CLUSTAL X (1.64b) multiple sequence alignment cMethanococcus -------------------------------MFISYWLLQNVFERHYIKK cMethanococcus2 -------------------------------------------------- cMethanobacterium -------------------------------------------------- Methanobacterium2 -------------------------------------------------- cMethanococcus3 -------------------------------------------------- *Methanococcus4 -------------------------------------------------- Archaeoglobus -------------------------------------------------- *Schizosaccharomyces -----------------------------------------MSATR---- *Saccharomyces ---------------------------------MFRSVATRLSACRGLAS Deinococcus -------------------------------------RRSCLDAPTLSLK Ecoli2 -------------------------------------------------- Ecoli3 -------------------------------------------------- Salmonella -------------------------------------------------- *Salmonella2 -------------------------------------------------- Haemophilus -------------------------------------------------- Buchnera2 -------------------------------------------------- Buchnera3 -------------------------------------------------- Buchnera -------------------------------------------------- Leptospira -------------------------------------------------- Thermotoga -------------------------------------------------- Clostridium -------------------------------------------------- Aquifex -------------------------------------------------- Neisseria -------------------------------------------------- Thiobacillus -------------------------------------------------- Pseudomonas2 -------------------------------------------------- *Pseudomonas3 -------------------------------------------------- Agrobacterium -------------------------------------------------- Brassica -------------MAAALQTNIRPVKFPATLRALTKQSSPAPFRVRCAAA Arabidopsis7 -------------MAAALQTNIRTVKVPATFRAVSKQS-LAPFRVRCAVA Arabidopsis6 -------------MAAFLQTNIRLEIIPGRYSSLTDHKFRAPYRIRCAAA Spirulina -------------------------------------------------- Spirulina2 -------------------------------------------------- Synechocystis -------------------------------------------------- Bacillus -------------------------------------------------- Bacillus2 -------------------------------------------------- Bacillus3 -------------------------------------------------- Bacillus4 -------------------------------------------------- Bacillus5 -------------------------------------------------- Bacillus7 -------------------------------------------------- Thermus7 -------------------------------------------------- Thermus8 -------------------------------------------------- Thermus5 -------------------------------------------------- Thermus6 -------------------------------------------------- Thermus4 -------------------------------------------------- Thermus9 -------------------------------------------------- Thermus3 -------------------------------------------------- Bacteroides -------------------------------------------------- Lactococcus -------------------------------------------------- *Pseudomonas -------------------------------------------------- *Ecoli -------------------------------------------------- Sphingomonas -------------------------------------------------- *Bacillus6 -------------------------------------------------- *Agrobacterium2 -------------------------------------------------- *Agrobacterium3 -------------------------------------------------- *Agrobacterium5 -------------------------------------------------- *Agrobacterium6 -------------------------------------------------- *Agrobacterium4 -------------------------------------------------- Mycobacterium -------------------------------------------------- Mycobacterium2 -------------------------------------------------- Mycobacterium3 -------------------------------------------------- Corynebacterium -------------------------------------------------- Sulfolobus -------------------------------------------------- cAjellomyces ---MFSLRTAQPAQSLFRAATNTYSTSLPRSAI--AARSFATVQSDIFKP cSchizosaccharomyces2 -----------------------MFKSLVR-------------KSSAFQP cSaccharomyces3 ----------------------MLNRTIAKR------TLATAAQAERTLP cKluyveromyces2 ----------------------MLRQGIAAQK-----KSFATLAAEQLLP cRattusnorvegicus -----AVAAGSAAKAIFKPALLCRPWEVLAAHE--APRRSISSQQTIPPS cRattusnorvegicus2 -----AIAAGSAAKAIFKPALLCRPWEVLAAHE--APRRSISSQQTIPPS cMusmusculus MALKVAIAAGGAAKAMLKPTLLCRPWEVLAAHV--APRRSISSQQTIPPS cHomosapiens6 MALKVATVAGSAAKAVLGPALLCRPWEVLGAHE--VPSRNIFSEQTIPPS cMacaca4 ----------------------------------------ISSQQTIPPS cHomosapiens7 -------------------------------------------------- cCelegans ---MSSNVLGHTLRSSKNVVQKAFVATSPNSDM--LRFRSPVLQTNTTKL cMacaca -------ALSG-VRWLTRALVSAGNPGAWRGLS--TSAAAHAASRSQAED cHomosapiens -----MAVLSG-VRWLTRALVSAGNPGAWRGLS--TSAAAHAASRSQAED cHomosapiens2 -----MAVLSG-VRWLTRALVSAGNPGAWRGLS--TSAAAHAASRSQAED cHomosapiens3 -----MAVLSG-VRWLTRALVSAGNPGAWRGLS--TSAAAHAASRSQAED cBostaurus -----MAALSR-VRWLTRALVAAPNPGAWRSLC--TSTVAQASSRTQGED cBostaurus2 -----MAALSR-VRWLTRALVAAPNPGAWRSLC--TSTVAQASSRTQGED *Homosapiens5 -------------------------------------------------- cCelegans2 -------MLSRTVSSLSR--VAPQTLGAVNAAS--SRQYSITAPRPPTE- cArabidopsis ---------------MSRQSFSLLKNLRSIASG----SKIQTRSVTYMPR cArabidopsis2 ---------------MSRQSSSLLKNLRSIASR----SKIQTRSVTYMPR cArabidopsis3 ---------------MSRRSLTLLKNLARNANG----SGIQTRSVTYMPR cArabidopsis4 ---------------MSRRSLTLLKNLARNANG----SGIQTRSVTYMPR cNicotiana ---------------MAKRTLPLLRHLLSSPSHGFSHSLTSTRSVTYMPR cArabidopsis5 ---------------MARRSVSIFNRLLANPPS---PFTSLSRSITYMPR cNicotiana3 ---------------MARKSFPILKQLIQQSTN------RFFTTN----- cSaccharomyces2 ---------------MLRNTFFRNTSRRFLATV----KQPS-IGRYTGKP cKluyveromyces ---------------MFRQSIVKQSCR-FLATK----KQPS-IGRYTGKP Solanum ----------------MALQIAKRLLRCRADSV----ASSVRFFDRTFTS cNicotiana2 ----------------MAFQIARRLLRSRAS------S-SIRYLDRSFSS cHomosapiens4 ---------------MAGPAWISKVSRLLGA----------FHNPKQVTR cMacaca3 --------------------------------------------QKQVTR cMacaca2 -------------------------------------------------- cBostaurus3 ---------------MAGPAWISKVSRLLGA----------FHNQKQVTR cCelegans3 ---------------MLG-KCIKKASSTVG----------------QSIR cThermus ---------------------MPLITTETG----------------KKMH cThermus2 ----------------------PLITTETG----------------KKMH Pyrococcus -------------------------------------------------- cCaldococcus ------------------------MVSHPCTADEAKPPSEGQLARFENGK cMethanococcus FLVLSMMKVCVIEGDGIGKEVIPEAXKILNELG--------EFEIIKGEA cMethanococcus2 -----MMKVCVIEGDGIGKEVIPEAIKILNELG--------EFEIIKGEA cMethanobacterium -----MYRITVIPGDGIGVEVMEAALHVLQALEI-------EFEFTHAEA Methanobacterium2 ---MKSMKIAVIPGDGIGVEVMEAALHILNTLDL-------DLEFIHADA cMethanococcus3 -MVISMHKICVIEGDGIGKEVVPATIQVLEATGL-------PFEFVYAEA *Methanococcus4 -----MHKICVIEGDGIGKEVVPATIQVLEATGL-------PFEFVYAEA Archaeoglobus -----MKKIVVIPGDGIGKEVMEAAMLILEKLDL-------PFEYSYYDA *Schizosaccharomyces ---R--IVLGLIPADGIGKEVVPAARRLMENLPAKHK---LKFDFIDLDA *Saccharomyces NAARKSLTIGLIPGDGIGKEVIPAGKQVLENLNSKHG---LSFNFIDLYA Deinococcus LSLMAKYRICLIEGDGIGHEVIPAAKRVLEAAG-------FDAEYVHAEA Ecoli2 MMSKN-YHIAVLPGDGIGPEVMTQALKVLD-AVRNRFA--MRITTSHYDV Ecoli3 -MSKN-YHIAVLPGDGIGPEVMTQALKVLD-AVRNRFA--MRITTSHYDV Salmonella -MSKN-YHIAVLPGDGIGPEVMAQALKVMD-AVRSRFD--MRITTSHYDV *Salmonella2 -MSKN-YHIAVLPGDGIGPEVMAQALKVMD-AVR--VL--ICVYHSHYDV Haemophilus --MQS-YNIAVLAGDGIGPEVMAEAIKVLN-RVQEKFG--FKLNFNEFFV Buchnera2 -MKKK-FRIAVLPGDGIGPEVMREAYKILN-ILERKFF--LKLELREFDI Buchnera3 -MKKK-FRIAVLPGDGIGPEIMREAYKILN-ILEKNFS--LPLEIREFSV Buchnera -MTKKLYKIAVLPGDGIGPEIIQEAYKIID-VLQKKFS--FNVKMHEYDI Leptospira --MKN---VAVLSGDGIGPEVMEIAISVLK-KALGAKV--SEFQFKEGFV Thermotoga ------MKIAVLPGDGIGPEVVREALKVLE-VVEKKTG--KTFEKVFGHI Clostridium ---MKEFKIAVIPGDGIGPDIVREAVKIMT-KVGEKYD--TKFNFVEVKA Aquifex ---MKKYKIAVLKGDGIGPEIVEQALRVLD-KIGEIYG--VEFEYREGLI Neisseria ----MTKHIAILRGDGIGPEIVAETVRVLDKLIEQGLD--AGYEYAP--L Thiobacillus -----MKKIAIFAGDGIGPEIVAAARQVLD-AVDQAAH--LGLRCTEGLV Pseudomonas2 ----MSKQILVLPGDGIGPEIMAEAVKVLE-LANDRFQ--LGFELAEDVI *Pseudomonas3 ----MSKQILVLPGDGIGPEIMAEAVKVLE-LANDRFQ--LGFELAEDVI Agrobacterium ---MTVRSVFLLPGDGIGPEAMTEVRKLIE-YMNSAHN--AGFTVSEGLV Brassica SPGKKRYNITLLPGDGIGPEVISIAKNVLQ-QAGSLEG--LEFSFQEMPV Arabidopsis7 SPGKKRYTITLLPGDGIGPEVVSIAKNVLQ-QAGSLEG--VEFNFREMPI Arabidopsis6 SPVKKRYNITLLPGDGIGPEVISVAKNVLQ-KAGFLQG--LEFDFQEMPF Spirulina --MTQNYRITLLSGDGIGPEIMAVAVDVLK-AVGKQLD--LNFEFKEALM Spirulina2 --MTQNYRITLLSGDGIGPEIMAVAVDVLK-AVGKQLD--LNFEFKEALM Synechocystis --MSQTYNVTLLPGDGIGPEIMAVAVAVLG-KVADQFG--FAFNFQEALI Bacillus ----MKMKLAVLPGDGIGPEVMDAAIRVLK-TVLDNDG--HEAVFENALI Bacillus2 ----MKMKLAVLPGDGIGPEVMDAAIRVLK-TVLDNDG--HEAVFENALI Bacillus3 ----MKMKLAVLPGDGIGPEVMDAAIRVLK-TVLDNDG--HEAVFENALI Bacillus4 ----MKKRIALLPGDGIGPEVLESATDVLK-SVAERFN--HEFEFEYGLI Bacillus5 ----MKKRIALLPGDGIGPEVLESATDVLK-SVAERFN--HEFEFEYGLI Bacillus7 ---MGNYRIAVLPGDGIGKEVTSGAVEVLK-AVGIRFG--HEFTFEYGLI Thermus7 ------MKVAVLPGDGIGPEVTEAALKVLR-ALDEAEG--LGLAYEVFPF Thermus8 ------MKVAVLPGDGIGPEVTEAALKVLR-ALDEAEG--LGLAYEVFPF Thermus5 ------MKVAVLPGDGIGPEVTEAALKVLR-ALDEAEG--LGLAYEVFPF Thermus6 ------MKVAVLPGDGIGPEVTEAALKVLR-ALDEAEG--LGLAYEVFPF Thermus4 ------MKVAVLPGDGIGPEVTEAALKVLR-ALDEAEG--LGLAYEVFPF Thermus9 ------MKVAVLPGDGIGPEVTEAALKVLR-ALDEAEG---GPTYEVFPF Thermus3 ------MRVAVLPGDGIGPEVTEAALRVLK-ALDEREG--LGLTYETFPF Bacteroides ----MDFKIAVLAGDGIGPEISVQGVEVMS-AVCEKFG--HKVNYEYAIC Lactococcus ----MSKKIVTLAGDGIGPEIMSAGLSVLK-AVSKKID--FEYELEAKDF *Pseudomonas -MPAHSFRIAAIPGDGIGLEVLPEGIRVLEAAALKHG---LALEFDTFEW *Ecoli --MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG---FALSFEQMEW Sphingomonas ---MRRYSIASIPGDGIGREVVPAAIEVLTAAAAKCG---FVLEFRHFDW *Bacillus6 -MTMKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGG--LSFSFTAFPW *Agrobacterium2 ---MREYKIAAIPADGIGPEVIAAGLQVLEALEKRSGD--FSIHTETFDW *Agrobacterium3 ---MREYKIAAIPADGIGPEVIAAGLQVLEALEKRSGD--FSIHTETFDW *Agrobacterium5 ---MREYKIAAIPADGIGPEVIAAGLQVLEALEQRSGD--FKIHTETFDW *Agrobacterium6 ---MREYKIAAIPADGIGPEVIAAGLQVLEALEQRSGD--FKIHTETFDW *Agrobacterium4 ---MREYKIAAIPADGIGPEVIAAGLQVLEALEQRSGD--FKIHTETFDW Mycobacterium ------MKLAIIAGDGIGPEVTAEAVKVLDAVVP--G-----VQKTSYDL Mycobacterium2 ------MKLAIIAGDGIGPEVTAEAVKVLDAVVP--G-----VQKTSYDL Mycobacterium3 ------MKLAIIGGDGIGPEVVAQAVKILDVVLP--G-----VQKTTYDL Corynebacterium ------MKLAVIGGDGIGPEVTAEALKVLNAVRD--D-----IETTDYDL Sulfolobus ----MGFTVALIQGDGIGPEIVSKSKRILA-KINELYS--LPIEYIEVEA cAjellomyces TKYGGKYTVTLIPGDGIGTEVAESVKTIFKADN-------VPIEWEQVDV cSchizosaccharomyces2 LKYGGKYTVTLIPGDGIGRETSNAVTEIFKTAN-------VPIEFEEIDV cSaccharomyces3 KKYGGRFTVTLIPGDGVGKEITDSVRTIFEAEN-------IPIDWETINI cKluyveromyces2 KKYGGRYTVTLIPGDGVGKEVTDSVVKIFENEN-------IPIDWETIDI cRattusnorvegicus AKYGGRHTVTMIPGDGIGPELMLHVKSVFRHAC-------VPVDFEEVHV cRattusnorvegicus2 AKYGGRHTVTMIPGDGIGPELMLHVKSVFRHAC-------VPVDFEEVHV cMusmusculus AKYGGRHTVTMIPGDGIGPELMLHVKSVFRHAC-------VPVDFEEVHV cHomosapiens6 AKYGGRHTVTMIPGDGIGPELMLHVKSVFRHAC-------VPVDFEEVHV cMacaca4 AKYGGRHTVTMIPGDGIGPELMLHVKSVFRHAC-------VPVDFEEVHV cHomosapiens7 -------------------------------------------DFEEVHV cCelegans ARYGGRHNVTVLPGDGIGPEMLHHVERILSAVQ-------APVDFEVVNL cMacaca VRVEGSFPVTMLPGDGVGPELMHAVKEVFKAAA-------VPVEFQEHHL cHomosapiens VRVEGSFPVTMLPGDGVGPELMHAVKEVFKAAA-------VPVEFQEHHL cHomosapiens2 VRVEGSFPVTMLPGDGVGPELMHAVKEVFKAAA-------VPVEFQEHHL cHomosapiens3 VRVEGSFPVTMLPGDGVGPELMHAVKEVFKAAA-------VPVEFQEHHL cBostaurus VRVEGAFPVTMLPGDGVGPELMHAVKEVFKAAS-------VPVEFQEHHL cBostaurus2 VRVEGAFPVTMLPGDGVGPELMHAVKEVFKAAS-------VPVEFQEHHL *Homosapiens5 -------------------------------------------------- cCelegans2 --LNQKLKVTIIPGDGVGPELIYTVQDIVKQTG-------IPIEFEEIFL cArabidopsis PGDGKPRPVTLIPGDGVGPLVTNAVQQVMEAMH-------APVYFEPFEV cArabidopsis2 PGDGKPRPVTLIPGDGVGPLVTNAVQQVMEAMH-------APVYFEPFEV cArabidopsis3 PGDGAPRAVTLIPGDGIGPLVTNAVEQVMEAMH-------APIFFEKYDV cArabidopsis4 PGDGAPRAVTLIPGDGIGPLVTNAVEQVMEAMH-------APIFFEKYDV cNicotiana PGDGTPRAVTLIPGDGIGPLVTGAVEQVMDAMH-------APVYFERYDV cArabidopsis5 PGDGAPRTVTLIPGDGIGPLVTGAVEQVMEAMH-------APVHFERYEV cNicotiana3 ---ASPRAVTLIPGDGVGPLVTDSVEQVMQAMK-------APVYFERYEV cSaccharomyces2 NPSTGKYTVSFIEGDGIGPEISKSVKKIFSAAN-------VPIEWESCDV cKluyveromyces NPKTGKYTVSFIEGDGVGPEISKSVKAIFSAAK-------VPIEWESCDV Solanum ESNSNLIRATLFPGDGIGPEIAESVRQIFKVAE-------VPIEWEEHYV cNicotiana2 ESNSNLIRATLFPGDGIGPEIADSVRQIFKTAE-------VPIEWEEHYV cHomosapiens4 GFTGGVQTVTLIPGDGIGPEISAAVMKIFDAAK-------APIQWEERNV cMacaca3 GFTGGVQTVTLIPGDGIGPEISAAVMKIFDAAK-------APIQWEERNV cMacaca2 -FTGGVQTVTLIPGDGIGPEISAAVMKIFDAAK-------APIQWEERNV cBostaurus3 GFAGGVKTVTLIPGDGIGPEISAAVMKIFDAAK-------APIQWEERNV cCelegans3 YSSGDVRRVTLIPGDGIGPEISASVQKIFEAAD-------APIAWDPVDV cThermus VLEDGRKLITVIPGDGIGPECVEATLKVLEAAK-------APLAYEVREA cThermus2 VLEDGRKLITVIPGDGIGPECVEATLKVLEAAK-------APLAYEVREA Pyrococcus -----------------------MVKSVTD-----------KIKFYEFEG cCaldococcus LIVPDNLIVAYFKGDGIGPEIVESAKKVLDAAVDKAYGGTRRIVWWEVTA cMethanococcus G-LECLKKYGNALPEDTIEKAK-EADIILFGAITSPKP-----GEVQNYK cMethanococcus2 G-LECLKKYGNALPEDTIEKAK-EADIILFGAITSPKP-----GEVQNYK cMethanobacterium G-NECFRRCGDTLPEETLKLVR-KADATLFGAVTT----------VPGQK Methanobacterium2 G-DACLKRTGTALPEETLEAVG-EARATLFGAAG------------ESAA cMethanococcus3 G-DEVYKRTGKALPEETIETAL-DCDAVLFGAAG------------ETAA *Methanococcus4 G-DEVYKRTGKALPEETIETAL-DCDAVLFGAAG------------ETAA Archaeoglobus G-DEALEKYGKALPDETLEACR-KSDAVLFGAAG------------ETAA *Schizosaccharomyces G-WGTFERTGKALPERTVERLKTECNAALFGAVQSP-T-----HKVAGYS *Saccharomyces G-FQTFQETGKALPDETVKVLKEQCQGALFGAVQSP-T-----TKVEGYS Deinococcus G-YEYFLDHGTSVPEATYDAVE-NTDATLFGAATSPSG-----EKPAGFF Ecoli2 G-GAAIDNHGQPLPPATVEGCE-QADAVLFGSVGGPKWEHLP-PDQQPER Ecoli3 G-GAAIDNHGQPLPPATVEGCE-QADAVLFGSVGGPKWEHLP-PDQQPER Salmonella G-GIAIDNHGHPLPKATVEGCE-QADAILFGSVGGPKWENLP-PESQPER *Salmonella2 G-GIAIDSSGIPLPKATVEGCE-QADAILFGSVGGPKMGKFA-PGKPAGA Haemophilus G-GAAIEHCGYPLPAETLKGCD-QADAILFGSVGGPKWTNLP-PDQQPER Buchnera2 G-GIAIDREGIALPEKTLRGCE-NSDAILFGSVGGKKWDYLP-IESRPER Buchnera3 G-GIAIDREGIALPEETLRGCE-NSDAILFGSVGGKKWDYLP-IESRPER Buchnera G-GISIDKHGTALTQETIEGCE-NSDAILFGSVGGSKWDHLPEIE-KPEK Leptospira G-GIAIDKTGHPLPPETLKLCE-ESSAILFGSVGGPKWETLP-PEKQPER Thermotoga G-GDAIDRFGEPLPEETKKICL-EADAIFLGSVGGPKWDDLP-PEKRPEI Clostridium G-GDAIDAYGEPLPKETIDVCK-SSAAVLLGAVGGPKWDNLE-GSKRPER Aquifex G-GEAIDKTGDPLPEETLKICK-ESDAILLGAVGGPKWDNLP-TDKRPEK Neisseria G-GEAYDEYGHPYPEFTQNLCR-KADAVLLGAVGSPQYDNLD-RPLRPER Thiobacillus G-GAALDASDDPLPAASLQLAM-AADAVILGAVGGPRWDAYP-PAKRPEQ Pseudomonas2 G-GAAIDKHGVPLADQTLQRAR-QADAVLLGAVGGPKWDRIE-RDIRPER *Pseudomonas3 G-GAAIDKHGVPLADQTLQRAR-QADAVLLGAVGGPKWDRIE-RDIRPER Agrobacterium G-GSAYDAHGVAISDADMEKAL-AADAILFGAVGGPKWDGVP-YEHRPEA Brassica G-GAALDLVGVPLPEETVSAAK-ESDAVLLGAIGGYKWDKNE-KHLKPET Arabidopsis7 G-GAALDLVGVPLPEETISAAK-ESDAVLLGAIGGYKWDNNE-KHLRPEK Arabidopsis6 G-GAALDLVGVPLPEETSTAAK-QSDAILLGAIGGYKWDKNE-KHLRPEM Spirulina G-GVAIDATGEPLPEESLQACR-DSDAVLLAAIGGYKWDNLP-RPERPET Spirulina2 G-GVAIDATGEPLPEESLQACR-DSDAVLLAAIGGYKWDNLP-RPERPET Synechocystis G-GAAIDATGQPLPEATLAQAK-DSDAVLLAAIGGYAWDNLP-RSQRPET Bacillus G-GAAIDEAGTPLPEETLDICR-RSDAILLGAVGGPKWDHNP-ASLRPEK Bacillus2 G-GAAIDEAGTPLPEETLDICR-RSDAILLGAVGGPKWDHNP-ASLRPEK Bacillus3 G-GAAIDEAGTPLPEETLDICR-RSDAILLGAVGGPKWDHNP-ASLRPEK Bacillus4 G-GAAIDEHHNPLPEETVAACK-NADAILLGAVGGPKWDQNL-SELRPEK Bacillus5 G-GAAIDEHHNPLPEETVAACK-NADAILLGAVGGPKWDQNL-SELRPEK Bacillus7 G-GAAIDEAGTPLPEETVRLCR-ESDAVLLGAVGGPKWDDNP-PHLRPEK Thermus7 G-GAAIDAFGEPFPEPTRKGVE-EAEAVLLGSVGGPKWDGLP-RKISPET Thermus8 G-GAAIDAFGEPFPEPTRKGVE-EAEAVLLGSVGGPKWDGLP-RKIRPET Thermus5 G-GAAIDAFGEPFPEPTRKGVE-EAEAVLLGSVGGPKWDGLP-RKIRPET Thermus6 G-GAAIDAFGEPFPEPTRKGVE-EAEAVLLGSVGGPKWG--T-GSVRPEQ Thermus4 G-GAAIDAFGEPFPEPTRKGVE-EAEAVLLGSVGGPKWDQNP-RELRPEK Thermus9 G-GAAIDAS-APFPEPTRKGVE-EAEAVLLGSVGGPRLGRPS-PQDPPGD Thermus3 G-GAAIDGYGEPFPEVTRKGVE-AAEAVLLGSVGGPKWDALP-RKIRPES Bacteroides G-ADAIDKVGDPFPEETYRVCK-NADAVLFSAVGDPKFDNDPTAKVRPEQ Lactococcus G-GIAIDKHGHPLPEETLQAVK-NADAILLAAIGHPKYNN---AKVRPEQ *Pseudomonas ASCDYYLQHGKMMPDDWAEQLK-QYDAIYFGAVDWPDK----VPDHISLW *Ecoli ASCEYYSHHGKMMPDDWHEQLS-RFDAIYFGAVGWPDT----VPDHISLW Sphingomonas S-CQTYLETGKMMPDDGLDRLR-DHDAVFLGAVGFPG-----VPDHISLW *Bacillus6 S-CDYYLEHGKMMPEDGIHTLT-QFEAVFLGAVGNPKL----VPDHISLW *Agrobacterium2 G-SDYYKKNGVMMPADGLEQLK-KFDAIFFGAVGAPD-----VPDHITLW *Agrobacterium3 G-SDYYKKNGVMMPADGLEQLK-KFDAIFFGAVGAPD-----VPDHITLW *Agrobacterium5 G-SDYYKKHGVMMPADGLDKLK-KFDAIFFGAVGAPD-----VPDHITLW *Agrobacterium6 G-SDYYKKHGVMMPADGLDKLK-KFDAIFFGAVGAPD-----VPDHITLW *Agrobacterium4 G-SDYYKKHGVMMPADGLDKLK-KFDAIFFGAVGAPD-----VPDHITLW Mycobacterium G-ARRFHATGEVLPDSVVAELR-NHDAILLGAIGDP-S----VPSGVLER Mycobacterium2 G-ARRFHATGEVLPDSVVAELR-NHDAILLGAIGDP-S----VPSGVLER Mycobacterium3 G-ARRYHTTGELLPESVLAELR-EHDAILLGAVGDP-S----VPSGVLER Corynebacterium G-ARRYLKNGELLTDEDLASLR-EHDAILLGAIGAPGS----VPPGILER Sulfolobus G-DRALARYGEALPKDSLKIID-KADIILKGPVG------------ESAA cAjellomyces SGLDAGNKHSEDLFKESIASL-KRNKLGLKGILHT------PVERS-GHQ cSchizosaccharomyces2 TGMEKNNKSSGDALHEAIQSL-KRNKVGLKGILFT------PFEKG-GHT cSaccharomyces3 KQTD--HKEG---VYEAVESL-KRNKIGLKGLWHT------PADQT-GHG cKluyveromyces2 SGLE--NTEN---VQRAVESL-KRNKVGLKGIWHT------PADQT-GHG cRattusnorvegicus SSNA----DE-EDIRNAIMAI-RRNRVALKGNIET------NHDLPPSHK cRattusnorvegicus2 SSNA----DE-EDIRNAIMAI-RRNRVALKGNIET------NHDLPPSHK cMusmusculus SSNA----DE-EDIRNAIMAI-RRNRVALKGNIET------NHNLPPSHK cHomosapiens6 SSNA----DE-EDIRNAIMAI-RRNRVALKGNIET------NHNLPPSHK cMacaca4 SSNA----DE-EDIRNAIMAI-RRNRVALKGNIET------NHNLPPSHK cHomosapiens7 SSNA----DE-EDIRNAIMAI-RRNRVALKGNIET------NHNLPPSHK cCelegans TSKE----DASEDLAEAITAI-KRNGVALKGNIET------KFDNP-SFV cMacaca SEVQNMASEEK--LEQVLSSM-KENKVAIIGKIHT------PMEYKGELA cHomosapiens SEVQNMASEEK--LEQVLSSM-KENKVAIIGKIHT------PMEYKGELA cHomosapiens2 SEVQNMASEEK--LEQVLSSM-KENKVAIIGKIHT------PMEYKGELA cHomosapiens3 SEVQNMASEEK--LEQVLSSM-KENKVAIIGKIHT------PMEYKGELA cBostaurus SEVQNMASEEK--LEQVLSSM-KENKVAIIGKIHT------PMEYKGELA cBostaurus2 SEVQNMASEEK--LEQVLSSM-KENKVAIIGKIHT------PMEYKGELA *Homosapiens5 -------------------------------------------------- cCelegans2 SEVHYTRSSS---IENAVESIGRNNNVALKGAIEESA----VLHTEGELQ cArabidopsis HGDMK------SLPEGLLESI-KKNKVCLKGGLKT------PVGGG--VS cArabidopsis2 HGDMK------SLPEGLLESI-KKNKVCLKGGLKT------PVGGG--VS cArabidopsis3 HGEMS------RVPPEVMESI-RKNKVCLKGGLKT------PVGGG--VS cArabidopsis4 HGEMS------RVPPEVMESI-RKNKVCLKGGLKT------PVGGG--VS cNicotiana HGDMK------SVPPEVMESI-RKNKVCLKGGLKT------PVGGG--VS cArabidopsis5 LGNMR------KVPEEVIESV-KRNKVCLKGGLAT------PVGGG--VS cNicotiana3 RGDMK------CIPEEVIDSI-KKNKVCLKGGLKT------PVGGG--VS cSaccharomyces2 SPIFVN--GLTTIPDPAVQSI-TKNLVALKGPLAT------PIGKG--HR cKluyveromyces SPIFVN--GLTTIPDPAVASI-NKNLIALKGPLAT------PIGKG--HR Solanum GTEVDPR-TNSFLTWESLESV-RRNKVGLKGPMAT------PIGKG--HR cNicotiana2 GKEIDPR-TNSFLTWESLESV-RRNKVGLKGPMAT------PIGKG--HR cHomosapiens4 TAIQGPG-GKWMIPSEAKESM-DKNKMGLKGPLKT------PIAAG--HP cMacaca3 TAIQGPG-GKWMIPSEAKESM-DKNKMGLKGPLKT------PIAAG--HP cMacaca2 TAIQGPG-GKWMIPSEAKESM-DKNKMGLKGPLKT------PIAAG--HP cBostaurus3 AAIQGPG-GKWMIPPEAKESM-DKNKMGLKGPLKT------PIAAG--HP cCelegans3 TPVKGRD-GVFRIPSRCIELM-HANKVGLKGPLET------PIGKG--HR cThermus GASVFRRGIASGVPQETIESI-RKTRVVLKGPLET------PVGYG--EK cThermus2 GASVFRRGIASGVPQETIESI-RKTRVVLKGPLET------PVGYG--EK Pyrococcus G-LSVFKKYGVPIREEDLEEIR-KMDAILFGATTTP-------FDVPRYK cCaldococcus G-EEAQKECGSLLPDGTLQAFK-LARVNLKGPLTTP--------VGGGFR cMethanococcus SPIITLRKMFHLYANVRPINNF-G-IGQLIGKIADYEFLNAKNIDIVIIR cMethanococcus2 SPIITLRKMFHLYANVRPINNF-G-IGQLIGKIADYEFLNAKNIDIVIIR cMethanobacterium SAIITLRRELDLFANLRPVKSLPG-VPCLY-----------PDLDFVIVR Methanobacterium2 DVIVRLRREFDLFANLRPVKSLPG-VPCLY-----------PDLDFVIVR cMethanococcus3 DVIVKLRHILDTYANIRPVKAYKG-VKCLR-----------PDIDYVIVR *Methanococcus4 DVIVKLRHILDTYANIRPVKAYKG-VKCLR-----------PDIDYVIVR Archaeoglobus DVIVRLRRELGTFANVRPAKAIEG-IECLY-----------PGLDIVVVR *Schizosaccharomyces SPIVALRKKMGLYANVRPVKSLDG-AKGKP-------------VDLVIVR *Saccharomyces SPIVALRREMGLFANVRPVKSVEG-EKGKP-------------IDMVIVR Deinococcus GAIRHLRQKYNLYANVRPTKTR-P-VPHSY-----------ENVDLVIVR Ecoli2 GALLPLRKHFKLFSNLRPAKLYQG-LEAFCPLRADI---AANGFDILCVR Ecoli3 GALLPLRKHFKLFSNLRPAKLYQG-LEAFCPLRADI---AANGFDILCVR Salmonella GALLPLRKHFKLFSNLRPAKLYQG-LEAFCPLRADI---AANGFDILCVR *Salmonella2 RRLLPLRKHFKLFSNLRPAKLYQG-LEAFCPLRADI---AANGFDILCVR Haemophilus GALLPLRKHFKLFCNLRPATLYKG-LEKFCPLRADI---AAKGFDMVVVR Buchnera2 ASLLPLRKHFNLFSNLRPAKLRVD-LKNLSPLRSDI---VRDGFDILCIR Buchnera3 ASLLPLRKHFNLFSNLRPAKLYSD-LKNLSPLRSNI---VRNGFDILCVR Buchnera AGLLKLRKHFNLFANIRPCKLSQH-LLDISPLKNSI---IKKGIDLICIR Leptospira GALLPLRKHFDLFANLRPAIIYPE-LKNASPVRSDI---IGNGLDILILR Thermotoga GGLLALRKMLNLYANIRPIKVYRS-LVHVSPLKEKV---IGSGVDLVTVR Clostridium -ALLGLRGALGLYANLRPAKVYNV-LKSASPLKNEI---IDEGVDLLVVR Aquifex -GLLRIRKELDLYANLRPAKVWDA-LISSSPLKEEV---VK-GTDMIVIR Neisseria -GLLAIRKDLNLFANLRPAVLYPE-LANASTLKPEI---VA-GLDILIVR Thiobacillus -GLLRLRKGLDLYANLRPAQIFPQ-LLDASPLRPEL---VR-DVDILVVR Pseudomonas2 -GLLKFRSQLGLFANLRPAILYPQ-LAAASSLKPEV---VA-GLDILIVR *Pseudomonas3 -GLLKIRSQLGLFANLRPAILYPQ-LAAASSLKPEV---VA-GLDILIVR Agrobacterium -GLLRLRKDLELFANLRPAICYPA-LAAASSLKPEL---VE-GLDILIVR Brassica -GLLQLRAGLKVFANLRPATVLPQ-LVDASTLKREV---AE-GVDLMVVR Arabidopsis7 -GLLQIRAALKVFANLRPATVLPQ-LVDASTLKREV---AE-GVDLMVVR Arabidopsis6 -GLLNIRRDLNVFANLRPATVLPQ-LVDASTLKKEV---AQ-GVDMMIVR Spirulina -GLLALRAGLGLFANRARLLFCPH-VLDASSLKREV---VE-GVDIMVVR Spirulina2 -GLLALRAGLGLFANRARLLFCPH-VLDASSLKREV---VE-GVDIMVVR Synechocystis -GLLAIREGLGLFANLRPATIFPQ-LIDASSLKREV---VE-GVDIMVVR Bacillus -GLLGLRKEMGLFANLRPVKAYAT-LLNASPLKRER---VE-NVDLVIVR Bacillus2 -GLLGLRKEMGLFANLRPVKAYAT-LLNASPLKRER---VE-NVDLVIVR Bacillus3 -GLLGLRKEMGLFANLRPVKAYAT-LLNASPLKRER---VE-NVDLVIVR Bacillus4 -GLLSIRKQLDLFANLRPVKVFES-LSDRSPLKKEY---ID-NVDFVIVR Bacillus5 -GLLSIRKQLDLFANLRPVKVFES-LSDRSPLKKEY---ID-NVDFVIVR Bacillus7 -GLLAIRKQLDLYANLRPVVCYDS-LVSRSPLKPDL---VQ-GVDFVIVR Thermus7 -GLLSLRKSQDLFANLRPAKVFPG-LERLSPLKEEI---AR-GVDVLIVR Thermus8 -GLLSLRKSQDLFANLRPAKVFPG-LERLSPLKEEI---AR-GVDVLIVR Thermus5 -GLLSLRKSQDLFANLRPAKVFPG-LERLSPLKEEI---AR-GVDVLIVR Thermus6 -GLLSLRKSQDLFANLRPAKVFPG-LERLSPLKEEI---AR-GVDVLIVR Thermus4 -GLLSIRKQLDLFANLRPVKVFES-LSDASPLKKEY---ID-NVDFVIVR Thermus9 -GASFLKEKPDLFANLRPAKVFPG-LERLSPLKEEI---AR-GVDVLIVR Thermus3 -GLLALRKSQDLFANLRPAKVFPG-LERLSPLKEEI---AR-GVDVLIVR Bacteroides -GLLAMRKKLGLFANIRPVQTFKC-LVHKSPLRAE----LVEGADFLCIR Lactococcus -GLLALRKELGLYANVRPLKIYPA-LKKLSPIRN------VENVDFLVIR *Pseudomonas GSLLKFRREFDQYVNIRPVRLFP---GVPCALANR----KVGDIDFVVVR *Ecoli GSLLKFRREFDQYVNLRPVRLFP---GVPCPLAGK----QPGDIDFYVVR Sphingomonas GLLLPIRREFEQYVNLRPVRLLP---GIASPLRDK----APGDIDFWVVR *Bacillus6 GLLLKIRRELELSINMRPAKQMA---GITSPLLH------PNDFDFVVIR *Agrobacterium2 GLRLPICQGFDQYANVRPTKVLP---GITPPLRNC----GPGDLDWVIVR *Agrobacterium3 GLRLPICQGFDQYANVRPTKVLP---GITPPLRNC----GPGDLDWVIVR *Agrobacterium5 GLRLPICQGFDQYANVRPTKILP---GITPPLRNC----GPGDLDWVIVR *Agrobacterium6 GLRLPICQGFDQYANVRPTKILP---GITPPLRNC----GPGDLDWVIVR *Agrobacterium4 GLRLPICQGFDQYANVRPTKILP---GITPPLRNC----GPGDLDWVIVR Mycobacterium GLLLRLRFELDHHINLRPARLYP---GVASPLSG-----NPG-IDFVVVR Mycobacterium2 GLLLRLRFELDHHINLRPARLYP---GVASPLSG-----NPG-IDFVVVR Mycobacterium3 GLLLRLRFELDHHINLRPARLYP---GVNSLLAG-----KPD-IDFVVVR Corynebacterium GLLLKMRFALDHHVNLRPSKLYD---GVESPLR------NPGKIDFVVVR Sulfolobus DVVVKLRQIYDMYANIRPAKSIPG-IDTKYG-----------NVDILIVR cAjellomyces SFNVALRQELDIYASIVLIKNIPG-YKTRHD-----------NVDLCIIR cSchizosaccharomyces2 SFNVALRKELDIYASLVLIKNIPG-FKTRHD-----------NVDFAIIR cSaccharomyces3 SLNVALRKQLDIYANVALFKSLKG-VKTRIP-----------DIDLIVIR cKluyveromyces2 SLNVALRKQLDIFANVALFKSIPG-VKTRLN-----------NIDMVIIR cRattusnorvegicus SRNNILRTSLDLYANVIHCKSLPG-VVTRHK-----------DIDILIVR cRattusnorvegicus2 SRNNILRTSLDLYANVIHCKSLPG-VVTRHK-----------DIDILIVR cMusmusculus SRNNILRTSLDLYANVIHCKSLPG-VVTRHK-----------DIDILIVR cHomosapiens6 SRNNILRTSLDLYANVIHCKSLPG-VVTRHK-----------DIDILIVR cMacaca4 SRNNILRTSLDLYANVIHCKSLPG-VVTRHK-----------DIDILIVR cHomosapiens7 SRNNILRTSLDLYANVIHWKSLPG-VVTRHK-----------DIDILIVR cCelegans SRNLELRRQLNLYANVLHCSTIPT-VPSRHT-----------GIDMVIIR cMacaca SYDMRLRRKLDLFANVVHVKSLPG-YMTRHN-----------NLDLVIIR cHomosapiens SYDMRLRRKLDLFANVVHVKSLPG-YMTRHN-----------NLDLVIIR cHomosapiens2 SYDMRLRRKLDLFANVVHVKSLPG-YMTRHN-----------NLDLVIIR cHomosapiens3 SYDMRLRRKLDLFANVVHVKSLPG-YMTRHN-----------NLDLVIIR cBostaurus SYDMRLRRKLDLFANVVHVKSLPG-YKTRHN-----------NLDLVIIR cBostaurus2 SYDMRLRRKLDLFANVVHVKSLPG-YKTRHN-----------NLDLVIIR *Homosapiens5 RTLVRLRRKLDLFANVVHVKSLPG-YMTRHN-----------NLDLVIIR cCelegans2 GLNMRLRRSLDLFANVVHIKTLDG-IKTRHGK----------QLDFVIVR cArabidopsis SLNVNLRKELDLFASLVNCFNLPG-LASRHE-----------NVDIVVIR cArabidopsis2 SLNVNLRKELDLFASLVNCFNLPG-LASRHE-----------NVDIVVIR cArabidopsis3 SLNVQLRKELDLFASLVNCFNLPG-LPTRHE-----------NVDIVVIR cArabidopsis4 SLNVQLRKELDLFASLVNCFNLPG-LPTRHE-----------NVDIVVIR cNicotiana SLNVQLRKELDLYASLVHCFNLQG-LPTRHE-----------NVDIVVIR cArabidopsis5 SLNMQLRKELDIFASLVNCINVPG-LVTRHE-----------NVDIVVIR cNicotiana3 SLNVLMRKELDLSASIVHCFTFPG-LPTRHE-----------DVDIVVIR cSaccharomyces2 SLNLTLRKTFGLFANVRPAKSIEG-FKTTYE-----------NVDLVLIR cKluyveromyces SLNLTLRKTFGLFANVRPAKSIEG-YKTTYE-----------NVNLVLIR Solanum SLNLTLRKELNLYANVRPCYSLPG-YKTRYD-----------DVNLITIR cNicotiana2 SLNLTLRKELNLYANVRPCYSLPG-YKTRYD-----------DVNLITIR cHomosapiens4 SMNLLLRKTFDLYANVRPCVSIEG-YKTPYT-----------DVNIVTIR cMacaca3 SMNLLLRKTFDLYANVRPCVSIEG-YKTPYT-----------DVNIVTIR cMacaca2 SMNLLLRKTFDLYANVRPCVSIEG-YKTPYT-----------DVNIVTIR cBostaurus3 SMNLLLRKTFDLYANVRPCVSIEG-YKTPYH-----------DVNIVTIR cCelegans3 SLNLAVRKEFSLYANVRPCRSLEG-HKTLYD-----------NVDVVTIR cThermus SANVTLRKLFETYANVRPVREFPN-VPTPYAGR---------GIDLVVVR cThermus2 SANVTLRKLFETYANVRPVREFPN-VPTPYAGR---------GIDLVVVR Pyrococcus SLIITLRKELDLYANLRIIPNF----KLRK--------------EIIIVR cCaldococcus SLNVTLRMVLDLYSNVRPVKWYGQPTPHCHP----------ENIDWVIFR . . : .* cMethanococcus ENTEDLYVGRE---------------R-----LEND-TAIAERVITRKGS cMethanococcus2 ENTEDLYVGRE---------------R-----LEND-TAIAERVITRKGS cMethanobacterium ENTEDLYVGDE---------------E-----YTPE-GAVAKRIITRTAS Methanobacterium2 ENTEDLYVGDE---------------E-----YTPE-GAVAKRIITRTAS cMethanococcus3 ENTEGLYKGIE---------------A-----EIDEGITIATRVITEKAC *Methanococcus4 ENTEGLYKGIE---------------A-----EIDEGITIATRVITEKAC Archaeoglobus ENTECLYMGFE---------------F-----GFGD-VTEAIRVITREAS *Schizosaccharomyces ENTECLYVKEE---------------R-MVQNTPGKRVAEAIRRISEEAS *Saccharomyces ENTEDLYIKIE---------------KTYIDKATGTRVADATKRISEIAT Deinococcus ENTQGLYVEQE---------------R-----RYGD-TAIADTVITREAS Ecoli2 ELTGGIYFGQP---------------KGREGSG-QYEKAFDTEVYHRFEI Ecoli3 ELTGGIYFGQP---------------KGREGSG-QYEKAFDTEVYHRFEI Salmonella ELTGGIYFGQP---------------KGREGSG-QYEKAFDTEVYHRFEI *Salmonella2 ELTGGIYFGQP---------------KGREGSG-QYEKAFDTEVYHRFEI Haemophilus ELTGGIYFGQP---------------KGREGDG-VQTKAFDTEVYYKYEI Buchnera2 ELTGGIYFGKP---------------KGRFKNK-NGEYAFDTEIYYDFEI Buchnera3 ELTGGIYFGKP---------------KGRSKNE-NGEYSFDTEIYYDFEI Buchnera ELTGGIYFGK----------------SNKITNI-DDPYAFDTEIYFRSEI Leptospira ELTGGIYFGQP---------------KGREGSG-QEEFAYDTMKYSRREI Thermotoga ELSYGVYYGQP---------------RGLD-----EEKGFDTMIYDRKTV Clostridium ELIGGIYFGDR---------------GTKEVNG--VETAFDTEKYNVDEV Aquifex ELTSGIYYGEP---------------RGIFEEN-GKRYAINTMKYTEDEI Neisseria ELTGDIYFGEP---------------RGIRVLENGEREGYNTMKYSESEI Thiobacillus ELTGDIYFGQP---------------RGLEVID-GKRRGFNTMVYDEDEI Pseudomonas2 ELTGGIYFGQP---------------REQRVLENGERQAYDTLPYSESEI *Pseudomonas3 ELTGGIYFGQP---------------REQRVLENGERQAYDTLPYSESEI Agrobacterium ELTGGVYFGEP---------------KQIIDLGNGQKRGIDTQIYDTFEI Brassica ELTGGIYFGVP---------------RGIKTNENGEEVGYNTEVYAAHEI Arabidopsis7 ELTGGIYFGEP---------------RGIKTNENGEEVGFNTEVYAAHEI Arabidopsis6 ELTGGIYFGEP---------------RGITINENGEEVGFNTEIYAAHEI Spirulina ELTGGIYFGQP---------------KGIFETETGKNEGSNTMAYGESEI Spirulina2 ELTGGIYFGQP---------------KGIFETETGKNEGSNTMAYGESEI Synechocystis ELTGGIYFGKP---------------KGIFETETGEKRGVNTMAYTVGEI Bacillus ELTGGLYFGRP---------------S--ERRGPGENEVVDTLAYTREEI Bacillus2 ELTGGLYFGRP---------------S--ERRGPGENEVVDTLAYTREEI Bacillus3 ELTGGLYFGRP---------------S--ERRGPGENEVVDTLAYTREEI Bacillus4 ELTGGLYFGQP---------------SKRYVNTEGEQEAVDTLFYKRTEI Bacillus5 ELTGGLYFGQP---------------SKRYVNTEGEQEAVDTLFYKRTEI Bacillus7 ELTGGIYFGQP---------------S--AVVENGEEKAVDTLLYKKEEI Thermus7 ELTGGIYFGEP---------------RG---MS--EAEAWNTERYSKPEV Thermus8 ELTGGIYFGEP---------------RG---MS--EAEAWNTERYSKPEV Thermus5 ELTGGIYFGEP---------------RG---MS--EAEAWNTERYSKPEV Thermus6 ELTGGIYFGEP---------------RG---MS--EAEAWNTERYSKPEV Thermus4 ELTGGIYFGEP---------------RG---MS--EAEAWNTERYSKPEV Thermus9 ELTGGIYFGEP---------------RG---MS--EAEAWNTERYSKPEV Thermus3 ELTGGIYFGEP---------------RG---MS--EAEAWNTERYSKPEV Bacteroides ELTGGMYFGEK---------------YQ------DNDKAYDTNMYTRPEI Lactococcus ELTGGIYFGQH---------------EL------ADDKARDVNDYSADEI *Pseudomonas ENTEGEYSSL----------------GGIMFENTENEIVIQESIFTRRGV *Ecoli ENTEGEYSSL----------------GGRVNEGTEHEVVIQESVFTRRGV Sphingomonas ENSEGEYSQI----------------GGRTGTG-ENEIVVQQAIFSRRGT *Bacillus6 ENSEGEYSEV----------------GGRIHRG-DDEIAIQNAVFTRKAT *Agrobacterium2 ENSEGEYSGH----------------GGRAHKGLPEEVGTEVAIFTRVGV *Agrobacterium3 ENSEGEYSGH----------------GGRAHKGLPEEVGTEVAIFTRVGV *Agrobacterium5 ENSEGEYSGH----------------GGRAHRGLPEEVGTEVAIFTRVGV *Agrobacterium6 ENSEGEYSGH----------------GGRAHRGLPEEVGTEVAIFTRVGV *Agrobacterium4 ENSEGEYSGH----------------GGRAHRGLPEEVGTEVAIFTRVGV Mycobacterium EGTEGPYTGN----------------GGAIRVGTPNEVATEVSVNTAFGV Mycobacterium2 EGTEGPYTGN----------------GGAIRVGTPNEVATEVSVNTAFGV Mycobacterium3 EGTEGPYTGT----------------GGAIRVGTPNEVATEVSVNTAFGV Corynebacterium EGTEGAYTGN----------------GGAIRVGTPHEIANETSVNTRYGA Sulfolobus ENTEDLYKGFE---------------HIVS-----DGVAVGMKIITRFAS cAjellomyces ENTEGEYSGLE---------------HQSVSG-----VVESLKIITRAKS cSchizosaccharomyces2 ENTEGEYSGLE---------------HQSVPG-----VVESLKIITEYKS cSaccharomyces3 ENTEGEFSGLE---------------HESVPG-----VVESLKVMTRPKT cKluyveromyces2 ENTEGEYSGLE---------------HESVPG-----VVESLKIMTRAKS cRattusnorvegicus ENTEGEYSSLE---------------HESVAG-----VVESLKIITKAKS cRattusnorvegicus2 ENTEGEYSSLE---------------HESVAG-----VVESLKIITKAKS cMusmusculus ENTEGEYSSLE---------------HESVAG-----VVESLKIITKAKS cHomosapiens6 ENTEGEYSSLE---------------HESVAG-----VVESLKIITKAKS cMacaca4 ENTEGEYSSLE---------------HESVAG-----VVESLKIITKAKS cHomosapiens7 ENTEGEYSSLE---------------HESVAG-----VVESLKIITKAKS cCelegans ENTEGEYSGNE---------------HEAVNAP-HPRVVESLKVVTREKS cMacaca EQTEGEYSSLE---------------HESARG-----VIECLKIVTRAKS cHomosapiens EQTEGEYSSLE---------------HESARG-----VIECLKIVTRAKS cHomosapiens2 EQTEGEYSSLE---------------HESARG-----VIECLKIVTRAKS cHomosapiens3 EQTEGEYSSLE---------------HESARG-----VIECLKIVTRAKS cBostaurus EQTEGEYSSLE---------------HESARG-----VIECLKIVTRTKS cBostaurus2 EQTEGEYSSLE---------------HESARG-----VIECLKIVTRTKS *Homosapiens5 EQTEGEYSSLE---------------HESARG-----VIECLKIVTRAKS cCelegans2 EQTEGEYSSLE---------------HELVPG-----VIECLKISTRTKA cArabidopsis ENTEGEYAGLE---------------HEVVPG-----VVESLKVITKFCS cArabidopsis2 ENTEGEYAGLE---------------HEVVPG-----VVESLKVITKFCS cArabidopsis3 ENTEGEYAGLE---------------HEVVPG-----VVESLKVITKFCS cArabidopsis4 ENTEGEYAGLE---------------HEVVPG-----VVESLKVITKFCS cNicotiana ENTEGEYSGLE---------------HEVVPG-----VVESLKVMTKFCS cArabidopsis5 ENTEGEYSGLE---------------HEVVPG-----VVESLKVITKFCS cNicotiana3 ENTEGEYAGLE---------------HEVVPG-----VVESLKVITKYCS cSaccharomyces2 ENTEGEYSGIE---------------HIVCPG-----VVQSIKLITRDAS cKluyveromyces ENTEGEYSGIE---------------HVVAPG-----VVQSIKLITQDAS Solanum ENTEGEYSGLE---------------HQVVRG-----VVESLKIITRQAS cNicotiana2 ENTEGEYSGVE---------------HQVVRG-----VVESLKIITRQAS cHomosapiens4 ENTEGEYSGIE---------------HVIVDG-----VVQSIKLITEGAS cMacaca3 ENTEGEYSGIE---------------HVIVDG-----VVQSIKLITEGGS cMacaca2 ENTEGEYSGIE---------------HVIVDG-----VVQSIKLITEGGS cBostaurus3 ENTEGEYSGIE---------------HVIVDG-----VVQSIKLITEAAS cCelegans3 ENTEGEYSGIE---------------HEIVPG-----VVQSIKLITETAS cThermus ENVEDLYAGIE---------------HMQTPS-----VAQTLKLISWKGS cThermus2 ENVEDLYAGIE---------------HMQTPS-----VAQTLKLISWKGS Pyrococcus ENSEGLYSGEG---------------AYDSN------KVVDFRIITRKGA cCaldococcus ENTEDVYAGIEWPFDSPEAQKIRDFLKKEFGIELTPDTGIGIKPISKWRT * : cMethanococcus ERIIRFAFEYAI-----KNNRK-------KVSCIHKANVLRITDGLFLEV cMethanococcus2 ERIIRFAFEYAI-----KNNRK-------KVSCIHKANVLRITDGLFLEV cMethanobacterium RRISQFAFQYAQ-----KEGMQ-------KVTAVHKANVLKKTDGIFRDE Methanobacterium2 RRISQFAFQYAQ-----KEGMQ-------KVTAVHKANVLKKTDGIFRDE cMethanococcus3 ERIFRFAFNLARER--KKMGKEG------KVTCAHKANVLKLTDGLFKKI *Methanococcus4 ERIFRFAFNLARER--KKMGKEG------KVTCAHKANVLKLTDGLFKKI Archaeoglobus ERIARYAFELAK-----REGRK-------KVTALHKANVMKKTCGLFRDV *Schizosaccharomyces TKIGKMAFEIAKSRQKIRESGTYSIHKKPLVTIIHKSNVMSVTDGLFRES *Saccharomyces RRIATIALDIALKRLQTRGQAT--------LTVTHKSNVLSQSDGLFREI Deinococcus DRIGKFAADLAMK----RSKRX---------TVVHKSNVLPVTQGLFMNT Ecoli2 ERIARIAFESARKR-------------RHKVTSIDKANVLQSSI-LWREI Ecoli3 ERIARIAFESARKR-------------RHKVTSIDKANVLQSSI-LWREI Salmonella ERIARIAFESARKR-------------RRKVTSIDKANVLQSSI-LWREI *Salmonella2 ERIARIAFESARKR-------------RCKVTSIDKANVLQSSI-LWREI Haemophilus ERIARAAFEAAMKR-------------NKKVTSVDKANVLQSSI-LWRET Buchnera2 ERIANLAFELASSR-------------RCKVCSIDKANVLESSV-LWREI Buchnera3 KRIAHLAFELASSR-------------RCKVCSIDKSNVLASSI-LWREI Buchnera KRIAKIAFQIAQSR-------------KKKIVSIDKANVLKSSI-LWRDT Leptospira ERIAKVAFQAARKR-------------NNKVTSIDKANVLTTSV-FWKEV Thermotoga ERIARTAFEIAKNR-------------RKKVTSVDKANVLYSSM-LWRKV Clostridium KRIAHSAFKAAMKR-------------RKKVTSVDKANVLDASR-LWRKT Aquifex RRIVRKGFEIARKR-------------RKKLTSVDKANVLEVSA-LWRQI Neisseria RRIAHVAFQSAQKR-------------SKKVCSVGKANVLETTE-LWREI Thiobacillus RRIAHVAFRAAQGR-------------RKQLCSVDKANVLETTR-LWREV Pseudomonas2 RRIARVGFDMARVR-------------NNRLCSVDKANVLASSQ-LWREV *Pseudomonas3 RRIARVGFDMARVR-------------NNRLCSVDKANVLASSQ-LWREV Agrobacterium ERIASVAFELARSR-------------DNRVCSMEKRNVMKSGV-LWNQV Brassica DRIARVAFETARKR-------------RGKLCSVDKANVLDASI-LWRRR Arabidopsis7 DRIARVAFETARKR-------------RGKLCSVDKANVLEASI-LWRKR Arabidopsis6 DRIARVAFETARKR-------------RGKLCSVDKANVLDASI-LWRKR Spirulina DRIGRVGFETAKKR-------------QGRLCSVDKANVLDVSQ-LWRDR Spirulina2 DRIGRVGFETAKKR-------------QGRLCSVDKANVLDVSQ-LWRDR Synechocystis DRIAKVAFETARKR-------------RGQLCSVDKANVLDVSQ-LWRDR Bacillus ERIIEKAFQLAQIR-------------RKKLASVDKANVLESSR-MWREI Bacillus2 ERIIEKAFQLAQIR-------------RKKLASVDKANVLESSR-MWREI Bacillus3 ERIIEKAFQLAQIR-------------RKKLASVDKANVLESSR-MWREI Bacillus4 ERVIREGFKMAATR-------------KGKVTSVDKANVLESSR-LWREV Bacillus5 ERVIREGFKMAAAR-------------KGKVTSVDKANVLESSR-LWREV Bacillus7 ERIVRMAFELARGR-------------RKKVTSVDKANVLSSSR-LWREV Thermus7 ERVARVAFEAARKR-------------RKHVVSVDKANVLEVGE-FWRKT Thermus8 ERVARVAFEAARKR-------------RKHVVSVDKANVLEVGE-FWRKT Thermus5 ERVARVAFELARKR-------------RKHVVSVDKANVLEVGE-FWRKT Thermus6 ERVARVAFEAARKR-------------RKHVVSVDKANVLEVGE-FWRKT Thermus4 ERVARVAFEAARKR-------------RKHVVSVDKANVLEVGE-FWRKT Thermus9 ERVARVAFEAARKR-------------RKHVVSVDKANVLEVGE-FRRKT Thermus3 ERVAKVAFEAARKR-------------RRHLTSVDKANVLEVGE-FWRKT Bacteroides ERILKVGFEYAMKR-------------RKHLTVVDKANVLASSR-LWRQI Lactococcus RRILHFAFKSAQSRP------------RKLLTSVDKQNVLATSK-LWRKM *Pseudomonas DRILKYAFDLAEKRE------------RKHVTSATKSNGMAISMPYWDKR *Ecoli DRILRYAFELAQSRP------------RKTLTSATKSNGLAISMPYWDER Sphingomonas DRILRYAFDFARRSG------------RRHVTSATKSNGLYHSMPFWDER *Bacillus6 ERVMRFAFELAKKR-------------RTLVTSATKSNGIYHAMPFWDEV *Agrobacterium2 TRIMRYAFKLAQARP------------RKLLTVVTKSNAQRHGMVMWDEI *Agrobacterium3 TRIMRYAFKLAQARP------------RKLLTVVTKSNAQRHGMVMWDEI *Agrobacterium5 TRIMRYAFKLAQARP------------RKLLTVVTKSNAQRHGMVMWDEI *Agrobacterium6 TRIMRYAFKLAQARP------------RKLLTVVTKSNAQRHGMVMWDEI *Agrobacterium4 TRIMRYAFKLAQARP------------RKLLTVVTKSNAQRHGMVMWDEI Mycobacterium RRVVADAFERARRR-------------RKHLTLVHKTNVLTLAGGLWLRT Mycobacterium2 RRVVADAFERARRR-------------RKHLTLVHKTNVLTFAGGLWLRT Mycobacterium3 RRVVQDAFERARQR-------------RKHLTLVHKNNVLTYAGTLWCRI Corynebacterium ERVIRYAFELAQSR-------------RKKLTLVHKTNVLVHGGGLWQRT Sulfolobus ERIAKVGLNFALRR-------------RKKVTCVHKANVMRITDGLFAEA cAjellomyces ERIAKFAFSFALANN------------RKKVTCIHKANIMKLADGLFRST cSchizosaccharomyces2 KRIAQFAFDFALQNG------------RKSVTCIHKANIMKLADGLFRRT cSaccharomyces3 ERIARFAFDFAKKYN------------RKSVTAVHKANIMKLGDGLFRNI cKluyveromyces2 ERIARFAFDFALKNN------------RKSVCAVHKANIMKLGDGLFRNT cRattusnorvegicus LRIAEYAFKLAQESG------------RKKVTAVHKANIMKLGDGLFLQC cRattusnorvegicus2 LRIAEYAFKLAQESG------------RKKVTAVHKANIMKLGDGLFLQC cMusmusculus LRIAEYAFKLAQESG------------RKKVTAVHKANIMKLGDGLFLQC cHomosapiens6 LRIAEYAFKLAQESG------------RKKVTAVHKANIMKLGDGLFLQC cMacaca4 LRIAEYAFKLAQESG------------RKKVTAVHKANIMKLGDGLFLQC cHomosapiens7 LRIAEYAFKLAQESG------------RKKVTAVHKANIMKLGDGLFLQC cCelegans EQITRFAFQFAKKYG------------RKKVTAVHKANIQKLGDGLFLKV cMacaca QRIAKFAFDYATKKG------------RSKVTAVHKANIMKLGDGLFLQC cHomosapiens QRIAKFAFDYATKKG------------RGKVTAVHKANIMKLGDGLFLQC cHomosapiens2 QRIAKFAFDYATKKG------------RGKVTAVHKANIMKLGDGLFLQC cHomosapiens3 QRIAKFAFDYATKKG------------RGKVTAVHKANIMKLGDGLFLQC cBostaurus QRIAKFAFDYATKKG------------RGKVTAVHKANIMKLGDGLFLQC cBostaurus2 QRIAKFAFDYATKKG------------RGKVTAVHKANIMKLGDGLFLQC *Homosapiens5 QRIAKFAFDYATKKG------------RGKVTAVHKANIMKLGDGLFLQC cCelegans2 ERIAKFAFDYATKTG------------RKKVTAVHKANIMKLGDGLFLRT cArabidopsis ERIAKYAFEYAYLNN------------RKKVTAVHKANIMKLADGLFLES cArabidopsis2 ERIAKYAFEYAYLNN------------RKKVTAVHKANIMKLADGLFLES cArabidopsis3 ERIAKYAFEYAYLNN------------RKKVTAVHKANIMKLADGLFLES cArabidopsis4 ERIAKYAFEYAYLNN------------RKKVTAVHKANIMKLADGLFLES cNicotiana ERIAKYAFEYAYLNN------------RKVLTAVHKANIMKLADGLFLES cArabidopsis5 ERIARYAFEYAYLNN------------RKKVTAVHKANIMKLADGLFLES cNicotiana3 ERIAKFAFEYADVNK------------RKKVTAVHKANIMKLADGLFLKS cSaccharomyces2 ERVIRYAFEYARAIG------------RPRVIVVHKSTIQRLADGLFVNV cKluyveromyces ERVIRYAFEYARAVD------------RSKVLVVHKSTIQRLADGLFVDV Solanum LRVAEYAFHYAKTHG------------RERVSAIHKANIMQKTDGLFLKC cNicotiana2 LRVAEYAFHYAKAHG------------RERVSAIHKANIMQKTDGLFLKC cHomosapiens4 KRIAEFAFEYARNNH------------RSNVTAVHKANIMRMSDGLFLQK cMacaca3 KRIAEFAFEYARNNH------------RSNVTAVHKANIMRMSDGLFLQK cMacaca2 KRIAEFAFEYARNNH------------RSNVTAVHKANIMRMSDGLFLQK cBostaurus3 KRIAEFAFEYARNNH------------RSNVTAVHKANIMRMSDGLFLQK cCelegans3 RNVASFAFEYARQNG------------RKVVTAVHKANIMRQSDGLFLSI cThermus EKIVRFAFELARAEG------------RKKVHCATKSNIMKLAEGP-KRA cThermus2 EKIVRFAFELARAEG------------RKKVHCATKSNIMKLAEGP-KRA Pyrococcus ERIAKFAVKLAKDR-------------STFLTFVHKANILESDR-FFRKI cCaldococcus QRHVRRAMEWAIRNG------------YKHVTIMHKGNIMKYTEGAFRQW . . * * . cMethanococcus FNEI---------------KKHY-------NIEADDYLVDSTAMNLIKHP cMethanococcus2 FNEI---------------KKHY-------NIEADDYLVDSTAMNLIKHP cMethanobacterium FYKV---------------ASEYP------QMEANDYYVDATAMYLITQP Methanobacterium2 FYKV---------------ASEYP------QMEATDYYVDATAMYLITQP cMethanococcus3 FYKV---------------AEEYD------DIKAEDYYIDAMNMYIITKP *Methanococcus4 FYKV---------------AEEYD------DIKAEDYYIDAMNMYIITKP Archaeoglobus CREV---------------AKDYP------EIQYNDYYIDAACMYLVMDP *Schizosaccharomyces CRHA-Q-----------SLDPSYA------SINVDEQIVDSMVYRLFREP *Saccharomyces CKEVYE-----------SNKDKYG------QIKYNEQIVDSMVYRLFREP Deinococcus ILDH---------------TKTVE------GLSTSTMIVDNAAMQLVRNP Ecoli2 VNEIA--------------T-EYP------DVELAHMYIDNATMQLIKDP Ecoli3 VNEIA--------------T-EYP------DVELAHMYIDNATMQLIKDP Salmonella VNDVA--------------K-TYP------DVELAHMYIDNATMQLIKDP *Salmonella2 VNDVA--------------K-TYP------DVELAHMYIDNATMQLIKDP Haemophilus VTEMA--------------K-DYP------EVTLEHIYIDNATMQLIKSP Buchnera2 VKKVS--------------K-NYP------DVHLSHLYIDNACMQIIKNP Buchnera3 VEEVS--------------K-NYP------NIILSHLYIDNACMQIIKNP Buchnera VNKMA--------------Y-KFP------NVKLEHMYIDNATMELIKNP Leptospira VIELH--------------KKEFS------DVQLNHLYVDNAAMQLIVNP Thermotoga VNEVA--------------R-EYP------DVELTHIYVDNAAMQLILKP Clostridium VNEVS--------------K-EYP------EVELSHLYVDNTAMQLVRKP Aquifex VEEEK--------------E-NYP------DVELEHLYIDNCAMQLVRRP Neisseria FEEI---------------GKEYP------DVELSHMYVDNAAMQLVRAP Thiobacillus VTEV---------------ARDYP------DVRLSHMYVDNAAMQLIRAP Pseudomonas2 VEEV---------------AKDYP------DVELSHMYVDNAAMQLVRAP *Pseudomonas3 VEEV---------------AKDYP------DVELSHMYVDNAAMQLVRAP Agrobacterium VTETH--------------AAKYK------DVQLEHMLADAGGMQLVRKP Brassica VTAL---------------AAEYP------DVELSHMYVDNAAMQLVRDP Arabidopsis7 VTAL---------------ASEYP------DVELSHMYVDNAAMQLVRDP Arabidopsis6 VTAL---------------ASEYP------DVELSHMYVDNAAMQLVRDP Spirulina IMAL---------------AADYP------EVELSHLYVDNAAMQLVRWP Spirulina2 IMAL---------------AADYP------EVELSHLYVDNAAMQLVRWP Synechocystis VMAI---------------AVDYP------DVELSHLYVDNAAMQLVRSP Bacillus AEETA--------------K-KYP------DVELSHMLVDSTSMQLIANP Bacillus2 AEETA--------------K-KYP------DVELSHMLVDSTSMQLIANP Bacillus3 AEETA--------------K-KYP------DVELSHMLVDSTSMQLIANP Bacillus4 AEDVA--------------Q-EFP------DVKLEHMLVDNAAMQLIYAP Bacillus5 AEDVA--------------Q-EFP------DVKLEHMLVDNAAMQLIYAP Bacillus7 AEEVA--------------N-EFP------DVTLEHMLVD-MRMQLIRAP Thermus7 VEEVG--------------R-GYP------DVALEHQYVDAMAMHLVRSP Thermus8 VEEVG--------------R-GYP------DVALEHQYVDAMAMHLVRSP Thermus5 VEEVG--------------R-GYP------DVALEHQYVDAMAMHLVRSP Thermus6 VEEVG--------------R-GYP------DVALEHQYVDAMAMHLVRSP Thermus4 VEEVG--------------R-GYP------DVALEHQYVDAMAMHLVRSP Thermus9 VEEVG--------------R-GYP------DVALEHQYVDAMAMHLVRSP Thermus3 VEEVH--------------K-GYP------DVALDHQYVDAMAMHLVKNP Bacteroides AQEMA--------------P-QYP------EVTTDYMFVDNAAMKMIQEP Lactococcus ADEIA--------------D-EYP------DVRLEHQLVDSCAMLLITNP *Pseudomonas TEAMA--------------A-HYP------HVSWDKQHIDILCARFVLQP *Ecoli VEAMA--------------E-NYP------EIRWDKQHIDILCARFVMQP Sphingomonas FAAIG--------------A-EYP------DVAADQYHVDILAARFVMSP *Bacillus6 FQQTA--------------A-DYS------GIETSSQHIDALAAFFVTRP *Agrobacterium2 AAEVS--------------K-EFP------DVTWDKMLVDAMTVRMTLKP *Agrobacterium3 AAEVS--------------K-EFP------DVTWDKMLVDAMTVRMTLKP *Agrobacterium5 AAEVA--------------T-EFP------DVTWDKMLVDAMTVRMTLKP *Agrobacterium6 AAEVA--------------T-EFP------DVTWDKMLVDAMTVRMTLKP *Agrobacterium4 AAEVA--------------T-EFP------DVTWDKMLVDAMTVRMTLKP Mycobacterium VDEVG--------------E-CYP------DVEVAYQHVDAATIHMITDP Mycobacterium2 VDEVG--------------E-CYP------DVEVAYQHVDAATIHMITDP Mycobacterium3 VQEVG--------------E-KYP------DVEVVYQHIDAATIYLVTEP Corynebacterium VDEVA--------------K-EYP------EVAVDYNHIDAATIYLVTDP Sulfolobus CRSVL-----------------KG------KVEYSEMYVDAAAANLVRNP cAjellomyces FHKVAE--------------S-YP------TLETNDMIVDNASMQAVARP cSchizosaccharomyces2 FYDVAN--------------G-YD------AITPKDLIVDNASMQAVSRP cSaccharomyces3 ITEIGQ--------------KEYP------DIDVSSIIVDNASMQAVAKP cKluyveromyces2 VNEIGA--------------NEYP------ELDVKNIIVDNASMQAVAKP cRattusnorvegicus CREVA---------------ARYP------QITFDSMIVDNTTMQLVSRP cRattusnorvegicus2 CREVA---------------ARYP------QITFDSMIVDNTTMQLVSRP cMusmusculus CREVA---------------AHYP------QITFDSMIVDNTTMQLVSRP cHomosapiens6 CREVA---------------ARYP------QITFENMIVDNTTMQLVSRP cMacaca4 CREVA---------------ARYP------QITFENMIVDNTTMQLVSRP cHomosapiens7 CREVA---------------ARYP------QITFENMIVDNTTMQLVSRP cCelegans ATDIAK--------------AEYP------DIEFNAMIVDNASMQLVSRP cMacaca CEEVA---------------ELYP------KIKFETMIIDNCCMQLVQNP cHomosapiens CEEVA---------------ELYP------KIKFETMIIDNCCMQLVQNP cHomosapiens2 CEEVA---------------ELYP------KIKFETMIIDNCCMQLVQNP cHomosapiens3 CEEVA---------------ELYP------KIKFETMIIDNCCMQLVQNP cBostaurus CEEVA---------------ELYP------KIKFEKMIIDNCCMQLVQNP cBostaurus2 CEEVA---------------ELYP------KIKFEKMIIDNCCMQLVQNP *Homosapiens5 CEEVA---------------ELYP------KIKFETMIIDNCCMQLVQNP cCelegans2 CEGVA---------------KQYP------KIQFESMIIDNTCMQLVSKP cArabidopsis CQEVA---------------KKYP------SIAYNEIIVDNCCMQLVARP cArabidopsis2 CQEVA---------------KKYP------SIAYNEIIVDNCCMQLVARP cArabidopsis3 CREVA---------------KKYP------SITYNEIIVDNCCMQLVAKP cArabidopsis4 CREVA---------------KKYP------SITYNEIIVDNCCMQLVAKP cNicotiana CPEVA---------------TKYP------GIKYNEIIVDNCCMQLVSRP cArabidopsis5 CREVA---------------KHYS------GITYNEIIVDNCCMQLVAKP cNicotiana3 CREVA---------------SKYP------EIQYEEIIVDNCCMQLVSRP cSaccharomyces2 AKELS---------------KEYP------DLTLETELIDNSVLKVVTNP cKluyveromyces AKKLS---------------SEYP------DIELQTELLDNTVLKTVQHP Solanum CREVA---------------EKYP------EIKYEEVVIDNCCMMLVKNP cNicotiana2 CREVA---------------EKYP------EIKYEEVVIDNCCMMLVKNP cHomosapiens4 CREVA---------------ESCK------DIKFNEMYLDTVCLNMVQDP cMacaca3 CREVA---------------ENCK------DIKFNEMYLDTVCLNMVQDP cMacaca2 CREVA---------------ENCK------DIKFNEMYLDTVCLNMVQDP cBostaurus3 CREVA---------------ENCK------DIKFNEMYLDTVCLNMVQDP cCelegans3 CREQA---------------ALYP------DIKFKEAYLDTVCLNMVQDP cThermus FEQVA---------------QEYP------DIEAVHIIVDNAAHQLVKRP cThermus2 FEQVA---------------QEYP------DIEAVHIIVDNAAHQLVKRP Pyrococcus VLDIA----------------RKE------DVKVREEIVDSFTIKLVKDP cCaldococcus AYDLILSEFRDYVVTEEEVNTKYGGKAPEGKIIVNDRIADNMLQQIITRP : * * cMethanococcus EKFD--VIVTTNMFGDILSDEASALIGG-LGLAPSANIGDDK-------A cMethanococcus2 EKFD--VIVTTNMFGDILSDEASALIGG-LGLAPSANIGDDK-------A cMethanobacterium QEFQ--TIVTTNLFGDILSDEAAGLIGG-LGLAPSANIGEKN-------A Methanobacterium2 QEFQ--TIVTTNLFGDILSDEAAGLIGG-LGLAPSANIGEKN-------A cMethanococcus3 QVFD--VVVTSNLFGDILSDGAAGTVGG-LGLAPSANIGDEH-------G *Methanococcus4 QVFD--VVVTSNLFGDILSDGAAGTVGG-LGLAPSANIGDEH-------G Archaeoglobus FRFD--VIVTTNMFGDIVSDLAAGLVGG-LGLAPSANVGERT-------A *Schizosaccharomyces ECFD--VVVAPNLYGDILSDGAASLIGS-LGLVPSANVGDNF-------V *Saccharomyces QCFD--VIVAPNLYGDILSDGAAALVGS-LGVVPSANVGPEI-------V Deinococcus QQFD--VMVMTNMFGDILSDLAAGLV------------------------ Ecoli2 SQFD--VLLCSNLFGDILSDECAMITGS-MGMLPSASLNEQG------FG Ecoli3 SQFD--VLLCSNLFGDILSDECAMITGS-MGMLPSASLNEQG------FG Salmonella SQFD--VLLCSNLFGDILSDECAMITGS-MGMLPSASLNEQG------FG *Salmonella2 SQFD--VLLCSNLFGDILSDECAMITGS-MGMLPSASLNEQG------FG Haemophilus ESFD--VLLCSNIFGDIISDEAAMITGS-MGMLPSASLNEEG------FG Buchnera2 TQFD--ILLCSNIFGDIISDECAMITGS-IGMLPSASLNNQK------FG Buchnera3 SQFD--VLLCSNIFGDIISDECAMITGS-IGMLPSASLNSKK------FG Buchnera SSFD--VILCSNLFGDIISDECAAIIGS-IGLLPSASLNKSG------FG Leptospira KQFD--VVLCENMFGDILSDEASIITGS-IGMLPSASLSESG------FG Thermotoga SQFD--VILTTNMFGDILSDESAALPGS-LGLLPSASFGDK--------N Clostridium SQFD--VILTNNIFGDILSDEASMITGS-IGMLASSSIREDS------FG Aquifex TSFD--VIVTGNIFGDILSDEAGVVVGS-LGMLPSASIGDR-------YA Neisseria KQFD--VIATGNIFGDILSDEASMLTGS-LGMLPSASLDENG------KG Thiobacillus AQFD--VLLTGNMFGDILSDEASQLTGS-IGMLPSASLGE-G------RA Pseudomonas2 KQFD--VMVTDNMFGDILSDEASMLTGS-IGMLPSASLDANN------KG *Pseudomonas3 KQFD--VMVTDNMFGDILSDEASMLTGS-IGMLPSASLDANN------KG Agrobacterium KQFD--VIVTDNLFGDMLSDVAAMLTGS-LGMLPSASLGAPDAKTGKRKA Brassica KQFD--TIVTNNIFGDILSDEASMITGS-IGMLPSASLSDSG------PG Arabidopsis7 KQFD--TIVTNNIFGDILSDEASMITGS-IGMLPSASLSDSG------PG Arabidopsis6 KQFD--TIVTNNIFGDILSDEASMITGS-IGMLPSASLGESG------PG Spirulina KQFD--TIVTGNLFGDILSDAAAMLTGS-IGMLPSASLGASG------PG Spirulina2 KQFD--TIVTGNLFGDILSDAAAMLTGS-IGMLPSASLGASP------GG Synechocystis RQFD--TIVTGNLFGDILSDIAAMLTGS-IGMLPSASLGSDG------PG Bacillus GQFD--VIVTENMFGDILSDEASVITGS-LGMLPSASLRSDR------FG Bacillus2 GQFD--VIVTENMFGDILSDEASVITGS-LGMLPSASLRSDR------FG Bacillus3 GQFD--VIVTENMFGDILSDEASVITGS-LGMLPSASLRSDR------FG Bacillus4 NQFD--VVVTENMFGDILSDEASMLTGS-LGMLPSASLSSSG------LH Bacillus5 NQFD--VVVTENMFGDILSDEASMLTGS-LGMLPSASLSSSG------LH Bacillus7 KQFD--VIVTENMFGDILSDEASMLSGS-LGMLPSASLSASG------PS Thermus7 ARFD--VVVTGNIFGDILSDLASVLPGS-LGLLPSASLGRG-------TP Thermus8 ARFD--VVVTGNIFGDILSDLASVLPGS-LGLLPSASLGRG-------TP Thermus5 ARFD--VVVTGNIFGDILSDLASVLPGS-LGLLPSASLGRG-------TP Thermus6 ARFD--VVVTGNIFGDILSDLASVLPGS-LGLLPSASLGRG-------TP Thermus4 ARFD--VVVTGNIFGDILSDLASVLPGS-LGLLPSASLGRG-------TP Thermus9 ARFD--VVVTGNIFGDILGNLRADLPGS-LGLLPSASLGRG-------TP Thermus3 ARFD--VVVTGNIFGDILSDLASVLPGS-LGLLPSASLGRG-------TP Bacteroides KFFD--VMVTENTFGDILTDEGSVISGS-MGLLPSASTGES-------TP Lactococcus QQFD--VIVTENLFGDILSDEASSLAGS-LGVMPSSSHGFNG------LA *Pseudomonas ERFDV-VVVASNLFGDILSDLGPACAGT-IGIAPSANLNPERNF----PS *Ecoli ERFD--VVVASNLFGDILSDLGPACTGT-IGIAPSANLNPERTF----PS Sphingomonas ERFN--VVVGSNLFGDILSDLGPGITGT-IAVAPSANLNPERRF----PS *Bacillus6 ETFD--VIVASKLFGDILTDISSSLMES-IGIAP-PDINPSGKY----PS *Agrobacterium2 QSLD--TIVATNLHADILSDLAGALAGS-LGVAPTANIDPERRF----PS *Agrobacterium3 QSLD--TIVATNLHADILSDLAGALAGS-LGVAPTANIDPERRF----PS *Agrobacterium5 ETLD--TIVATNLHADILSDLAGALAGS-LGVAPTANIDPERRF----PS *Agrobacterium6 ETLD--TIVATNLHADILSDLAGALAGS-LGVAPTANIDPERRF----PS *Agrobacterium4 ETLD--TIVATNLHADILSDLAGALAGS-LGVAPTANIDPERRF----PS Mycobacterium GRFD--VIVTDNLFGDIITDLAAAVCGG-IGLAASGNIDATRAN----PS Mycobacterium2 GRFD--VIVTDNLFGDIITDLAAAVCGG-IGLAASGNIDATRAN----PS Mycobacterium3 SRFD--VIVTDNLFGDIITDLAAAVCGG-IALAASGNIDATRTN----PS Corynebacterium SRFD--VIVTDNLFGDILTDEAGAVSGG-IGLAASGNIDATGTN----PS Sulfolobus QMFD--VIVTENVYGDILSDEASQIAGS-LGIAPSANIGDKK-------A cAjellomyces QQFD--VMVMPNLYGGILSNVGAALVGG-PGIVPGCNMG-------RDVA cSchizosaccharomyces2 QQFD--VLVMPNLYGSILSNIGSALVGG-PGVIPGANFG-------RDYA cSaccharomyces3 HQFD--VLVTPSMYGTILGNIGAALIGG-PGLVAGANFG-------RDYA cKluyveromyces2 HQFD--VLVTPNLYGSILGNIGSALIGG-PGLVPGANFG-------REYA cRattusnorvegicus QQFD--VMVMPNLYGNIVNNVCAGLVGG-PGLVAGANYG-------HVYA cRattusnorvegicus2 QQFD--VMVMPNLYGNIVNNVCAGLVGG-PGLVAGANYG-------HVYA cMusmusculus QQFD--VMVMPNLYGNIVNNVCAGLVGG-PGLVAGANYG-------HVYA cHomosapiens6 QQFD--VMVMPNLYGNIVNNVCAGLVGG-PGLVAGANYG-------HVYA cMacaca4 QQFD--VMVMPNLYGNIVNNVCAGLVGG-PGLVAGANYG-------HVYA cHomosapiens7 QQFD--VMVMPNLYGNIVNNVCAGLVGG-PGLVAGANYG-------HVYA cCelegans QQFD--VMLMPNLYGNIISNIACGLVGG-PGLVSGMNIG-------EDYA cMacaca YQFD--VLVMPNLYGNIIDNLAAGLVGG-AGVVPGESYS-------AEYA cHomosapiens YQFD--VLVMPNLYGNIIDNLAAGLVGG-AGVVPGESYS-------AEYA cHomosapiens2 YQFD--VLVMPNLYGNIIDNLAAGLVGG-AGVVPGESYS-------AEYA cHomosapiens3 YQFD--VLVMPNLYGNIIDNLAAGLVGG-AGVVPGESYS-------AEYA cBostaurus YQFD--VLVMPNLYGNIIDNLAAGLVGG-AGVVPGESYS-------AEYA cBostaurus2 YQFD--VLVMPNLYGNIIDNLAAGLVGG-AGVVPGESYS-------AEYA *Homosapiens5 YQFD--VLVMPNLYGNIIDNLAAGLVGG-AGVVPGESYS-------AEYA cCelegans2 EQFD--VMVMPNLYGNIIDNLAAGLVGG-AGVVPGQSVG-------RDFV cArabidopsis EQFD--VMVTPNLYGNLVANTAAGIAGG-TGVMPGGNVG-------AEYA cArabidopsis2 EQFD--VMVTPNLYGNLVANTAAGIAGG-SGVMPGGNVG-------AEYA cArabidopsis3 EQFD--VMVTPNLYGNLVANTAAGIAGG-TGVMPGGNVG-------ADHA cArabidopsis4 EQFD--VMVTPNLYGNLVANTAAGIAGG-TGVMPGGNVG-------ADHA cNicotiana EQFD--VMVTPNLYGNLVANTAAGIAGG-TGVMPGGNVG-------ADHA cArabidopsis5 EQFD--VMVTPNLYGNLIANTAAGIAGG-TGVMPGGNVG-------AEHA cNicotiana3 EQFD--VMVTPNLYGNLIANTAAGLAGG-TGVLPGGNVG-------LIKP cSaccharomyces2 SAYTDAVSVCPNLYGDILSDLNSGLSAGSLGLTPSANIG-------HKIS cKluyveromyces EAYDDVVVVCPNLYGDILSDLNSGLSAGSLGLTPSANIG-------HTVS Solanum ALFD--VLVMPNLYGDIISDLCAGLIGG-LGLTPSCNIGE------GGIA cNicotiana2 ALFD--ILVMPNLYGDIISDLCAGVIGG-LGLTPSCNIGE------GGIA cHomosapiens4 SQFD--VLVMPNLYGDILSDLCAGLIGG-LGVTPSGNIGA------NGVA cMacaca3 SQFD--VLVMPNLYGDILSDLCAGLIGG-LGVTPSGNIGA------NGVA cMacaca2 SQFD--VLVMPNLYGDILSDLCAGLIGG-LGVTPSGNIGA------NGVA cBostaurus3 SQFD--VLVMPNLYGDILSDLCAGLIGG-LGVTPSGNIGA------NGVA cCelegans3 SQYD--VLVMPNLYGDILSDLCAGLVGG-LGVTPSGNIG-------KGAA cThermus EQFE--VIVTTNMNGDILSDLTSGLIGG-LGFAPSANIG-------NEVA cThermus2 EQFE--VIVTTNMNGDILSDLTSGLIGG-LGFAPSANIG-------NEVA Pyrococcus WNLG--IILSENMFGDILSDLATIHAGS-IGIVPSGNYGED-------IA cCaldococcus GEYN--VIVTPNLNGDYISDEANPLVGG-IGMAAGLDMGDG-------IA . . : : cMethanococcus LFEP----------------VHGSAPDIAGKGIANPMASILSIAMLFD-- cMethanococcus2 LFEP----------------VHGSAPDIAGKGIANPMASILSIAMLFD-- cMethanobacterium LFEP----------------VHGSAPQIAGKNIANPTAMILTTTLMLK-- Methanobacterium2 LFEP----------------VHGSAPQIAGKNIANPTAMILTTTLMLK-- cMethanococcus3 LFEP----------------VHGSAPDIAGKKIANPTATILSAVLMLR-- *Methanococcus4 LFEP----------------VHGSAPDIAGKKIANPTATILSAVLMLR-- Archaeoglobus IFEP----------------VHGAAFDIAGKGIANPTAMILTACMMLR-- *Schizosaccharomyces MSEP----------------VHGSAPDIAGRGIANPVATFRSVALMLE-- *Saccharomyces IGEP----------------CHGSAPDIAGKGIANPIATIRSTALMLE-- Deinococcus -------------------------------------------------- Ecoli2 LYEP----------------AGGSAPDIAGKNIANPIAQILSLALLLR-- Ecoli3 LYEP----------------AGGSAPDIAGKNIANPIAQILSLALLLR-- Salmonella LYEP----------------AGGSAPDIAGKNIANPIAQILSLALLLR-- *Salmonella2 LYEP----------------AGGSAPDIAGKNIANPIAQILSLALLLR-- Haemophilus LYEP----------------AGGSAPDIAGKGIANPIAQILSAAMMLR-- Buchnera2 LYEP----------------AGGSAPDIEGKNIANPIAQILSLSMLIR-- Buchnera3 LYEP----------------AGGSAPDIEGKNIANPIAQILSLSMLIR-- Buchnera LYEP----------------AGGSAPNIAGKTIANPIAQILSLSMLLK-- Leptospira LYEP----------------SGGSAPDIAGKGVANPIAQVLSAALMLR-- Thermotoga LYEP----------------AGGSAPDIAGKNIANPIAQILSLAMMLE-- Clostridium MYEP----------------IHGSAPDIAGLDIANPLAQILSAAMLME-- Aquifex LYEP----------------VHGSAPDIAGKGIANPIATILSAAMMLK-- Neisseria LYEP----------------SHGSAPDIAGQNKANPLATILSLAMLLR-- Thiobacillus MYEP----------------IHGSAPDIAGQDKANPLATILSVAMMLR-- Pseudomonas2 MYEP----------------CHGSAPDIAGQGIANPLATILSVSMMLR-- *Pseudomonas3 MYEP----------------CHGSAPDIAGQGIANPLATILSVSMMLR-- Agrobacterium MYEP----------------VHGSAPDIAGKSIANPIAMIASFAMCLR-- Brassica LFEP----------------IHGSAPDIAGQDKANPLATILSAAMLLK-- Arabidopsis7 LFEP----------------IHGSAPDIAGQDKANPLATILSAAMLLK-- Arabidopsis6 LFEP----------------IHGSAPDIAGQDKANPLATILSAAMLLK-- Spirulina VFEP----------------VHGSAPDIAGQDKANPLAQVLSAAMMLR-- Spirulina2 VFEP----------------VHGSAPDIAGQDKANPLAQVLSAAMMLR-- Synechocystis LFEP----------------VHGSAPDIAGQDKANPLAQVLSAAMMLR-- Bacillus MYEP----------------VHGSAPDIAGQGKANPLGTVLSAALMLR-- Bacillus2 MYEP----------------VHGSAPDIAGQGKANPLGTVLSAALMLR-- Bacillus3 MYEP----------------VHGSAPDIAGQGKANPLGTVLSAALMLR-- Bacillus4 LFEP----------------VHGSAPDIAGKGMANPFAAILSAAMLLR-- Bacillus5 LFEP----------------VHGSAPDIAGKGMANPFAAILSAAMLLR-- Bacillus7 LYEP----------------VHGSAPDIAGMNKANPIAAILSAAMMLR-- Thermus7 VFEP----------------VHGSAPDIAGKGIANPTAAILSAAMMLE-- Thermus8 VFEP----------------VHGSAPDIAGKGIANPTAAILSAAMMLE-- Thermus5 VFEP----------------VHGSAPDIAGKGIANPTAAILSAAMMLE-- Thermus6 VFEP----------------VHGSAPDIAGKGIANPTAAILSAAMMLE-- Thermus4 VFEP----------------VHGSAPDIAGKGIANPTAAILSAAMMLE-- Thermus9 VFEP----------------VHGSAPDYAGKGR-NPTAAILSAAMMLE-- Thermus3 VFEP----------------VHGSAPDIAGKGIANPTAAILSAAMMLE-- Bacteroides VFEP----------------IHGSWPQAKGLNIANPLAQILSVAMLF--- Lactococcus LYEP----------------IHGSAPDIAGKGIANPVSMILSIAMMLR-- *Pseudomonas LFEP----------------VHGSAPDIFGKNIANPIAMIWSGALMLE-- *Ecoli LFEP----------------VHGSAPDIYGKNIANPIATIWAGAMMLD-- Sphingomonas MFEP----------------VHGSAPDIAGQGIANPIGQIWSGAMMLE-- *Bacillus6 MFEP----------------VHGSAPDIAGQ--ALPIRSARFGQRS---- *Agrobacterium2 MFEP----------------IHGSAFDITGKGIANPVATFWTAAQMLE-- *Agrobacterium3 MFEP----------------IHGSAFDITGKGIANPVATFWTAAQMLE-- *Agrobacterium5 MFEP----------------IHGSAFDITGKGIANPIATFWTAAQMLE-- *Agrobacterium6 MFEP----------------IHGSAFDITGKGIANPIATFWTAAQMLE-- *Agrobacterium4 MFEP----------------IHGSAFDITGKGIANPIATFWTAAQMLE-- Mycobacterium MFEP----------------VHGSAPDIAGQGIADPTAAIMSVALLLS-- Mycobacterium2 MFEP----------------VHGSAPDIAGQGIADPTAAIMSVALLLS-- Mycobacterium3 MFEP----------------VHGSAPDIAGQGIADPTAAIMSLALLLA-- Corynebacterium MFEP----------------VHGSAPDIAGQGIADPTAAILSAAMLLR-- Sulfolobus LFEP----------------VHGAAFDIAGKNIGNPTAFLLSVSMMYERM cAjellomyces VFEPGCR--------------HVGLD-IKGKDQANPTALILSGSMLLR-- cSchizosaccharomyces2 LFEPGCR--------------HVGLS-ITGRGEANPTAAILSACLMLR-- cSaccharomyces3 VFEPGSR--------------HVGLD-IKGQNVANPTAMILSSTLMLN-- cKluyveromyces2 VFEPGSR--------------HVGLD-IKGQNVANPTAMILSSTLMLR-- cRattusnorvegicus VFETATR--------------NTGKS-IANKNIANPTATLLASCMMLD-- cRattusnorvegicus2 VFETATR--------------NTGKS-IANKNIANPTATLLASCMMLD-- cMusmusculus VFETATR--------------NTGKS-IANKNIANPTATLLASCMMLD-- cHomosapiens6 VFETATR--------------NTGKS-IANKNIANPTATLLASCMMLD-- cMacaca4 VFETATR--------------NTGKS-IANKNIANPTATLLASCMMLD-- cHomosapiens7 VFETATR--------------NTGKS-IANKNIANPTATLLASCMMLD-- cCelegans VFETGTR--------------NTGTT-LAGKDLANPTAFIRAAVDMLR-- cMacaca VFETGAR--------------HPFAQ-AVGRNIANPTAMLLSASNMLR-- cHomosapiens VFETGAR--------------HPFAQ-AVGRNIANPTAMLLSASNMLR-- cHomosapiens2 VFETGAR--------------HPFAQ-AVGRNIANPTAMLLSASNMLR-- cHomosapiens3 VFETGAR--------------HPFAQ-AVGRNIANPTAMLLSASNMLR-- cBostaurus VFETGAR--------------HPFAQ-AVGRNIANPTAMLLSASNMLR-- cBostaurus2 VFETGAR--------------HPFAQ-AVGRNIANPTAMLLSASNMLR-- *Homosapiens5 VFETGAR--------------HPFAQ-AVGRNIANPTAMLLSASNMLR-- cCelegans2 IFEPGSR--------------HSFQE-AMGRSIANPTAMILCAANMLN-- cArabidopsis VFEQGASA------------GNVGKDTTEEQKNANPVALLLSSAMMLR-- cArabidopsis2 VFEQGASA------------GNVGKDTTEEQKNANPVALLLSSAMMLR-- cArabidopsis3 VFEQGASA------------GNVGKDKIVLENKANPVALLLSSAMMLR-- cArabidopsis4 VFEQGASA------------GNVGKDKIVLENKANPVALLLSSAMMLR-- cNicotiana VFEQGASA------------GNVGNEKILEQKKANPVALFLSSAMMLR-- cArabidopsis5 IFEQGASA------------GNVGNDKMVEQKKANPVALLLSSAMMLR-- cNicotiana3 VFEQGASP------------GNVGHEKILKLKKANPVALLLSSAMMLR-- cSaccharomyces2 IF----------------EAVHGSAPDIAGQDKANPTALLLSSVMMLN-- cKluyveromyces IF----------------EAVHGSAPDIAGQNKANPTALLLSSVMMLN-- Solanum LA----------------EAVHGSAPDIAGKNLANPTALLLSSVSMLR-- cNicotiana2 LA----------------EAVHGSAPDIAGKNLANPTALLLSAVTMLR-- cHomosapiens4 IF----------------ESVHGTAPDIAGKDMANPTALLLSAVMMLR-- cMacaca3 IF----------------ESVHGTAPDIAGKDMANPTALLLSAVMMLR-- cMacaca2 IF----------------ESVHGTAPDIAGKDMANPTALLLSAVMMLR-- cBostaurus3 IF----------------ESVHGTAPDIAGKDMANPTALLLSAVMMLR-- cCelegans3 VFDEIQFFIQTKLTKFLYRSVHGTAPDIAGQDKANPTALLLSAVMMLR-- cThermus IFEA----------------VHGSAPKYAGKNVINPTAVLLSAVMMLR-- cThermus2 IFEA----------------VHGSAPKYAGKNVINPTAVLLSAVMMLR-- Pyrococcus LFEP----------------IHGSAPDIAGKGIANPIGAILSAAMMLD-- cCaldococcus VAEP----------------VHGSAPKYAGKNVINPTAEILSGMYLLS-- cMethanococcus YIGEKEK-GDLI----REAVKYCLINK-KVTPDLGGD------LKTKDVG cMethanococcus2 YIGEKEK-GDLI----REAVKYCLINK-KVTPDLGGD------LKTKDVG cMethanobacterium HLNKKQE-AQKI----EKALQKTLMRG-IMTPDLGGT------ASTMEMA Methanobacterium2 HLNKKQE-AQKI----EKALQKTLAEG-LVTPDLGGK------LGTMEMA cMethanococcus3 YLGEYEA-ADKV----EKALEEVLALG-LTTPDLGGN------LNTFEMA *Methanococcus4 YLGEYEA-ADKV----EKALEEVLALG-LTTPDLGGN------LNTFEMA Archaeoglobus HFGYVEE-AKKV----EEAVEKTIKEG-KKTPDLGGN------LKTMEFA *Schizosaccharomyces FMGHQDA-AADI----YTAVDKVLTEGKVLTPDLGGK------SGTNEIT *Saccharomyces FLGHNEA-AQDI----YKAVDANLREGSIKTPDLGGK------ASTQQVV Deinococcus -------------------------------------------------- Ecoli2 YSLDADDAACAI----ERAINRALEEG-IRTGDLARG---AAAVSTDEMG Ecoli3 YSLDADDAACAI----ERAINRALEEG-IRTGDLARG---AAAVSTDEMG Salmonella YSLDANDAATAI----EQAINRALEEG-VRTGDLARG---AAAVSTDEMG *Salmonella2 -TADANDAATAI----EQAINRALEEG-VRTGDLARG----AAVSTDEMG Haemophilus YSFNLNEAADAI----ESAVQKVLASG-HRTADLADD---STPVSTAEMG Buchnera2 YSMNLNEIADKI----DLSVHYALKEG-YRTLDISDG---KNYIKTNEMG Buchnera3 HSMNLNEIADKI----DSSVYRALKAG-YRTLDISDG---KNYIKTNEMG Buchnera YSLHLPFLSSCI----DEAVHEALVKK-YMTMDISKNP--QNFLKTNEIG Leptospira YSFSMEEEANKI----ETAVRKTIASG-KRTRDIAEVG--STIVGTKEIG Thermotoga HSFGMVEEARKI----ERAVELVIEEG-YRTRDIAEDP--EKAVSTSQMG Clostridium YSLDMSEAARDV----EAAVEKVLNEG-YRTADIYIEG--TKKVGTSEMG Aquifex YSFNMDKAHDLI----EKAIEETLNQG-YRTPDIYSEG--CIKVGTKEIT Neisseria YSLNDEA------------------------------------------- Thiobacillus HSLNAEPWAQRV----EAAVQRVLDQG-LRTADIAAPG--TPVIGTKAMG Pseudomonas2 YSFSQATAADAI----EQAVSKVLDQG-LRTGDIWSEG--CRKVGTREMG *Pseudomonas3 YSFSQATAADAI----EQAVSKVLDQG-LRTGDIWSEG--CRKVGTREMG Agrobacterium YSFNMVDEATKL----EAAIANVLDKG-IRTADIMADG--CRQVGTSDMG Brassica YGLGEEKAAKRI----EDAVLGALNKG-FRTGDIYSAG--TKLVGCKEMG Arabidopsis7 YGLGEEKAAKRI----EDAVLVALNNG-FRTGDIYSAG--TKLVGCKEMG Arabidopsis6 YGLGEEKAAKMI----EDAVVDALNKG-FRTGDIYSPGNVCKLVGCKEMG Spirulina YGLDEPAASDPV----EKAVLKVLDWG-YPTGDIMSEG--MKAVGCRKWG Spirulina2 YGLDEPAASDPV----EKAVLKVLDWG-YPTGDIMSEG--MKAVGCRKWG Synechocystis YGLDQPQAADRL----EDAVKKVLEQG-YRTGDILSPG--TQLVGCRQMG Bacillus YSFGLEKEAAAI----EKAVDDVLQDG-YCTGDLQVANG--KVVSTIELT Bacillus2 YSFGLEKEAAAI----EKAVDDVLQDG-YCTGDLQVANG--KVVSTIELT Bacillus3 YSFGLEKEAAAI----EKAVDDVLQDG-YCTGDLQVANG--KVVSTIELT Bacillus4 TSFGLEEEAKAV----EDAVNKVLASG-KRTRDLARSE---EFSSTQAIT Bacillus5 TSFGLEEEAKAV----EDAVNKVLASG-KRTRDLARSE---EFSSTQAIT Bacillus7 LSFGLTAEAGG-----RARVWQALALG-SGSR-LGQRR---PHLSTNEMV Thermus7 HAFGLVELARKV----EDAVAKALLET-PPPDLGGSAG-------TEAFT Thermus8 HAFGLVELARKV----EDAVAKALLET-PPPDLGGSAG-------TEAFT Thermus5 HAFGLVELARKV----EDAVAKALLET-PPPDLGGSAG-------TEAFT Thermus6 HAFGLVELARKV----EDAVAKALLET-PPPDLGGSAG-------TEAFT Thermus4 HAFGLVELARKV----EDAVAKALLET-PPPDLGGSAG-------TEAFT Thermus9 QLR-PGGLARKV----EDA-AKALLET-PPPDLGGSE--------ARAFT Thermus3 HAFGLVELARRV----EAAVAKALRET-PPPDLGGSAG-------TQAFT Bacteroides EYFDCKAEGALI----RKAVDASLDAN-VRTPEIQVEGG--EKFGTKEVG Lactococcus ESFGQEDGAAMI----EKAVTQTFTDG-ILTKDL--GG----TATTKEMT *Pseudomonas FLGQGDERYQRAHDDMLNAIERVIADG-SVTPDMGGT------LSTQQVG *Ecoli FLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGN------ATTPQVA Sphingomonas HLGEAEPAALVMRALETALIAPDIAR----TPDLGGN------GTTAGFA *Bacillus6 -------------------------------------------------- *Agrobacterium2 HLGEKD-----AATRLMSAVERVTEAG-ILTPDVGGT------ADTQQVT *Agrobacterium3 HLGEKD-----AATRLMSAVERVTEAG-ILTPDVGGT------ANTQQVT *Agrobacterium5 HLGERD-----AAARLMGAVERVTEAG-ILTPDVGGT------ANTSQVT *Agrobacterium6 HLGERD-----AAARLMSAVERVTEAG-ILTPDVGGT------ANTSQVT *Agrobacterium4 HLGERD-----AAARLMSAVERVTEAG-ILTPDVGGT------ANTRQVT Mycobacterium HLGEHD---------AAARVDRAVEAH-LATRGSER-------LATSDVG Mycobacterium2 HLGEHD---------AAARVDRAVEAH-LATRGSER-------LATSDVG Mycobacterium3 HLGEDE---------PAARLDQAVASY-LATRGNGR-------FSTGEVG Corynebacterium HLGDED---------NAVRIETAIAAD-VAGRDNSQP------ISTTEVG Sulfolobus YELSNDDRYIKASRALENAIYLVYKERKALTPDVGGN------ATTDDLI cAjellomyces HLG-LDEHANRI---SKAVYDVIG-EGVTRTRDMGGQ------ASTHEFT cSchizosaccharomyces2 HLG-LKDYADLI---NAATYSVIE-EGKTLTKDLGGS------ASTGDFT cSaccharomyces3 HLG-LNEYATRI---SKAVHETIA-EGKHTTRDIGGS------SSTTDFT cKluyveromyces2 HLG-LNAYADRI---SKATYDVIS-EGKSTTRDIGGS------ASTSEFT cRattusnorvegicus HLK-LHSYATSI---RKAVLASMD-NENMHTPDIGGQ------GTTSQAI cRattusnorvegicus2 HLK-LHSYATSI---RKAVLASMD-NENMHTPDIGGQ------GTTSQAI cMusmusculus HLK-LHSYATSI---RKAVLASMD-NENMHTPDIGGQ------GTTSQAI cHomosapiens6 HLK-LHSYATSI---RKAVLASMD-NENMHTPDIGGQ------GTTSEAI cMacaca4 HLK-LHSYATSI---RKAVLASMD-NENMHTPDIGGQ------GTTSEAI cHomosapiens7 HLK-LHSYATSI---RKAVLASMD-NENVRFPSHPTL------LPRPVSP cCelegans FLG-LQSHADMI---SDSLFRTLV-DKRIHTADIGG---------TSKVR cMacaca HLN-LEYHSNMI---ADAVKKVIK-VGKVRTSDMGGY------ATCHDFT cHomosapiens HLN-LEYHSSMI---ADAVKKVIK-VGKVRTSDMGGY------ATCHDFT cHomosapiens2 HLN-LEYHSSMI---ADAVKKVIK-VGKVRTRDMGGY------STTTDFI cHomosapiens3 HLN-LEYHSSMI---ADAVKKVIK-VGKVRTRDMGGY------STTTDFI cBostaurus HLN-LEHHSNMI---AEAVKKVIK-VGKVRTSDMGGY------ATCQDFT cBostaurus2 HLN-LEHHSNMI---AEAVKKVIK-VGKVRTRDMGGY------STTTDFI *Homosapiens5 HLN-LEYHSSMI---ADAVKKVIK-VGKVRTRDMGGY------STTTDFI cCelegans2 HLH-LDAWGNSL---RQAVADVVK-EGKVRTRDLGGY------ATTVDFA cArabidopsis HLQ-FPSFADRL---ETAVKRVIA-EGNCRTEDLGGN------STTQEVV cArabidopsis2 HLQ-FPSFADRL---ETAVKRVIA-EGNCRTEDLGGN------STTQEVV cArabidopsis3 HLQ-FPSFADRP---ETAVKKVTA-EGKCRTKDLGGT------STTQEVV cArabidopsis4 HLQ-FPSFADRL---ETAVKKVIA-EGKCRTKDLGGT------STTQEVV cNicotiana HLQ-FPSFADRL---KTSVKRVIA-EGKYMTKDLGGN------CTTQEIT cArabidopsis5 HLR-FPTFADRL---ETAVKQVIK-EGKYRTKDLGGD------CTTQEVV cNicotiana3 HLE-FPSFADRL---ETAVKRVIA-EGKVRTKDLGGD------STTQEVV cSaccharomyces2 HMG-LTNHADQI---QNAVLSTIASGPENRTGDLAGT------ATTSSFT cKluyveromyces HMG-LTEHADKI---EKAVLTTIASDAKNRTGDLGGS------ASTSSFT Solanum HLE-LHDKADRI---QDAILKTIA-GGKVPN----WR------PWRHCYN cNicotiana2 HLE-LHDKADRI---QGAVLNTIA-EGKYRTGDLGGT------SSTTDFT cHomosapiens4 HMG-LFDHAARI---EAACFATIK-DGKSLTKDLGGN------AKCSDFT cMacaca3 HMG-LFDHAARI---EAACFATIK-DGKSLTKDLGGN------AKCSDFT cMacaca2 HMG-LFDHAARI---EAACFATIK-DGKSLTKDLGGN------AKCSDFT cBostaurus3 HMG-LFDHAAKI---ETACFATIK-DGKSLTKDLGGN------SKCSDFT cCelegans3 YMN-LPQHAARI---EKAVFDAIA-DGRAKTGDLGGT------GTCSSFT cThermus YLE-EFATADLI---ENALLYTLE-EGRVLTGDVVGYDR---GAKTTEYT cThermus2 YLE-EFATADLI---ENALLYTLE-EGRVLTGDVVGYDR---GAKTTEYT Pyrococcus YLG-LDG--SII----WKAVGRYVRRG-NLTPDMEGR------ATTLEVT cCaldococcus DFVGWPEVKLLV----EYAVKQAIAHK-QVTYDLAREMGGVTPISTTEYT cMethanococcus DEILNYIRKKLKGY------------------------------------ cMethanococcus2 DEILNYIRKKLKGY------------------------------------ cMethanobacterium EAIKEEIVKGE--------------------------------------- Methanobacterium2 AEIARHLED----------------------------------------- cMethanococcus3 EEVAKRVREE---------------------------------------- *Methanococcus4 EEVAKRVREE---------------------------------------- Archaeoglobus NEVASLLD------------------------------------------ *Schizosaccharomyces DAVLANIHN----------------------------------------- *Saccharomyces DDVLSRL------------------------------------------- Deinococcus -------------------------------------------------- Ecoli2 DIIARYVAEGV--------------------------------------- Ecoli3 DIIARYVAEGV--------------------------------------- Salmonella DIIARYVAEGV--------------------------------------- *Salmonella2 DIIARYVAEGV--------------------------------------- Haemophilus TLITQAI------------------------------------------- Buchnera2 DIIAEFLDNGK--------------------------------------- Buchnera3 DIIAKFLINGK--------------------------------------- Buchnera DKISDLLAKKA--------------------------------------- Leptospira QLIESFL------------------------------------------- Thermotoga DLICKKLEEIW--------------------------------------- Clostridium NLVLERL------------------------------------------- Aquifex DKILENLERLKDAYT----------------------------------- Neisseria -------------------------------------------------- Thiobacillus AAVVNALNLKD--------------------------------------- Pseudomonas2 DAVVAALKNL---------------------------------------- *Pseudomonas3 DAVVAALKNL---------------------------------------- Agrobacterium DAVLAEFKALSA-------------------------------------- Brassica EEVLKSVDSHVQASV----------------------------------- Arabidopsis7 EEVLKSVDSQVPASV----------------------------------- Arabidopsis6 EEVLKSVDSKVPV------------------------------------- Spirulina ICY----------------------------------------------- Spirulina2 ICY----------------------------------------------- Synechocystis EQLLSILDEM---------------------------------------- Bacillus DRLIEKLNNSAAGPRIFQ-------------------------------- Bacillus2 DRLIEKLNNSAARPRIFQ-------------------------------- Bacillus3 DRLIEKLNN----------------------------------------- Bacillus4 EEVKAAIMSENTISNV---------------------------------- Bacillus5 EEVKAAIMSENTISNV---------------------------------- Bacillus7 EEIKAAVLDYTAIAQIMTVYA----------------------------- Thermus7 ATVLRHLA------------------------------------------ Thermus8 ATVLRHLA------------------------------------------ Thermus5 ATVLRHLA------------------------------------------ Thermus6 ATVLRHLA------------------------------------------ Thermus4 ATVLRHLA------------------------------------------ Thermus9 ATVLRHLA------------------------------------------ Thermus3 EEVLRHL------------------------------------------- Bacteroides AWIVDYIRKA---------------------------------------- Lactococcus EAILKNCQ------------------------------------------ *Pseudomonas AAISDTLARLD--------------------------------------- *Ecoli DAICKIILR----------------------------------------- Sphingomonas QAVRSTLLGL---------------------------------------- *Bacillus6 -------------------------------------------------- *Agrobacterium2 DAVCEAIAGSNILNMAAVG------------------------------- *Agrobacterium3 DAVCEAIAGSNIL------------------------------------- *Agrobacterium5 EAVCNAIAGSNII------------------------------------- *Agrobacterium6 EAVCNAIAGSNII------------------------------------- *Agrobacterium4 EAVCNAIAGSNILKMAAAE------------------------------- Mycobacterium ERIAAAL------------------------------------------- Mycobacterium2 ERIAAAL------------------------------------------- Mycobacterium3 ERIAAAL------------------------------------------- Corynebacterium DRIVKALQS----------------------------------------- Sulfolobus NEIYNKLG------------------------------------------ cAjellomyces RAVLDKMESAL--------------------------------------- cSchizosaccharomyces2 HAILERMESL---------------------------------------- cSaccharomyces3 NEIINKLSTM---------------------------------------- cKluyveromyces2 NAVIEKLAKL---------------------------------------- cRattusnorvegicus QDIIRHIRIINGRAVEA--------------------------------- cRattusnorvegicus2 QDIIRHIRIINGRAVEA--------------------------------- cMusmusculus QDIIRHIRIINGRAVEA--------------------------------- cHomosapiens6 QDVIRHIRVINGRAVEA--------------------------------- cMacaca4 QDIIRHIRVINGRAVEA--------------------------------- cHomosapiens7 CSLL---------------------------------------------- cCelegans ISLIF--------------------------------------------- cMacaca EAVIAALPHP---------------------------------------- cHomosapiens EAVIAALPHP---------------------------------------- cHomosapiens2 KSVIGHLQTKGS-------------------------------------- cHomosapiens3 KSVIGHLQTKGSNL------------------------------------ cBostaurus EAVIGALSNP---------------------------------------- cBostaurus2 KSVIGHLHPYGG-------------------------------------- *Homosapiens5 KSVIGHLQTKGS-------------------------------------- cCelegans2 DAVIDKFRI----------------------------------------- cArabidopsis DAVIANLD------------------------------------------ cArabidopsis2 DAVIANLD------------------------------------------ cArabidopsis3 DAGIAKLD------------------------------------------ cArabidopsis4 DAVIAKLD------------------------------------------ cNicotiana DAVIANLD------------------------------------------ cArabidopsis5 DAVIAALE------------------------------------------ cNicotiana3 DAIIAALD------------------------------------------ cSaccharomyces2 EAVIKRL------------------------------------------- cKluyveromyces DAVIERL------------------------------------------- Solanum N------------------------------------------------- cNicotiana2 NAICDHL------------------------------------------- cHomosapiens4 EEICRRVKDLD--------------------------------------- cMacaca3 EEICRRVKDLD--------------------------------------- cMacaca2 EEICRRVKDLD--------------------------------------- cBostaurus3 EEICRRVKDLD--------------------------------------- cCelegans3 ADVCARVKDLE--------------------------------------- cThermus EAIIQNLGKTPRKTQVRGYKPFRLPQVDGAIAPIVPRSRRVVGVDVFVET cThermus2 EAIIQNLGKTPRKTQVRGYKPFRLPQVDGAIAPIVPRSRRVVGVDVFVET Pyrococcus NGIISEIYRLDEYEIDEVWRDEVRLGRILLEIS----------------- cCaldococcus DVLVDYIRHADLKPSRASEGLP---------------------------- cMethanococcus -------------------------------------------------- cMethanococcus2 -------------------------------------------------- cMethanobacterium -------------------------------------------------- Methanobacterium2 -------------------------------------------------- cMethanococcus3 -------------------------------------------------- *Methanococcus4 -------------------------------------------------- Archaeoglobus -------------------------------------------------- *Schizosaccharomyces -------------------------------------------------- *Saccharomyces -------------------------------------------------- Deinococcus -------------------------------------------------- Ecoli2 -------------------------------------------------- Ecoli3 -------------------------------------------------- Salmonella -------------------------------------------------- *Salmonella2 -------------------------------------------------- Haemophilus -------------------------------------------------- Buchnera2 -------------------------------------------------- Buchnera3 -------------------------------------------------- Buchnera -------------------------------------------------- Leptospira -------------------------------------------------- Thermotoga -------------------------------------------------- Clostridium -------------------------------------------------- Aquifex -------------------------------------------------- Neisseria -------------------------------------------------- Thiobacillus -------------------------------------------------- Pseudomonas2 -------------------------------------------------- *Pseudomonas3 -------------------------------------------------- Agrobacterium -------------------------------------------------- Brassica -------------------------------------------------- Arabidopsis7 -------------------------------------------------- Arabidopsis6 -------------------------------------------------- Spirulina -------------------------------------------------- Spirulina2 -------------------------------------------------- Synechocystis -------------------------------------------------- Bacillus -------------------------------------------------- Bacillus2 -------------------------------------------------- Bacillus3 -------------------------------------------------- Bacillus4 -------------------------------------------------- Bacillus5 -------------------------------------------------- Bacillus7 -------------------------------------------------- Thermus7 -------------------------------------------------- Thermus8 -------------------------------------------------- Thermus5 -------------------------------------------------- Thermus6 -------------------------------------------------- Thermus4 -------------------------------------------------- Thermus9 -------------------------------------------------- Thermus3 -------------------------------------------------- Bacteroides -------------------------------------------------- Lactococcus -------------------------------------------------- *Pseudomonas -------------------------------------------------- *Ecoli -------------------------------------------------- Sphingomonas -------------------------------------------------- *Bacillus6 -------------------------------------------------- *Agrobacterium2 -------------------------------------------------- *Agrobacterium3 -------------------------------------------------- *Agrobacterium5 -------------------------------------------------- *Agrobacterium6 -------------------------------------------------- *Agrobacterium4 -------------------------------------------------- Mycobacterium -------------------------------------------------- Mycobacterium2 -------------------------------------------------- Mycobacterium3 -------------------------------------------------- Corynebacterium -------------------------------------------------- Sulfolobus -------------------------------------------------- cAjellomyces -------------------------------------------------- cSchizosaccharomyces2 -------------------------------------------------- cSaccharomyces3 -------------------------------------------------- cKluyveromyces2 -------------------------------------------------- cRattusnorvegicus -------------------------------------------------- cRattusnorvegicus2 -------------------------------------------------- cMusmusculus -------------------------------------------------- cHomosapiens6 -------------------------------------------------- cMacaca4 -------------------------------------------------- cHomosapiens7 -------------------------------------------------- cCelegans -------------------------------------------------- cMacaca -------------------------------------------------- cHomosapiens -------------------------------------------------- cHomosapiens2 -------------------------------------------------- cHomosapiens3 -------------------------------------------------- cBostaurus -------------------------------------------------- cBostaurus2 -------------------------------------------------- *Homosapiens5 -------------------------------------------------- cCelegans2 -------------------------------------------------- cArabidopsis -------------------------------------------------- cArabidopsis2 -------------------------------------------------- cArabidopsis3 -------------------------------------------------- cArabidopsis4 -------------------------------------------------- cNicotiana -------------------------------------------------- cArabidopsis5 -------------------------------------------------- cNicotiana3 -------------------------------------------------- cSaccharomyces2 -------------------------------------------------- cKluyveromyces -------------------------------------------------- Solanum -------------------------------------------------- cNicotiana2 -------------------------------------------------- cHomosapiens4 -------------------------------------------------- cMacaca3 -------------------------------------------------- cMacaca2 -------------------------------------------------- cBostaurus3 -------------------------------------------------- cCelegans3 -------------------------------------------------- cThermus NLLPEALGKALEDLAAGTPFRLKMISNRGTQVYPPTGGLTDLVDHYRCRF cThermus2 NLLPEALGKALEDLAAGTPFRLKMISNRGTQVYPPTGGLTDLVDHYRCRF Pyrococcus -------------------------------------------------- cCaldococcus -------------------------------------------------- cMethanococcus ------------------------------------------------ cMethanococcus2 ------------------------------------------------ cMethanobacterium ------------------------------------------------ Methanobacterium2 ------------------------------------------------ cMethanococcus3 ------------------------------------------------ *Methanococcus4 ------------------------------------------------ Archaeoglobus ------------------------------------------------ *Schizosaccharomyces ------------------------------------------------ *Saccharomyces ------------------------------------------------ Deinococcus ------------------------------------------------ Ecoli2 ------------------------------------------------ Ecoli3 ------------------------------------------------ Salmonella ------------------------------------------------ *Salmonella2 ------------------------------------------------ Haemophilus ------------------------------------------------ Buchnera2 ------------------------------------------------ Buchnera3 ------------------------------------------------ Buchnera ------------------------------------------------ Leptospira ------------------------------------------------ Thermotoga ------------------------------------------------ Clostridium ------------------------------------------------ Aquifex ------------------------------------------------ Neisseria ------------------------------------------------ Thiobacillus ------------------------------------------------ Pseudomonas2 ------------------------------------------------ *Pseudomonas3 ------------------------------------------------ Agrobacterium ------------------------------------------------ Brassica ------------------------------------------------ Arabidopsis7 ------------------------------------------------ Arabidopsis6 ------------------------------------------------ Spirulina ------------------------------------------------ Spirulina2 ------------------------------------------------ Synechocystis ------------------------------------------------ Bacillus ------------------------------------------------ Bacillus2 ------------------------------------------------ Bacillus3 ------------------------------------------------ Bacillus4 ------------------------------------------------ Bacillus5 ------------------------------------------------ Bacillus7 ------------------------------------------------ Thermus7 ------------------------------------------------ Thermus8 ------------------------------------------------ Thermus5 ------------------------------------------------ Thermus6 ------------------------------------------------ Thermus4 ------------------------------------------------ Thermus9 ------------------------------------------------ Thermus3 ------------------------------------------------ Bacteroides ------------------------------------------------ Lactococcus ------------------------------------------------ *Pseudomonas ------------------------------------------------ *Ecoli ------------------------------------------------ Sphingomonas ------------------------------------------------ *Bacillus6 ------------------------------------------------ *Agrobacterium2 ------------------------------------------------ *Agrobacterium3 ------------------------------------------------ *Agrobacterium5 ------------------------------------------------ *Agrobacterium6 ------------------------------------------------ *Agrobacterium4 ------------------------------------------------ Mycobacterium ------------------------------------------------ Mycobacterium2 ------------------------------------------------ Mycobacterium3 ------------------------------------------------ Corynebacterium ------------------------------------------------ Sulfolobus ------------------------------------------------ cAjellomyces ------------------------------------------------ cSchizosaccharomyces2 ------------------------------------------------ cSaccharomyces3 ------------------------------------------------ cKluyveromyces2 ------------------------------------------------ cRattusnorvegicus ------------------------------------------------ cRattusnorvegicus2 ------------------------------------------------ cMusmusculus ------------------------------------------------ cHomosapiens6 ------------------------------------------------ cMacaca4 ------------------------------------------------ cHomosapiens7 ------------------------------------------------ cCelegans ------------------------------------------------ cMacaca ------------------------------------------------ cHomosapiens ------------------------------------------------ cHomosapiens2 ------------------------------------------------ cHomosapiens3 ------------------------------------------------ cBostaurus ------------------------------------------------ cBostaurus2 ------------------------------------------------ *Homosapiens5 ------------------------------------------------ cCelegans2 ------------------------------------------------ cArabidopsis ------------------------------------------------ cArabidopsis2 ------------------------------------------------ cArabidopsis3 ------------------------------------------------ cArabidopsis4 ------------------------------------------------ cNicotiana ------------------------------------------------ cArabidopsis5 ------------------------------------------------ cNicotiana3 ------------------------------------------------ cSaccharomyces2 ------------------------------------------------ cKluyveromyces ------------------------------------------------ Solanum ------------------------------------------------ cNicotiana2 ------------------------------------------------ cHomosapiens4 ------------------------------------------------ cMacaca3 ------------------------------------------------ cMacaca2 ------------------------------------------------ cBostaurus3 ------------------------------------------------ cCelegans3 ------------------------------------------------ cThermus LYTGEGEAKDPEILDLVSRVASRFRWMHLEKLQEFDGEPGFTKAQGED cThermus2 LYTGEGEAKDPEILDLVSRVASRFRWMHLEKLQEFDGEPGFTKAQGED Pyrococcus ------------------------------------------------ cCaldococcus ------------------------------------------------