CLUSTAL X (1.64b) multiple sequence alignment Methanococcus ---------------------------METYEKIELGIIVIIL----LILIESVILMTVE Methanococcus2 ---------------------------METSKKLVIVAVLSIT----LILTYAYLISIIE Ecoli --------------MDSHTLIQALIYLGSAALIVPIAVRLGLG----SVLGYLIAGCIIG *Klebsiella --------------MDSHTLIQALIYLGAAALIVPIASVLGLG----SVLGYLIAGCIIG *Ecoli9 -------------MEGSDFLLAGVLFLFAAVAAVPLASRLGIG----AVLGYLLAGIAIG *Myxococcus ----------------MSFLQQALVFLAAVVLADPLSRRLGLG----SVLGYLAGGAVIG Ecoli7 --------------------MSHWTTFKQTATKLWVTLRHDI-----LALAVFLNGLLIF Helicobacter ----------MFEKLKFFKIKKDDEIQPEVNLNSEIYEQFKVFR---LPLILIQLLVLLG Helicobacter2 ----------MFEKLKFFKIKKDDENQPEVNLNSEIYEQFKVFR---LPLILIQLLVLLG *Streptomyces -----------------------------------------------MHIVIMGCGRVGS *Mycobacterium2 -----------------------------------------------MRVVVMGCGRVGA *Azorhizobium -----------------------------------------------MKVVICGAGQVGF Vibrio -----------------------------------------------MKIIILGAGQVGG *Haemophilus -----------MSQLANPELMKVVILLASSVTIVPLFKRLGLG----SVLGYLVAGCLIG *Arabidopsis ------MIPHQEVNEEEASLFDFLWLLLASVIFVPLFQKIPGGS---PVLGYLAAGILIG Archaeoglobus ---------------------------MSSTSTPFLKIGIFLSL---VVLAGTVGYHFVE Deinococcus --TPLRSTGWRREPGPVSLLCARRPAAPGTRRGAKVFYTWAVNRSPLLLSGLLLGLLAFG Synechocystis --------------------MGLGSSSQENLLNLIDRQGRRLRQELMAGAITLAGLFVVG Thermotoga ----------MPEILINYKTNREDYKRQSKYCNICMRRYKSVKKNVIILALMIVFVFVFG Synechocystis2 ----------------------------MQDSNQRLKLGVLFF----VVTLVLATLGYIC *Methanobacterium3 ------------------------------------------------MTGVIAGPSVLG *Pyrococcus -----------------------------------------------MYIVIMGAGRIGT *Aquifex2 ------------------MRFVRKKKRRKRLIDIYENRLFEILSLFRLPLLMLHTVLTIG *Ecoli8 ----------------MHHATPLITTIVGGLVLAFILGMLANKLRISPLVGYLLAGVLAG Methanobacterium2 --------------------------MVLVIEIIRKHLPRVLKVPATRILLLVLAVIIYG *Synechocystis4 -----------------------------------------------MYILIGGMGSMGS *Mycobacterium3 -----------------------------------------------MKVAVAGAGAVGR Mycobacterium MAGSWRRLRGLNEKLTAQPGYALVGVLRIPQRRASPARVISRRVVVAVVALLLTAGIVYV Methanobacterium ----MTLALGGVGLIAYVFSLTVSVVTMTLQDTISGARIRRLMQSMNNHFILCGFGRVGS *Synechocystis3 ----MKPHIIVCGLGQTGYRIFSLLKQQGAEVIGVSDRPVPGENPSNIVVGQLNSTATLT Aquifex ------------MRKLLYELLEDDRSFVFYIYNTFSFSVILISVILTLYDEFYGFHSKLH *Bacillus ---------MFCTFFEKHHRKWDILLEKSTGVMEAMKVTSEEKEQLSTAIDRMNEGLDAF *Archaeoglobus2 --------MTENGRYEYIVIGSEAAGVGLVRELTAAGKKVLAVDKSKEKIELLEDEGFDA Methanococcus GWDF-FTAFYTAVVTISTVGYGDYT-----------P-QTFLGKLSVIIYIFAGVGAVAY Methanococcus2 GVDY-FTALYFSVITITTTGYGDFT-----------P-KTFLGRTLTVVYLCVGVGIVMY Ecoli PWGLRLVTDAESILHFAEIGVVLMLF-----IIGLELDPQRLWKLRAAVFGCGALQMVIC *Klebsiella PWALRLVNDAEAILHFAEIGVVLMLV-----AMGLELDPQRLWKLRASVFDGGALQMVAC *Ecoli9 PWGLGFISDVDEILHFSELGVVFLMF-----IIGLELNPSKLWQLRRSIFGVGAAQVLLS *Myxococcus PWGLKLISDVEHIFHVAELGVVVLLL-----FVSLELQTSRLWALRRSVFGLGGAQVLFT Ecoli7 KTIYGMSVNLLDIFHIKAFSELDLS--------LLANAPLFMLGVFLVLNSIGLLFRAKL Helicobacter TLGYFALENYSLMQAFFQTTYTMTATGF---GALNESQFGPISIFLTSILMFFGAGIIAF Helicobacter2 TLGYFALENYSLMQAFFQTTYTMTATGF---GALNESQFGPISIFLTSILMFCGTGIIAF *Streptomyces ALAQALEQQGHTVAVIDRDPTSFRR-----------LGSSFGGRRVTGIGFDQDTLREAG *Mycobacterium2 SVADGLSRIGHEVAIIDRDSAAFNR-----------LSPQFAGERVLGQGFDRDVLLRAG *Azorhizobium GIAERLASEQNDVSIVDASPRRIQI-----------ATDQLDVRGVVGHGSHPDVLARAG Vibrio TLAENLVGENNDITIVDNNADRLRE-----------LQDKYDLRVVNGHASHPDVLHEAG *Haemophilus PSVFGIVQEPTAVVHLAELGVVMFLF-----IIGLEMYPERLWAMRKAIFGRGLLQVGLC *Arabidopsis PYGLSIIRNVHGTRAIAEFGVVLLLFN-----IGLELSVERLSSMKKYVFGLGSAQVLVT Archaeoglobus GWDW-FDSLYMTVITITTTGYGEVK------------PMGPGGRVISMLLMFVGVGTFLY Deinococcus SLGYRLTEGWSWLDCLYMTEMVLTTVG-----FGEVHPLSPAGKAFSILLMLFGIGLMLY Synechocystis TAWYRYVEDWTWLDAFYMTTITLATVG-----FGETHPLSPASRLFTILLILMGLLTIGY Thermotoga TVAFHLIEGWNLFDSFFFTLITVSTVG-----YSIPENLSQAGKVIASILISAGVTIVLY Synechocystis2 FGWTTTEAVYMVVITVFGVGYGEVR-----------PLTTTAERVFTMGVILAGTTSAVY *Methanobacterium3 AVSSGSIESLAELGVILLLFTIGLE-----------MSAERFGEFRRTALIGGTLQICLT *Pyrococcus LVARMLESEGHDVAIIEMNRERARE-----------ISEYISGLVIEGDATDQKVLENAN *Aquifex2 TLGYMILSDGDFINSLYMTVITVGTIGY---GEVVEGSDTLIGRTFTTFLALGGIGVFTT *Ecoli8 PFTPGFVADTKLAPELAELGVILLMFG------VGLHFSLKDLMAVKAIAIPGAIAQIAV Methanobacterium2 TAGFHFIEGESWTVSLYWTFVTIATVG-----YGDYSPSTPLGMYFTVTLIVLGIGTFAV *Synechocystis4 NLAKNLLKMGHTVAAVDTDPLACQY-----------AREKIGVMAFEGSAVNTSVLLEAG *Mycobacterium3 SVTRELVENGHDITLIERNPDHLDA------------AAIPEAHWRLGDACELSLLESIH Mycobacterium DRDGYLDAQGDRLTFLDCLYYAAVTLS-----TTGYGDITPISEFARAINIFVITPLRIA Methanobacterium AVFKELQKRNQKSIIIEKDREIVEKELWDDPNVLAIPESAADEETLRAAGIKRARGVIIT *Synechocystis3 RAAIHTAQTLVLATSDDALNLAILTQARILNPRIRIVNRLFNHALGKRLDTTLPDHVSLS Aquifex PVVLEIEWVASGIIAFELIGRYILAEN-------KLKYLTNSLTILDFIALIPTFQIFRA *Bacillus IQLYNESEIDEPLIQLDDDTAELMKQAR-----DMYGQEKLNEKLNTIIKQILSISVSEE *Archaeoglobus2 VIADPTDESFYRSLDLEGVSAVLITGSDDEFNLKILKALRSVSDVYAIVRVSSPKKKEEF Methanococcus TMGNIAS--FFIEGHFRKYFRLRKMMDRIKKLNNHYIICGYGRLGKVIAEEFKKCNIPFV Methanococcus2 LFSLIAE--FIVEGKFEEFVRLKKMKNKIKTLKDHYIICGYGRLGKVVGEKFIEENIPFI Ecoli GGLLGLF--CMLLGLRWQVAELIGMTLALSSTAIAMQAMNERNLMVTQMGRSAFAVLLFQ *Klebsiella GVLIGLF--CMLLGLRWQVAELIGMTLALSSTAIAMQAMNERNLTVSQMGRSAFAVLLFQ *Ecoli9 AALLAGL--LMLTDFAWQAAVVGGIGLAMSSTAMALQLMREKGMNRSESGQLGFSVLLFQ *Myxococcus GALLASV--GLLCSLTWGAAIVTGFGLSLSSTAFALQLLVERNRLTTPYGQLAFGILLFQ Ecoli7 AWAISII--LLLIALIYTLHFYPWLKFSIGFCIFTLVFLLILRKDFSHSSAAAGTIFAFI Helicobacter SVAILVS--VVNKGTLTRLIKEKGMIYKIARLKDHYVICYHNEYTIELSKQFRSAQIPFV Helicobacter2 SVAILVS--VVNKGTLTRLIKEKGMIYKIARLKDHYVICYHNEYTIELSKQFRSAQIPFV *Streptomyces IEEAGAF--AAVSSGDNSNIIAARVAREMFGVENVAARIYDPRRAEVYQRLG----IPT- *Mycobacterium2 IQGADAF--AAVSSGDNSNIISARLARETFGVPRVVARIYDAKRAEVYERLG----IPT- *Azorhizobium IEQADML--IAVTLHDEVNMVACQVGHSLFNVPTSPASAPRPICSPNGAGG--------- Vibrio AQDADML--VAVTNTDETNMAACQVAFTLFNTPNRVARIRSPEYLAEKEALFKSGAIPVD *Haemophilus GCLLTFSG-IYLLGLTKEVSFIAGMGFTLSSTAIVMQSLEERGLTSTSKGQRVISTLIFE *Arabidopsis AAVVGLLA-HYVAGQAGPAAIVIGNGLALSSTAVVLQVLQERGESTSRHGRASFSVLLFQ Archaeoglobus AVNVFMG--LIVEGRIEK-----RWEKMIEKMEDHFILCGYGLMGREIIKELPKD----K Deinococcus LLTLLAE--YVLRSVTDPDAQRRRKEKKVLSLREHTIVCGYGQVGEAVATALRGAG--RT Synechocystis MVNRFTE--AFIQGYFQDSLRRRQEQKVIERLADHYILCGYGRTGQQIAFEFAVENIPFV Thermotoga GFTSVTS--MIVEGHIGEYFKSRRMRKMIDRLKDHFIVVGAGRTGRHTTLEIMKAKKPFV Synechocystis2 IVGAFVQ--MVTEGEIHRALGNQQRQRQIANLTDHTIICGFGRMGQVLAKQLKQSGLPFS *Methanobacterium3 VSVVTIL--TMVLGLSPGKAVFLGFLISLSSTAVVLKVLQDFHETEAPHGQASLAILIFQ *Pyrococcus IKNANAF--AALTGKDDANILACILAKHLNPNIMTILRITDPGKKKIFEDVKELK-TYFD *Aquifex2 SVTILIR--IFFQEDFIGVLRAWKMLRDIEKLRGHFIIVGFNKTSQELIRLLRKRKIEIV *Ecoli8 ATLLGMAL-SAVLGWSLMTGIVFGLCLSTASTVVLLRALEERQLIDSQRGQIAIGWLIVE Methanobacterium2 AVERLLE---FLINREQMK----LMGLIDVAKSRHVVICGWSESTLECLRELRGS--EVF *Synechocystis4 VRKAGAV---IAALQEDALNLALVTLSKHYGVPQIVVRMSDGDFAEPYRLAGATHIISTT *Mycobacterium3 LEEFDVV--VAATGDDKVNVVLSLLAKTEFAVPRVVARVNDPRNEWLFNDAWG-----VD Mycobacterium FLILLVG--TTLEVLTETSRQAYKIQRWRSRVRNHTVVIGYGTKGKTAVAAMVSDELVPG Methanobacterium TGDDVDN--LFITLTCRELNPDIWIVTRASKRENIKRLYRAGANRVISPEISGGEDIYFA *Synechocystis3 VSALAAPI-FSFAALGNQAIGQLRLFDQTWPIQEIVIHQDHPWLNLPLADLWDDPSRMLI Aquifex VRLIVLIA-RVLRLTYRYRFFFGFFANIIKEFAFELIFVFALILVVIFSILLIVFSVEHG *Bacillus GEKELKSNRIFISWLRWPLFIRIGVIILCLILLFGQIIYILEPKQFTSVFEGIWWAVVTV *Archaeoglobus2 EEAGANLVVLVADAVKQAFMDKIKKMETLKKIEKLKRIMESLRGKRLGIFTHDNPDPDSM Methanococcus IIDSDEKLLEEALEKDPN-------LICIVGDATSDDILKKAKIEKAKGL---------- Methanococcus2 AIDINEDVLKEEYEKYPDK------FLYIVGDAKKEEVLKKAKIDKAKGL---------- Ecoli DIAAIPLVAMIPLLATSSA------STTMGAFALSALKVAGALVLVVLLGR---YVTRPA *Klebsiella DIAAIPLVAMIPLLAASGG------ATSLMAFALSALKVAAALALVVVLGR---YLTRPL *Ecoli9 DLAVIPALALVPLLA---G------SADEHFDWMKVGMKVLAFVGMLIGGR---YLLRPV *Myxococcus DLAVVPLLALLPLLGD-GG------APSPGTVWLLLLKDVGVLLAEVLSGR---YLVRPA Ecoli7 SFTTLLFYSTYGALYLSEG------FNPRIESLMTAFYFSIETMSTVGYG---------- Helicobacter VVDNDPSFEEEAIKHKYP--------YYIIGDPHTNLAMLKTHLSSARGVV---ALSKIL Helicobacter2 VVDNDPNFEEEAIKHKYP--------YYIIGDPHTNLAMLKTHLSSARGVV---ALSKIL *Streptomyces --VATVRWTADQMLRRLLP------SGAEPLWRDPTGGVQLAEVHTSSS----------- *Mycobacterium2 --ITTVPWTTDRLLNALMQ------DTETAKWRDPTGTVAVAEVVLHED----------- *Azorhizobium ------------------------------------------------------------ Vibrio HLIAPEELVTSYIERLIQY------PGALQVVSFAEQKVSLVAVKAYYGG---------- *Haemophilus DIAIVPLLASVAFLAPHSK------EATPHTDWVSIGIALSAVVGLIVTGK---WLMNPL *Arabidopsis DLAVVVLLILIPLISPNSSKGGIGFQAIAEALGLAAVKAAVAITAIIAGGR---LLLRPI Archaeoglobus VVVIDSDIGKVSAAREDG-------YVAVHGDATDDFTLEKAGIGKAKAL---------- Deinococcus VVVIDQRPAHLEWAEAHG-------LYTLVGDATDEDVLRRAGIEHAAAL---------- Synechocystis VIDASPEVIIQAKLRD---------YAVLQGDATLDEILLAAHIERAICI---------- Thermotoga VIDQSEEAIARLKDFLGEE------FPYVVGDATEEEILMKAGVERARSL---------- Synechocystis2 IIDNQPSQVAIAEELG---------YLAHCGDATREEQLQMLGVMRAKTL---------- *Methanobacterium3 DVAAVPMILTVPFLGGVVG--------DPSSALGTLLTAGAVLPWEPCIGK---VLVPRL *Pyrococcus IVVSPEDIAANYIFR----------TLVTPGFNRVLLPREGAEIIQFQID---------- *Aquifex2 VVDSRREVERQIKESK-VK-------YYIIEEPYKRVVLEAAGIYKAMGMV---VN---- *Ecoli8 DLVMVLTLVLLPAVAGMMEQGDVGFATLAVDMGITIGKVIAFIAIMMLVGR---RLVPWI Methanobacterium2 VLAEDENVRKKVLRSG---------ANFVHGDPTRVSDLEKANVRGARAV---------- *Synechocystis4 ELALNRVINAIEYPQVDA-------MMHFEQGQIEVLKLSIPPNCTIVGR---------- *Mycobacterium3 VAVSTPRMLASLIEEA-----------VTIGDLVRLMEFRTGQANLVEIT---------- Mycobacterium EIVVVDTDSGVLERAAAAG------LVTVHGDATKSDVLRLAGTQHASS----------- Methanobacterium AMEPTMVKITVKHDVDDIG--REARIILKHGCTLEDIEYHLPEFKEPLVRK---IG---V *Synechocystis3 YYLPAHSETDLVGAVVNNLTLQSGDHLIVGQKPQPKTKRRSPWRKFSKLITNLREYQRYV Aquifex GGNEKINTFFDALYYVIIT-----ATTVGYGDITPTTPLGKALAMVLGVLG------LFL *Bacillus STVGYGDYVPHTPLGQAAG------ILLILSGASFVTAYFATLSAAAFSR---------Q *Archaeoglobus2 SSAYALREIAKQFDVIADILYYG--EILHQKNRAMVNLLEIPMIRAPEVDLS----HYDA Methanococcus -ISVVSSDAENVFITLSA-KKLNPNIYIVAKAEKPSTLDKLIKAGADRAVCPYIVGGMEI Methanococcus2 -IATLPSDADNVFLTLTA-RELNPNILITAKADEKEAIRKLKIAGANRVVSPYLIGGLRM Ecoli LRFVARSGLREVFSAVAL-FLVFGFGLLLEEVGLSMAMGAFLAGVLLASSEYRHALESDI *Klebsiella LRFVARSGLREVFSAVAC-SWSSALGLLLEEVGLSMAMGAFLAGVLLASSEYRHALENDI *Ecoli9 FRFIAASGVREVFTAATL-LLVLGSALFMDALGLSMALGTFIAGVLLAESEYRHELETAI *Myxococcus FRAVAATHRQELFTATAL-LLVVATASVINAVGLSMGLAASLAGVLLADSEYRHELEADL Ecoli7 -DIVPVSESARLFTIS-----VIISGITVFATSMTSIFGPLIRGGFNKLVKGNNHTMHRK Helicobacter PVNVALMVSVRLFEKELK----RKPYYIIASAHSDEGLEKLKKLGADMVVSPTKLMAQRV Helicobacter2 PVNVALMVSVRLFEKELK----RKPYYIIASAHSDEGLEKLKKLGADMVVSPTKLMAQRV *Streptomyces ---WVGHKISRLQEET----GVRVAFVTRLGEAI-------------------------- *Mycobacterium2 ---WVGHRATDLEQAT----GARIAFLIRFGTGVLPEPKTVLQAGDKVYIAAISGRAAEA *Azorhizobium ------------------------------------------------------------ Vibrio --PLVGNALSALREHMPH-IDTRVAAIFRQGRPIRPQGTTIIEADDEVFFVAASNHIRSV *Haemophilus FRLISKARIREMMTAGAL-LVVLGAALAMEIGGLSMAMGAFVAGVMMSESAFRHQLEADI *Arabidopsis YKQIAENRNAEIFSANTL-LVILGTSLLTARAGLSMALGAFLAGLLLAETEFSLQVESDI Archaeoglobus --ICCMSDASNAFAILTA-KELNPRIKTVAILRSPDAEKKMRRVGVDILLSPYRDAAKKI Deinococcus -VSVLSSDPANLYVVLSA-KGLNPGLRVIARASDESAARKMRRAG--------------- Synechocystis -VSALSSDAENLYTVLSA-KTLNPKIRAIARASSEEAVQKLKRAGADEVVSPYITGGKRL Thermotoga -VVTLPDDAKSTFVVLTA-KSLNPNLEIVSRVSDMKALSKLVYAGADKVIATSELAGVRL Synechocystis2 -ATVLPEDATNVFITLTA-RELNSRLTILARGEIPETERKLRLAGADQVILPLTVGAVQM *Methanobacterium3 FDVVAATGSREIFLLTVI-LVCASVTWLTGEVGLSPALGAFLVGSIVANTEYAHRAQGTI *Pyrococcus -EDCEVAGKPVKELNLPK-DSLIIAVYDEKGNLTIPSGDTIIPKKGQVIIFAKNSALQEV *Aquifex2 -LGDDAKNIAVIVTARLM-RPKKEDFFIYSFASSEDTAQKLEELGANRAVVPYRLLATRV *Ecoli8 MARSAATGSRELFTLSVLALALGVAFGAVELFDVSFALGAFFAGMVLNESELSHRAAHDT Methanobacterium2 -IVDLESDSETIHCILGI-RKIDESVRIIAEAERYENIEQLRMAGADQVISPFVISGRLM *Synechocystis4 --SVAAIAQDPRFPSGTL---IIGYQANAHEDLKIPNGNTLLEDGSTILAVTKPELVRQL *Mycobacterium3 -LPDNTPWGGKPVRKLQLPRDAALVTILRGPRVIVPEADEPLEGGDELLFVAVTEAEEEL Mycobacterium -IIVATSRDDTAVLVTLTAREIAPKAKIVASIREAENQHLLRQSGADTVVVSSETAGRLL Methanobacterium SDGGELERFLKILERDPARKSSLKRIYESVSGIHSHWISGPDRESIDAVIDELKSEGILL *Synechocystis3 QQVIWVVLFLLLMIFLATFIYVSIDQHIAPVDALYFSVGMITGAGGKEEVAEKSPDIIKV Aquifex FSLITATVSTAFFHYVNMLKMGMVSFRELKNHIVVCGWNETGEVMLEEIMKYWEEKGERK *Bacillus HRYIEGKVAYKGRDHIILIGWNEKTNRLLKDLQLGAPSKTVVLIDESLTEGPLIENVHFI *Archaeoglobus2 FAIVDSSGPGVNNSIPPDIDISIVIDHHPAEKVVAEFVDLREDVGATATILTEYIKELKI Methanococcus ARIAINPDIVEFIHSLVAT------------EEDMEVRRYIVK-NKELDNKLLKDSGIR- Methanococcus2 AEVSVRPGILDFLSTFIKIAK-------DEYEEDIELRKFVIEKDSELAYKSLKDANIR- Ecoli EPFKGLLLGLFFIGVGMSIDFG--TLLENPLRIVILLLGFLIIKIAMLWLIARPLQVPNK *Klebsiella EPVKGLLLGLFFIGVGMSIDFA--PWSPNPLRIVILLVGFPAIKMLMLWLIAQPLGVPRA *Ecoli9 DPFKGLLLGLFFISVGMSLNLG--VLYTHLLWVVISVVVLVAVKILVLYLLARLYGVRSS *Myxococcus APFKGLLMGLFFISVGMTVNLS--LILQKPLLVFGLVLGLVALKGAVLYGLGRMALGRRE Ecoli7 DHFIVCGHSILAINTILQLNQ------RGQNVTVISNLPEDDIKQLEQRLGDNADVIPG- Helicobacter SAMAVRPDMENILERFINKKD----------TLLDLEE-VIVPKTSWLVLRKLKEAHFRE Helicobacter2 SAMAVRPDMENILERFINKKD----------TLLDLEE-VIVPKTSWLVLRKLKEAHFRE *Streptomyces ------------------------------------------------------------ *Mycobacterium2 AAIAALPPSEDFESGARR------------------------------------------ *Azorhizobium ------------------------------------------------------------ Vibrio MSELQRLEKPYRRIMIVGGGNIGASLAKRLEQNYSVKLIERNYQRAEKLSEELENTIVFC *Haemophilus EPFRGLLLGLFFMGVGMSLDLH--LVFNHWILLLGIVFLYILGKASAVYIIARITRLDHR *Arabidopsis APYRGLLLGLFFMTVGMSIDPK--LLLSNFPVIVGTLGLLIVGKTMLVVIMGKLFGISII Archaeoglobus ISLLSEKAVAEFVETVISG--------------AKSLNLEKVVADEYMDGKTLRELDLR- Deinococcus ------------------------------------------------------------ Synechocystis AAAALRPQVVSFVDGILTGAD-------R---SFYMEEFRIGAEDCPYIGQTLREAQLR- Thermotoga AQMALNPTTISFLDILSFGEE------------SFRIEEVVIPPESPVANKTLGEINLA- Synechocystis2 ADLITQSNRRDFLNRPDERGFLN----DLLASVEVQMDELIVAPDSPAMGRTIMEMEVR- *Methanobacterium3 LPFQEVFLSFFFVSLGMLLDLR--FFLDHIYLIVLAVIGVLMIKVVMNSLVGFVMGYSAR *Pyrococcus KKIMEKKKKEQ------------------------------------------------- *Aquifex2 AAYVFHAGSAFISDLFDRIAFG--------EETEIDILEVTVPEDSELVGKQLKELDLR- *Ecoli8 LPLRDAFAVLFFVSVGMLFDP--LILIQQPLAVLATLAIILFGKSLAAFFLVRLFGHSQR Methanobacterium2 SRSIDDGYEAMFVQDVLAEES------------TRRMVEVPIPEGSKLEGVSVLDADIH- *Synechocystis4 IDFMGLCQS--------------------------------------------------- *Mycobacterium3 SRLLLPSM---------------------------------------------------- Mycobacterium GIATTTPSVVEMIEDLLTP----------------EAGLAVAEREVEQAEVGGSPRHLR- Methanobacterium GVNLNDEEIKEVARKHGRLVEIIIKPEMSIVENHGVDDIRREAEIIINHGCTIEDIEYYL *Synechocystis3 FTVVMMIAGAGVIGICYALLNDFILGSRFSQFLDAAKLPDRHHIIICGLGGVSMAIIEEL Aquifex KPIVVVTDQELETRHEFYYKKGDYVSEEVLKNAGVEHADMIIILAEKGVDLTEDSIDAR- *Bacillus RGHAADDGTLKRANITEAES------------VMITADQYKSETDADMLSVLTLLSVKG- *Archaeoglobus2 TPSKILATALFFGIKSETDEFKR----NTRTADFLACAFLYPFVDQDLIEKIESPSISTE Methanococcus -EKTGATILAVKKGDKTITSPPP------DTVINIGDIIYAFGTKEQLEKLKRYVEGVE- Methanococcus2 -GKTGATILGIRREKEFCINPYP------EFILKPGDVIYAFGTEENLKYLENLVKKKKK Ecoli QRRWFAVLLGQGSEFAFVVFGAAQMANVLEPEWAKSLTLAVALSMAATPILLVILNRLEQ *Klebsiella QHRWFAVLLGQGSEFAFVVFGPARMADVLDGEWPKALTLAVALSMATTPILLVLLTRLEK *Ecoli9 ERMQFAGVLSQGGEFAFVLFSTASSQRLFQGDQMALLLVTVTLSMMTTPLLMKLVDKWLS *Myxococcus PALDLAVVISQGGEFAFVLFSLATAQHVMERSLSELLVVVVGLSMA---VLYAAHERWVR Ecoli7 DSNDSSVLKKAGIDRCRAILALS------DNDADNAFVVLSAKDMSS--DVKTVLAVSDS Helicobacter IAKAFVIGITQKDGKYIPMPDGE----TIIASESKLLMVGTSEGVATCKQLISNHQRPKE Helicobacter2 IAKAFVIGITQKDGKYIPMPDGE----TIIASESKLLMVGTSEGVATCKQLITSHQKPKE *Streptomyces ------------------------------------------------------------ *Mycobacterium2 ------------------------------------------------------------ *Azorhizobium ------------------------------------------------------------ Vibrio GDAADQELLSEENIDQVDVFIALTNEDETNIMSAMLAKRMGAKKVMVLIQRGAYVDLVQG *Haemophilus EAIGRMSLMAHGGEFAFVLFSAAATAEVISNEEQATFTAAVIISMLFSPIIAQIARKLIQ *Arabidopsis SAIRVGLLLAPGGEFAFVAFGEAVNQGIMSPQLSSLLFLVVGISMAITPWLAAGGQLIAS Archaeoglobus -RRTGCIVVAVVRRGDVILPEAD-------TRLEKGDILYILCSGEAPLEL--------- Deinococcus ------------------------------------------------------------ Synechocystis -AQSGALILAIRRQDRKLIVGPMG-----DTHLLDADSLICLGTVEQLRALNQLLCPLNP Thermotoga -KRAGTIVIAIRRGGEVIFNPTG------DTKILPEDRLMVVGKSDHFEKLHRLIEEG-- Synechocystis2 -SKGAFIVIALRRADGSTILHPHP-----SQILNENDTIIVIGHRSEIPRFAEQYQFKRK *Methanobacterium3 VVVLLGLVLAQIGEFSFILSETGLRYGLMDRLTFQAFLSVSLITMAITPFLISLSPRISE *Pyrococcus ------------------------------------------------------------ *Aquifex2 -KNLGVTVIAVRKPDGKLIVTVSG-----ETKIEPGDTLILFGHPKNLRKAQRILLRKVE *Ecoli8 TALTIAASLAQIGEFAFILAGLGMALNLLPQAGQNLVLAGAILSIMLNPVLFALLEKYLA Methanobacterium2 -DVTGVIIIGVGRGDELIIDPPR------DYSFRAGDIILGIGKPEEIERLKNYISA--- *Synechocystis4 ------------------------------------------------------------ *Mycobacterium3 ------------------------------------------------------------ Mycobacterium -----DIVLGVVRDGQLLRIGAP-----EVDAIEASDRLLYIRQVGR------------- Methanobacterium PGFSEPLRRNVGVSSMEEIDSFMKTLKSEPRKLESLDRLYTLSGGGIHSHRISGPDSKSL *Synechocystis3 IHQGHEIVVIEKDTDNRFLHTARSLGVPVIVEDARLERTLACANINRAEAIVVATSDDTV Aquifex -TILSSMLARDLNPKATIIAEILLRENAKTVKRKNIIDYIIVDGEVVGQMISNFLKRKDI *Bacillus -LNPLAYCIVEILTDRFVTNAER-------AGANQIIGTSEFISRAMLQHYQVKLRRLNS *Archaeoglobus2 TLDILGTAIKNRQVYSSFLISFAGFINDRDALPQAADFLLKLEGISTVVVFGVIKDTVYV Methanococcus ------------------------------------------------------------ Methanococcus2 KL---------------------------------------------------------- Ecoli SSTE---EAREAD---EID--EEQPR-VIIAGFGRFGQITGRLLLSSGVKMVVLDHDPDH *Klebsiella SSSG---QARDAD---EID--EEQPR-VIVAGFGRFGQIAGRLLLSSGVKMVILDHDPDH *Ecoli9 RQFNGPEEEDEKP---WVN--DDKPQ-VIVVGFGRFGQVIGRLLMANKMRITVLERDISA *Myxococcus PRFK-PKASGREF---DVAPTEDNP--VIIAGFGRVGQVVGRLLRAKRIGFTAIDASPEQ Ecoli7 KNLN------------KIK--MVHPD-IILSPQLFGSEILARVLNGEEINNDML------ Helicobacter VDYISL------------------------------------------------------ Helicobacter2 VDYISL------------------------------------------------------ *Streptomyces ------------------------------------------------------------ *Mycobacterium2 ------------------------------------------------------------ *Azorhizobium ------------------------------------------------------------ Vibrio GVIDVAISPQQAT---ISALLTHVRR-ADIVNVSSLRRGAAEAIEAVAHGDESTSKVVGR *Haemophilus RTEPKHLDQLDEN---DLDTIVDLEDNVLVIGFGRFSQIVCQTLLIRGISVSVIDRNIEN *Arabidopsis RFELHDVRSLLPV---ESET-DDLQGHIIICGFGRVGQIIAQLLSERLIPYVALDVSSDR Archaeoglobus ------------------------------------------------------------ Deinococcus ------------------------------------------------------------ Synechocystis ARVRLPKNHR-------------------------------------------------- Thermotoga ------------------------------------------------------------ Synechocystis2 QLKARWQEAALTP----------------------------------------------- *Methanobacterium3 RIVRADLHPRIKNGRVYRRPSVDLRDHLIIIGMGITGRRLADTCEDHGIPYIGLDVNPEA *Pyrococcus ------------------------------------------------------------ *Aquifex2 AKV--------------------------------------------------------- *Ecoli8 KTETLEEQTLEEAIEEEKQIPVDICNHALLVGYGRVGSLLGEKLLASDIPLVVIETSRTR Methanobacterium2 ------------------------------------------------------------ *Synechocystis4 ------------------------------------------------------------ *Mycobacterium3 ------------------------------------------------------------ Mycobacterium ------------------------------------------------------------ Methanobacterium ELVERELREEG---FLIGVNLELSEIKSIIQESGRVVEMLLKHDLGNMDDKEIIIRRGGR *Synechocystis3 NLEIGLTAKAIAPSLPVVLRCQDAQFSLSLQEVFEFETVLCPAELATYSFAAAALGGKIL Aquifex PQILDYFLDKVDY--LEIKPKEEKTIREIIQEFGKKGKLLGIKRGRDFIFLPDLDMEVTP *Bacillus RTESS------------------------------------------------------- *Archaeoglobus2 SARNKDVRIHMGEVLRRAFGDVGSAGGHAHAAGAQIPLGIFGETNEKDLLAKLITEAITK Methanococcus ------------------------------------------------------------ Methanococcus2 ------------------------------------------------------------ Ecoli IETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQLTEMVKEHFPHLQII *Klebsiella VDTLRKFDMKVFYGDATRVDLLESAGAEKAEVLINAIDDPHVSLELVARVKEHFPHLQII *Ecoli9 VNLMRKYGYKVYYGDATQVDLLRSAGAEAAESIVITCNEPEDTMKLVEICQQHFPHLHIL *Myxococcus IDFMKRFGSQVFYGDASRLDLLRAARADKAKVFVLAIDDIEASLRTARAVQQHFPHLTLF Ecoli7 VSMLLNSGHGIFS-DN---DEQETKADSKESAQK-------------------------- Helicobacter ------------------------------------------------------------ Helicobacter2 ------------------------------------------------------------ *Streptomyces ------------------------------------------------------------ *Mycobacterium2 ------------------------------------------------------------ *Azorhizobium ------------------------------------------------------------ Vibrio AIGDIKLPPGTTIGAIVRGEEVLIAHDRTVIEQDDHVVMFLVNKKYVSDVEALFQPSPFF *Haemophilus IRAAAKFGFKVYYGDGIRLDVLRAAGIEKAKCVVLGINDTQRIEHIVSQMKEAYPNLPIL *Arabidopsis VTIGRSLDLPVYFGDAGSKEVLHKIGAGRACAAVVALDAPGANYRCVWALSKFYPNVKTF Archaeoglobus ------------------------------------------------------------ Deinococcus ------------------------------------------------------------ Synechocystis ------------------------------------------------------------ Thermotoga ------------------------------------------------------------ Synechocystis2 ------------------------------------------------------------ *Methanobacterium3 VRRARDEGLNVYYGDGTHLAVLRHFNVPEAAVMVIAIADYRSTVHAIHEARALNEGMKII *Pyrococcus ------------------------------------------------------------ *Aquifex2 ------------------------------------------------------------ *Ecoli8 VDELRERGVRAVLGNAANEEIMQLAHLECAKWLILTIPNGYEAGEIVASARAKNPDIEII Methanobacterium2 ------------------------------------------------------------ *Synechocystis4 ------------------------------------------------------------ *Mycobacterium3 ------------------------------------------------------------ Mycobacterium ------------------------------------------------------------ Methanobacterium ILDSKHYLPGVKQVVTRNLNIRNMDDLKRCMEELENPDARRSLKALYSISRNIHSHTVAA *Synechocystis3 GNGMTDDLLWVALATLITPNHPFADQLVKIAAQKSDFVPLYLERGGKTIHSWELLGTHLD Aquifex EDTLILVKEK-------------------------------------------------- *Bacillus ------------------------------------------------------------ *Archaeoglobus2 RLLSAVGMEQS------------------------------------------------- Methanococcus ------------------------------------------------------------ Methanococcus2 ------------------------------------------------------------ Ecoli ARARDVDHYIRLRQAGVEKPERETFEGALKTGRLALESLGLGPYEARERADV-FRRFNIQ *Klebsiella SRARDVDHYIQLRQAGVEAPERETFEAALKSGRMTLEALGLGAYEARERPDL-FRRFNLQ *Ecoli9 ARARGRVEAHELLQAGVTQFSRETFSSALELGRKTLVTLGMHPHQAQRAQLH-FRRLDMR *Myxococcus VRARNRVHAYELLDMGIERVMRETFLDRLEMGAGVLQELGLTYSESRRAQERRMMEHDER Ecoli7 ------------------------------------------------------------ Helicobacter ------------------------------------------------------------ Helicobacter2 ------------------------------------------------------------ *Streptomyces ------------------------------------------------------------ *Mycobacterium2 ------------------------------------------------------------ *Azorhizobium ------------------------------------------------------------ Vibrio L----------------------------------------------------------- *Haemophilus TRTYDRKTTVSLIKQDVDFIVRETFESAITLSRATLMKLGIDKIEAEEIIKEVRTLDQER *Arabidopsis VRAHDVVHGLNLEKAGATAVVPETLEPSLQLAAAVLAQAKLPTSEIANTINEFRTRHLSE Archaeoglobus ------------------------------------------------------------ Deinococcus ------------------------------------------------------------ Synechocystis ------------------------------------------------------------ Thermotoga ------------------------------------------------------------ Synechocystis2 ------------------------------------------------------------ *Methanobacterium3 ARIRGFENTEMLYTAGADVVVSEKREATRRISDEIFSCYSGVCELEE------------- *Pyrococcus ------------------------------------------------------------ *Aquifex2 ------------------------------------------------------------ *Ecoli8 ARAHYDDEVAYITERGANQVVMGEREIARTMLELLETPPAGEVVTG-------------- Methanobacterium2 ------------------------------------------------------------ *Synechocystis4 ------------------------------------------------------------ *Mycobacterium3 ------------------------------------------------------------ Mycobacterium ------------------------------------------------------------ Methanobacterium ADIKIIMKIEDDLRKRGILLGVNLREDEIWEIVESEMMEKFCIE---------------- *Synechocystis3 SGDVLYLTMPATALEQLWRSPRATADPLDSFLV--------------------------- Aquifex ------------------------------------------------------------ *Bacillus ------------------------------------------------------------ *Archaeoglobus2 ------------------------------------------------------------ Methanococcus ------------------------------------------------------------ Methanococcus2 ------------------------------------------------------------ Ecoli MVEEM-AMVENDTKARAAVYKRTSAMLSEIITEDREHLS-LIQRHGWQGTEEGKHTGNMA *Klebsiella MVEEMVAMAENDPRRGVAVFKRTSDMLTGIINEDRHHLS-LVQRHGWQGTEEGRHTGDIA *Ecoli9 MLREL-----I-P------MHADTVQIS-RAREARRELEEIFQREMQQ--E--RRQLDGW *Myxococcus LLRET-----G-R------FHRDEQKLVGLGDKDRKELERLFEKEEG------RNPTEPR Ecoli7 ------------------------------------------------------------ Helicobacter ------------------------------------------------------------ Helicobacter2 ------------------------------------------------------------ *Streptomyces ------------------------------------------------------------ *Mycobacterium2 ------------------------------------------------------------ *Azorhizobium ------------------------------------------------------------ Vibrio ------------------------------------------------------------ *Haemophilus LNEEV--------------LHGFSNEIVKKYWTPRPFIKPHLDTKALNKETEEILSEKIE *Arabidopsis LTELC--------------EASGSSLGYGYSRTSKPKPQPSDASGDNQIIEGGTVVI--- Archaeoglobus ------------------------------------------------------------ Deinococcus ------------------------------------------------------------ Synechocystis ------------------------------------------------------------ Thermotoga ------------------------------------------------------------ Synechocystis2 ------------------------------------------------------------ *Methanobacterium3 ------------------------------------------------------------ *Pyrococcus ------------------------------------------------------------ *Aquifex2 ------------------------------------------------------------ *Ecoli8 ------------------------------------------------------------ Methanobacterium2 ------------------------------------------------------------ *Synechocystis4 ------------------------------------------------------------ *Mycobacterium3 ------------------------------------------------------------ Mycobacterium ------------------------------------------------------------ Methanobacterium ------------------------------------------------------------ *Synechocystis3 ------------------------------------------------------------ Aquifex ------------------------------------------------------------ *Bacillus ------------------------------------------------------------ *Archaeoglobus2 ------------------------------------------------------------ Methanococcus --------- Methanococcus2 --------- Ecoli DEPETKPSS *Klebsiella DEPENKPSA *Ecoli9 DEFE----- *Myxococcus EPPPA---- Ecoli7 --------- Helicobacter --------- Helicobacter2 --------- *Streptomyces --------- *Mycobacterium2 --------- *Azorhizobium --------- Vibrio --------- *Haemophilus EEISNDHS- *Arabidopsis --------- Archaeoglobus --------- Deinococcus --------- Synechocystis --------- Thermotoga --------- Synechocystis2 --------- *Methanobacterium3 --------- *Pyrococcus --------- *Aquifex2 --------- *Ecoli8 --------- Methanobacterium2 --------- *Synechocystis4 --------- *Mycobacterium3 --------- Mycobacterium --------- Methanobacterium --------- *Synechocystis3 --------- Aquifex --------- *Bacillus --------- *Archaeoglobus2 ---------