CLUSTAL X (1.64b) multiple sequence alignment Serratia -------------------MKLYNLKDHN-EQVSFAQAIKQGLGKQQGLFFPLDLPEFEL Ecoli -------------------MKLYNLKDHN-EQVSFAQAVTQGLGKNQGLFFPHDLPEFSL Haemophilus -------------------MNLYNIKHPE-EQVTFSQAVRQGLGRDQGLFFPEVIP--QL Corynebacterium -------------------MDYISTRDASRTPARFSDILLGGLAPDGGLYLPATYPQLDD Methylobacillus -------------------MKYISTRGQS-PALSFSEILLGGLAPDGGLYLPEQYPQFSA Deinococcus ----------------IDRMKYVSTRSQT-DLGSFCDVLLSGLAPDGGLAMPAFIPTFSA Pseudomonas MDRTPGAARGPASTAKVLNMRYISTRGQA-PALNFEDVLLAGLASDGGLYVPENLPRFTL Schizosaccharomyces ----------------MSSQVSYLSTRGGSSNFSFEEAVLKGLANDGGLFIPSEIPQLPS Eremothecium -----------------MSQVYRSTRSSSEDTKSFEEAVIQGLAEDGGLFLPAVIPRLRE Saccharomyces --------------MPNASQVYRSTRSSSPKTISFEEAIIQGLATDGGLFIPPTIPQVDQ Helicobacter -------------------MPFVPTRSLKERKIDFIEAVLNPNAPKGGLYTLEHFETLEW Mycobacterium ------------------------------------------------------------ Thermotoga ------------------------------------------------------------ Serratia TEIDHLLEQDF-----VTRSSRILSAFIG-EEVPETALKKRVQA------------AFEF Ecoli TEIDEMLKLDF-----VTRSAKILSAFIG-DEIPQEILEERVRA------------AFAF Haemophilus NNINELLELPL-----VERSQKILGALID-GELPQATLDAMVKN------------AFTF Corynebacterium A-QLSKWREVLANEGYAALAAEVISLFVD--DIPVEDIKAITAR-------AYTYPKFNS Methylobacillus D-ALSAMRGMN----YRDLAFTILSRLID--DIPADDLRIIVDKTYRADVYAYARPGQDA Deinococcus A-ELEALRGLS----YPDLAYAVMRPFIS--DIPEADLRALLHA-------TYRAEVFGS Pseudomonas E-EIASWVGLP----YHELAFRVMRPFVAG-SIADADFKKILEE-------TYGVFAHDA Schizosaccharomyces G-WIEAWKDKS----FPEIAFEVMSLYIPRSEISADELKKLVDR---------SYSTFRH Eremothecium ETLFEHWAHLS----FQDLAMEIMKFYIADWEIPAPELRELIER---------SYSSFRS Saccharomyces ATLFNDWSKLS----FQDLAFAIMRLYIAQEEIPDADLKDLIKR---------SYSTFRS Helicobacter Q----DCLGMS----YSELVEHVFELLNL--EIPKNLLASALKR----------YENFDN Mycobacterium ---MSGQQTTT-----HQPWPGVIAAYRD--RLPVGDDWTPVTLL-----------EGGT Thermotoga ------------------MKLGILEKYRR--FLPVTDKTPMLSLN-----------EGNT :: :. Serratia PAPVAKVTDDVS------CLELFHGPTLAFKDFGGRFMAQMLAEVAGEQP---------- Ecoli PAPVANVESDVG------CLELFHGPTLAFKDFGGRFMAQMLTHIAGDKP---------- Haemophilus PAPLEKVEENIY------ALELFHGPTLAFKDFGGRFMAQALAAVRGDGK---------- Corynebacterium EDIVPVTELEDN----IYLGHLSEGPTAAFKDMAMQLLGELFEYELRRRN--------ET Methylobacillus EDITPTYKLEDD----LYLLSLSNGPTLAFKDMAMQLLGNLFEYVLAQKG--------ET Deinococcus PDITPLTPLGESG---LYLLELSNGPSLAFKDMAMQFMGHAFEYVLEKRD--------QR Pseudomonas SGAAAPVERRTN-----GCVELFHGPTLAFKDFALQLLGRLLDHVLAKRG--------ER Schizosaccharomyces PETTPLKSLKNG----LNVLELFHGPTFAFKDVALQFLGNLFEFFLTRKNGNKPEDERDH Eremothecium EEVTPLRKNVTGDDENLHILELFHGPTYAFKDVALQFVGNLFEYFLERKNRDVSEEERTH Saccharomyces DEVTPLVQNVTGDKENLHILELFHGPTYAFKDVALQFVGNLFEYFLQRTNANLPEGEKKQ Helicobacter PKNPAPIFALNER---LFVQELYHGPSLAFKDMALQPLASLFSNLAVGKN--------EK Mycobacterium PLIAAPRLSEQTG-CTIHLKVEGLNPTGSFKDRGMTMAVT---DALARGQ---------- Thermotoga PLIPLVNMSRELG-INIYVKYEGSNPTGSFKDRGMVVAVA---KALEEGS---------- .*: :*** . Serratia VTILTATSGDTGAAVAHAFYGLKNVRVVILYPQGKISPLQEKLFCTLGG-NIHTVAIDGD Ecoli VTILTATSGDTGAAVAHAFYGLPNVKVVILYPRGKISPLQEKLFCTLGG-NIETVAIDGD Haemophilus ITILTATSGDTGAAVAHAFYGLENINVVILYPKGKISPLQEKLFCTLGG-NIRTVAINAD Corynebacterium INILGATSGDTGSSAEYAMAGREGIRVFMLTPAGRMTPFQQAQMFGLDDPNIFNIALDGV Methylobacillus TNILGATSGDTGSAAEYAMRGKQGVKVFMLSPHQKMSRFQTAQMFSLQDDNIFNIAVKGV Deinococcus VNILGATSGDTGSAAEYAMLGKARVNVFMLSPQGRMSAFQQAQMYSLNEPNIFNIAIEGV Pseudomonas VVIMGATSGDTGSAAIEAAAVADNVDIFIIDPHNRVSEVERRQMTTIHGDNIHNIAIEGN Schizosaccharomyces LTVVGATSGDTGSAAIYGLRGKKDVSVFILFPNGRVSPIQEAQMTTVTDPNVHCITVNGV Eremothecium LTVVGATSGDTGSAAIYGLRGKQDVSVFILYPHGRISPIQEEQMTTVEDENVHTMAIEGS Saccharomyces ITVVGATSGDTGSAAIYGLRGKKDVSVFILYPTGRISPIQEEQMTTVPDENVQTLSVTGT Helicobacter YLVLVSTSGDTGPATLEGLAGMPNVFVVCLYPKDGTSLVQKLQMVTQNASNLKVFGVSGD Mycobacterium RAVLCASTGNT-SASAAAYAARAGITCAVLIPQGKIAMGKLAQAVMHGA---KIIQIDGN Thermotoga KAIMCASTGNT-SASAAAYAARAGIKAIVLIPEGKIALGKLAQAMIYGA---VVLQVRGN :: :::*:* .: . : : * : : . : . Serratia FDACQALVKQAFDDQELKDAL-----HLNSANSINISRLLAQICYYFEAVAQLPQEARNQ Ecoli FDACQALVKQAFDDEELKVAL-----GLNSANSINISRLLAQICYYFEAVAQLPQETRNQ Haemophilus FDACQALVKQAFDDVELRQAI-----GLNSANSINISRLLAQVCYYFEAVAQLPKEKRDN Corynebacterium FDDCQDVVKAVSADAEFKKDN-----RIGAVNSINWARLMAQVVYYVSSWIRTTTSNDQK Methylobacillus FDDCQDIVKAVSNDHAFKAKN-----KIGAVNSINWARVAAQVVYYFKGYFAVTADNAQQ Deinococcus FDDCQDLVKEVNADAEFKAKY-----HIGAVNSINWGRVLAQAVYYFRAYFALGLPADAE Pseudomonas FDDCQEMVKASFADQGFLKGT-----RLVAVNSINWARIMAQIVYYFHAALQLGAP-HRS Schizosaccharomyces FDDCQDLVKQIFGDVEFNKKH-----HIGAVNSINWARILSQITYYLYSYLSVYKQGKAD Eremothecium FDNCQDIVKSIFVDEEFNRKH-----NIAAVNSINWARILAQITYYFYSYFRATDGQPGR Saccharomyces FDNCQDIVKAIFGDKEFNSKH-----NVGAVNSINWARILAQMTYYFYSFFQATNGKDSK Helicobacter FDDAQNALKNLLKDDDFNEALKARQLKLSVANSVNFGRIAFQIVYHIWGFLELYKKGAIN Mycobacterium FDDCLELARKMAADFPM----------ISLVNSVNPVRIEGQKTAVFEIVDALGTAPHVH Thermotoga FDKCLELVKEITSKYP-----------ITLVNSINPYRLEGQKTAAFEIVDELGDAPDYH ** . : . : .**:* *: * . Serratia ----LVISVPSGNFGDLTAGLLAKSLGLPVKRFIAATNANDTVPRFLTSGQWQPHA---- Ecoli ----LVVSVPSGNFGDLTAGLLAKSLGLPVKRFIAATNVNDTVPRFLHDGQWSPKA---- Haemophilus ----VVVSVPSGNFGNLTAGLIAKTLGLPIKRFVASTNANDTVPRYLKSGNWDPKT---- Corynebacterium ----VSFSVPTGNFGDICAGHIARQMGLPIDRLIVATNENDVLDEFFRTGDYRVRS---- Methylobacillus ----VSFAVPSGNFGNVCAGHIARMMGLPIAKLVVATNENDVLDEFFKTGVYRPRG---- Deinococcus ----AD------------------------------------------------------ Pseudomonas ----VAFSVPTGNFGDIFAGYLARNMGLPVSQLIVARNRNDILHR-FMSGNASTRH---- Schizosaccharomyces D---VRFIVPTGNFGDILAGYYAKRMGLPTKQLVIATNENDILNRFFKTGRYEKADSTQV Eremothecium ----VKFIVPSGNFGDILAGFYAKQMGLPIEKLVIATNENDILDRFLREGVYERSE---- Saccharomyces K---VKFVVPSGNFGDILAGYFAKKMGLPIEKLAIATNENDILDRFLKSGLYERSD---- Helicobacter SKEKITLAIPSGNFGNALGAFYAKKMGLNIAKIKVVTNSNDVLREFIETGRYDLTK---- Mycobacterium ----A---LPVGNAGNITA-YWKGYTEYHADGLIDRLPRMLGTQAAGAAPLVLGEP---- Thermotoga ----F---IPVGNAGNISA-YWMGYKEYYQHGFSTKLPKMMGFQAEGAAPIVRGHP---- Serratia -------TVATLSNAMDVSQPNNWPRVEELFR---------------------------- Ecoli -------TQATLSNAMDVSQPNNWPRVEELFR---------------------------- Haemophilus -------TVATLSNAMDVSRPNNWPRVEELFK---------------------------- Corynebacterium ----SADTHETSSPSMDISRASNFERFIFDLL------GRD----ATRVNDLFGTQVRQG Methylobacillus ----SANTYHTSSPSMDISKASNFERFVFDLV------GRD----AAKVRELWGKVDAGG Deinococcus ------------------------------------------------------------ Pseudomonas ----TLTP--SVSPSMDIMVSSNFERLLFDLH------GRN----GKAVAELLDAFKASG Schizosaccharomyces SPSGPISAKETYSPAMDILVSSNFERYLWYLALATEAPNHTPAEASEILSRWMNEFKRDG Eremothecium ----DVTA--THSPAMDILVSSNFERLLWFFAREQLAQGDD-QEAGSIVNRWFEQLREER Saccharomyces ----KVAA--TLSPAMDILISSNFERLLWYLAREYLANGDD-LKAGEIVNNWFQELKTNG Helicobacter -----RSLKQTFSPAMDILKSSNVERALFSLFG------------FERTLELMQALEEEK Mycobacterium -----VSHPETIATAIRIGSPASWTSAVEAQQ---------------------------- Thermotoga -----IENPETVATAIRIGNPANWEKAVRARD---------------------------- Serratia -----RKVWQLK-----ELGHAAVSDETTKDTMRELAEL-----GYISEPHAAIAYRALR Ecoli -----RKIWQLK-----ELGYAAVDDETTQQTMRELKEL-----GYTSEPHAAVAYRALR Haemophilus -----RNGWDLT-----DLGSGMLSDSETEDTLKAMQSK-----GYLCEPHGAIAYQVLK Corynebacterium GFSLADDANFEKAAAEYGFASGRSTHADRVATIADVHSR----LDVLIDPHTADGSHVAR Methylobacillus SFDLNDGGWFAK-VADYGFVSGSSNHANRMQTIKATHER----YGVTIDTHTADGLKVAL Deinococcus ------------------------------------------------------------ Pseudomonas KLSVEDQRWTEA--RK-LFDSLAVSDEQTCETIAEVYRS----SGELLDPHTAIGVRAAR Schizosaccharomyces TVTVRPEVLEAA---RRDFVSERVSNDETIDAIKKIYES----DHYIIDPHTAVGVETGL Eremothecium RFDVPEHLLDAI---RYHFDSERVDNYNTLASIRHIYEHAQNPERYVIDPHTAVGICAAN Saccharomyces KFQVDKSIIEGA---SKDFTSERVSNEETSETIKKIYESSVNPKHYILDPHTAVGVCATE Helicobacter FYALKPKELALL---QEHFSCASCSDEDCLKTIQEVYAE----HQYLIDPHTATALNASL Mycobacterium -----QSKGRFL----------AATDEEILAAYHLVARA----EGVFVEPASAASIAGLL Thermotoga -----ESGGDID----------MVSDEEILRAQRLLAQK----EGIFCEPASAASIAGLL Serratia DQLQ----------EGEFGLFLGTAHPAKFKESVEAILG-------QELPLPKALALRAE Ecoli DQLN----------PGEYGLFLGTAHPAKFKESVEAILG-------ETLDLPKELAERAD Haemophilus DQLK----------ASETGIFLCTAHPAKFKESVERILG-------IQLPLPETLDKHNQ Corynebacterium QWRD---------EVNTPIIVLETALPVKFADTIVEA-------IGEAPQTPERFAAIMD Methylobacillus EHR----------EAGTPMLVLETALPAKFEDAIVEA-------LGHKPERPHSLEGLES Deinococcus ------------------------------------------------------------ Pseudomonas ECRR---------SLSVPMVTLGTAHPVKFPEAVEKAG------IGQAPALPAHLADLFE Schizosaccharomyces RCLEK------TKDQDITYICLSTAHPAKFDKAVNLALSSYSDYNFNTQVLPIEFDGLLD Eremothecium RQIAH------DQNNEIHYISLATAHPAKFADAVNEALSSYDDYNFD-DVLPDRLRRLGD Saccharomyces RLIAK------DNDKSIQYISLSTAHPAKFADAVNNALSGFSNYSFEKDVLPEELKKLST Helicobacter KTHEKTLVSATASYEKFPKTTLLALNEQKKNDDDKAALET----LKNSYNTPDSQRLDDL Mycobacterium KAIDGG-------WVARGSTVVCTITGNGLKDPDTALKD-------MPSVSPVPVDAVAV Thermotoga KKHRQG-------IFRGGEIVVCTLTGNGLKDPNIVISQ-------LEPPRIIEGRVEEI Serratia LPLLSHTLPA-SFGELRKFLMGLPA------- Ecoli LPLLSHNLPA-DFAALRKLMMNHQ-------- Haemophilus LPLLSDEMDN-DFAQLRAYLLKS--------- Corynebacterium APFKVSDLPN-DTDAVKQYIVDAIANTSVK-- Methylobacillus LPQRFEVMEA-DAAVIKQFIVEHI-------- Deinococcus -------------------------------- Pseudomonas REERCTVLPN-ELAKVQAFVSQHGNPGKPL-- Schizosaccharomyces EERTCIFSGKPNIDILKQIIEVTLSREKA--- Eremothecium LEKRIKYVDNTDVDVIKSIIEEELINMGIYNP Saccharomyces LKKKLKFIERADVELVKNAIEEELAKMKL--- Helicobacter FERGIKHQEVLKLNEIKSSILLWLENTH---- Mycobacterium VEQLGLV------------------------- Thermotoga LEVLDI--------------------------