CLUSTAL X (1.64b) multiple sequence alignment Methanobacterium ------------------------------------------------------------ Methanococcus ------------------------------------------------------------ Archaeoglobus ------------------------------------------------------------ Helicobacter ------------------------------------------------------------ Campylobacter ------------------------------------------------------------ Aquifex ------------------------------------------------------------ Mycoplasma ------------------------------------------------------------ Mycoplasma2 ------------------------------------------------------------ Thermotoga ------------------------------------------------------------ Bacillus ------------------------------------------------------------ Corynebacterium ------------------------------------------------------------ Mycobacterium MISGEVGIGASFQWCLLISMEGSTERHAWGMGRASLAEKSPLNCSKAGAPGRIRTCDLLL Saccharomyces ------------------------------------------------------------ Schizosaccharomyces ------------------------------------------------------------ Saccharomyces2 ---------------------------------------------------MFGIVYLKN Ecoli ------------------------------------------------------------ Haemophilus ------------------------------------------------------------ Cricetulus -----------------------------------------MDGLVAQCSARLLQQEKEI Homosapiens -----------------------------------------MDVLVSECSARLLQQEEEI Celegans -----------------------------------MSANKELQQGYSDYSAASDQAALLN Arabidopsis2 ---------------------------------------------------MFIFPKDEN Arabidopsis ------------------------------------------------------------ Chlamydophila ------------------------------------------------------------ Chlamydia ------------------------------------------------------------ Synechocystis ------------------------------------------------------------ Buchnera ------------------------------------------------------------ Pyrococcus ------------------------------------------------------------ Deinococcus ------------------------------------------------------------ Rickettsia ------------------------------------------------------------ Treponema ------------------------------------------------------------ Borrelia ------------------------------------------------------------ Methanobacterium ------------------------------------------------------------ Methanococcus ------------------------------------------------------------ Archaeoglobus ------------------------------------------------------------ Helicobacter ------------------------------------------------------------ Campylobacter ------------------------------------------------------------ Aquifex ------------------------------------------------------------ Mycoplasma ------------------------------------------------------------ Mycoplasma2 ------------------------------------------------------------ Thermotoga ------------------------------------------------------------ Bacillus ------------------------------------------------------------ Corynebacterium ------------------------------------------------------------ Mycobacterium RRQMLYPLSYGGVQITCCTSGLQQISASGWLGDIIQFVPASGKMSPLLTATPSELLRGWL Saccharomyces -----------------MASTANMIS-QLKKLSIAE------------------------ Schizosaccharomyces -----------------MATSVDQISKSLSTLGLQD------------------------ Saccharomyces2 RSLLCKNPFSSYPRYGFMPSFDTQFSNQFRKLEINIGRKRYSSKTLN------------- Ecoli ------------------------------------------------------------ Haemophilus ------------------------------------------------------------ Cricetulus KSLTAEIDRLKNCGHLEDSPSLDQLREENLKLKYR-LNILQRSLQAEK------------ Homosapiens KSLTAEIDRLKNCGCLGASSNLEQLQEENLKLKYR-LNILRKSLQAE------------- Celegans RLITAMQKGELTDELLEHIPELGDAKKLNDKLKYR-KSILEKSIAEQAAKNKKNGVKATS Arabidopsis2 RRETLTTKLRFSADHLTFTTVTEKLRATAWRFAFSSRAKSVVAMAAN------------- Arabidopsis ----------------------------------------MATIVAS------------- Chlamydophila ------------------------------------------------------------ Chlamydia ------------------------------------------------------------ Synechocystis ------------------------------------------------------------ Buchnera ------------------------------------------------------------ Pyrococcus ------------------------------------------------------------ Deinococcus ------------------------------------------------------------ Rickettsia ------------------------------------------------------------ Treponema ------------------------------------------------------------ Borrelia ------------------------------------------------------------ Methanobacterium --------------------------------------------MFRYIEKEARDSITAA Methanococcus ----------------------------------------------MDIKSNIINALKEV Archaeoglobus --------------------------------------------MFLRFIEEVIKALGEY Helicobacter ---------------------------------------------MHTLIKG------VL Campylobacter ------------------------------------------------------------ Aquifex ---------------------------------------------MKELVKEK--VLKAL Mycoplasma ---------------------------------------------MFFIINDLKECISAL Mycoplasma2 ---------------------------------------------MLFINTDLQECLNAL Thermotoga ---------------------M----------------------LVNAIRQKVSEVISKA Bacillus ----------------MNIAEQ----------------------MKDVLKEEIKAAVLKA Corynebacterium -----------------MTPAD----------------------LATLIKETAVEVLTSR Mycobacterium LLRRIRALWPQPIGWTFVTPAD----------------------LAELLKTTAIVVLAER Saccharomyces -------------PAVAKDSHP-----------------------DVNIVDLMRNYISQE Schizosaccharomyces -------------LPVFREADI-----------------------HHNPVDVYRSYISSE Saccharomyces2 -------------TKYTDQPEG-----------------------PIYPLDVLRLDISKA Ecoli -----------------MNIQA-------------------------LLSEKVRQAMIAA Haemophilus -----------------MNIQS-------------------------ILSDKIKQAMILA Cricetulus ------------RRRPTKNMIN----------------------INSRLQDVFGCAIKAA Homosapiens ------------RNKPTKNMIN----------------------IISRLQEVFGHAIKAA Celegans TSSPSSSTSAPAEKKAKKDGKTGGAPPKQAKKVDYVTVEDYGSSIFGRLQSLFKKAIEDA Arabidopsis2 -------------EEFTGNLKR-------------------------QLAKLFDVSLKLT Arabidopsis -------------KEFTGNPRR-------------------------QLAKLFDVSLKLT Chlamydophila ----------------MSTLLS-------------------------ILSVICSQAIAKA Chlamydia ----------------MTTLLS-------------------------FLTSLCSAAIHQA Synechocystis ----------------MVSILT-------------------------QLNDHFAQALEGQ Buchnera ----------------------------------------------MNLKNTIKKDIQDA Pyrococcus --------------------------------------------MLMEIRESVKERIEEI Deinococcus ------------------------------------------------------------ Rickettsia ----------------------------------------------MNIFNQLKQDIIAA Treponema ---------------------------------------------MQDLCEMWRHAVARV Borrelia --------------------------------------MLKRKKMNKSVKKKIKDEINVI Methanobacterium LEKLGIKVPPE-----IKLEEPPNPQLGDLASTVSFELAGKLRR------APIEITADIM Methanococcus ISKE-ICKEID-----IKLDKTPNLELGDYSVNICFRLAKELKK------NPKIIAEELV Archaeoglobus GDKK-------------FLRES---EHADLASTIAFKLAKERKK------SPKEIADEIV Helicobacter EEILEAEVI---------IEYPKDREHGHYATPIAFNLAKVFKK------SPLAIAEELA Campylobacter ------------------------------------------------------------ Aquifex KELYNTQVEN------FKVEKPKEEAHGDLASNVAFLLARELKK------PPVNIAQELA Mycoplasma KLKFDDQKE--------LVKLVKNNSFNGFSSTIIFQLKSENHK------KIADSIVEWF Mycoplasma2 NLEFDEHKE--------LVKLVKNNSFSGFASTVVFHLKGVNQK------ETAQQIAAWL Thermotoga -YGSEIEFE---------VEIPPRKEFGDLSTNVAMKLAKTLKK------NPREIAQEIV Bacillus GLAEESQIPN------VVLETPKDKTHGDYSTNMAMQLARVAKK------APRQIAEEIV Corynebacterium ELDTSVLPEQ------VVVERPRNPEHGDYATNIALQVAKKVGQ------NPRDLATWLA Mycobacterium GLDAAALPQT------VTVERPRNPEHGDYSSNLAMQLGKKVGA------NPLELAGWLA Saccharomyces LSKISGVDS-------SLIFPALEWTNTMERGDLLIPIPRLRIKGAN----PKDLAVQWA Schizosaccharomyces LSKINGVDV-------SLIYPALETSISKDSADLNLPVPRLRVKGK-----PQELAQKWA Saccharomyces2 LHDISGIDH-------SLILNALESTNSMDRGDLLLPLPKIKVADP------VAVANRWA Ecoli GA--PADCE-------PQVRQSAKVQFGDYQANGMMAVAKKLG--MA----PRQLAEQVL Haemophilus GA--DQSCD-------ALIRQSGKPQFGDYQANGIMAAAKKLG--LN----PREFAQKVL Cricetulus YP-DLDNPP-------LVVTPSQQPKFGDYQCNSAMGISQMLKAKEQKVN-PRGIAENIT Homosapiens YP-DLENPP-------LLVTPSQQAKFGDYQCNSAMGISQMLKTKEPEVN-PGEFAENIT Celegans FP-GLDVP--------LLLAETPNPQFGDYQCNSAMPIAAKLKANKINKR-PGDVAKEIQ Arabidopsis2 VP-DEPSVE-------PLVAASALGKFGDYQCNNAMGLWSIIKGKGTQFKGPPAVGQALV Arabidopsis VP-DEPNVE-------PLIEP---GKFGDYQCNNAMGLWSLIKGKGTQFRGPPAVGQALI Chlamydophila FP-NLEDWA-------PEITPSTKEHFGHYQCNDAMKLARVLK--KA----PRAIAEAIV Chlamydia FP-ELEELT-------LDITPSTKEHFGHYQCNDAMKLARVLH--KS----PRAIAESIV Synechocystis FPSDVTLPT-------PLVVPASNPKFGDFQCNIALPLAKQLG--QP----PRAIAMEIV Buchnera LIKIAIINCD------PVITLNKKTKIGHYQLNNLIKIANISN------LKPFELANRII Pyrococcus IKEIAPQWEGE-----IELKETPDPKLGDFGTPIAFKLAKLLKR------PPIEIAEKIV Deinococcus -----------------------TRRLRHARRLPDGEGGRGQPR-------PDRRAXAQT Rickettsia SQKLYNNKEIANT---ATIETPKDSFNGDLSSNIAMIIASKES------IAPREVALKFK Treponema LSQLQGPAVEPVEGAQLVMEEPPEPGMGDIAFPLFLFAKRVRRS-------PAQLAQQLC Borrelia VTNLALSNNIKLDNININIQKPPKSDLGDISILM-FEIGKTLKLP------IEIISEEII Methanobacterium SVIETP-----EIFETIESKGPYINFFVDYGRFSSRLLESIQ---DDYGSHPPRDER--V Methanococcus DKLKAMNI---EGVKEIKAVNGYINFYIDYNKFAKNLMEEIDKKGNNYGRGDKKSIK--I Archaeoglobus ENLEVES----EYIGSVESVNGYINFFASY-EFLEDTVNVILDEDENYGHLNLKG-E--I Helicobacter LKIGSHEK-TQGFFDRVVACKGYINFTLS-LDFLERFTQKALELKEQFGSQVKSERSQKI Campylobacter -----FQI-HGLFWNQLEAVNGYLNFRIS-KTFLNELANQALTNPNDFTKGEKNKES--F Aquifex D----FLS-KDETFKSVEAVKGFINFRFS-EDFLKEEFKKFLLSGEAYFKEDLGKGLK-V Mycoplasma LK----NK-KDNYQNVFIANNNFINFQISYQKYLE-----YLIKTPCFT-K--KNIK--I Mycoplasma2 LK----HK-KAHYRRVFVANNNFINFEISPQKYLD-----FLKTKPTFA-P--KPTK--V Thermotoga KSLDE----DPSFDRIEIMGPGFINFFLS-NELLRGVVKTVLEKKDEYGRENVGNGMK-V Bacillus AHFDK---GKASIEKLDIAGPGFINFYMN-NQYLTKLIPSVLEAGEAYGETNIGNGER-V Corynebacterium EALAA----DDAIDSAEIAGPGFLNIRLA-AAAQGEIVAKILAQGETFGNSDHLSHLD-V Mycobacterium EVLAQ----AGGIADVEVAGPGFINMRLD-ASAQAMIVNTVINADKNFGHSDDLAGYQ-I Saccharomyces EKFP----CGDFLEKVEANGP-FIQFFFNPQFLAKLVIPDILTRKEDYGSCKLVE-NKKV Schizosaccharomyces EAFP----K--DLVEVTANGI-FLRFNFNGPSLTKLILPIIWEQRENYGRNESGS-GKVA Saccharomyces2 IELS----THGCIGKVCAKGP-FLQFFLDQRYLIQSTVPNILLQKGKYGQKKSRH-QKKV Ecoli THLD----LNGIASKVEIAGPGFINIFLDPAFLAEHVQQALASDRLGVATPE----KQTI Haemophilus DNLQ----LSDIAEKLEIAGPGFINIFLNPTWLTTEISAALSHKNLGIQATN----KQTV Cricetulus KHLP----NNEYIDRVEIAGPGFINVHLRKDFVSEQLTNLLVNGIQLPALGEN----KKV Homosapiens KHLP----AMDVLKRVEFAGPGFINGHLRKDFVSEQLTSLLVNGVQLPALGEN----KKV Celegans AKLPT---KIDFVEKIDVMPAGFINIFLNTDYLRRQISLLASEGVKLPKLTR-----KRV Arabidopsis2 KSLP----TSEMVESCSVAGPGFINVVLSAKWMAKSIENMLIDGVDTWAPTLS---VKRA Arabidopsis QSLP----TSEMVESCSIAGPGFVNVVLSSKWMAKSIENMLVDGIDTWAPTLS---VKRA Chlamydophila AELP----QEPFSL-IEIAGAGFINFTFSPVFLNQQLEHFKDALKLGFQVSQ----PKKI Chlamydia AHIP----PTPFSS-IEIAGAGFINFTFSKEFLASQLQTFSKELANGFRAAS----PQKV Synechocystis DKVN----LSEICEPLTIAGPGFINIKLLPDYLGEQLIKLQQNQQLGVSLVKG---EERI Buchnera LNIK----KKYMYKEITFSQPGFINFLINPYWISEQLEKIFLSPRLGINHVN----AQNI Pyrococcus EKLKLN---LPEGIKDVKAVNGYINVFIDYPHFARILINDILAKGDRFGSSEIGKGKK-V Deinococcus VVLP-------AGIRRVEATGPFLNFFLDAGAFVRGVVERPFELPKREG----K-----V Rickettsia EVLVT----LPYIASIEIAGPGFINFTIK-AESWQAAIKDILQHEEKFFEIDIDKNSN-I Treponema TLLEED--TSMCAYGTPQARGPYLNVFLNKECVAAHTLDAIFAQGERYGHTQYLQGKR-I Borrelia KNLK-------TKYEIKAVGP-YLNIKISRKEYINNTIQMVNTQKDTYGTSKYLDNKK-I ::. Methanobacterium ILEHTSANPNGPLHIGHIRNAIIGDSLARILRMAGYDVETQYYVNDMGRQIAMIVWGLLN Methanococcus ILEHTSANPNGPLHIGHLRNAIIGDCLKRILEFYGYDVETHYYVNDMGRQMALVVYGIEL Archaeoglobus LIEHTSANPDGPLHIGHIRNSIIGDTIARIFAKAGFDVKTHYYVNDMGRQTAITVLGIEK Helicobacter FLEFVSANPTGPLHIGHARGAVFGDSLAKIARFLGHEVLCEYYVNDMGSQIRLLGVSVWL Campylobacter LLEYVSANPTGPLHIGHARGAVFGDTLTRLARHLGYKFNTEYYVND-------------- Aquifex QLEYVSANPTGPLHLGHGRGAVVGDTLARLFKFFNYDVTREYYINDAGRQVYLLGISIYY Mycoplasma LIESVSANPTGRIHLGHVRIAFFGDVLNNLAKLLGYTTVCEYWVNDYGQQARVFSFSVYQ Mycoplasma2 LIEWVSANPTGELHLGHVRNAFFGHVLNNLMVFLGFQTVREYWVNDYGQQARVFGFSVYQ Thermotoga QFEYGSANPTGPFTVGHGRQIIIGDVLSEVYKELGYDVTREMYINDAGKQIRLLAQSLWA Bacillus QVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAGYDVSREYYINDAGNQINNLALSVEV Corynebacterium NLEFVSANPTGPIHLGGTRWAAVGDSLGRVLEASGAKVTREYYFNDHGRQIDRFALSLLA Mycobacterium NLEFVSANPTGPIHIGGTRWAAVGDALGRLLSTQGAAVVREYYFNDHGAQVDRFTNSLIA Saccharomyces IIEFSSPNIAKPFHAGHLRSTIIGGFLANLYEKLGWEVIRMNYLGDWGKQFGLLAVGFER Schizosaccharomyces VIEFSSPNIAKPFHAGHLRSTIIGSFLANLHESQGWKVHRVNYLGDWGKQFGLLAIGYKK Saccharomyces2 VVEFSSPNIAKPFHAGHLRSTIIGGFLSNLYEAMGWSVTRMNYLGDWGRQFGLLAVGFKR Ecoli VVDYSAPNVAKEMHVGHLRSTIIGDAAVRTLEFLGHKVIRANHVGDWGTQFGMLIAWLEK Haemophilus VIDYSSPNVAKEMHVGHLRSTIIGDAVARTLEFLGHNVIRANHVGDWGTQFGMLIAYLEK Cricetulus IVDFSSPNIAKEMHVGHLRSTIIGESMSRLFEFAGYDVLRLNHVGDWGTQFGMLIAHLQD Homosapiens IVDFSSPNIAKEMHVGHLRSTIIGESISRLFEFAGYDVLRLNHVGDWGTQFGMLIAHLQD Celegans LVDFSSPNIAKEMHVGHLRSTIIGDSICRLFEA----VLRVNHIGDWGTQFGMLIAHLYD Arabidopsis2 VVDFSSPNIAKEMHVGHLRSTIIGDTLARMLEYSHVEVLRRNHVGDWGTQFGMLIEYLFE Arabidopsis VVDFSSPNIAKEMHVGHLRSTIIGDTLARMLEYSKVEVLRRNHVGDWGTQFGMLIEFLFE Chlamydophila IIDFSSPNIAKDMHVGHLRSTIIGDSLARIFSYVGHDVLRLNHIGDWGTAFGMLITYLQE Chlamydia IIDFSSPNIAKDMHVGHLRSTIIGDCLARCFSFVGHDVLRLNHIGDWGTAFGMLITYLQE Synechocystis VVDFSSPNIAKEMHVGHLRSTIIGDCLARVLEFRGYDVLRLNHVGDWGTQFGMLITYLKE Buchnera VIDYSSPNIAKEMHIGHLRSTIIGDVMARILDFLGHNVIRANHI---------------- Pyrococcus IVEHTSVNPTKPLHMGHARNAILGDVMARILRFLGYEVEVQNYIDDLGIQFAQVYWGYLR Deinococcus VIEHTSVNPNKELHVGHLRNVVLGDSMARILRAAGHTVEVQNYIDDTGRQAAESLFATQH Rickettsia NIEYVSANPTGPMHIGHARGAVYGDVLARILQKVGYSVTKEYYVNDAGSQINDLVSTVLL Treponema MVEFSSPNTNKPLHVGHLRNNAIGESLSRIIAFCGADVFKVNIINDRGVHICKSMCAYQK Borrelia ILEFSSPNTNKPLHVGHLRNDVIGESLSRILKAVGAKITKINLINDRGVHICKSMLAYKK .: : * : * * * . . Methanobacterium LDGDLEDYPGDK---------MDHRVGKLYFEVNQRLKENPGIR---------------- Methanococcus FGLDKE----KK---------KDHAIAETYVKINKYLEEHPEEE---------------- Archaeoglobus FGLKDK-----K---------PDHAVAEAYIEANKLLESNPELE---------------- Helicobacter AYKEHVLKES-------------VTYPEVF----YKGEYIIEIA---------------- Campylobacter ------------------------------------------------------------ Aquifex RYLEKCPERDEE---------TFKEIKEIFEKDGYRGEYVKEIA---------------- Mycoplasma SL---QLKKN-------------IAIQQHP--DGYSGIVIDKIA---------------- Mycoplasma2 AL---HLQQN-------------IKVTPHP--DGYEGELVDSIA---------------- Thermotoga RYNQ------------------LLGVEKEIPEGGYRGEYLVDIA---------------- Bacillus RYFE------------------ALGLEKPMPEDGYRGEDIIAIG---------------- Corynebacterium -----------------------AAKGEPTPEDGYGGEYIKEIA---------------- Mycobacterium -----------------------AAKGELTPADGYAGTYVTDIA---------------- Saccharomyces YGNEEALVKD-----------PIHHLFDVYVRINKDIEEEGDSIPLEQSTN--------- Schizosaccharomyces YGDEDQLKSN-----------PIRHLYDVYVKVNADATEEDEKIQKDKAEAESKGLPYTP Saccharomyces2 YGDEKTLQKQ-----------PIQHLFDVYVKINMDLAKEEINGNSKCGIS--------- Ecoli QQQENAG---EM---------ELADLEGFYRDAKKHYDEDEE-------FA--------- Haemophilus MQNEHAS---EM---------ELQDLEAFYREAKKHYDEDEV-------FA--------- Cricetulus QFPDYLTVSP-----------PIGDLQAFYKESKKRFDTEEE-------FK--------- Homosapiens KFPDYLTVSP-----------PIGDLQVFYKESKKRFDTEEE-------FK--------- Celegans RFPDFLKKLP-----------DISDLQAFYKESKKRFDEDEQ-------FK--------- Arabidopsis2 KFPDTDSVTET----------AIGDLQVFYKASKHKFDLDEA-------FK--------- Arabidopsis KFPDTESVTET----------AIGDLQVFYRESKLKFDLNPE-------FK--------- Chlamydophila NPCDYS---------------DLEDLTSLYKKAYVCFTNDEE-------FK--------- Chlamydia TSQEAIH--------------QLEDLTALYKKAHARFAEDSE-------FK--------- Synechocystis VYPEALVTADAL---------DIGDLVTFYKQAKQRFDQDEQ-------FR--------- Buchnera ------------------------------------------------------------ Pyrococcus LKEEFERIMNELRERGLKDNPIDHALGLLYVEVNRRLEDNPELE---------------- Deinococcus YGRVWDG---------------VQKYDQWLGEGYVQLNADPQ-K---------------- Rickettsia RYKEA------------------LGEPITIPVGLYPGEYLIPLG---------------- Treponema FAHGKTPAHTGIK--------SDRFVGDWYVQFNRYAQQYPEEA---------------- Borrelia FGNGITPEKAFKK--------GDHLIGDFYVKYNKYSQENENAE---------------- Methanobacterium -----DEVDELIRKYE-AGENEE------------------------------LFRKVVE Methanococcus -----EKILELMRKYEDALENNED------------------------NEITKKFEFAVN Archaeoglobus -----EQVEKLMLAYE---EGDE--------------------------KTVEKFRRAVE Helicobacter -----KKAHNDLEPSLFKENEE--------------------------TIIEVLSDYAKD Campylobacter ------------------------------------------------------------ Aquifex -----ERLRKLVGESLCKPEEANLKEVREKILKEESIELYYTKKYEPKDVVDLLSNYGLD Mycoplasma -----SEIENFPVDNLNFEEFCK------------------------TSFLDHFLVNCTQ Mycoplasma2 -----KTITGIPLDKLSFEEFLQ------------------------QPFLDQLLADCTA Thermotoga -----RDLVNEIGDRYKDLWNEE--------------------------VEEFFKQTALN Bacillus -----KRLAEEYGDRFVNEEESE--------------------------RLAFFREYGLK Corynebacterium -----EAIVEKHPEALA-LEPAA--------------------------TQELFRAEGVE Mycobacterium -----AQVMQQAPYALS-LPESE--------------------------MHETVREIGVD Saccharomyces -----GKAREYFKRMEDGDEEA-----------------------------LKIWKRFRE Schizosaccharomyces PLSLHDKAREFFKRMEDGDEES-----------------------------LKVWARFRD Saccharomyces2 -----GEARSFFKNLENGDENA-----------------------------IKIWNRFRS Ecoli -----ERARNYVVKLQSGDEYF-----------------------------REMWRKLVD Haemophilus -----EKARNYVVKLQSGDEYC-----------------------------RTMWKRLVD Cricetulus -----KRAYQCVVSLQSKDPDF-----------------------------IKAWNLICD Homosapiens -----KRAYQCVVLLQGKNPDI-----------------------------TKAYLLMSD Celegans -----KRAYEYVVKLQSHDGDI-----------------------------VKAWNTICD Arabidopsis2 -----EKAQQAVVRLQGGDPVY-----------------------------RKAWAKICD Arabidopsis -----EKAQQAVVRLQGGDPVY-----------------------------RQAWAKICE Chlamydophila -----KRSQQNVVALQAKDPQA-----------------------------IAIWEKICE Chlamydia -----KRSQHNVVALQSGDAQA-----------------------------LALWKQICS Synechocystis -----ETSRQAVVALQAGDAKS-----------------------------IKAWQLLCE Buchnera ------------------------------------------------------------ Pyrococcus -----NEIRDIMKKLESGELYG---------------------------------RKLAE Deinococcus -----PELESGIMEIMHKLEAG-------------------------------ELRPLVE Rickettsia -----EILSKEYGNKLLTMNDVER--------------------------FKIIKSFAVE Treponema ----EHDVRDLLQRWESADPHVR-----------------------------ALWRTMNE Borrelia -----KEIQDLLLLWEQKDVST-----------------------------IELWKKLNK Methanobacterium YCLSGMEETMKRLHVHHDRFVWEGQFVRDGTVDRVIESLRK------------TGYTGEN Methanococcus YALDGIKETLKNLNIKHDTFVWESSYVRNGMVKKVIEKLME------------TGKVIKE Archaeoglobus TALEGIKQTLKTINVEHDEFVWESEFVRNGYVGKVLGILEE------------RGLVKKN Helicobacter LMLLEIKGNLDALDIHFDSYASEKEVFK--HKDAVFDRLEKA-----------NALYEKD Campylobacter ------------------------------------------------------------ Aquifex LMMKEIREDLSLMDISFDVWFSERSLYDSGEVERLINLLKEK-----------GYVYEKD Mycoplasma KVLSLIKSDLNKIHVFIDSWKFESEIVKKTNFNDLLEQLKP------------NSYFYQD Mycoplasma2 KVLEVIKQDLATIHIHFDSWKFESQVVKETDYKKLLTQFKD------------EAHYEKD Thermotoga RILSSMKDTLEKIGSSFDVYFSEKSLIEDGTVEEVLKLLKNK-----------DVVYEKD Bacillus YELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKALEALREK-----------GHVYEED Corynebacterium MMFEHIKSSLHEFGTDFDVYYHENSLFESGAVDKAVQVLKDN-----------GNLYENE Mycobacterium LMFTHIKKSLHEFGTDFDVYTHEDSMHASGRVDEAIARLRDT-----------GNVYEKD Saccharomyces FSIEKYIDTYARLNIKYDVYS--GESQVSKESMLKAIDLFKE---------K-GLTHEDK Schizosaccharomyces LSITKLKDTYDRLNIHYDEYD--GESQVSLELMNKMVDELRS---------L-NLIEEDG Saccharomyces2 LSIHHYIQTYSRLNINFDIFS--GESQVSKESMNEALDIFRK---------N-NLVKEID Ecoli ITMTQNQITYDRLNVTLTRDDVMGESLYNPMLPGIVADLKAK-----------GLAVESE Haemophilus ITMQQNQHNYARLNVTLTEKDVMGESLYNPMLPSIVKDLKKQ-----------GLAVEND Cricetulus VSRAEFNKIYDALDITLIER---GESFYQDRMKDIVKEFEDK-----------GYVQVDD Homosapiens VSRQELNKIYDALDVSLIER---GESFYQDRMNDIVKEFEDR-----------GFVQVDD Celegans VSKKYNQIVYNYLDIKIKDV---GESFYQDKMIELVKWVKTN---------KPDMLREED Arabidopsis2 ISRTEFAKVYQRLRVELEEK---GESFYNPHIAKVIEELNSK-----------GLVEESE Arabidopsis ISRNEFAKVYKRLRIELEEK---GESFYNPYIANVIEELSSK-----------GLVEESK Chlamydophila TSEKAFQKIYDILDIVVEKR---GESFYNPFLPEIIEDLEKK-----------GLLTVSN Chlamydia VSEKSFQTIYSILDVELHTR---GESFYNPFLAEVVADLESK-----------NLVTLSD Synechocystis QSRREFQLIYDCLDITIEER---GESFYNPFLPGVVELLQEK-----------DLLVEDN Buchnera ------------------------------------------------------------ Pyrococcus EVVRAQMVTTYKLGVKYDLLVWESDIVRRKLFEIALELLSKN---------E-NFYIPSD Deinococcus QTVKAQLQTCFRLGARYDLLNWESDVVGSGFLAQAMNILEGS---------R-YTSRPTE Rickettsia KMLDLNRKDLADLGIKHDVFFSEQSLYDKGEIEKTVKLLERMGLIYEGTLPAPKGKVHED Treponema WALRGIKQTYERTGISFDKLYFESETYTKGREEVRRGLACG------------VFYQMED Borrelia WAIEGIKETYEITNTSFDKIYLESEIFKIGKNVVLEGLEKG------------FCYKRED Methanobacterium DVL----YLDLEEFG----LEKELVLTRSDGTSLYSTRDIAYHLQKSEE----------- Methanococcus ETY----MLDLSDFG----IEKKMVLARANGTSLYSTRDIAYHLDKLSK----------- Archaeoglobus GAW----TIELEGF------DKEVVLRRENGTTLYITRDLAYHMWKNEN----------- Helicobacter SKT----WLKSSLYQ----DESDRVLIKEDKSYTYLAGDIVYHDEKFQQN---------- Campylobacter ------------------------------------------------------------ Aquifex GAL----WLKTSLFG----DDKDRVVKRSDGTYTYFASDIAYHYNKFKRG---------- Mycoplasma NAL----WLKTTLYG----DDKDRVLIRSDKRASYFGTDVAYHLEKLQRG---------- Mycoplasma2 GAI----WLKTTLYG----DDKDRVLVRQDNRPSYFGTDVAYHLDKAARG---------- Thermotoga GAV----WLKVSAFI----DEEDKVLVRSDGTYTYFMTDIAYHYKKYKRG---------- Bacillus GAT----WFRSTTFG----DDKDRVLIKKDGTYTYLLPDIAYHKDKLDRG---------- Corynebacterium GAW----WLRSTEFG----DDKDRVVIKSDGDAAYIAGDIAYVADKFSRG---------- Mycobacterium GAL----WLRTSAFG----DDKDRVVIKSDGKPAYIAGDLAYYLDKRQRG---------- Saccharomyces GAV----LIDLTKFN---KKLGKAIVQKSDGTTLYLTRDVGAAMDRYEKY---------- Schizosaccharomyces GAL----LIDLSKHD---KKLGKAIVQKRDGTTLYLTRDIGTAYKRYEKY---------- Saccharomyces2 GAL----VIDLTQWS---KRLGRVVVQKSDGTTLYLTRDVGAAIERKKNL---------- Ecoli GAT----VVFLDEFKNKEGEPMGVIIQKKDGGYLYTTTDIACAKYRYETL---------- Haemophilus GAL----VVYLDEFKNKDGDPMGVIVQKKDGGFLYTTTDIAAAKYRYETL---------- Cricetulus GRK----IVFVPGCS------IPLTIVKSDGGFTYDTSDLAAIKQRLFEE---------- Homosapiens GRK----IVFVPGCS------IPLTIVKSDGGYTYDTSDLAAIKQRLFEE---------- Celegans GRQ----IMFPTGCD------IPLTVVKSDGGFTYDTSDLAALKYRMLEE---------- Arabidopsis2 GAR----VIFLEGFD------IPLMVVKSDGGFNYASTDLTALWYRLNEE---------- Arabidopsis GAR----VIFIEGFK------IPLIVVKSDGGFNYASTDLTALWYRLNEE---------- Chlamydophila DAK----CVFHEAFS------IPFMVQKSDGGYNYATTDLAAMRYRIEED---------- Chlamydia GAK----CVFHEAFS------IPLMIQKSDGGYNYATTDVAAMRYRIQQD---------- Synechocystis GAQ----CVFLDGFTNKDGDRLPLIVQKSDGGYNYATTDLAALNYRLNTD---------- Buchnera ------------------------------------------------------------ Pyrococcus GKYRGAFVMDLRKLFP-DMKNPILVLRRSDGTATYTGKDIAYHLWKFGKIDVDLLYKEWD Deinococcus GKYAGAFIMDVSEFMP----GLE------------------------------------- Rickettsia WEYRVQKLFKSTNYG----DSQDRPIEKADGSWSYFASDLAYAKDKIDRG---------- Treponema NSI----WVDLSSLG-----LDKKALLRSDGTTMYITQDIGTAIFRAQDWP--------- Borrelia GAICIDLPSDSDEKADT--KVKQKVLIRSNGTSIYLTQDLGNIAVRTKEFN--------- Methanobacterium -------------------GDVIIDVLGSDHKLAAEQVGIAVELLGGKRP------EVIF Methanococcus -------------------CDIGIDVLGADHKLTAEMVKAALKLLGSKVP------EVIF Archaeoglobus -------------------YERFINVLGADHKLYGAQLSKILELLGLKPP------EIIF Helicobacter -------------------YTKYINIWGADHHGYIARVKASLEFLGYDSS----KLEVLL Campylobacter ------------------------------------------------------------ Aquifex -------------------FEKVINVWGADHHGYIPRVKAALKMLEIPED----WLEILL Mycoplasma -------------------FDILFNVWGTDHEGHIKRMYCAFDALKNTTKT---SLKIFA Mycoplasma2 -------------------FDLLYDIWGSDHEGHIKRMHCVYEGLKIHQKC---QLKITA Thermotoga -------------------FRKVYDIWGSDHHGHIPRMKAAMKALDIPDD----FFNVIL Bacillus -------------------FDKLINVWGADHHGYIPRMKAAIEALGYEKG----TLEVEI Corynebacterium -------------------HNLNIYMLGADHHGYIARLKAAAAALGYKPE----DVEVLI Mycobacterium -------------------FDLCIYMLGADHHGYIARLKAAAAAFGDDPA----IVEVLI Saccharomyces ------------------HFDKMIYVIASQQDLHAAQFFEILKQMGFEWA------KDLQ Schizosaccharomyces ------------------KFDKSIYVVSSQQDMYFSQLFKIFELMGFDWA------KKCV Saccharomyces2 ------------------HFDKMVYVISSQQDLYMSQFFMILKKMNFEWA------KDLQ Ecoli ------------------HADRVLYYIDSRQHQHLMQAWAIVRKAGYVP---ES--VPLE Haemophilus ------------------KANRALVFSDTRQSQHMQQAWLITRKAGYVP---DS--FSLE Cricetulus ------------------KANKIIYVVDNGQAVHFQTIFAAAQMIGWY----DPKVTQVT Homosapiens ------------------KADMIIYVVDNGQSVHFQTIFAAAQMIGWY----DPKVTRVF Celegans ------------------KCDWNIYVVDSGQSLHLETVYAAGRDFGWY----DESIQRVE Arabidopsis2 ------------------KAEWIIYVTDVGQQQHFNMFFKAARKAGWLPD-NDKTYPRVN Arabidopsis ------------------KAEWIIYVTDVGQQQHFDMFFKAARKAGWLPD-DDKTYPRVS Chlamydophila ------------------HADKIIIVTDLGQSLHFQLLEATAIAAGYLQP------GIFS Chlamydia ------------------QADRILIVTDSGQSLHFQLLEATCLAAGYLPSK-----GIFS Synechocystis ------------------GAEKIIYVTDAGQANHFAQFFQVAEKAGILTDP-----TQVV Buchnera ------------------------------------------------------------ Pyrococcus STTWTTAPDGKSMPNKFGNANIVINVIGAEQKHPQLAIKYALQLLGFEDA-----AANLY Deinococcus ------------------------------------------------------------ Rickettsia -------------------ANHLIYVLGADHSGYVKRIEAIVKALGQEKVK----VDVKI Treponema -------------------FDQLLYVVGNEQNYHFKVLFFVLRLLGYPWA------QQLH Borrelia -------------------FEEMIYVVGSEQIQHFKSLFFVAEKLGLSKN------KKLI Methanobacterium YEFITLPEGS----MSTRRGVFI--SVDELMDEAHSRALHEVKKRR-----DLPDDVADD Methanococcus YEFISLPEGS----MSTRRGRFI--STDELLEEAIKRAKEECNKR----------GVEEN Archaeoglobus FEFVSLPEGS----MSTRRGKFI--SADELISKVRDEAWKILSER------DMEEDEKRK Helicobacter AQMVRLLKDNEPYKMSKRAGNFI--LIKDVIDD--------------------------- Campylobacter ------------------------------------------------------------ Aquifex VQMVKLFREGKEVKMSKRAGTFV--TLRELLDE--------------------------- Mycoplasma LQLVTLYKNKELVRLSKRAGNVI--TIETMLSM--------------------------- Mycoplasma2 LQLVMLYKNKEIVRLSKRAGNVI--TIKQMLQM--------------------------- Thermotoga HQFVTLKRGGEIVRMSTRAGEFV--TLDELLDE--------------------------- Bacillus IQLVHLYKNGEKMKMSKRTGKAV--TMRDLIEE--------------------------- Corynebacterium GQMVNLLRDGKAVRMSKRAGTVV--TLDDLVEA--------------------------- Mycobacterium GQMVNLVCDGQLVRMSKRSGNVI--TLDDLVEA--------------------------- Saccharomyces HVNFGMVQG-----MSTRKGTVV--FLDNILEETKEKMHEVMKK---NENKYAQIEHPEE Schizosaccharomyces HINYGLVQG-----MSTRKGKAV--FLDDIMEVAKEEMHKVMQK---NEEKYAQVENPEE Saccharomyces2 HINFGMVQG-----MSTRKGNVV--FLDTILDEARDKALQIMEN---NKMKISQVDNPQR Ecoli HHMFGMMLGKDGKPFKTRAGGTV--KLADLLDEALERARRLVA----EKNPDMPADELEK Haemophilus HKNFGMMLGKDGKPFKTRTGGTV--KLADLLDEAIERATVLIN----EKNTNLSNDEKEA Cricetulus HVGFGVVLGEDKKKFKTRSGETV--RLVDLLGEGLKRSMDKLKEK--ERDKVLTEEELTA Homosapiens HAGFGVVLGEDKKKFKTRSGETV--RLMDLLGEGLKRSMDKLKEK--ERDKVLTAEELNA Celegans HVAFGLVLGDDKKKFKTRSGETV--RLLDLLSEGVKRATEKLIEK--GRETAMSEEQLVA Arabidopsis2 HVGFGLVLGEDGKRFRTRATDVV--RLVDLLDEAKTRSKLALIER--GKDKEWTPEELDQ Arabidopsis HVGFGLVLGDDNKRFRTRAAEVV--RLADLLDEAKDRSKAALIER--GKDKEWSPEELDQ Chlamydophila HVGFGLVLDPQGKKLKTRSGENV--KLRELLDTAIEKAEEALR----EHRPELTDEAIQE Chlamydia HVGFGLVLDTQGRKFKTRSGENI--KLRELLDTAVEKAKESLK----AHRPDISEEELAY Synechocystis HVPFGLVKGEDGKKLKTRAGDTI--RLKDLLTEAVTRARQDLETRLTAEERSETEEFKTE Buchnera ------------------------------------------------------------ Pyrococcus HLAYEHVERPEG-KFSGRKGTWVGFTVDEVIQEAVKRARELIEEK----NPALSDEEKAE Deinococcus ------------------------------------------------------------ Rickettsia CQLVNFVENGVPIKMSKRLGSFA--SVQDVNKE--------------------------- Treponema HVSYGMVNLPHG-RMKSREGTVV--DADDILDRLHSAAEEEIAKK----GRENALKHAQC Borrelia HLSHGMVNLVDG-KMKSREGNVI--DADNLISNLIELIIPEMTQK------IENKESAKK Methanobacterium IAESIGNGAIRYYIARLSPEKHIVFRWDDALSFER--GCASIQYAHARACKLLE------ Methanococcus IAYDIGLGAVRYNIARISPEKPMVFRWEEALDFEKV-GCPFIQYAHARCCSILK------ Archaeoglobus IADAVAVGAIRFDFIKIAPEKHMTFDWSKALDFERQ-TASYIQYSHARACSILR------ Helicobacter ----VGKDALRFIFLSKRLDTHLEFDVNTLKKQDSSNPIYYIHYANSRIHTML------- Campylobacter ------------------------------------------------------------ Aquifex ----VGKDAVRFIFLTKRSDTPLDFDVEKAKEKSSENPVYYVQYAHARISGIFREF-KER Mycoplasma ----ISEDAARWFMLSQNNGTIIKIDLDIANLQNSANPVYYVQYAFARMNSILR------ Mycoplasma2 ----LSEDAARWFMLSQTNNSIIKIDLDTANLQNSSNPVYYVQYAYARMCSVLK------ Thermotoga ----VGRDATRYFFAMVDPNTHMVFDIDLAKAKSMDNPVYYVQYAHARIHNLFS-----N Bacillus ----VGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLR-----Q Corynebacterium ----IGIDAARYSLIRSSVDSSLDMDLGLWESQSSDNPVYYVQYGHARLCSIAR-----K Mycobacterium ----IGVDAARYSLIRSSVDTPIDIDLALWSSSSNENPVYYVQYAHARLSALAR-----N Saccharomyces VADLVGISAVMIQDMQGKRINNYEFKWERMLSFEG-DTGPYLQYAHSRLRSVERNA-SGI Schizosaccharomyces VADIVGKTAIRIQDSTGKRINNYAFDWSRMTSFEG-DTGPYLQYAHSRLSSVRRNV-N-Y Saccharomyces2 VADLIGVSAIIIQDMKSKRINNYEFNWNRMLSFEG-DTGPYLQYTHSRLRSLERTS-SDF Ecoli LANAVGIGAVKYADLSKNRTTDYIFDWDNMLAFEG-NTAPYMQYAYTRVLSVFRKA-EID Haemophilus VIEAVGIGAVKYADLSKNRTTDYVFDWDNMLSFEG-NTAPYMQYAYTRIRSIFNKT-DIN Cricetulus AQTSIAYGCIKYADLSHNRLNDYIFSFDKMLDDRG-NTAAYLLYAFTRIRSIARLA-NVD Homosapiens AQTSVAYGCIKYADLSHNRLNDYIFSFDKMLDDRG-NTAAYLLYAFTRIRSIARLA-NID Celegans ARDAVAFGCVKYADLSHTRTQDYVFSFDRMLEDRG-NTAVYLLYAYTRIQSIFEKD-EVK Arabidopsis2 TAEAVGYGAVKYADLKNNRLTNYTFSFDQMLNDKG-NTAVYLLYAHARICSIIRKS-GKD Arabidopsis IAEAVGYGALKYADLKTNRITGYTFSFDQMLNDKG-DTAVYLLYAHARICSIIRKS-GKD Chlamydophila RAPVIGINAIKYSDLSSHRTSDYVFSFEKMLRFEG-NTAMFLLYAYVRIQGIKRRL-GIS Chlamydia QGPILGINAIKYADLSSHRINDYVFSFEKMLRFEG-NTAMSLLYAYVRIQGIKRRM-GLE Synechocystis VAQRVGIGAVKYADLSQNRTSDYVFSFDKMLALQG-NTAPYMLYAYARIQSISREG-GID Buchnera ------------------------------------------------------------ Pyrococcus VAEKVGIGAIRYNLIKYSPDKKIIFRWEDVLNFEG-ESAPYIQYAHARCSSILRKA-EEE Deinococcus ------------------------------------------------------------ Rickettsia ----VGKDIIRFMMLTRQNDKPLDFDLVKVKEQSRENPIFYVQYAHVRTKSILSKARELM Treponema IAENVAIAALHYFLLQVSPQKDMVFHPEESLSFNG-NTGPYLQYMGARISSLLKKV--QE Borrelia NALNIALGAIHYYLLKSAIHKDIVFNKKESLSFTG-NSGPYIQYVGARINSILEKY---- Methanobacterium -KASFTGEEDIEDG-WKPEGDERELVRLLARFPVVVEESALARRVHPVAQYAQDLANTFN Methanococcus -EAENKGVKDEAVFNYELTSEEKELIKMLDEFKDIIKESAESRRVHILANYLLELAKAFN Archaeoglobus -KAVEDGMPELEFKGELCTAGERKLVMLLSKMPYVVKRIVSELRPNVFAEYLLSVAGTFN Helicobacter EKSPFSKEEILQTPLKNLNAEEKYLLFSALSLPKAVESSFEEYGLQKMCEYAKTLASEFH Campylobacter ------------------------------------------------------------ Aquifex YKKDVSVEELINYVQHLEEEAEIKLIKKVLFFKDELVDITLKREPHLLTYYLIDLAGDFH Mycoplasma IANSDQLKEITDCSL-LINEKEISLLNQLVYYPFMLQKAMETGELHLLTNFLYETASLFH Mycoplasma2 VVDQAALAQVNDCSL-LTHEKEIALLDQLVYFKSLLEKVQVSHELHLLTNYLYETATLFH Thermotoga AEKKGVKFEEGKHLELLGNEEERVLMRNLGMFNTALKEVAQMFAPNRLTNYLQSLAESFH Bacillus GEEQGLKPAADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASALH Corynebacterium AETLGVTEEGA-DLSLLTHDREGDLIRTLGEFPAVVKAAADLREPHRIARYAEELAGTFH Mycobacterium AAEFGLIPDTG-HLELLSHDKEGALLRTVGEFPQVLKTAAALREPHRVCRYLEDLAGDYH Saccharomyces TQEKWINAD----FSLLKEPAAKLLIRLLGQYPDVLRNAIKTHEPTTVVTYLFKLTHQVS Schizosaccharomyces TDEEIMGAN----LELLTEPDAYDLVRLLGQYPDVLKNAFRFQETSTVVTYLFKLTHAVS Saccharomyces2 TTDMLIHAD----FSNLNEPQLVELVRLLAQYPDVLRRAFETQEPATIVTYLFKVCHQVS Ecoli ---EEQLAA---APVIIREDREAQLAARLLQFEETLTVVAREGTPHVMCAYLYDLAGLFS Haemophilus ---STALLA---APLTIKDDKERTLAIKLLQFEEAVQTVGKEGTPHVLCAYLYELAGIFS Cricetulus -EEMLQKAARE-TKIVLDHEKEWKLGRCILRFPEILQKMLDDLFLHTLCDYIYELATTFT Homosapiens -EEMLQKAARE-TKILLVHEKEWKLGRCILRFPEILQKILDDLFLHTLCDYIYELATAFT Celegans NVDLVKYIAST-PTLPLDHPGEFKLAKQLLKLSDCVLLVLDSLMLHQMCDYVYQLATLFH Arabidopsis2 -IDELKKTG----KLALDHADERALGLHLLRFAETVEEACTNLLPSVLCEYLYNLSEHFT Arabidopsis -IDELKKTG----KIALDHAAERALGLHLLQFAETVEEACTTLLPNVLCKYLYYLSEEFT Chlamydophila ---QLSLE----GPPEIQEPAEELLALTLLRFPEALESTIKELCPHFLTDYLYNLTHKFN Chlamydia ---SPPQE----GPLAVHEPAEEALALTLLRFPEILDLTLRELCPHFLTDYLYALTNKFN Synechocystis ---FAQMDS---GEIVLTEPTELVLAKNLLQFADVIETVEISLLPNRLCDYLYELSKVFN Buchnera ------------------------------------------------------------ Pyrococcus GIKVDPETLFKNADFTKLSERERELVIMLSKFPRIVEQAGKDVKPHLIAWFANELASLFN Deinococcus ------------------------------------------------------------ Rickettsia PEAYNSFKEGKYNLSLLSSEEEIEIIKLLAAWTKTLEASVKYFEPHRIAFYLINLASKFH Treponema DVEQKGPREVRCDPALLTHEAEWELVKALARFPACVTRAAQGHDPSVITGYLYTLSKSFS Borrelia -KALSIPVMEKIDFELLKHEKEWEIIKIISELEENIINAAKDLNPSILTSYSYSLAKHFS Methanobacterium SFYRSTPVIGS---------DFEGARLRLVDSVRKTLRNALNLLGIHAPETM---- Methanococcus RFYANCPILMTK--VDD---DVKKSRLKLVKSTKTVLETGLELLGINCPGRM---- Archaeoglobus DFYRDHPVLKAE--S-----EVRMHRLAIVDATRVVLRNGLELLGIEPLERM---- Helicobacter RFYNAGKILD----TPK---AKELLKICLMVSLSLTN--AFKLLGIEIKTKISSKD Campylobacter -------------------------------------------------------- Aquifex HYYNHHRILG----MEE---NVMFSRLALVKGIKEVVRLGLNLMGVSAPERM---- Mycoplasma SWYKVCKINDD---KNS---LLSAQRLALLRSLQFIVKQILDVLKISTPQQM---- Mycoplasma2 SWYKACKINDP---AQY---NLTQQRLLLLQSLHHVFGQLLQILNITAPQQM---- Thermotoga AFYTKHVIV---DPENP---ELSNARLNLALATGIVLRKGLKLIGVSAPERM---- Bacillus SFYNAEKVI---DPENE---EKSRARLALMKATQITLNNALQLIGVSAPEKM---- Corynebacterium RFYDSCHILPKADEDTA---PIHTARLALAAATRQTLANALRLVGVSAPEKM---- Mycobacterium RFYDSCRVLPQGDEKPT---DLHTARLALCQANRQVIANGLAILGVSAPERM---- Saccharomyces SCYDVLWVAGQTEE-------LATARLALYGAARQVLYNGMRLLGLTPVERM---- Schizosaccharomyces KLYDILWVRGRERD-------IQLARLALFGAAKQVLNNGMTLLGLTPLERM---- Saccharomyces2 SCYKKIWVSGKPAD-------IAIPRLAVYSASRQVLHNAMSLLGLVPVDRM---- Ecoli GFYEHCPILSAENEE------VRNSRLKLAQLTAKTLKLGLDTLGIETVERM---- Haemophilus SFYEHCPILNAEDES------IKLSRLKLALLTEKTLKQGLTLLGIKTVEKM---- Cricetulus EFYDSCYCVEKDRQTGKVL-KVNMWRMLLCEAVAAVMAKGFDILGIKPVQRM---- Homosapiens EFYDSCYCVEKDRQTGKIL-KVNMWR-ILCETVAAVMAKGFDTLGIKPGPRV---- Celegans DFYNECYVIEN--KEGEKP-FVHMHRLALCDVTRKVMSTCFKILGLREVNKM---- Arabidopsis2 RFYSNCQVNGS---------PEETSRLLLCEATAIVMRKCFHLLGITPVYKI---- Arabidopsis KFYSNCQVNGS---------AEETSRLLLCET-AIVMRKCFHLLGITPVYKL---- Chlamydophila GFFRDSHIQDSPYAK---------SRLFLCALAEQVLATGMHLLGLKTLERL---- Chlamydia AFFRDCHIEGSDSQQ---------ERLYLCGLTERTLSTGMHLLGLKTLNHL---- Synechocystis RFYENCPVLKASDPQR-------GSRLLLCDLTARTLKLGLSLLGIPVLDRM---- Buchnera -------------------------------------------------------- Pyrococcus KFYMDHPVLKAEEG-------VREARLLLVMAVEQVLKNALYLMGIEAPERM---- Deinococcus -------------------------------------------------------- Rickettsia SMWNFGKENSDYRFIIENNKELTLARLALASVIQKIIASGLEVIGVEPMVTM---- Treponema RFYHDCPILCEARP------DYACARLELVRAVRIVLRTAMRLVLIPFLEEM---- Borrelia TYYQEVKVIDTNNIN------LTAARIEFLKAILQTIKNCMYLLNIPYMLKM----