CLUSTAL X (1.64b) multiple sequence alignment Methanococcus3 ------------------------------------------------------------ Pyrococcus MTFLIKRETQVDQILRDIRAVVNQMVPKEAKITEIEFEGPELVIYVKNPEAIMKDGELIK Methanococcus --------MSAEEVLENIRKEIIKKSPKEAKIVDVQFEGPEVVVYVKNPEIFTN--EIIK Methanobacterium ---------MVSEMLEEIKRTIMQRLPERVQVAKVEFEGPEVVIYTKNPEIITENGNLIR Archaeoglobus ----------MTKYLDEIREKVKEYLPPKVRVKSIEFEGPQLVIYVENPQELAEV-DIVK Bostaurus ------------------------------------------------------------ Homosapiens ------------------------------------------------------------ Schizosaccharomyces ------------------------------------------------------------ Saccharomyces ------------------------------------------------------------ Methanococcus2 ------------------------------------------------------------ Archaeoglobus2 ------------------------------------------------------------ Vibrio ------------------------------------------------------------ Deinococcus ------------------------------------------------------------ Arabidopsis ------------------------------------------------------------ Plasmodium ------------------------------------------------------------ Methanococcus3 ------------------------------------------------------------ Pyrococcus DLAKVLKKRISVRPDPEVLLPPEEAEKLIFEIVPKEAEITNIAFDPSVGEVLIEAKKPGL Methanococcus SLAKDLRKRISIRPDPSVLVEPEIAKQKILEIVPEEAEITNFVFDANTGEVIIESKKPGL Methanobacterium DIAKDIRKRIIIRSDRSVLMDPEKAIRKIHEIVPEEAKITNISFDDVTCEVIIEARKPGL Archaeoglobus KLAKDLRKRIIIRADPKSLKPPEKARQIIMQIVPEDARISNIFFDEENGEVIIEAEKPGV Bostaurus ------------------------------------------------------------ Homosapiens ------------------------------------------------------------ Schizosaccharomyces ------------------------------------------------------------ Saccharomyces ------------------------------------------------------------ Methanococcus2 ------------------------------------------------------------ Archaeoglobus2 ------------------------------------------------------------ Vibrio ------------------------------------------------------------ Deinococcus ------------------------------------------------------------ Arabidopsis ------------------------------------------------------------ Plasmodium --------------------MNYYHQTKIIIQVLGAGQTVGRSCVIVELENRKVMFDCGC Methanococcus3 ------------------------------------------------------------ Pyrococcus VIGKNGETLRLITQKVKWAPKVVRTPPLQSQTIYSIRQILQTESKDRRKFLRQVGRNIYR Methanococcus VIGKEGKTLEMIKKAIRWAPKPVRTPPIQSETIKAIRATLYRERHEVKEILRRIGRRIHR Methanobacterium VIGKYGSTSREIVKNTGWAPKILRTPPISSEIIERIRRTLRKNSKERKKILQQLGNRIHQ Archaeoglobus VIGKQGSTFREIMRAVGWSPRVVRTPPIKSKIIDNIRNYLLSVREERSEILKRIGERIHR Bostaurus ----------------------------------------------------------MS Homosapiens ------------------------------------------------------------ Schizosaccharomyces ---------------------------------MSKRKEFDEDAPVDPSVSLEFTIFYKG Saccharomyces ------------------------------------------------------------ Methanococcus2 ------------------------------------------------------------ Archaeoglobus2 ------------------------------------------------------------ Vibrio ------------------------------------------------------------ Deinococcus ------------------------------------------------------------ Arabidopsis ------------------------------------------------------------ Plasmodium HLGYKDERKYPNFNLLIRGPDKINHCQKEEFIDDEIEENIEDDEIEENVNDQHINDDNIN Methanococcus3 ---------MEIIFRGAALEVGRSCIEIKTDKSKILLDCGVKLG----KEIEYPILDN-- Pyrococcus KPEYK-SRWIRITGLGGFREVGRSALLVQTDESFVLVDFGVNVAMLNDPYKAFPHFDAPE Methanococcus DIVVRGDYWIRVSFLGGAREVGRSCLYVQTPDTRVLIDCGINVACED---KAFPHFDAPE Methanobacterium KPKYD-NDWARLTAMGGFREVGRSCLYLQTPNSRVLLDCGVNVAGGD-DKNSYPYLNVPE Archaeoglobus TSLID-EKWVRVTFLGGSREVGRSCYLLQTPESRILIDCGVNVS----NLSSTPYLYVPE Bostaurus AIPAEESDQLLIRPLGAGQEVGRSCIILEFKGRKIMLDCGIHPGLEG--MDALPYIDLID Homosapiens ------------------------------------------------------------ Schizosaccharomyces LLSNQCQDLLEFINLGAGNEVGRSCHVIQYKGKTVMLDAGVHPAYTG--LSALPFFDEFD Saccharomyces -MERTNTTTFKFFSLGGSNEVGRSCHILQYKGKTVMLDAGIHPAYQG--LASLPFYDEFD Methanococcus2 --------MVLLKFHGGCQQIGMSCVEVETQKGRVLLDCGMSPD-----TGEIPKVDD-- Archaeoglobus2 --------MTTINFLGGCREVGRSAVMVDG----IMIDYGVKPS------DPPEFPLN-G Vibrio -MYSGVENNMEVVHHGGKASVTGSCHELRADGQALLIDCGLFQG-----ADERPLAVEFA Deinococcus ------------------------------------------------------------ Arabidopsis -------MAIDCLVLGAGQEIGKSCVVVTINGKKIMFDCGMHMGCDD--HNRYPNFSLIS Plasmodium NINDDYKDKSDQKRNNRDIEKVEVKVEENVEEPNFYDNSNADVVNISIVNSSITDKEKLI Methanococcus3 -SIRD----VDKVFISHAHLDHSGALPVLFHRK-MDVPVITTELSKKLIKVLLKDMVKIA Pyrococcus FQYVLREGLLDAIIITHAHLDHCGMLPYLFRYNLFDGPIYTTPPTRDLMVLLQKDFIEIQ Methanococcus FSIED----LDAVIVTHAHLDHCGFIPGLFRYG-YDGPVYCTRPTRDLMTLLQKDYLEIA Methanobacterium FT-LDS---LDAVIITHAHLDHSGFLPYLYHYG-YDGPVYCTAPTRDLMTLLQLDHIDIA Archaeoglobus VQPLDA---LDAVVITHAHLDHCGLVPLLYKFG-YRGPIYLTPPTRDLMVLLQLDFLEVA Bostaurus PAEID------LLLISHFHLDHCGALPWFLQKTSFKGRTFMTHATKAIYRWLLSDYVKVS Homosapiens ------------------------------------------------------------ Schizosaccharomyces LSTVD------VLLISHFHLDHVASLPYVMQKTNFRGRVFMTHPTKAVCKWLLSDYVKVS Saccharomyces LSKVD------ILLISHFHLDHAASLPYVMQRTNFQGRVFMTHPTKAIYRWLLRDFVRVT Methanococcus2 -KAVD------AVIVSHAHLDHCGAIPFYKFKK-----IYCTHPTADLMFITWRDTLNLT Archaeoglobus2 LSPRA-------VILSHGHLDHIGVAPNLMYYD---PEVILTPPSHELSMILLRDSMKIM Vibrio LGHVD------ALILTHAHIDHIGRLPWLLAAG-FKQPIYCTAATAELVPLMLEDGLKLQ Deinococcus ------------------------------------------------------------ Arabidopsis -KSGDFDNAISCIIITHFHMDHVGALPYFTEVCGYNGPIYMSYPTKALSPLMLEDYRRVM Plasmodium NNLKRINEIIDCVIISHFHMDHIGALPFFTEILKYRGIILMSYPTKALSPILLLDSCRVT Methanococcus3 ETE-----------------------------NKKIPYNNHDVKEAIRHTIPLNYND--K Pyrococcus QSN-----------------------------GQDPLYRPRDIKEVIKHTITLDYGEV-R Methanococcus KKE-----------------------------GKEVPYTSKDIKTCVKHTIPIDYGVT-T Methanobacterium HRE-----------------------------DEPLPFNVKHVKKSVKHTITLDYGEV-T Archaeoglobus GRE-----------------------------GTNPPYSSNLIREALKHTITLDYGVV-T Bostaurus NIS-----------------------------ADDMLYTETDLEESMDKIETINFHEV-K Homosapiens ----------------------------------DMLYTETDLEESMDKIETINFHEV-K Schizosaccharomyces NVG-----------------------------MEDQLYDEKDLLAAFDRIEAVDYHST-I Saccharomyces SIGSSSS---------------------SMGTKDEGLFSDEDLVDSFDKIETVDYHST-V Methanococcus2 KAY-----------------------------KE------EDIQHAMENIECLNYYEE-R Archaeoglobus2 HPP-----------------------------PF----TKRELRQFESNIREVEYEE--P Vibrio LGMS----------------------------PKQSERVLTEVRRLLRVQDYQKWFAVQP Deinococcus ------------------------------------------------------------ Arabidopsis VDRR----------------------------GEEELFTTTHIANCMKKVIAIDLKQT-I Plasmodium DMKWEKKNFERQIKMLNEKSDELLNYNINCIKKDPWNINEDNIYNCIDKVIGLQINET-- Methanococcus3 KYYKDFSYELFSAGHIPGSASILLNYQNN-KTILYTGDVKLRDTRLTKGADLSYTKDDID Pyrococcus DISPDIRLTLHNAGHILGSAIVHLHIGNGLHNIAITGDFKFIPTRLLEPANAKFPR--LE Methanococcus DISPTIKLTLHNAGHVLGSAIAHLHIGEGLYNLAYTGDIKFETSRLLEPAVCQFPR--LE Methanobacterium DIAPDIRLTLHNAGHILGSAMAHLHIGDGQHNMVYTGDFKYEQSRLLEAAANRFPR--IE Archaeoglobus DISPDVRLTFYNAGHILGSAIAHFHIGEGHYNIAFTGDFKFEKTRLFDRAATNFPR--LE Bostaurus EVAGIKFWCYH-AGHVLG--AAMFMIEIAGVKLLYTGDFSRQEDRHLMAAEIPNIK--PD Homosapiens EVAGIKFWCYH-AGHVLG--AAMFMIEIAGVKLLYTGDFSRQEDRHLMAAEIPNIK--PD Schizosaccharomyces EVEGIKFTPYH-AGHVLG--ACMYFVEMAGVNILFTGDYSREEDRHLHVAEVPPKR--PD Saccharomyces DVNGIKFTAFH-AGHVLG--AAMFQIEIAGLRVLFTGDYSREVDRHLNSAEVPPLS--SN Methanococcus2 QITENIKFKFYNAGHILG--SASIYLEVDGKKILYTGDINEGVSRTLLPADTDIDE--ID Archaeoglobus2 ITVGDYEVEFFNAGHIPG--SASIHMRGD-VNILYSGDIRLEETRLLEGANTDYPE--TD Vibrio KCADSLWVRFQPAGHILGSAYVEIRRPNG-EVVVFSGDLGPSHTPLLPDPQSPERA---D Deinococcus -------------------------------------------------RFHAAPA--VD Arabidopsis QVDEDLQIRAYYAGHVLG--AVMVYAKMGDAAIVYTGDYNMTTDRHLGAAKIDRLQ--LD Plasmodium FELGDMSITPYYAGHVLG--ACIYKIEVRNFSVIYTGDYNTIPDKHLGSANIPSLN--PE : Methanococcus3 ILIIESTYG--NSIHPDRKAVELSFIEKIKEILFRGGVALIPVFAVDRAQEILLILNDYN Pyrococcus TLVMESTYGGANDIQMPREEAEKRLIEVIHNTIKRGGKVLIPAMAVGRAQEVMMVLEEYA Methanococcus TLIIESTYGAYDDVLPEREEAERELLRVVSETTDRGGKVLIPVFGVGRAQELMLVLEEGY Methanobacterium TLVMESTYGGHEDVQPSRNRAEKELVKTIYSTLRRGGKILIPVFAVGRAQELMIVLEEYI Archaeoglobus ALVMEATYGGPNDFQPSRKEAEERLIEVINRTLDRGGKVLIPTFAVGRSQEVMIVLEEAM Bostaurus ILIIESTYG--THIHEKREEREARFCNTVHDIVNRGGRGLIPVFALGRAQELLLILDEYW Homosapiens ILIIESTYG--THIHEKREEREARFCNTVHDIVNRGGRGLIPVFALGRAQELLLILDEYW Schizosaccharomyces VLITESTYG--TASHQPRLEKEARLLNIIHSTIRNGGRVLMPVFALGRAQELLLILDEYW Saccharomyces VLIVESTFG--TATHEPRLNRERKLTQLIHSTVMRGGRVLLPVFALGRAQEIMLILDEYW Methanococcus2 VLIIESTYGSPLDIKPARKTLERQLIEEISETIENGGKVIIPVFAIGRAQEILLIINNYI Archaeoglobus2 ILIVESTYFG--TEHPDRKELERAFVESVIDTLDMGGHAIIPAFAVGRTQEVLMILERYG Vibrio YLFIETTYG--DKQHEDVQSRGQRLRAMIERSLTDGGAILIPAFSVGRTQELLFDIEQLI Deinococcus AVVIETTYA--NRTHRGWVETRAEFAQALRDSVRQNGKILIPSSAIERAQTILHTLKEMM Arabidopsis LLISESTYA--TTIRGSKYPREREFLQAVHKCVAGGGKALIPSFALGRAQELCMLLDDYW Plasmodium IFISESTYA--TYVRPTKKASELELCNLVHECVHKGGKVLIPVFAIGRAQELSILLDDYW .. *:*: : : .* ::* .: *:* : :. Methanococcus3 ---------IDAPIYLDG-MAVEVTKLMLNYKHMLNE--SSQLEKALKN---VKIIEKSE Pyrococcus R--IG-G--IEVPIYLDG-MIWEATAIHTAYPEYLSRRLREQIFKEGYNPFLSEIFHPVA Methanococcus N--QG-I--FNAPVYLDG-MIWEATAIHTAYPEYLSKEMRQKIFHEGDNPFLSEVFKRVG Methanobacterium R--TGII--DEVPVYIDG-MIWEANAIHTARPEYLSKDLRDQIFHMGHNPFISDIFHKVN Archaeoglobus R--EKRL--RETYVYLDG-MIYEATAIHTAYPEYLNAQLRDLIFYHGINPFISENFVRVD Bostaurus QNHPELH---DIPIYYASSLAKKCMAVYQTYVNAMNDKIRKQININ--NPFVFKHISNLK Homosapiens QNHPELX---DXPIYYASSLAKKCMAVYQTYVNAMNDKIRKQININ--NPFVFKHISNLK Schizosaccharomyces NNHLDLR---SVPIYYASSLARKCMAIFQTYVNMMNDNIRKIFAER--NPFIFRFVKSLR Saccharomyces SQHADELGGGQVPIFYASNLAKKCMSVFQTYVNMMNDDIRKKFRDSQTNPFIFKNISYLR Methanococcus2 R--SGKLR--DVPIYTDG-SLIHATAVYMSYINWLNPKIKNMVENR-INPF-GEIKKADE Archaeoglobus2 -----------ITPYVDG-MGKEVAQVIQRHPDFIRS--PKELKRAVRN----AIPVEWR Vibrio FSQQIDA---NLPIILDSPMAQRVTRSYRRFKQLWGREAKARLQMHR-HPLAFEQCITVE Deinococcus D--SGEVP--RIPVFLDSPMAARATNEYFEYGDELIPPVREALRNG-EDPFRPSTLHTVT Arabidopsis ERMN-----IKVPIYFSSGLTIQANMYYKMLISWTSQNVKEKHNTH--NPFDFKNVKDFD Plasmodium KK-MK----IHYPIYFGCGLTENANKYYKIYSSWINS---SCMSNEKENLFDFANISPFL . . Methanococcus3 DRIKAIENLSKN-----GGIVVTTAGMLDGGPILYYLKLFMHNPKNALLLTGYQVRDSNG Pyrococcus NSRERQDIIDSNE----PAIIIASSGMLVGGPSVEYFKQLAPDPKNSIIFVSYQAEGTLG Methanococcus STNERRKVIDSDE----PCVILATSGMLTGGPSVEYLKHLAPDEKNAIIFVGYQAEGTLG Methanobacterium GMDERREIVEGE-----PSIILSTSGMLTGGNSLEYFKWLCEDPDNSLVFVGYQAEGSLG Archaeoglobus SSSKREEVISDPS----PSIIIATSGMLNGGPVMEYFRHLAEDERNTIVFVGYQAEGTLG Bostaurus S----MDHFDDIG----PSVVMASPGMMQSGLSRELFESWCTDKRNGVIIAGYCVEGTLA Homosapiens S----MDHFDDIG----PSVVMASPGMMQSGLSRELFESWCTDKRNGVIIAGYCVEGTLA Schizosaccharomyces N----LEKFDDIG----PSVILASPGMLQNGVSRTLLERWAPDPRNTLLLTGYSVEGTMA Saccharomyces N----LEDFQDFG----PSVMLASPGMLQSGLSRDLLERWCPEDKNLVLITGYSIEGTMA Methanococcus2 S-----LVFNKE-----PCIIVSTSGMVQGGPVLKYLKLLK-DPKNKLILTGYQAEGTLG Archaeoglobus2 Q----RERVLEE-----PSAVVTTAGMLNGGPAMFYISRLYNDEKSKILLTGYQVEGTNG Vibrio DHRTHERLVNRLASTGEAAIVVAASGMCQGGRIMDYLKALLPDKRTDLILAGFQAEGTLG Deinococcus TSAESQRLNRYDG----PAIIMAGNGMMTGGRIQHHLKHHLWKPSTSLIIVSYQSPSSLG Arabidopsis R-----SLIHAPG----PCVLFATPGMLCAGFSLEVFKHWAPSPLNLVALPGYSVAGTVG Plasmodium N-----NYLNEKR----PMVLFATPGMLHTGLSLKAFKAWAGNPQNLIVLPGYCVQGTVG :.: ** * : . . : : .: .: . Methanococcus3 RHLIETGKIFI-----GKDEIKP-NLEVCMYN-FSCHAGMDELHEIIKKVN---PELLII Pyrococcus RQVQSGIREIPMVGEEGRTEVIKVNMEVHTIDGFSGHADRRELMNYVAKVRPR-PERIIT Methanococcus RKVQSGWKEIPIITRNGKTKSIPINLQVYTIEGFSGHSDRKQLIKYIRRLKPS-PEKIIM Methanobacterium RRIQKGWKEIPLKDEDDKMRVYNVRMNIKTIEGFSGHSDRRQLMEYVKRISPK-PEKILL Archaeoglobus RKIQKGWKEVPFP-VDGRREVVEVKMEVETVDGFSGHSDRKQLMNYIRYLNSK-PEKVAT Bostaurus KHIMSEPEEITT--MSGQ--KLPLKMSVDYIS-FSAHTDYQQTSEFIRALK---PPHVIL Homosapiens KHIMSEPEEITT--MSGQ--KLPLKMSVDYIS-FSAHTDYQQTSEFIRALK---PPHVIL Schizosaccharomyces KQITNEPIEIVS--LSGQ--KIPRRMAVEELS-FAAHVDYLQNSEFIDLVN---ADHIIL Saccharomyces KFIMLEPDTIPS--INNPEITIPRRCQVEEIS-FAAHVDFQENLEFIEKIS---APNIIL Methanococcus2 RELEEGAKEIQP----FKN-KIPIRGKVVKIE-FSAHGDYNSLVRYIKKIP-K-PEKAIV Archaeoglobus2 DMALKTGMLNLG----TR--VVKLKMGVEQYD-FSAHADDRQLKEYVKRVVDRGAEVVFT Vibrio RSIQSGQPSVWI-----EGTEVEVNAHIHTMSGYSAHADKADLLRFIAGIPEK-PKQVHL Deinococcus GRIVAGQGTVHL----MG-EDVAVRAQVHTIGGFSAHADQDDLLAFLDTAG---KPHVWL Arabidopsis HKLMAGKPTTVD---LYNGTKVDVRCKVHQVA-FSPHTDAKGIMDLTKFLS---PKNVVL Plasmodium HKLIMGEKQISL----DGTTYIKVLCKIIYLS-FSAHADSNGIQQLIKHVS---PKNVIF : :: * . Methanococcus3 QHGEEVQATILRN-WALEHG-------------FDAI----------------------- Pyrococcus VHGEPQKCLDLATSIHRKFG-------------ISTR----------------------- Methanococcus VHGEESKCLDFADTVRRLFK-------------KQTY----------------------- Methanobacterium CHGDNYKTLDLASSIYRTYR-------------IETK----------------------- Archaeoglobus VHGDESKCIDLASSIYKTYR-------------IETR----------------------- Bostaurus VHGEQNEMARLKAALIREYED-------NDEVHIEVH----------------------- Homosapiens VHGEQNEMARLKAALIREYED-------NDEVHIEVH----------------------- Schizosaccharomyces VHGEQTNMGRLKSALASKFH--------NRKVDVKVY----------------------- Saccharomyces VHGEANPMGRLKSALLSNFAS-------LKGTDNEVHVF--------------------- Methanococcus2 MHGERYQSLSFAMTIWKTLK-------------IPTF----------------------- Archaeoglobus2 IHGEE--TEAFAEWIKDNIG-------------VEAY----------------------- Vibrio IHGEASAKQAFAAELTQLGY--------------SVL----------------------- Deinococcus VHGEVNVMDAFLPLLAERGLK-------G-----DIV----------------------- Arabidopsis VHGEKPSMMILKEKITSELDIPCFVPANGETVSFASTTY--------------------- Plasmodium VHGEKNGMQKLAKYISNKHMINSMCPSLGQQCHFDFIKHNINYIYIHKNIHKHILQLKKK **: : Methanococcus3 ---------TPKLGEKIRI----------------------------------------- Pyrococcus ---------APNNLDTIRLR---------------------------------------- Methanococcus ---------VPMNLDAIRVK---------------------------------------- Methanobacterium ---------TPLNLETVRIQ---------------------------------------- Archaeoglobus ---------APMNLETIRFV---------------------------------------- Bostaurus ---------NPRNTEAVTLNFRGEKLAKVMG----------------------------- Homosapiens ---------NPRNTEAVTLNFRGEKLAKVMG----------------------------- Schizosaccharomyces ---------TPRNCVPLYLPFKGERLVRALG----------------------------- Saccharomyces ---------NPRNCVEVDLEFQGVKVAKAVGNIVNEIYKEENVEIKEEIAAKIEPIKEEN Methanococcus2 ---------VPVRGTILPI----------------------------------------- Archaeoglobus2 ---------APKNGEIYVI----------------------------------------- Vibrio ------------------------------------------------------------ Deinococcus ------------------------------------------------------------ Arabidopsis ---------IKANASDMFLKSCSNPNFKFSNSTQLRVTDHRTADGVLVIEKSKKAKIVHQ Plasmodium ITKNKHINTTNIQKTDLYINENKKKKNKKIKKECTYVNKKIKVPFNAYMFYIPLTHKPYI Methanococcus3 ------------------------------------------------------------ Pyrococcus ------------------------------------------------------------ Methanococcus ------------------------------------------------------------ Methanobacterium ------------------------------------------------------------ Archaeoglobus ------------------------------------------------------------ Bostaurus ----------FLADKKPEQGQRVSGILVK--RNFNYHILSPCDLSNYT-DLAMSTVKQTQ Homosapiens ----------FLADKKPEQGQRVSGILVK--RNFNYHILSPC------------------ Schizosaccharomyces ----------KVAVHKPKEGDIMSGILIQ--KDANYKLMSAEDLRDFS-DLTTTVLTQKQ Saccharomyces EDNLDSQAEKGLVDEEEHKDIVVSGILVSDDKNFELDFLSLSDLREHHPDLSTTILRERQ Methanococcus2 ------------------------------------------------------------ Archaeoglobus2 ------------------------------------------------------------ Vibrio ------------------------------------------------------------ Deinococcus ------------------------------------------------------------ Arabidopsis DEISEVLHEKNHVVSLAHCCPVKVKGESEDDDVDLIKQLSAKILKTVSGAQIHESENCLQ Plasmodium FLFSKKNLLQYLKTKHIPIIIEHKEQKINSDQLFLYKNEKISNYHKKDKKKKAIDEHKLK Methanococcus3 ------------------------------------------------------------ Pyrococcus ------------------------------------------------------------ Methanococcus ------------------------------------------------------------ Methanobacterium ------------------------------------------------------------ Archaeoglobus ------------------------------------------------------------ Bostaurus AIPYTGPFNLLYYQLQKLTG--DVEELEIQE-KPALKVFKNITV-IQEPGMVVL------ Homosapiens ------------------------------------------------------------ Schizosaccharomyces VIPFFSSMELANFHLKQMFG--YVKQSKTKAGQPQYTVMDAITLTLIQEHKLAL------ Saccharomyces SVRVNCKKELIYWHILQMFGEAEVLQDDDRVTNQEPKVKEESKDNLTNTGKLILQIMGDI Methanococcus2 ------------------------------------------------------------ Archaeoglobus2 ------------------------------------------------------------ Vibrio ------------------------------------------------------------ Deinococcus ------------------------------------------------------------ Arabidopsis SREKEESQFSSLLMSSYSSDSTAARDQHAPLLRPRHDGSFSSSSSSARPTALAVLLGRIT Plasmodium VRNKLIQKKINIQTNCDNNKNNKNKCFNNYLNHSYVSSKDANMSNVIDHPYIDEHFVGEN Methanococcus3 ------------------------------------------------------------ Pyrococcus ------------------------------------------------------------ Methanococcus ------------------------------------------------------------ Methanobacterium ------------------------------------------------------------ Archaeoglobus ------------------------------------------------------------ Bostaurus -----------EWLANPSNDMYADTVTTVILEVQSNPKIRKGAVQKVSKKLEMHVYS--- Homosapiens ------------------------------------------------------------ Schizosaccharomyces -----------EWVGNIMNDTIADSVITILLGIESSPASVKLTSHKCN-HLHSHLDKPPK Saccharomyces KLTIVNTLAVVEWTQDLMNDTVADSIIAILMNVDSAPASVKLSSHSCDDHDHNNVQSNAQ Methanococcus2 ------------------------------------------------------------ Archaeoglobus2 ------------------------------------------------------------ Vibrio ------------------------------------------------------------ Deinococcus ------------------------------------------------------------ Arabidopsis GHRAPSMLVRETAARALEERRIDWGYSKPVVAADILWNAALVLASAVMLVGTVEERPNEP Plasmodium KNEHIITNINDLINKNNSNCYLTNQNVYSSPNLTIQSPKSDDDEISPISNNDNEESDMSQ Methanococcus3 ------------------------------------------------------------ Pyrococcus ------------------------------------------------------------ Methanococcus ------------------------------------------------------------ Methanobacterium ------------------------------------------------------------ Archaeoglobus ------------------------------------------------------------ Bostaurus ---------KRLEIMLQDIFG----------EDCVSVKDGSILSVTVDGKTANINLETRT Homosapiens ------------------------------------------------------------ Schizosaccharomyces -VSKEEDRIKKLMMFLDNQFG----------ESMTKTEKG--VEIKFEKYEASIDFSTMK Saccharomyces GKIDEVERVKQISRLFKEQFGDCFTLFLNKDEYASNKEETITGVVTIGKSTAKIDFNNMK Methanococcus2 ------------------------------------------------------------ Archaeoglobus2 ------------------------------------------------------------ Vibrio ------------------------------------------------------------ Deinococcus ------------------------------------------------------------ Arabidopsis IRVWICVYGLQCLFHVVLVWSEYWRRNSTRRARDLESYDHEDYNIEYDYEQDSDDNSTTY Plasmodium KKKQPLIKKNNIHSDDKYKNEHMNENQINNNNNNNIYEQDVLENDSSSNDEQKPFNFVLK Methanococcus3 ------------------------------------------------------------ Pyrococcus ------------------------------------------------------------ Methanococcus ------------------------------------------------------------ Methanobacterium ------------------------------------------------------------ Archaeoglobus ------------------------------------------------------------ Bostaurus VECEEGSEDDESLREMVELAAQRLYEALTPVH---------------------------- Homosapiens ------------------------------------------------------------ Schizosaccharomyces VECSN-----EALRSRVVHVLSRAINTILPFSEASQNDVSEDDFENEESDDDKIFEQQTK Saccharomyces ILECN-S---NPLKGRVESLLNIGGNLVTPLC---------------------------- Methanococcus2 ------------------------------------------------------------ Archaeoglobus2 ------------------------------------------------------------ Vibrio ------------------------------------------------------------ Deinococcus ------------------------------------------------------------ Arabidopsis RLSVIFLAIDVFFAVFCVVLACLVGIALCCCLPCIIALLYAVAGTNLETPFLAGFIQEGV Plasmodium KDKVNLPLLNLRFKEIITIAYQTFYNFVLTFFQEIVNTENKDKIDFLGKRVLIKNVKYND Methanococcus3 -------------------------------------------------- Pyrococcus -------------------------------------------------- Methanococcus -------------------------------------------------- Methanobacterium -------------------------------------------------- Archaeoglobus -------------------------------------------------- Bostaurus -------------------------------------------------- Homosapiens -------------------------------------------------- Schizosaccharomyces IEDDVKNENKTEPVEEQKSEEKNEQPNLKKEELS---------------- Saccharomyces -------------------------------------------------- Methanococcus2 -------------------------------------------------- Archaeoglobus2 -------------------------------------------------- Vibrio -------------------------------------------------- Deinococcus -------------------------------------------------- Arabidopsis SEAELGVLPLYKFKAFHSNEKNITGPGLLHMSEFI--------------- Plasmodium SYFFYLSFHSLRAIHDGQNNLIMQWSYVDDYPNSIIQKFIKCLHKYNQME