methanococcus ------------------------------------------------------------ METHANOBACTERIUM ------------------------------------------------------------ Methanobacterium2 ------------------------------------------------------------ Methanobacterium3 ------------------------------------------------------------ Archaeoglobus ------------------------------------------------------------ Sulfolobus ------------------------------------------------------------ Arabidopsis KISLARPALKFNEEAVLALYSGESPSHHNRFSLSILSRFLFNVYIYGSRRCEICNRASNI Tetrahymena EIAYA------------------------------------------------------- Homosapiens GPACAYVNLNICANGSEQGGVLLLENPKGDNRLDLLKLKSVVTSIFGVKNTELAVFH-DE Homosapiens2 GPACAYVNLNICANGSEQGGVLLLENPKGDNRLDLLKLKSVVTSIFGVKNTELAVFH-DE Celegans G-------ITVVD-GSKK--VRVHVKTEKEHLKGYADLLYHVRSALDLWNGKIALKNVDG Saccharomyces ------------------------------------------------------------ Saccharomyces2 ------------------------------------------------------------ Schizosaccharomyces ------------------------------------------------------------ Nosema ------------------------------------------------------------ Chlamydia ------------------------------------------------------------ Chlamydophila ------------------------------------------------------------ Borrelia ------------------------------------------------------------ Treponema ------------------------------------------------------------ Mycobacterium ------------------------------------------------------------ Mycobacterium2 ------------------------------------------------------------ Rickettsia ------------------------------------------------------------ Staphylococcus ------------------------------------------------------------ Thermus ------------------------------------------------------------ Helicobacter ------------------------------------------------------------ Helicobacter2 ------------------------------------------------------------ Campylobacter ------------------------------------------------------------ Haemophilus ------------------------------------------------------------ Ecoli ------------------------------------------------------------ Pseudomonas ------------------------------------------------------------ Streptococcus ------------------------------------------------------------ Bacillus ------------------------------------------------------------ Fervidobacterium ------------------------------------------------------------ Thermotoga ------------------------------------------------------------ Aquifex ------------------------------------------------------------ Ciona ------------------------------------------------------------ Synechocystis ------------------------------------------------------------ Mycoplasma ------------------------------------------------------------ Deinococcus ------------------------------------------------------------ Pyrococcus ------------------------------------------------------------ Pyrococcus2 ------------------------------------------------------------ Methanococcus ------------------------------------------------------------ METHANOBACTERIUM ------------------------------------------------------------ Methanobacterium2 ------------------------------------------------------------ Methanobacterium3 ------------------------------------------------------------ Archaeoglobus ------------------------------------------------------------ Sulfolobus ------------------------------------------------------------ Arabidopsis LVIKGSFEFEVRVPSRRWEGSLVKLLLTQIVYFIILMYLVWQITVSCIENVPVATVVLGE Tetrahymena ------------------------------------------------------------ Homosapiens TEIQNQTDLLSLSGKTLCVTAGSAPSLINSSSTLLCQYINLQLLNAKPQECLMGTVGTLL Homosapiens2 TEIQNQTDLLSLSGKTLCVTAGSAPSLINSSSTLLCQYINLQLLNAKPQECLMGTVGTLL Celegans SAVHPTVDVTSLVGQTLQLVR--------------------------------------- Saccharomyces ------------------------------------------------------------ Saccharomyces2 ------------------------------------------------------------ Schizosaccharomyces ------------------------------------------------------------ Nosema ------------------------------------------------------------ Chlamydia ------------------------------------------------------------ Chlamydophila ------------------------------------------------------------ Borrelia ------------------------------------------------------------ Treponema ------------------------------------------------------------ Mycobacterium ------------------------------------------------------------ Mycobacterium2 ------------------------------------------------------------ Rickettsia ------------------------------------------------------------ Staphylococcus ------------------------------------------------------------ Thermus ------------------------------------------------------------ Helicobacter ------------------------------------------------------------ Helicobacter2 ------------------------------------------------------------ Campylobacter ------------------------------------------------------------ Haemophilus ------------------------------------------------------------ Ecoli ------------------------------------------------------------ Pseudomonas ------------------------------------------------------------ Streptococcus ------------------------------------------------------------ Bacillus ------------------------------------------------------------ Fervidobacterium ------------------------------------------------------------ Thermotoga ------------------------------------------------------------ Aquifex ------------------------------------------------------------ Ciona ------------------------------------------------------------ Synechocystis ------------------------------------------------------------ Mycoplasma ------------------------------------------------------------ Deinococcus ------------------------------------------------------------ Pyrococcus ------------------------------------------------------------ Pyrococcus2 ------------------------------------------------------------ Methanococcus ------------------------------------------------------------ METHANOBACTERIUM ------------------------------------------------------------ Methanobacterium2 ------------------------------------------------------------ Methanobacterium3 ------------------------------------------------------------ Archaeoglobus ------------------------------------------------------------ Sulfolobus ------------------------------------------------------------ Arabidopsis HLHLSVGDDLLSKRNA-------------------------------------------- Tetrahymena ------------------------------------------------------------ Homosapiens LENPLGQNGLTHQGLLYEAAKVFGLRSRKLKLFLNETQTQEITEDIPVKTLNMKTVYVSV Homosapiens2 LENPLGQNGLTHQGLLYEAAKVFGLRSRKLKLFLNETQTQEITEDIPVKTLNMKTVYVSV Celegans ------------------------------------------------------------ Saccharomyces ------------------------------------------------------------ Saccharomyces2 ------------------------------------------------------------ Schizosaccharomyces ------------------------------------------------------------ Nosema ------------------------------------------------------------ Chlamydia ------------------------------------------------------------ Chlamydophila ------------------------------------------------------------ Borrelia ------------------------------------------------------------ Treponema ------------------------------------------------------------ Mycobacterium ------------------------------------------------------------ Mycobacterium2 ------------------------------------------------------------ Rickettsia ------------------------------------------------------------ Staphylococcus ------------------------------------------------------------ Thermus ------------------------------------------------------------ Helicobacter ------------------------------------------------------------ Helicobacter2 ------------------------------------------------------------ Campylobacter ------------------------------------------------------------ Haemophilus ------------------------------------------------------------ Ecoli ------------------------------------------------------------ Pseudomonas ------------------------------------------------------------ Streptococcus ------------------------------------------------------------ Bacillus ------------------------------------------------------------ Fervidobacterium ------------------------------------------------------------ Thermotoga ------------------------------------------------------------ Aquifex ------------------------------------------------------------ Ciona ------------------------------------------------------------ Synechocystis ------------------------------------------------------------ Mycoplasma ------------------------------------------------------------ Deinococcus ------------------------------------------------------------ Pyrococcus ------- Pyrococcus2 ------- Methanococcus ------- METHANOBACTERIUM ------- Methanobacterium2 ------- Methanobacterium3 ------- Archaeoglobus ------- Sulfolobus ------- Arabidopsis ------- Tetrahymena ------- Homosapiens LPTTADF Homosapiens2 LPTTADF Celegans ------- Saccharomyces ------- Saccharomyces2 ------- Schizosaccharomyces ------- Nosema ------- Chlamydia ------- Chlamydophila ------- Borrelia ------- Treponema ------- Mycobacterium ------- Mycobacterium2 ------- Rickettsia ------- Staphylococcus ------- Thermus ------- Helicobacter ------- Helicobacter2 ------- Campylobacter ------- Haemophilus ------- Ecoli ------- Pseudomonas ------- Streptococcus ------- Bacillus ------- Fervidobacterium ------- Thermotoga ------- Aquifex ------- Ciona ------- Synechocystis ------- Mycoplasma ------- Deinococcus -------