CLUSTAL X (1.8) multiple sequence alignment Bacillus ------------------------------------------------------------ Bacillus3 ------------------------------------------------------------ Escherichia_coli ------------------------------------------------------------ Escherichia_coli3 ------------------------------------------------------------ Ecoli ------------------------------------------------------------ Salmonella ------------------------------------------------------------ Escherichia_coli2 ------------------------------------------------------------ Haemophilus ------------------------------------------------------------ Helicobacter ------------------------------------------------------------ Helicobacter2 ------------------------------------------------------------ Schizosaccharomyces ------------------------------------------------------------ Schizosaccharomyces2 MSFQQPSNGAQGGNNNALEKTSSNEATSSSSTQVSSLSASGISVSTPRVSPFEPERNMQV Thermotoga ------------------------------------------------------------ Archaeoglobus ------------------------------------------------------------ Synechocystis ------------------------------------------------------------ Synechocystis2 ------------------------------------------------------------ Bacillus2 ------------------------------------------------------------ Mycobacterium ------------------------------------------------------------ Mycobacterium2 ------------------------------------------------------------ Pseudomonas ------------------------------------------------------------ Pseudomonas2 ------------------------------------------------------------ oldDeinococcus ------------------------------------------------------------ Deinococcus2 ------------------------------------------------------------ Lactococcus ------------------------------------------------------------ PlasmidpNZ4000 ------------------------------------------------------------ oldMethanococcus ------------------------------------------------------------ Methanococcus ------------------------------------------------------------ oldLactococcus ------------------------------------------------------------ Lactococcus3 ------------------------------------------------------------ Lactococcus2 ------------------------------------------------------------ Aquifex ------------------------------------------------------------ newDeinococcus ------------------------------------------------------------ Deinococcus3 ------------------------------------------------------------ Lactococcus4 ------------------------------------------------------------ Bacillus ------------------------------------------------------------ Bacillus3 ------------------------------------------------------------ Escherichia_coli ------------------------------------------------------------ Escherichia_coli3 ------------------------------------------------------------ Ecoli ------------------------------------------------------------ Salmonella ------------------------------------------------------------ Escherichia_coli2 ------------------------------------------------------------ Haemophilus ------------------------------------------------------------ Helicobacter ------------------------------------------------------------ Helicobacter2 ------------------------------------------------------------ Schizosaccharomyces ------------------------------------------------------------ Schizosaccharomyces2 QSSQHLEANVQSPVSSQTTYATPSAYAVPQESEIELHESEMVPQKPKKKKRSRRNRKASR Thermotoga ------------------------------------------------------------ Archaeoglobus ------------------------------------------------------------ Synechocystis ------------------------------------------------------------ Synechocystis2 ------------------------------------------------------------ Bacillus2 ------------------------------------------------------------ Mycobacterium ------------------------------------------------------------ Mycobacterium2 ------------------------------------------------------------ Pseudomonas ------------------------------------------------------------ Pseudomonas2 ------------------------------------------------------------ oldDeinococcus ------------------------------------------------------------ Deinococcus2 ------------------------------------------------------------ Lactococcus ------------------------------------------------------------ PlasmidpNZ4000 ------------------------------------------------------------ oldMethanococcus ------------------------------------------------------------ Methanococcus ------------------------------------------------------------ oldLactococcus ------------------------------------------------------------ Lactococcus3 ------------------------------------------------------------ Lactococcus2 ------------------------------------------------------------ Aquifex ------------------------------------------------------------ newDeinococcus ------------------------------------------------------------ Deinococcus3 ------------------------------------------------------------ Lactococcus4 ------------------------------------------------------------ Bacillus ------------------------------------------------------------ Bacillus3 ------------------------------------------------------------ Escherichia_coli ------------------------------------------------------------ Escherichia_coli3 ------------------------------------------------------------ Ecoli ------------------------------------------------------------ Salmonella ------------------------------------------------------------ Escherichia_coli2 ------------------------------------------------------------ Haemophilus ------------------------------------------------------------ Helicobacter ------------------------------------------------------------ Helicobacter2 ------------------------------------------------------------ Schizosaccharomyces ------------------------------------------------------------ Schizosaccharomyces2 KKIPATQSSSADMDTLHVCPTCGSCSDSKKPQSNKKHRGRRVKHSPKSTLEVPDGIPDIK Thermotoga ------------------------------------------------------------ Archaeoglobus ------------------------------------------------------------ Synechocystis ------------------------------------------------------------ Synechocystis2 ------------------------------------------------------------ Bacillus2 ------------------------------------------------------------ Mycobacterium ------------------------------------------------------------ Mycobacterium2 ------------------------------------------------------------ Pseudomonas ------------------------------------------------------------ Pseudomonas2 ------------------------------------------------------------ oldDeinococcus ------------------------------------------------------------ Deinococcus2 ------------------------------------------------------------ Lactococcus ------------------------------------------------------------ PlasmidpNZ4000 ------------------------------------------------------------ oldMethanococcus ------------------------------------------------------------ Methanococcus ------------------------------------------------------------ oldLactococcus ------------------------------------------------------------ Lactococcus3 ------------------------------------------------------------ Lactococcus2 ------------------------------------------------------------ Aquifex ------------------------------------------------------------ newDeinococcus ------------------------------------------------------------ Deinococcus3 ------------------------------------------------------------ Lactococcus4 ------------------------------------------------------------ Bacillus ------------------------------------------------------------ Bacillus3 ------------------------------------------------------------ Escherichia_coli ------------------------------------------------------------ Escherichia_coli3 ------------------------------------------------------------ Ecoli ------------------------------------------------------------ Salmonella ------------------------------------------------------------ Escherichia_coli2 ------------------------------------------------------------ Haemophilus ------------------------------------------------------------ Helicobacter ------------------------------------------------------------ Helicobacter2 ------------------------------------------------------------ Schizosaccharomyces ------------------------------------------------------------ Schizosaccharomyces2 ALSASMGSSSQHASRYNEGRGSFDTLGTHYHLSKSRKSSSSDSLYSVSSMSIKNDSNSDS Thermotoga ------------------------------------------------------------ Archaeoglobus ------------------------------------------------------------ Synechocystis ------------------------------------------------------------ Synechocystis2 ------------------------------------------------------------ Bacillus2 ------------------------------------------------------------ Mycobacterium ------------------------------------------------------------ Mycobacterium2 ------------------------------------------------------------ Pseudomonas ------------------------------------------------------------ Pseudomonas2 ------------------------------------------------------------ oldDeinococcus ------------------------------------------------------------ Deinococcus2 ------------------------------------------------------------ Lactococcus ------------------------------------------------------------ PlasmidpNZ4000 ------------------------------------------------------------ oldMethanococcus ------------------------------------------------------------ Methanococcus ------------------------------------------------------------ oldLactococcus ------------------------------------------------------------ Lactococcus3 ------------------------------------------------------------ Lactococcus2 ------------------------------------------------------------ Aquifex ------------------------------------------------------------ newDeinococcus ------------------------------------------------------------ Deinococcus3 ------------------------------------------------------------ Lactococcus4 ------------------------------------------------------------ Bacillus ------------------------------------------------------------ Bacillus3 ------------------------------------------------------------ Escherichia_coli ------------------------------------------------------------ Escherichia_coli3 ------------------------------------------------------------ Ecoli ------------------------------------------------------------ Salmonella ------------------------------------------------------------ Escherichia_coli2 ------------------------------------------------------------ Haemophilus ------------------------------------------------------------ Helicobacter ------------------------------------------------------------ Helicobacter2 ------------------------------------------------------------ Schizosaccharomyces ------------------------------------------------------------ Schizosaccharomyces2 LSSSSSSDVSGSDENLPIDKTLYLSVEDPSFMVHPRRPSATKSCSAAVDCPHTTIPKPPY Thermotoga ------------------------------------------------------------ Archaeoglobus ------------------------------------------------------------ Synechocystis ------------------------------------------------------------ Synechocystis2 ------------------------------------------------------------ Bacillus2 ------------------------------------------------------------ Mycobacterium ------------------------------------------------------------ Mycobacterium2 ------------------------------------------------------------ Pseudomonas ------------------------------------------------------------ Pseudomonas2 ------------------------------------------------------------ oldDeinococcus ------------------------------------------------------------ Deinococcus2 ------------------------------------------------------------ Lactococcus ------------------------------------------------------------ PlasmidpNZ4000 ------------------------------------------------------------ oldMethanococcus ------------------------------------------------------------ Methanococcus ------------------------------------------------------------ oldLactococcus ------------------------------------------------------------ Lactococcus3 ------------------------------------------------------------ Lactococcus2 ------------------------------------------------------------ Aquifex ------------------------------------------------------------ newDeinococcus ------------------------------------------------------------ Deinococcus3 ------------------------------------------------------------ Lactococcus4 ------------------------------------------------------------ Bacillus ------------------------------------------------------------ Bacillus3 ------------------------------------------------------------ Escherichia_coli ------------------------------------------------------------ Escherichia_coli3 ------------------------------------------------------------ Ecoli ------------------------------------------------------------ Salmonella ------------------------------------------------------------ Escherichia_coli2 ------------------------------------------------------------ Haemophilus ------------------------------------------------------------ Helicobacter ------------------------------------------------------------ Helicobacter2 ------------------------------------------------------------ Schizosaccharomyces ----DLTELPTKSTAQFSDETFTVQPRLKSTHSSIADNEDREVDSQVDENTRVVEEDVCF Schizosaccharomyces2 QSDTDLTELPTKSTAQFSDETFTVQPRLKSTHSSIADNEDREVDSQVDENTRVVEEDVCF Thermotoga ------------------------------------------------------------ Archaeoglobus ------------------------------------------------------------ Synechocystis ------------------------------------------------------------ Synechocystis2 ------------------------------------------------------------ Bacillus2 ------------------------------------------------------------ Mycobacterium ------------------------------------------------------------ Mycobacterium2 ------------------------------------------------------------ Pseudomonas ------------------------------------------------------------ Pseudomonas2 ------------------------------------------------------------ oldDeinococcus ------------------------------------------------------------ Deinococcus2 ------------------------------------------------------------ Lactococcus ------------------------------------------------------------ PlasmidpNZ4000 ------------------------------------------------------------ oldMethanococcus ------------------------------------------------------------ Methanococcus ------------------------------------------------------------ oldLactococcus ------------------------------------------------------------ Lactococcus3 ------------------------------------------------------------ Lactococcus2 ------------------------------------------------------------ Aquifex ------------------------------------------------------------ newDeinococcus ------------------------------------------------------------ Deinococcus3 ------------------------------------------------------------ Lactococcus4 ------------------------------------------------------------ Bacillus ------------------------------------------------------------ Bacillus3 ------------------------------------------------------------ Escherichia_coli ------------------------------------------------------------ Escherichia_coli3 ------------------------------------------------------------ Ecoli ------------------------------------------------------------ Salmonella ------------------------------------------------------------ Escherichia_coli2 ------------------------------------------------------------ Haemophilus ------------------------------------------------------------ Helicobacter ------------------------------------------------------------ Helicobacter2 ------------------------------------------------------------ Schizosaccharomyces PMQEESHVNKGIDFDELDNFAEEELQKQRQNTDHFRSRQYSTCKPFEPHWNDLSPHDPND Schizosaccharomyces2 PMQEESHVNKGIDFDELDNFAEEELQKQRQNTDHFRSRQYSTCKPFEPHWNDLSPHDPND Thermotoga -------------------------------------MEE-----------KRLSAKKGL Archaeoglobus -------------------------------------MRIP----------ATIKKKMAL Synechocystis ----------------------MPNKP---------QFRQSN----LVSHFNYFNS-PES Synechocystis2 ----------------------MPQTQPGIEDFLLRQLRHPQEEEEEEDYFDYFYDEPGS Bacillus2 ------------------------------------------------------------ Mycobacterium --------------------------------------MFPGFDALPEVLRPVARP--QP Mycobacterium2 ----------------------------------MGVEMFPGFDPLPEALRPVTKPRLYT Pseudomonas ------------------------------------------------------------ Pseudomonas2 ------------------------------------------------------------ oldDeinococcus ---------------------------------------------------------IRT Deinococcus2 ------------------------------------------------------------ Lactococcus ------------------------------------------------------------ PlasmidpNZ4000 ------------------------------------------------------------ oldMethanococcus ------------------------------------------------------------ Methanococcus ------------------------------------------------------------ oldLactococcus ------------------------------------------------------------ Lactococcus3 ------------------------------------------------------------ Lactococcus2 ------------------------------------------------------------ Aquifex ------------------------------------------------------------ newDeinococcus --------------------------------MMWRMAASPAADATSPSSQSAPPRPPTD Deinococcus3 ------------------------------------------------------------ Lactococcus4 ------------------------------------------------------------ Bacillus -------------------MKAHTG-------------KDWFWYQMGPQERS-------- Bacillus3 ------------------------------------------------------------ Escherichia_coli ------------------MLSAFQL-------------ENNRLTRLEVEESQ-------- Escherichia_coli3 ------------------MLSAFQL-------------ENNRLTRLEVEESQ-------- Ecoli ------------------MLSAFQL-------------ENNRLTRLEVEESQ-------- Salmonella ------------------MLSAFQL-------------EKNRLTRLEVEESQ-------- Escherichia_coli2 ------------------MLSAFQL-------------ENNRLTRLEVEESQ-------- Haemophilus ------------------MINAFAI-------------NDSRLVRIDEDQTD-------- Helicobacter ------------------MVNVFFK-------------QQKFVIKKRFNDFNGFDI---- Helicobacter2 ------------------MVNVFFK-------------QQKFVIKKRFNDFNGFDI---- Schizosaccharomyces PSSSLHSNNAEKAAEVPLRSSYYSGGRRSVTSMSDSPYRFSFFSSNQNETIHASVLSDLL Schizosaccharomyces2 PSSSLHSNNAEKAAEVPLRSSYYSGGRRSVTSMSDSPYRFSFFSSNQNETIHASVLSDLL Thermotoga PPGTLVYTG-KYREDFEIEVMNYS------------IEEFREFKTTDVESVLP-FR---- Archaeoglobus PPATPVFTGEKKVEETKITAAIYDE----------KSVEFKELEVGELESVVRSAL---- Synechocystis IPGTLNLSP--NAPPPRIILIDYN------------KNQATKIELKNPLDCEA-YV---- Synechocystis2 EPGTLSIEP--DAPPSRIVLVDYS------------PSHAVRKSDISPNALRP-YL---- Bacillus2 -------------------MINITA----------ITTEHQLLKNIPIERVEQ------- Mycobacterium PNAHPVAQPPAQALVDCGVYVCGQR----------LPGKYT-YAAALREVREIELT---- Mycobacterium2 PHVHPIFPPLTEPLVDCGVYVGGHR----------LPDKYTTYTAALSRVREIELM---- Pseudomonas ----MFEEENAQWGLVHALVLDGK-------------GGARSIARTELDDLQLQ------ Pseudomonas2 ---MQAYESGDERGLIYGYVLNGR-------------GGGRRVGRNQIAVLDLL------ oldDeinococcus IWTANPPVTRRPTPPRRPHAPHPSE-----------RGRRPVLTYYRSIGGKLTVTD--- Deinococcus2 -----------------------------------------MLTYYRSIGGKLTVTD--- Lactococcus -----------------------------------------MIKPEKTING--------- PlasmidpNZ4000 -----------------------------------------MIKPEKTING--------- oldMethanococcus ------------------MITVIAI-----------AKDGSIVEPKLDEISFEDYR---- Methanococcus ------------------MITVIAI-----------AKDGSIVEPKLDEISFEDYR---- oldLactococcus ------------------MIKNYEL-----------SNEKKLISTSEMKN---------- Lactococcus3 ------------------MIKNYEL-----------SNEKKLISTSEMKN---------- Lactococcus2 ------------------MIKNYEL-----------SNEKKLISTSEMKN---------- Aquifex --------MIKYECVIKLYVNTFKG--------------FEEIDEEKLKEYKG------- newDeinococcus AGPGDPLLDGSGQPAPHAEAHVFRD----------GKVRHLPLDLNLARGLLD------- Deinococcus3 ----------MSAPLPCGALYPEP--------------HDSCQGPRQWSG---------- Lactococcus4 ------------------MIDYIEVD-----------GGNNNLKELKCSNSN-------- Bacillus ------------KARDLIHFSHWPQ-CEKWFENNHHVNFLRVDT---------T------ Bacillus3 ---------------DLIHFSHWPQ-CEKWFENNHHVNFLRVDT---------T------ Escherichia_coli ------------PLVNAVWIDLVEP-DDDERLRVQSELGQRPATRPELEDIEASA--RFF Escherichia_coli3 ------------PLVNAVWIDLVEP-DDDERLRVQSELGQRPATRPELEDIEASA--RFF Ecoli ------------PLVNAVWIDLVEP-DDDERLRVQSELGQSLATRPELEDIEASA--RFF Salmonella ------------SLIDAVWVDLVEP-DDDERLRVQSELGQSLATRPELEDIEASA--RFF Escherichia_coli2 ------------PLVNAVWIDLVEP-DDDERLRVQSELGQRPATRPELEDIEASA--RFF Haemophilus -------------LNTAIWLDLLEP-TGEEREMLQEGLGQSLASFLELEDIEASA--RFF Helicobacter ------------EENEVLWFELINP-TPNELATLSQEYAIHYNT-DHSQRVSSVT--KYW Helicobacter2 ------------EENEVLWFELINP-TPNELATLSQEYAIHYNT-DHSQRVSSVT--KYW Schizosaccharomyces DDGATSFRSLFCPEKGVWWLDCLDP-TDIEMRVLSKAFSIHPLTTEDIRVQEARE--KVE Schizosaccharomyces2 DDGATSFRSLFCPEKGVWWLDCLDP-TDIEMRVLSKAFSIHPLTTEDIRVQEARE--KVE Thermotoga ------------DSSTPTWINITGIHRTDVVQRVGEFFGIHPLVLEDILNVHQRP--KVE Archaeoglobus ------------ALNKKLWIDVVGVHDESLIAKICEFLGIHPLAAEDILNTAQRV--KIE Synechocystis ------------DTESVSWINIDGLGNHTTWEQLGEVFKLHPVALEDIVNVPQRP--KVV Synechocystis2 ------------GTNTVSWMDIEGLGSEEVLKEVGEIFKLHPLLLEDIVNVPQRA--KVE Bacillus2 ------------PDIAWYWVDFYGP-EDTETALLRDFFHFHPLAIEDCFQHMQRP--KLD Mycobacterium ------------GQEAFVWIGLHEP-DENQMQDVADVFGLHPLAVEDAVHAHQRP--KLE Mycobacterium2 ------------GNEGFVWIGLHEP-EASHMHNVADVFGLHPLAVEDAVHAHQRP--KLE Pseudomonas -------------PQESLWLHWDRS-HPQTQTWLRKSSGLSEFACDLLLEENTRP--RLL Pseudomonas2 -------------PEESLWLHWDRG-VPEAQAWLRDSAGLSEFACDLLLEEATRP--RLL oldDeinococcus ------------HYMDGCWIDAAAP-TTEELARVSRETGLELDYLKYPLDPDERS--RFE Deinococcus2 ------------HYMDGCWIDAAAP-TTEELARVSRETGLELDYLKYPLDPDERS--RFE Lactococcus ----------------TKWIETIQI-NAEERATLEDQYGIDEDIIEYVTDNDESTNYVYD PlasmidpNZ4000 ----------------TKWIETIQI-NAEERATLEDQYGIDEDIIEYVTDNDESTNYVYD oldMethanococcus ----------------LIWIDCYDP-KDEELYKLSKKIGISVSDLQIGLDEQEIP--RVE Methanococcus ----------------LIWIDCYDP-KDEELYKLSKKIGISVSDLQIGLDEQEIP--RVE oldLactococcus ------------------FTYVLNP-TREEIGNISEYYDFPFDYLSGILDDYENA--RFE Lactococcus3 ------------------FTYVLNP-TREEIGNISEYYDFPFDYLSGILDDYENA--RFE Lactococcus2 ------------------FTYVLNP-TREEIGNISEHYDFPFDYLSGILDDYENA--RFE Aquifex --------------KYVIWFDLFNP-TEEEIEFLRKQTGFSMPPKEILGDIEISS--KYI newDeinococcus ------------DPQAFVWFDLVNP-DPADLEALREPFDLHPLAIEDALVGGQR--VKVE Deinococcus3 --------------TELGWADGGRVGGRARPHRRGTRPLAGRFSAQPAGAGRRAGAGPLD Lactococcus4 --------------SLHSVVYLFNP-KDKIYDFFKEEYQLDLENLLYEEEEVIHEISDTK Bacillus ETEN--EAVFGSIVYDQ-GL-----GEEKDHTVFHFYITRQYFFTINF---DFSILREIK Bacillus3 ETEN--EAVFGSIVYDQ-GL-----GEEKDHTVFHFYITRQYFFTINF---DFSILREIK Escherichia_coli EDDD--GLHIHSFFFFE-DA-----EDHAGNSTVAFTIRDGRLFTLRE---RELPAFRLY Escherichia_coli3 EDDD--GLHIHSFFFFE-DA-----EDHAGNSTVAFTIRDGRLFTLRE---RELPAFRLY Ecoli EDDD--GLHIHSFFFFE-DA-----EDHAGNSTVAFTIRDGRLFTLRE---RELPAFRLY Salmonella EDED--GLHIHSFFFFE-DA-----EDHAGNSTVAFTIRDGRLFTLRE---RELPAFRLY Escherichia_coli2 EDDD--GLHIHSFFFFE-DA-----EDHAGNSTVAFTIRDGRLFTLRE---RELPAFRLY Haemophilus EDED--GLHLHSFFYCE-DE-----DNYADLASVAFTIRDGRLFTLRD---RELPAFRLY Helicobacter EDSS--SVTINAFFTNQ-DE-----NETFHTEMATFILSNNILFTIYY---GTLEIFDSI Helicobacter2 EDSS--SVTINAFFTNQ-DE-----NETFHMEMATFILSNNILFTIYY---GTLEIFDSI Schizosaccharomyces LFGS-YYFVCFRSFEQDPE-----LANYLEPLNMYIVVFREGLLTFHF---SSATHPASV Schizosaccharomyces2 LFGS-YYFVCFRSFEQDPE-----LANYLEPLNMYIVVFREGLLTFHF---SSATHPASV Thermotoga FFEN-YVFIVLKMFTYDKNL------HELESEQVSLILTKNCVLMFQE---KIGDVFDPV Archaeoglobus DYDD-HLFLVLKILLYN---------ETLEIDQLSLVLKKNLVATFEE---REYWILDSI Synechocystis EYEN-HLIFISRMVTLDQSS------QTFISEQISFILGKHYLLTIQEE--PKYDCLFSV Synechocystis2 DYND-HVMVIAHRVRPNREE------DGFESEQVSFVLGKRYLLTFQEG--HIIDCFNPL Bacillus2 HYDG-YRFYVIHALN----K------ETLETEEVDIFQGEKFVVTFHL---HETPGIAKV Mycobacterium RYDE-TLFLVLKTVNYVPHESVVLAREIVKTGEIMIFVGKDFVVTVRH---GEHGGLSEV Mycobacterium2 RYDD-TLFLVLKTVNYVPHESVVLARQIVETGEVMIFVGKNFVVTVRH---GEHGELSEV Pseudomonas PLPDSELLLFLRGVNLNPG------AEPEDMVSVRIFAAASRVISLRL---RPLRATDEL Pseudomonas2 DLGAESLLVFLRGVNLNPG------AEPEDMVSLRVFADARRVISLRL---RPLKAVADL oldDeinococcus REDGQLLIIMQTSYRLAEDSD-----IPYDTVPLGILHTDHCLVTVCS--LEENPVVKDV Deinococcus2 REDGQLLIIMQTSYRLAEDSD-----IPYDTVPLGILHTDHCLVTVCS--LEENPVVKDV Lactococcus INEDYQLFIFLAPYALDKDA------LRYITQPFGMLLHKGVLFTFN---QSGIPEVNTA PlasmidpNZ4000 INEDDQLFIFLAPYALDKDA------LRYITQPFGMLLHKGVLFTFN---QSGIPEVNTA oldMethanococcus EDEDFYLIIYKAPLFEEDIT---------TTS-LGIYIKNNLLLTIHSDKIKAIGRLHKL Methanococcus EDEDFYLIIYKAPLFEEDIT---------TTS-LGIYIKNNLLLTIHSDKIKAIGRLHKL oldLactococcus TDDNDNNLILLQYPPLSNYGE-----VATFPYSLVWTKNESVILALN-------HEIDNG Lactococcus3 TDDNDNNLILLQYPPLSNYGE-----VATFPYSLVWTKNESVILALN-------HEIDNG Lactococcus2 TDDNDNNLILLQYPALSNYGE-----VATFPYSLVWTKNESVILALN-------HEIDNG Aquifex EDKDYLEVTLSFVIPQK---------EEILVEPVVFYIKEKFFVTVRY---RDIPSIMIF newDeinococcus PYDT-FWFVVLHGASLPSQ-------DRLQLHEMALFIGQRFVLTIQH---QPLFADEEI Deinococcus3 PRRAVPRAHLRDGAQFAHPE-----QPDEFTERVSIFAFPPRTDSPHGAVLTHSRSGTRA Lactococcus4 TGKEELKILFILPHQNLKN------DLNRKIKALVILKLEEKLIIVTS---EKEDFISDF Bacillus GKEVVRQ--MERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSK----S Bacillus3 GKEVVRQ--MERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSK----S Escherichia_coli RMRARSQ--SMVDGNAYELLLDLFETKIEQLADEIENIYSDLEQLSRVIMEGHQGDEYDE Escherichia_coli3 RMRARSQ--SMVDGNAYELLLDLFETKIEQLADEIENIYSDLEQLSRVIMEGHQGDEYDE Ecoli RMRARSQ--SMVDGNAYELLLDLFETKIEQLADEIENIYSDLEQLSRVIMEGHQGDEYDE Salmonella RMRARSQ--AMVDGNAYELLLDLFETKIEQLADEIENIYSDLEKLSRVIMEGHQGDEYDE Escherichia_coli2 RMRARSQ--SMVDGNAYELLLDLFETKIEQLADEIENIYSDLEQLSRVIMEGHQGDEYDE Haemophilus RMRSRSQ--RLLECNSYEVLLDLFETKIEQLADVIENIYADLEELSRVILNGKQDEAFDE Helicobacter QKKVLAS--PKKFEDGFDILTKIFEVYFEKGVECLEWINKQTSLLRKNIIFKETS-THDD Helicobacter2 QKKVLAS--PKKFEDGFDILTKIFEVYFEKGVECLEWINKQTSLLRKNIIFKETS-THDD Schizosaccharomyces RRRARQL-RDYVHVSSDWLCYALIDDITDAFVPLIRGIETETEAIEDSVLVGRSE-DSSD Schizosaccharomyces2 RRRARQL-RDYVHVSSDWLCYALIDDITDAFVPLIRGIETETEAIEDSVLVGRSE-DSSD Thermotoga RERIRYNRGIIRKKRADYLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERP----EKE Archaeoglobus RSRLKSG-GRMRKLAGDYLAYTILDAVVDSYFEALLKISDEIEVLEDEVVSG-----DST Synechocystis RERIRTKKGAIRQKNADYLFYALIDAIIDGFFPVMEVYGELVQSLQSEIISCP----TNK Synechocystis2 RERIRTNQGKVCQQGADYLCYLLIDMLIDEYFPLLEDYEERIEALEDTIIRNP----NSS Bacillus2 RERLYAS-PDILKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIEESRPHKT----YGT Mycobacterium RKRMDAD-PEHLRLGPYAVMHAIADYVVDHYLEVTNLMETDIDSIEEVAFAPG----RKL Mycobacterium2 RKRMDTD-PEHLRLGSYAVMHAISDYVVDRYLAVTNLMEGDIDAIEEVAFAPG----RKL Pseudomonas LVQLAEG---KGPKTASELILYMAQYLTHKVQDLVTDLSEVVDLEEEKLDADER---YTP Pseudomonas2 LEDLEAG---KGPKTASEVVYYLAHYLTDRVDTLISGIADQLDAVEELVEADER---ASP oldDeinococcus VSGLVRR--VSTVKKNRLTLQLFLRNAQR-FLIDVRQINKRVDAIEDKMENATR----NR Deinococcus2 VSGLVRR--VSTVKKNRLTLQLFLRNAQR-FLIDVRQINKRVDAIEDKMENATR----NR Lactococcus LYSALDN--PEVKSVDAFILQTLFTVVVS-FIPISRAITKKRNYLDKMLNRKTK----NS PlasmidpNZ4000 LYSALDN--PEVKSVDAFILETLFTVVVS-FIPISRAITKKRNYLDKMLNRKTK----NS oldMethanococcus ISTKKPR--IVFERGIGFLLYHILNEITRSYSRILMNLEDELEELEDKLLAGYD----RE Methanococcus ISTKKPR--IVFERGIGFLLYHILNEITRSYSRILMNLEDELEELEDKLLAGYD----RE oldLactococcus LIFEREY--DYKRYKHQVIFQVMYQMTHT-FHDYLRDFRTRRRRLEQGIKNSTK----ND Lactococcus3 LIFEREY--DYKRYKHQVIFQVMYQMTHT-FHDYLRDFRTRRRRLEQGIKNSTK----ND Lactococcus2 LIFEREY--DYKRYKHQLIFQVMYQMTHT-FHDYLRDFRTRRRRLEVGIKNSTK----ND Aquifex KNRTNFQ--RKFFQFPESLFAEILGIEVDRIGDRLELLGNKIKDIWRQMFVEQS----EE newDeinococcus VERWQLVP-AAWRSSASSLTYVILDTIVDNLRELTDQIERELREVRTTMTRSQVV--HPE Deinococcus3 LGTVWALVGRETVNTAQEVTYELLDQTADGFFLAADALEAQVDALEEQIFRSPR----FN Lactococcus4 FKNTGEN----VER-SEVNFIQLLNVSIQKVIKDVKEKREEISLLETQIQSSGP---SGT : Bacillus ILNRVHLLRHELMIWKNLILSAKKIEMALKETFLP------QNEGKKDYQRTQLKIDRGF Bacillus3 ILNRVHLLRHELMIWKNLILSAKKIEMALKETFLP------QNEGKKDYQRTQLKIDRGF Escherichia_coli ALSTLAELEDIGWKVRLCLMDTQRALNFLVRKARL------PGGQLEQAREILRDIESLL Escherichia_coli3 ALSTLAELEDIGWKVRLCLMDTQRALNFLVRKARL------PGGQLEQAREILRDIESLL Ecoli ALSTLAELEDIGWKVRLCLMDTQRALNFLVRKARL------PGGQLEQAREILRDIESLL Salmonella ALSTLAELEDIGWKVRLCLMDTQRALNFLVRKARL------PGGQLEQAREILRDIESLL Escherichia_coli2 ALSTLAELEDIGWKVRLCLMDTQRALNFLVRKARL------PGGQLEQAREILRDIESLL Haemophilus ALNTLTEQEDTSSKVRLCLMDTQRALGFLVRKTRL------PTNQLEQAREILRDIESLQ Helicobacter ILVRLSNLQEFNVTLRDSFFDKRRIITALLRSNKV------DSDTKNNLNIILTDFSSLV Helicobacter2 ILVRLSNLQEFNVALRDSFFDKRRIITALLRSNKV------DSDTKNNLNIILTDFSSLV Schizosaccharomyces MLRRIGECRKKTMGMFRLLYGKADVIKMLAKRCNEKWTIAPTGEIGLYLGDIQDHLVTMT Schizosaccharomyces2 MLRRIGECRKKTMGMFRLLYGKADVIKMLAKRCNEKWTIAPTGEIGLYLGDIQDHLVTMT Thermotoga TVQRTHQLKRNLVELRKTIWPLREVLSSLYRDVPP----LIEKETVPYFRDVYDHTIQIA Archaeoglobus LIGKIHSLKREILAFRNAVWPLRDVLSFFTRVEHE----LIGEEVKVYYRDVYDHAVRLM Synechocystis SLAKIHQLQQDLLIMRRAIWPQRDAINSLLRDGSD----LISDEVRVFLRDCYDHTIQIL Synechocystis2 LMEEIYHIRRELLALRRLIWPLRHVMNVLLRDTTNS---IVTADVRIYFRDCYDHIIQVL Bacillus2 LMNEVFDLRTDLLHLRRTIIPMRDLLYRILSLDHV----KEQRETKAYFSDIYDHLLKLS Mycobacterium DIEPIYLLKREVVELRRCVNPLSTAFQRMQTESKD----LISKEVRRYLRDVADHQTEAA Mycobacterium2 NVEPIYLLKREVIELRRCVAPLSAALQRMQTDNKD----LISKELRRYLRDVADHQTEAA Pseudomonas EHGNVLQIRRRAAGLKRFLAPQRDIFAQLTRIKLP----WFCDDDADYWNELNNSLTRYL Pseudomonas2 DQHQLRTLRRRSAGLRRYLAPQRDIYSQLARYKLS----WFVEDDADYWNELNNRLTRNL oldDeinococcus ELLDLLKLEKSLVYFITGLKANEAMMERVKRDRIFE---MYEED-SELLDDVLIENLQA- Deinococcus2 ELLDLLKLEKSLVYFITGLKANEAMMERVKRDRIFE---MYEED-SELLDDVLIENLQAI Lactococcus DLVSLSYLQQTLTFLSSAVQTNLSELDRLPKTHFGV---GADQDKIDLFEDVQIEGEQVQ PlasmidpNZ4000 DLVSLSYLQQTLTFLSSAVQTNLSELDRLPKTHFGV---GADQDKIDLFEDVQIEGEQVQ oldMethanococcus VMEKILGLRKTLVYFHKSLIANRDVLVLLKRKYLPI---TTKED-RENFEDLYYDTLQLI Methanococcus VMEKILGLRKTLVYFHKSLIANRDVLVLLKRKYLPI---TTKED-RENFEDLYYDTLQLI oldLactococcus QIVDLIAIQASLIYFEDALHNNMQVLQDFID-YLRE---DDEDGFAEKIYDIFVETDQAY Lactococcus3 QIVDLIAIQASLIYFEDALHNNMQVLQDFID-YLRE---DDEDGFAEKIYDIFVETDQAY Lactococcus2 QIVDLIAIQASLIYFEDALHNNMQVLQNFID-YLRE---DDEDGFAEKIYDIFVETDQAY Aquifex MIRELAFYDELNITLRESINEKIRIITKALKSPLIN------AHTKKELRIIYEDLTTLL newDeinococcus LLQRIFSLEEVTHEAYTVALSLRDTLPTFVHAPEEAP--VGGPAQAPYYRDVHDHAIGVV Deinococcus3 PVEPVFDLKHLLGQARRLTTDAREASALLGRQAST-------AAEQVRYRDVQDSFTRVG Lactococcus4 IFDEILRLKKYLILLDFIIDSDRKILSFIKREQMEN---IKEIHMQTEVTLLEERMDTLE Bacillus TYISEFEGELNNLLHSEEVITSH-------RGNEIVKALTIFTTLFTPITALGALWGMNF Bacillus3 TYISEFEGELNNLLHSEEVITSH-------RGNEIVKALTIFTTLFTPITALGALWGMNF Escherichia_coli PHNESLFQKVNFLMQAAMGFINI-------EQNRIIKIFSVVSVVFLPPTLVASSYGMNF Escherichia_coli3 PHNESLFQKVNFLMQAAMGFINI-------EQNRIIKIFSVVSVVFLPPTLVASSYGMNF Ecoli PHNESLFQKVNFLMQAAMGFINI-------EQNRIIKIFSVVSVVFLPPTLVASSYGMNF Salmonella PHNESLFQKVNFLMQAAMGFINI-------EQNRIIKIFSVVSVVFLPPTLVASSYGMNF Escherichia_coli2 PHNESLFQKVNFLMQAAMGFINI-------EQNRIIKIFSVVSVVFLPPTLVASSYGMNF Haemophilus PHNESLFQKVNFLMQAAMGYINI-------EQNKIMKFFSVVSVMFLPATLVASTYGMNF Helicobacter ESTTVNLNSLDNIQNLFASQVNV-------EQNKIIKLFTVATMAMMPPTLIGTIYGMNF Helicobacter2 ESTTVNLNSLDNIQNLFASQVNV-------EQNKIIKLFTVATMAMMPPTLIGTIYGMNF Schizosaccharomyces SNLSQFEKILSRTHSNYLAQLTSNSIEENSRTNGALGKITLIGTLLVPMNLVTGLFGMNV Schizosaccharomyces2 SNLSQFEKILSRTHSNYLAQLTSNSIEENSRTNGALGKITLIGTLLVPMNLVTGLFGMNV Thermotoga DTVETFRDIVSGLLDVYLSSVSN-------KTNEVMKVLTIIATIFMPLTFIAGIYGMNF Archaeoglobus EVLETQRELLVSLRDLFLSAVSN-------KLNEIMKVLTMIATIFIPLSFIAGVYGMNF Synechocystis DMIETYRDLASNLTDIYLSSVSN-------RMNEIMKTLTVISSIFIPLTFIAGIYGMNF Synechocystis2 DIIEAYRELASSLMEVYMTAMSN-------KMNEVMKFLTVISTIFIPLTFIAGVYGMNF Bacillus2 EIVESNRDMTSDLRDSYVTLNSN-------RMNAIMMTLTIVSTIFIPLTFIAGVYGMNF Mycobacterium DQIASYDDMLNSLVQAALARVGM-------QQNMDMRKISAWAGIIAVPTMIAGIYGMNF Mycobacterium2 DQIASYDDMLNSLVQAALARVGM-------QQNNDMRKMAAWAGIVAMPTMVAAIYGMNF Pseudomonas EELELTRERVGLVLEAEDRRLSV-------RMNRTMYRFGIITGIFLPMSFLTGLLGINV Pseudomonas2 EELELIRERISVLQEAESRRITE-------RMNRTMYLLGIITGFFLPMSFVTGLLGINV oldDeinococcus ------------------------------------------------------------ Deinococcus2 EMASIASNILTSMAGAFASVINN-------NVNQVVKVLTVTTILVAIPTLVSGFFGMNV Lactococcus RMFEIETQVVDRIDHTLNSLANN-------NLNDTMKFLTIWSLTMAVPTIITGFYGMNV PlasmidpNZ4000 RMFEIETQVVDRIDHTLNSLANN-------NLNDTMKFLTIWSLTMAVPTIISGFYGMNV oldMethanococcus DMSATYREVLTSMMDITLSLENI-------KMNQIMKILTMVTTIFAVPMWITGIYGMNF Methanococcus DMSATYREVLTSMMDITLSLENI-------KMNQIMKILTMVTTIFAVPMWITGIYGMNF oldLactococcus TETKIQLKLLENLRDLFSNNVSN-------NLNIVMKIMTSATFVLGIPAVIVGFYGMNV Lactococcus3 TETKIQLKLLENLRDLFSNNVSN-------NLNIVMKIMTSATFVLGIPAVIVGFYGMNV Lactococcus2 TETKIQLKLLENLRDLFSNIVSN-------NLNIVMKIMTSATFVLGIPAVIVGFYGMNV Aquifex EYTSFYMEKIDSIQNSLLGLITI-------RQNEAVKVFTVLATIFLPATLIASIFGMNF newDeinococcus ERLGAERDLSQRVFDVYQSLAAQ-------QQSEVARQLTVVSTIFLPLTFLTGFFGQNF Deinococcus3 SRLDGLRESLSSLLDLHLALQGQ-------RMNEVMRTLTSVSVVFLPLTFLAGVWGMKF Lactococcus4 SLVRAYNKYLSSLDTIINNNSSF-------QLNNIMKTLTELTVVLTIPTITYGFWGINL Bacillus S------VMPELNWKYGYLFSLLLIVTSTVLIYLYL-------RKKGWTGDMLQERKKKK Bacillus3 S------VMPELNWKYGYLFSLLLIVTSTVLIYLYL-------RKKGWTGDMLQERKKKK Escherichia_coli E------FMPELKWSFGYPGAIIFMILAALAPYLYF-------KRKNWL----------- Escherichia_coli3 E------FMPELKWSFGYPGAIIFMILAGLAPYLYF-------KRKNWL----------- Ecoli E------FMPELKWSFGYPGAIIFMILAGLAPYLYF-------KRKNWL----------- Salmonella E------FMPELKWSFGYPGAIIFMILAGLAPYLYF-------KRKNWL----------- Escherichia_coli2 E------FMPELKWSFGYPGAIIFMISRAWHRICTLSGRTGCKKRERWLSLAKPPVIQRL Haemophilus D------FMPELHFKYGYPMAIGLMIAAALTPYIYF-------RRKGWL----------- Helicobacter K------FMPELEWQYGYLFALIVMAISTILPVIYF-------KKKGWL----------- Helicobacter2 K------FMPELEWQYGYLFALIVMAISTILPVIYF-------KKKGWL----------- Schizosaccharomyces PVP----GRDTNNLAWFFGILGVLLGSIAIGWIITM-------RYNAF------------ Schizosaccharomyces2 PVP----GRDTNNLAWFFGILGVLLGSIAIGWIITM-------RYNAF------------ Thermotoga E------YMPELRWKWGYPVVLAVMGVIAVIMVVYF-------KKKKWL----------- Archaeoglobus K------YMPELEWKYGYPAVLTVMAVIALVMIAFF-------RRKGWL----------- Synechocystis NPDKSPWNMPELNWYWGYPVIWMVMLTVGGMMLYFF-------WRKGWFRNLNDVEKGNR Synechocystis2 ---K---EMPELNSRWGYYITWIVMLLIAGGSLYFF-------WRKGWLSPSYDLGEK-- Bacillus2 D------FMPELHWKYGYFAVLGLMAALVIGMLIWF-------VHKGWFNIFK------- Mycobacterium H------FMPELDSRWGYPTVIGGMVLICLFLYHVF-------RNRNWL----------- Mycobacterium2 R------FMPELNWTWSYPLVMAGMTIVCLVLYWQF-------RNRNWL----------- Pseudomonas G------GIPFSASPYGFVIACLLMVSVALGQWWLF-------RRLRWV----------- Pseudomonas2 G------GIPGADAPHGFWLACLLIGGVATFQWWVF-------RRLRWL----------- oldDeinococcus ------------------------------------------------------------ Deinococcus2 EG------LPFSDSPYGFWLVMTVAMGIASLLAFLF-------YRWKVF----------- Lactococcus KK------LPLAGMQDAWMLTLGISVALIVAMLIML-------KFWRKM----------- PlasmidpNZ4000 K-------LPLAGMQYAWMLTLGISVVLIVAMLIML-------KVWRKM----------- oldMethanococcus SY------LPLANNPQGFWLVMALMVVIIMIFVYIF-------RRSGWI----------- Methanococcus SY------LPLANNPQGFWLVMALMVVIIMIFVYIF-------RRSGWI----------- oldLactococcus P-------IPGQNFNWMVWLILVLGILLCVWVTWWL-------HKKDML----------- Lactococcus3 P-------IPGQNFNWMVWLILVLGILLCVWVTWWL-------HKKDML----------- Lactococcus2 P-------IPGQNFNWMVWLILVFGILLCVWVTWWL-------HKKDML----------- Aquifex K------HMPELHWKYGYPYSLFLMVFVTLVLLFWV-------RRKGWL----------- newDeinococcus EYLTQKIASERAFWVWGFGSYLLSLLAIAWVIRRVS--------RWGRDG---------- Deinococcus3 Q------HMPELATRYGYAFAWLTFLLIGGLLTYWF-------KRRGWW----------- Lactococcus4 K-------LPFQGVPYGSLLVIVISLLISLLVWYWLK------KKKSL------------ Bacillus KPRKRRTL-- Bacillus3 KPRKRRTL-- Escherichia_coli ---------- Escherichia_coli3 ---------- Ecoli ---------- Salmonella ---------- Escherichia_coli2 QVFNPFTSFS Haemophilus ---------- Helicobacter ---------- Helicobacter2 ---------- Schizosaccharomyces ---------- Schizosaccharomyces2 ---------- Thermotoga ---------- Archaeoglobus ---------- Synechocystis ---------- Synechocystis2 ---------- Bacillus2 ---------- Mycobacterium ---------- Mycobacterium2 ---------- Pseudomonas ---------- Pseudomonas2 ---------- oldDeinococcus ---------- Deinococcus2 ---------- Lactococcus ---------- PlasmidpNZ4000 ---------- oldMethanococcus ---------- Methanococcus ---------- oldLactococcus ---------- Lactococcus3 ---------- Lactococcus2 ---------- Aquifex ---------- newDeinococcus ---------- Deinococcus3 ---------- Lactococcus4 ----------