CLUSTAL X (1.64b) multiple sequence alignment Chlamydophila ---------------------------------------MKAGDTYRNFIIKSCKDLPEI Chlamydia ---------------------------------------MKTGDTYRNFVVKLSQDLPEI Schizosaccharomyces --MNYAKLSIAFSKKTIKTHNCRLFQRW-----------LHVGDKVHDFRVVDTKKVPEL Homosapiens MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPEL Saccharomyces ---------MLRFQRFASSYAQAQAVRK-----------YPVGGIFHGYEVRRILPVPEL Deinococcus ------------------------------------------------------------ Treponema -----------------------------------------MSTLLHGFEIIWRHSLAEL Borrelia ------------------------------------------MKKKKIFKLISKTYLEEH Chlamydophila ESKLLEAEHKPTGASIMMIVNNDEENVFNICFRTCPQTSNGVAHVLEHMVLCGSENYPVR Chlamydia ESKLIEVEHTPTGATIMMIVNDDDENVFNISFRTCPQDSSGVAHVLEHMALCGSESYPIR Schizosaccharomyces QLNYTRLKHEPTNADMIHLDREDPNSVFSIGFQTPAENDEGIPHILEHTTLCGSNKYPVR Homosapiens FLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCR Saccharomyces RLTAVDLVHSQTGAEHLHIDRDDKNNVFSIAFKTNPPDSTGVPHILEHTTLCGSVKYPVR Deinococcus ------------------------------------------------------------ Treponema SAVGVYARHKKTGLELYHILNEDPENLFAFCFMTAEEASTGVAHILEHSVLCGSQHYPLK Borrelia DAEGYYFKHESGLEVFHLKSDSFKENAFCIAFKTIPSNNTGVAHVLEHTIFCGSSKYKIK Chlamydophila DPFFSMTRRSLNTFINAFTGPDFTCYPAASQIPEDFYNLLSVYIDAVFHPLLTKQSFLQE Chlamydia DPFFSMTRRSLNTFMNAFTGADFTCYPAASQIPEDFYNLLSVYIDAVFHPLLTENSFLQE Schizosaccharomyces DPFFKMLNRSLATFMNAFTASDFTFYPFATVNTTDYKNLRDVYLDATLFPKLRKLDFLQE Homosapiens NPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFSPCLRELDFWQE Saccharomyces DPFFKMLNKSLANFMNAMTGPDYTFFPFSTTNPQDFANLRGVYLDSTLNPLLKQEDFDQE Deinococcus ------------------------------------------------------------ Treponema DPFLILAKQSVKTFLNALTFPDKTVYPASSLVETDYFNVMSVYADAVFFPLIEEWTFKQE Borrelia DPFLYLLKGSLNTFLNAMTFPDKTIYPAASTIEKDYFNLFNIYADSIFNPLLKKESFMQE Chlamydophila AWRYEFNSENH----LCYTGVVFNEMKGAMMSGEARLSEALNAAIFPSVTYGVNSGGEPR Chlamydia AWRYERTEEGN----LSYTGIVFNEMKGALMSGESRLSEAMNAALFPSVTYGVNSGGDPK Schizosaccharomyces GWRFEHADVNDKKSPIIFNGVVYNEMKGQVSDSSYIFYMLFQQHLFQGTAYGFNSGGDPL Homosapiens GWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPL Saccharomyces GWRLEHKNITDPESNIVFKGVVYNEMKGQISNANYYFWSKFQQSIYPSLN---NSGGDPM Deinococcus -----------------------------------------------------RPAGLPR Treponema GHRFEFNEHNQ----LTLQGVVLNEMRGVYADFHTLVYKHATHATTRGSVYAHDSGGHPT Borrelia GYNINPKDFKV-----SG--IVFNEMKGSYSNKNSLINEIVSSSLFEEGAYKYDSGGIPT ..* * Chlamydophila EIVTLSHEDVRAFHQSQYSINRCLFYFYGNIKPSRHLDFLEEKLLRQATKLEKQAVSVPL Chlamydia AIVSLNLETVRAFYESQYTLSRCLFYFYGNIKPSRHLDFLEEKLLRRVGKVEKQSVTLPL Schizosaccharomyces AIPDLKYEELVKFHRSHYHPSNAKILSYG-SFPLEDNLSALSETFRPFSKRE-LNLPNTF Homosapiens CIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIE-PSTVVPA Saccharomyces KITDLRYGDLLDFHHKNYHPSNAKTFTYGNLPLVDTLKQLNEQFSGYGKRARKDKLLMPI Deinococcus GALPPVERLLFQLRQSGFAPGAGHHRRTGDVALPAARSRREHSRPDQFQRAAPHGRELPR Treponema VIPRLTYESFKAFHKKHYHPSNCKLFLYGNIPTEKQMAFIEDKCLSKFSARKALPPIPPI Borrelia NIIDLTYESFLDFYKKYYTLENCKIFLCGNTQTEKNLNFIEKYIIRPYKKEKSNVNINIE . : . : * Chlamydophila QKRFKEPV-RNILTYPVD--HQEEDKVLFGISWLTCSILEQQELLALHVLEIILMGTDAS Chlamydia QKRFKEPV-RVIERYPSD--GADEDKVLFGLAWLTCSIFDQQDLLALHVLDLVLMGTDAA Schizosaccharomyces LKEFDQEK-RVVEYGPLDPVMAPGRQVKTSISFLANDTSNVYETFALKVLSKLCFDGFSS Homosapiens QTPWDKPREFQITCGPDSFATDPSKQTTVSVSFLLPDITDTFEAFTLSLLSSLLTSGPNS Saccharomyces DLKKDIDV---KLLGQIDTMLPPEKQTKASMTWICGAPQDTYDTFLLKVLGNLLMDGHSS Deinococcus LRYRARRT--------------------GAARLEAGYASDPDLSLRWGVLSDVLLGNAAA Treponema PAYQSPRT---YTGYAPASEGMDLTRCAVLLSWLLPESDKAEQLMDVFLLEHVLLGHDAA Borrelia NVKRWEKGKKLTYKIPKE---NDNSLGVYTINWLCTEINNIEDSIGLEILSEILLDDSCS . : :* : . : Chlamydophila PLKSRLLKS--GFCKQTEMSIENDIREIPMTLVCKGCSPAGAQKLEALIFASLEEIIREG Chlamydia PLKSRLLKS--GLCKQVDMSIDSELHEIPVYIVCRGCSHSGSQKLESLILASLEEILQEG Schizosaccharomyces PFYKALIESGLGTDFAPNSGYDSTTKRGIFSVGLEGASEESLAKIENLVYSIFNDLALKG Homosapiens PFYKALIESGLGTEFSPDVGYNGYTREAYFSVGLQGIVEKDIETVRSLIDRTIDEVVETR Saccharomyces VMYQKLIESGIGLEFSVNSGVEPTTAVNLLTVGIQGVS--DIEIFKDTVNNIFQNLLETE Deinococcus PLTRPLIESGLGSALADLSGYRDDFREAAFAVGLKGLSSGKAAQVQELVLSTLRQIADEG Treponema PLAQALLESELGEDLYAYNGSHIDLKRMLFFVGMTGVQHTQVDALKACVFETLESLVAHG Borrelia -FTINILKSGIGEDIAHISGINTDLKESIFSFGLQNVVENKEKEFKNLVFSELKNLVKNK : :::* * . . . . .. : : .: Chlamydophila --ISENIVEGAVHQLELSRKEITGYSLPYGLSLFFRSGLLKQHGGSAEDGLRIHSLFSEL Chlamydia --IPMHLVEGAVHQLELARKEIAGYSIPYGLSLFFRAGLLRQHGGKAEDGLRIHTLFANL Schizosaccharomyces --FENEKLEAILHQMEISLKHKS---AHFGIGLAQSLPFNWFNGADPADWLSFNKQIEWL Homosapiens --IEDDRIEALLHKIEIQMKHQS---TSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKF Saccharomyces HPFDRKRIDAIIEQLELSKKDQK---ADFGLQLLYSILPGWTNKIDPFESLLFEDVLQRF Deinococcus --IDPALIEASLHQFEISQKEVSNAGYPYGLGVMFRLLGPWMNGGDPVTGLRLDAELSKL Treponema --IPPQEVETALNALEFSNTEVRRSDGPFSLVLMQRSLRGWLHGAGPESSLRYIPALQAL Borrelia --IPKELIKGILFGYEFALKEEKG--QNFPIALMIKSFKGWLNGLHPIKTLQTSYYINEI : :. : *: .. : : : : . * : : Chlamydophila RNSLK--NSDYLAKLIRKYFLDNPHFARVILLPDTELVAKDNKDEQQLLLSVSEKLTD-- Chlamydia RENIQ--KPDYLPRLVRKYFLDNPHYARVIFLPDSQLIAQENKEERNVLHTIQMQMSE-- Schizosaccharomyces KQKNS--DGKLFQKLIKKYILENKSRFVFTMLPSSTFPQRLQEAEAKKLQERTSKLTD-- Homosapiens RQCLQE-NPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSP-- Saccharomyces RGDLETKGDTLFQDLIRKYIVHKP-CFTFSIQGSEEFSKSLDDEEQTRLREKITALDE-- Deinococcus RADLE--RGPVFEDLIRHWLLDNPHRVTLVVT---------------------------- Treponema REKVHH-HPHYVENLILTHLLRNPQYTVLSVHPDPDFSKKLDEQLEKYVQDFSRTLTQ-- Borrelia TNKLEK-GIYYFENLIEKYLIFNNHYTLISFIPSHDTEKEMEEEIEKKLMAREIEIKQNP . : : : . . Chlamydophila ENKEKIQQNVRELTESQEQKEDLN--GILPNLALDKVPTSGKEFPLIKEGLSQ-GEVLHH Chlamydia EELERVEAVSKRLEAYQSQEEDLN--KVLPLFALDKVPSLGKEFVLEKEVFAE-GEVLHH Schizosaccharomyces EDIAEIEKTSVKLLEAQSTPADT---SCLPTLSVSDIPETIDETKLKFLDIAG-MKAQWY Homosapiens GDRQQIYEKGLELRSQQSKPQDA---SCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYC Saccharomyces QDKKNIFKRGILLQEKQNEKEDL---SCLPTLQIKDIPRAGDKYSIEQKNNTM-----SR Deinococcus ------------------------------------------------------------ Treponema PAAARLRADQESLRVRQTTPDPEELLALLPHIKREQLPVPTPELSETMQFFGS-VPVLVH Borrelia EEFLQFKKDYNQFKKYQNKKDSKADIAKLPLLKIEDLPKQIEKSLDLNEIKEL--NLHSF Chlamydophila ECFTNDIVFIDVVLDIP-PLSGEELPWLRLLVFLMLQLGCGGRSYKEHLEFLLEHTGGVD Chlamydia DCFTNDIIFVELVFDLP-ALSAEELPWLRLLVFVLLQLGSGNRSYKEHLEFLLEHTGGVD Schizosaccharomyces DLAAG-LTYIRLLLPLK-NFPESLIPYLPVYCDACLNLGTHSESIGDLEHQIRRYTGGIS Homosapiens AQPTNGMVYFRAFSSLN-TLPEELRPYVPLFCSILTKLGCGLLDYREQAQQIELKTGGMS Saccharomyces ITDTNGITYVRGKRLLNDIIPFELFPYLPLFAESLTNLGTTTESFSEIEDQIKLHTGGIS Deinococcus ------------------------------------------------------------ Treponema ELATNDITYLHLAIPAD-MLSVKEAQLLPLYGYALTGMGTETHHWSVVSAEIARLTGGFA Borrelia KFKSNNIFNVNLFFKLD-FLEKEDYIYLSLFKRALQDLSTKNYSYININNKIQNTLGQIN Chlamydophila VSYDFSPHA--------------NKNSFLS-PSVSIRGKALSSKSEKLCGIVSDMLTSVD Chlamydia VLYEFSSQA--------------TDTDRLS-PSISIRGKALISKAEYLFQVIRETLTTVD Schizosaccharomyces ISPSAVTNN--------------SDVSKYE-LGIAISGYALDKNVGKLVELINKAFWNTN Homosapiens ASPHVLPDD--------------SHMDTYEQVGVLFSSLCLDRNLPDMMQLWSEIFNNPC Saccharomyces THVEVTSD---------------PNTTEPR-LIFGFDGWSLNSKTDHIFEFWSKILLETD Deinococcus ------------------------------------------------------------ Treponema ARCIVAGDQGSEILPLLRGQNTLQRSDIVGRAWLVVSVKMLSRFIVQAISYVCAHVRSLS Borrelia ISESYDED---------------IDGNILN--SFNISFKSFNNKVKESFELIKEILININ Chlamydophila FT-DIPRIRELLMQHNEALTNSVRNSPMSYAVSMACSGNSITGAMSYLTTGLPYVKKIRE Chlamydia FS-DIARLKELLMQHAESLTNSVRNSPMGYAVSLACCNKSIAGGLAYQMAGLPYVKYIRE Schizosaccharomyces LS-NTDKLAIMLKTSVSGITDGIAEKGHSFAKVSSASGLTEKTSITEQLGGLTQVKLLSQ Homosapiens FE-EEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKR Saccharomyces FHKNSDKLKVLIRLLASSNTSSVADAGHAFARGYSAAHYRSSGAINETLNGIEQLQFINR Deinococcus ------------------------------------------------------------ Treponema FT-DTRRLKDILAQYKNDLDSAAMHSGHSIALAKANARVNAAKAVEELWTGVTQIRLVRA Borrelia FH-DYERLKEITLSLKNDFKSLLIPKGHLLAMLRSKSKLKLNEYLKELQNGITGREFWQK Chlamydophila LTKN------FDQNIDEAVVILQRLYTKCFSGKRQIVI--SGSAHNYQQLKDNKFYGLLD Chlamydia LLSN------FDSQAQEIIDRLQTLYKKCFVGRRQLVI--SSSKANYQVLHDQRFFGLLD Schizosaccharomyces LSREE-----SFGPLVEKLTAIREILRGTSGFKAAINA--SPTQHEVVEKALQKFMKSRG Homosapiens IAEMT-----DIKPILRKLPRIKKHLLNGDNMRCSVNA--TPQQMPQTEKAVEDFLRSIG Saccharomyces LHSLLDNEETFQREVVDKLTELQKYIVDTNNMNFFITSD-SDVQAKTVESQISKFMERLP Deinococcus ------------------------------------------------------------ Treponema LWTECTETVASPSLAAKLKALHEKLLTAGVIGCVCGTETSLHTALDALAKPLACFRAPLS Borrelia AKTDT----ESLKEIANKLDNLKNKIILKNNLSALIMGN-TDDILKNLENEFFNLKESLE Chlamydophila -----------YLIVIPEPWEN----PSINLYVTSRGLHIPA------RAAFNALAFPIG Chlamydia -----------ERLEGGELWKN----PVLDVVKDSRGIVIPA------RGAYNVLAFPLG Schizosaccharomyces -----------VNQQTQTKSTS----KERNGINSIKTYHELP------FQTYFAAKSCLG Homosapiens RSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVN Saccharomyces HG---------SCLPNGPKTSD----YPLIGSKCKHTLIKFP------FQVHYTSQALLG Deinococcus ------------------------------------------------------------ Treponema ---------TYFIHHTSAPTAHEQQIPSAHGVLFQEALQHMRTRN---MLTLLPAPVQVG Borrelia ----------ESNHYNGLLNLD------ANSKALREIIIIQS------KVAFNAICFPSY Chlamydophila D-------IAYDHPDAAALTVAAEILDNVVLHTKIREQGGAYGSGAAANLSRGSFYCYSY Chlamydia S-------LAYDHPDAAVLSVAAEVLGNVILHTRIREQGGAYGSGASANLGRGAFYCYSY Schizosaccharomyces --------VPYTHPDGAPLQILSSLLTHKYLHGEIREKGGAYGAGLSYSGIDGVLSFFTY Homosapiens YVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYG-GXAKLSHNGIFTLYSY Saccharomyces --------VPYTHKDGSALQVMSNMLTFKHLHREVREKGGAYGGGASYSALAGIFSFYSY Deinococcus ------------------------------------------------------------ Treponema FAALSLAHPRLPLERRGVEQVFARYLSTEPFWEKIRTIGGAYGAFTLPDPVHGIFSSLTY Borrelia ---------KINDENYPKANFLEHVLRSGIFWEKIRVMGGAYG--ASASIANGIFSFASY Chlamydophila RDPEIATTYKTFLKGVSEIA------SGNFTKEDIYEGALGVVQGLDMPVAPGSRASVAF Chlamydia RDPEVATTYQVLLQGIRDMA------AGDFSEEDVHEGILGVIQNLDDPISPGSRGSASY Schizosaccharomyces RDSDP------------------------------------------------------- Homosapiens RDPNTIETLQSFGKAVDWAK------SGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHF Saccharomyces RDPQPLKSLETFKNSGRYILN-----DAKWGVTDLDEAKLTIFQQVDAPKSPKGEGVTYF Deinococcus ------------------------------------------------------------ Treponema RDPNPLHSLDVIFKTIEHLHADHKGTSSLFNQKTMERLIIGAYSTAVTPETPEHKSFASF Borrelia RDPNFTKTYQAFEKSLEELAN------NKMTDDEIYTYLIGLIGTNIYVKTKATEALQSY Chlamydophila YRLKSGRIPVLRQAFRRSVLEVTKEHICMVMDKYLES----TVQETTLISFAGEEMLRNN Chlamydia YRSRSGKVPFVRQAFRQAVLSTTKAQICEVVRNRLEG----CLSEASFVSFAGEEMLQKS Schizosaccharomyces ------------------------------------------------------------ Homosapiens LY---GLSDEMKQAHREQLFAVSHDKLLAVSDRYLG-----TGKSTHGLAILGPENPK-- Saccharomyces MS---GVTDDMKQARREQLLDVSLLDVHRVAEKYLL------NKEGVST-VIGPGIEG-- Deinococcus ------------------------------------------------------------ Treponema LRFLNGTTETERIAAIEHILDARVTDMHLCTQLLWAQR---TCAEAAVVSTATSIREAAT Borrelia RRKMLNISDSLRQDIRNAYFTITPQDIKEISTKILTQIRQHNSIASLVNNQIYEEEKNNL Chlamydophila VLTLDKDFPIVPAI Chlamydia AKELNEAFQIEAAF Schizosaccharomyces -------------- Homosapiens -IAKDPSWIIR--- Saccharomyces -KTVSPNWEVKEL- Deinococcus -------------- Treponema LEPYFSKLEAEPPL Borrelia EKLIGKEYSLKKIY