CLUSTAL X (1.8) multiple sequence alignment Escherichia RTSQYLLSTLKETP-----------ADAEVISHQLMLRAGMIRK---LASGLYTWLPTGV Haemophilus RTSQYLFSTLKETP-----------NDAQVVSHQLMLRAGMIRP---MASGLYNWLPTGI Rickettsia LLSKYFLPILKEEP-----------SEAKVISHKLMLRSGMIMK---QAAGLYTWLPLGL Zymomonas RLSRYFLPVMKETP-----------ADAQIISHKLMLRAGMIRQ---TASGIYAWLPLGL Synechocystis RLSQMLFVTLRDDP-----------ADAEIPSHKLLVRAGFIRR---LGSGLYAYLPLIW tMycobacterium RMSELFLRTLRDDP-----------ADAEVASHKLLIRAGYIRP---VAPGLYSWLPLGL Aquifex RWSRYFLYTEKEEP-----------KEAEAPSHRLLLKAGFIKQ---VSAGIYELLPPAY Thermotoga RMKDLYAPTLKETP-----------SDVETVSHEYLLRGGFIRK---VAAGIYTYLPLGR Bacillus RQSLTLIPTLREVP-----------ADAEAKSHQLLLRAGFIRQ---NTSGVYSYMPLAY Treponema -MSAFFAPTLRSAP-----------ADATIASHQLLMRAGYVRK---IANGLFAYLPLGL Chlamydia RTSLLFYRTSKNVN-----------KEASVLSYELLQKAGYLFK---TSKGIYSYTPLFQ Helicobacter LFSKLFAPTLKEPP-----------KDAVLKSHKHLAQAGYIYQ---VGSGIYNFLPLAK 2Saccharomyces ----SLSNNT----------------LKSETTQELLQTVGFVRR---SQVGLFQWLPLGL Candida TVPKSYGNQLSKFK-----------YSKQIPTHEVLTKLGYITY---PRAGLVNWSKMGL Drosophila KQTRLGLEATKED-------------NLPDWYSQVITKGEMIEY--YDVSGCYILRQWSF Homo KQTRLGLEAKKEE-------------NLADWYSQVITKSEMIEY--HDISGCYILRPWAY Caenorhabditis --TLLGVGTKKDD-------------NYSEWYSEVITKAEMIEY--YDVSGCYVLRPWSF Saccharomyces -AKLIGITVDKAL-------------DFPGWYQQILTKGEMLDY--YDVSGCYILRPPSY Borellia ---MSDFIASKED-------------DYSKWYLDIVQKAKLADY--SPVKGCMVIMPYGY Deinococcus KKAQQYGVTPQSV-------------DFNDWYNEVVKKADLADN--SPVAGAMVVRPYGS lMycobacterium -------MTRQED-------------DFSAWYNEVVAKAGLIDR--GPAKGTMVIRPYGY pMycoplasma -------MANKDQ-------------NLTLWYDQLLSKAQLVSY--GDVKGTNCFLPNSW gMycoplasma -------MTKKTQ-------------DLTSWYDQLLVKAKLICH--GEVKGTVCFLNNSW Methanococcus -------------------------MEFSEWYSDILEKAEIYDV-RYPIKGCGVYLPYGF Methanobacterium MQKPIKKDPNRYHG--------EKMTEFSEWFHNILEEAEIIDQ-RYPVKGMHVWMPHGF Archaeoglobus NNSSSNSKTNKYCSPLPILMTLPSKENFSEWYHEVIQTAEIMDV-RYPVKGLYVWFPFGF Pyrococcus -----MVERKRWS------------ENFSEWFNEVIEEAGILDK-RYPVKGMNVWLPYGL Sulfolobus ----MQITREKWS------------KNFSEWFDWVLREGEFYDYGRYPIKGMGVWMPYGF Aeropyrum --MLGPPSREKWS------------SDFPRWFDWVIETAEVYDYGRYPVKGMGVWMPYGF : * Escherichia RVLKKVENIVREEMN-NAG-------------------AIEVSMPVVQPADLWQESGRWE Haemophilus RVLKKVEKVVREEMN-KGG-------------------AIEVLMPVVQPAELWEESGRWD Rickettsia KVLKNIENVVRSNMN-KVG-------------------ALEVLMPCIQPAHLWIESGRFE Zymomonas RVLGRNEKIIREEQA-RAG-------------------AAELLMPTLQTADLWPESGRYD Synechocystis RVLEKVKRIVQEEMN-RTG-------------------AQECLLPQLQPSELWKMSGRWD tMycobacterium RVLRNIERVIRDEMN-AIG-------------------GQEILFPALLPRAPYETTNRWT Aquifex KVLKKVESIIRKEMD-RSG-------------------AQELLLTVLNPKELWEETGRWE Thermotoga RVLLKIENIVREEMN-RIG-------------------AQEILMPILQPAELWKQSGRWD Bacillus KVIQNIQQIVREEME-KID-------------------AVEMLMPALQQAETWQESGRWY Treponema RVRHKIEAIIREELE-AIG-------------------CLECTAPVVTPAELWKESGRWY Chlamydia RVILKMTEIIREELN-AIG-------------------GQEVCLPLLQPAELWEKTGRWK Helicobacter KVLDKIENITHKRMQ-EHG-------------------AQNILMSFVVLASLWEKSGRLD 2Saccharomyces RSLNKVSNAIRNRMDSDGG-------------------AIEVSLSAISSKALWQATDRWN Candida LIQNKISQIIRQRMD-EIQ-------------------FEEVSLSLISHKELWKLTNRWD Drosophila AIWKAIKTWFDAEIT-RMG-------------------VKECYFPIFVSKAVLEKEKTHI Homo AIWEAIKDFFDAEIK-KLG-------------------VENCYFPMFVSQSALEKEKTHV Caenorhabditis AVWESIQEWFDSGIK-KLG-------------------VKNCYFPMFVSNAALEREKTHI Saccharomyces AIWENIQKWFDDKIK-AIG-------------------VQNAYFPMFVSSRVLEKEKDHV Borellia SIWSKIQSILDKKFK-ETG-------------------HENAYFPMLIPYSFLEREKDHI Deinococcus ALWENIQRWLDDRFK-ASG-------------------HESLIFPTLIPMNFIMKEADHV lMycobacterium RIWELLQDELDSKIK-ELG-------------------HENAYFPMLIPENYFNREAEHV pMycoplasma NLWLQIQRLYNNATA-LIKLKDKVILKQFIPIEPLPYTVEQVQLPTLSFYSEYQKEKRHV gMycoplasma GLWMEIQQLYNDAIA-NKNQLSAIALTKFQPTTSFCYQVFQVQLPTLSFYSEYQKEKTHI Methanococcus KIRRYTFEIIRNLLD-ESG-------------------HDEALFPMLIPEDLLAKEAEHI Methanobacterium MIRKNTLKILRRILD-R-D-------------------HEEVLFPLLVPEDELAKEAIHV Archaeoglobus KIRQLVYSKLREIMD-R-E-------------------HDEVYFPALIPETELGKEGEHI Pyrococcus KIMKNIEKFIHEEME-RTG-------------------HQEVLFPALIPETEFKKEAEHI Sulfolobus KLRQNIIGIIRNFLD-STG-------------------HEEVLFPLLIPEDLLRRESTHI Aeropyrum QIRRRVLEVVRGLLD-STG-------------------HEEVLFPLLIPEHLLRRESEHI . . . Escherichia QYGP---ELLRFV----DRGERPFVLGPTHEEVITDLIRN-ELSSYKQLPLNFYQIQTKF Haemophilus QYGP---ELLRFE----DRGNRNFVLGPTHEEVITDLVRR-EVSSYKQLPLNLYQIQTKF Rickettsia HYGK---EMLKFQ----DRHDNTLLFGPTNEDMITDIFRR-NIKSYKDLPKNLYHIQWKF Zymomonas AYGP---EMLRFK----DRHNCELLYGPTNEEMITALIRH-NLQSYAILAGIFYHIQWKF Synechocystis TYTESEGIMFALR----DRLERELGLGPTHEEVITAIAKE-MIRSYRQLPVNLYQIQTKF tMycobacterium QYGD---SVFRLK----DRRGNDYLLGPTHEELFTLTVKG-EYSSYKDFPLTLYQIQTKY Aquifex TYGE---ELFKLK----DRNGREYCLGPTHEEEITDLVRR-VVRSYRQLPVILYQIQVKF Thermotoga DYGP---EMMKLK----DRHERDFTLGPTHEEIVTDLVKN-ELRSYKQLPLTLYQIANKY Bacillus TYGP---ELMRLK----DRHGREFALGATHEEVITSLVRD-EVKSYKRLPLTLYQIQSKF Treponema RMGA---ELLRAK----NRLDHELLFSPTAEESFTALVRG-DCTSYKHFPLSLYQINAKY Chlamydia AFLS-EKLLYVLK----DRENEAMCLAPTHEEVVSEFVAQ-WLTGREQLPIHLYQIGTKF Helicobacter KYGK---ELLVFK----DRKDNDFVLSPTLEENITEIAAN-FIKSYKQLPVHLYQIHTKF 2Saccharomyces NS-----ELFKLK----DSKGKQYCLTATCEEDITDLMKN-YIASYKDMPITIYQMTRKY Candida QE-----EIFKL------V-GDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKF Drosophila ADFAP--EVAWVTKSGDSDLAEPIAVRPTSETVMYPAYAK-WVQSYRDLPIRLNQWNNVV Homo ADFAP--EVAWVTRSGKTELAEPIAIRPTSETVMYPAYAK-WVQSHRDLPIKLNQWCNVV Caenorhabditis ADFAP--EVAWVTRAGNSEMAEPIAIRPTSETVMYPSYKK-WVQSHRDLPIKLNQWCNVV Saccharomyces EGFAP--EVAWVTRAGSSELEEPIAIRPTSETVMYPYYAK-WVQSYRDLPLKLNQWNSVV Borellia DGFSP--EFAIIKDAGGESLAEPLVLRPTSETIIWNMYSK-WIKSYRDLPLKINQWANVV Deinococcus EGFAP--ELFTVNKIGTEELAEPYVMRPTSETIIGHMWSG-WLNSYRDLPFLHYQWGSVF lMycobacterium EGFHP--ELAVVTHAGGKELSEPLVIRPTSETVIGDMMAK-WITSHRDLPLRLNQWSNVV pMycoplasma EGFNP--ELFLIEQIGTKKLHDPLVLRPTSEIAFCNLWKK-QSFSYQNLPVIYNQWTCVF gMycoplasma KGFNP--ELFLINQVGQKQLNDPLVLRPTSEIAFCNLWKK-QELSYHDLPLIYNQWTQVF Methanococcus KGFED--EVYWVTHGGKTQLDVKLALRPTSETPIYYMMKL-WVKVHTDLPIKIYQIVNTF Methanobacterium KGFED--EVYWVTHGGLSKLQRKLALRPTSETVMYPMFAL-WVRSHTDLPMRFYQVVNTF Archaeoglobus KGFED--EVYWITHGGLTPLDVKLALRPTSETAMYPMFRL-WVRNHADLPLKVYQIVNTF Pyrococcus AGFEG--EVFWITHAGHEPLDVKLILRPTSETAMYSMFAL-WIRSHADLPFKVYQIVNVY Sulfolobus KGFEE--EVFWVTKGGSTDLDVKLALRPTSEVAITTMENL-WLKSYKQLPKKYYQIVSVF Aeropyrum RGFEG--EVYWVTHGGREELDVKLALRPTSETSITYMETF-WIKSYRQLPKKYYQVVSIF . .* * . :. : Escherichia RDEVRPRFGVMRSREFL-MKDAYSFHTSQESLQETYDAMYAAYSKIFS-RMGLDFRAVQA Haemophilus RDEVRPRFGVMRSREFI-MKDAYSFHTTQESLQATYDVMYQVYSNIFN-RLGLDFRAVQA Rickettsia RDEIRPRFGVMRGREFL-MKDAYSFDINQKNAVNTYNKMYKAYMNTFR-DLGVFAIPVIA Zymomonas RDEVRPRFGVMRGREFL-MKDAYSFDIDETAGRHNYNRMFVGYLNSFS-RLGLRAIPMQA Synechocystis RDEIRPRFGLMRGREFI-MKDAYSFHSDEASLKATYGAMDQAYRNIFS-RCGLDFRPVDA tMycobacterium RDEARPRAGILRAREFV-MKDSYSFDIDAAGLKAAYHAHREAYQRIFD-RLQVRYVIVSA Aquifex RDEKRPRFGLIRAREFI-MKDAYSFDTDDMSAMISYEAMKFAYQRIFN-KLRLNVIMAEA Thermotoga RDEIRPRFGLLRAREFI-MKDAYSFHASWESLDETYEQFKKAYSRIME-RLGVRYMIIEA Bacillus RDEKRPRFGLLRGREFI-MKDAYSFHASAESLDETYQKMYEAYSNIFA-RCGINVRPVIA Treponema RDEIRPRYGLMRAREFT-MADAYSFHTDCACLARTYEKFAHAYRAIFR-RIGLSVIAVHA Chlamydia RDEIRPRFGLMRAKEFL-MEDSYTFSDSPEQMEEQYAKLRLAYQRIFD-RLNLKYVIVAA Helicobacter RDEIRPRFGLVRAREFI-MKDGYSFHEDAESLDKEFLNTQSAYKEILS-DLGLDFRIVEA 2Saccharomyces RDEIRPRGGILRGREFL-MKDAYSFASNEEDAFASFQKLDDTYNKIFK-DLKIPFVSAWA Candida RNEKRPRGGLLRGKEFL-MKDAYSFDLNESEAMKTYEKVVGAYHKIFQ-DLGIPYVKAEA Drosophila RWEFKQPTPFLRTREFL-WQEGHTAFADKEEAAKEVLDILDLYALVYTHLLAIPVVKGRK Homo RWEFKHPQPFLRTREFL-WQEGHSAFATMEEAAEEVLQILDLYAQVYEELLAIPVVKGRK Caenorhabditis RWEFKHPTPFLRTREFL-WQEGHTAFANPADAEKEVFQILDLYAGVYTDLLAIPVVKGRK Saccharomyces RWEFKHPQPFLRTREFL-WQEGHTAHLTAKDAEEEVLQILDFYAGVYEELLAVPVVKGRK Borellia RWEKRT-RPFLRTTEFL-WQEGHTAHATEEEALEETLLILDVYKRFIEDYLAIPVFCGKK Deinococcus RAELRT-KAFLRTSEFF-WHEGHTAHADEAEARAEVRQQLDLYHEFCRDVLALPVVRGEK lMycobacterium RWELRP-RMLLRTIEFL-WQEGHSAHIEKSDALRETLFALDIYTTLARDMAAIPIVSGEK pMycoplasma RAEKNT-RPFLRNSEFY-WQETHGLFSDGVNSESAAIAFWKLYQDIIVNQLCIPAFVGLK gMycoplasma RAEKNT-RPFLRNSEFY-WQETHGLFVDQSQSEQAAISFWNLYQDLIINKLCIPAFVGLK Methanococcus RYETKHTRPLIRLREIMTFKEAHTAHSTKEEAENQVKEAISIYKKFFD-TLGIPYLISKR Methanobacterium RYETKHTRPLIRVREITTFKEAHTIHATASEAEEQVERAVEIYKEFFN-SLGIPYLITRR Archaeoglobus RYETKHTRPLIRLREITSFKEAHTVHKDFEEAAEHVKKAIGFYKEFYD-FLAIPYMVIRR Pyrococcus RYETKHTRPLIRVREISRFFEAHTAHADFEDAERQIKEDLEIFDNLMK-RLAIAYIISKR Sulfolobus RYETKATRPMIRLREITTFKEAHTVHETYDDAQKQVEEAIEIYKKIFD-TLTIPYVLSER Aeropyrum RYETKATRPMIRLREVTTFKEAHTVHESFEDAERQVLEAIEVYKAIFD-RLLIPYVISKR * * . .:* *. : : : : Escherichia DTGS--IGGSASHEFQVLAQSGEDDVVFSDTSDYAANIELAEAIAP----KEPRAAATQE Haemophilus DTGS--IGGSASHEFQVLASSGEDDVVFSTESDFAANIELAEAIAI----GE-RQAPTAE Rickettsia DNGP--IGGNLSHEFHIVAETGESTIYYDKR----------------------------- Zymomonas DTGP--IGGDLSHEFIVLAPNGERHVFYHSN----------------------------- Synechocystis DSGA--IGGSGSQEFMVLADAGEDEILYTEDGLYSANVEKAVSLAP-----DAKPSPFSG tMycobacterium VSGA--MGGSASEEFLAESPSGEDAFVRCLESGYAANVEAVVTARP----DTLPIDGLPE Aquifex DVGQ--IGGKMSHEFIAFTDYGEAKVAYCENCGYAANAEIVPLP------KPEEEKEEEK Thermotoga ETGA--IGGNASHEFVVPAKIGETNVLFCEKCGYQASDEKAEYKG-----EYTQEQEEEK Bacillus DSGA--MGGKDTHEFMALSAIGEDTIAYSDESQYAANIEMAEVLH-----QEVPSDEEPK Treponema HLGA--MGGQESEEFMVESAVGDNTLLLCPHCTYAANCEKAVGQRPLPDTHDTHLKDEHE Chlamydia DGGK--IGKGKSEEFHVLCSLGEDTICVSGS--YGANVEAAQAIPP----SYVYDSNLLP Helicobacter DSGA--IGGSKSREFVVLTECGEDTIVVCQNCDYAANIEIAKRSKR----PEPLNVPKAQ 2Saccharomyces DSGD--IGGEFSKEFHLIHESGEDTLMSCKHCGDISTLDMSQSYPE-------------- Candida DSGD--IGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYP--------------- Drosophila TEKEKFAGGDYTTTVEAFISASGRAIQGATSHHLGQNFSKMFEIVYEDP----------- Homo TEKEKFAGGDYTTTIEAFISASGRAIQGGTSHHLGQNFSKMFEIVFEDP----------- Caenorhabditis SEKEKFAGGDFTTTVEAYVACNGRGIQGATSHHLGQNFSKMFDISYEDP----------- Saccharomyces TEKEKFAGGDFTTTCEGYIPQTGRGIQGATSHHLGQNFSKMFNLSVENP----------- Borellia SEKEKFAGAVSTYSIEALMQDK-KALQAATSHYLGLNFAKAFDVKFQD------------ Deinococcus TASERFAGAVATYSIEGMMRDG-KALQSGTSHYLGQNFSRAFDVKYQT------------ lMycobacterium TAGERFAGALNTYTIEAMMRDG-KALQSATTHYLGDNFARAFNIRYTT------------ pMycoplasma SPNERFAGAQNTWTVESIMPDG-QALQCATSHDLGQTFTKPFGLTFQN------------ gMycoplasma SESEKFAGAKNTWTIEAIMPDG-QSLQCATSHDLGDTFTKSFTISYQS------------ Methanococcus PEWDKFPGAEYTMAFDTIFPDG-RTMQIATVHNLGQNFSKTFEIIFET------------ Methanobacterium PPWDKFPGSEYTVAFDTLMPDG-KTLQIGTVHNLGQTFARTFEIKFET------------ Archaeoglobus PEWDKFPGAAYTIAFDTIMPDG-RTLQIGTVHHLADNFARTFDIKYEA------------ Pyrococcus PEWDKFPGAFYSLGAEVVMPDG-RTLQIGTMHNYKQNFAKAYNILYEK------------ Sulfolobus PEWDRFAGALHTYAFDTIMPDG-RAMQIGTVHHLGQNFSKALDFKIQK------------ Aeropyrum PEWDKFAGALYTIAFDTIMPDG-RALQIGTVHHLGQSFTRAFDFRIQM------------ * : . Escherichia ---------MTLVDTPNAKTIA-------ELVEQFNLPIEKTVKTLLVKAVEG-SSFPQV Haemophilus ---------MCLVDTPNAKTIA-------ELVEQFNLPIEKTVKTLIVKGAD--ENQPLV Rickettsia ----------------------------------FKILKDN---------P--------- Zymomonas ----------------------------------WEQPTRH---------I--------- Synechocystis ---------YKKQSAPNTATIA-------KMCQCLDCDASNVVKNVLYQAVYN-SGKAVL tMycobacterium ---------AVVHDTGDTPTIASLVAWANEADLGRTVTAADTLKNVLIKVRQP-GGDTEL Aquifex --------PMEKVHTPNVHTIE-------ELSKFLDVHPSKIMKAVLYIVNEK-----EP Thermotoga --------PLKKVPTPGVKTIE-------EVSEFLGVPPSKIVKSLLYKGRE------GY Bacillus --------ALEKVHTPNVKTIE-------ELTAFLQVSAEACIKSVLFKADD------RF Treponema GSDLKTPAAMREVHTPHVKTIE-------ELEHFLHVPAHRCIKTLIYRIDTVPQAAGHF Chlamydia ---------VEEVATPNIRTVE-------DLEVFFNTPKHKILKTLVVKTRQK--DSEKF Helicobacter ---------LAKFPTPNTTSAQ-------SVAEFFKTEPYFVLKALVRKVIHK--DKETL 2Saccharomyces ----------------------------------KDGQYSGDVDCKYALTKDH---S-TL Candida ----------------------------------KEIDETIEVSVIYFTTEDK---S-TL Drosophila ------E-KTQQKKYVYQNSWG---------------ITTRTIGVMIMVHADN----QGL Homo ------K-IPGEKQFAYQNSWG---------------LTTRTIGVMTMVHGDN----MGL Caenorhabditis ------A-KEGERAFAWQNSWG---------------LSTRTIGAMVMIHGDD----KGL Saccharomyces ------LGSDHPKIFAYQNSWG---------------LSTRVIGVMVMIHSDN----KGL Borellia --------KDGKMRHVFASSWG---------------VSTRLIGALIMVHSDE----KGL Deinococcus --------REQKEEFAHTTSWA---------------ISSRIIGAIIMTHGDD----SGL lMycobacterium --------AEEQQAFVHTTSFG---------------LSTRMIGAIVMVHGDD----KGL pMycoplasma --------QANQQAIPYSFSCG---------------ISTRILGALLLTHSDD----FGL gMycoplasma --------KTNQKMTPSSFSCG---------------MSTRILGAIFLTHSDD----YGL Methanococcus --------PTGDKDYAYQTCYG---------------ISDRVIASIIAIHGDE----KGL Methanobacterium --------PEGDHEYVHQTCYG---------------LSDRVIASVIAIHGDE----SGL Archaeoglobus --------PNGEHYYAHQTCYG---------------ISERCIAALISVHGDD----LGL Pyrococcus --------EDGTHDYVHQTTFG---------------MSERLLAAVIAIHGDD----RGM Sulfolobus --------KDGSLDYPHQTSYG---------------ISDRAVASVIAIHGDD----HGP Aeropyrum --------RDERLDHPWQTSYG---------------VSDRVVASLIAVHGDD----RGL Escherichia ALL-VRGDHELNEVKAEKLP---QVASPLTFAT-------------EEEIRAVVKAGPGS Haemophilus ALI-IRGDHELNEIKAQKHP---LVADPLEFAD-------------ETEIKAKIGSGVGS Rickettsia -------DIDVEEIKG-------------------------------------------- Zymomonas -------EADFDDPKALQS----------------------------------------- Synechocystis VLVSIRGDQEVNEVKLTNEL---TKLAPHYESTNILSLTVPDEKEQQKWAAKPLPLGYIS tMycobacterium LAIGVPGDREVDDKRLGAAL---EPADYALLDDD------------DFAKHPFLVKGYIG Aquifex VLVLIRGDREIDENKLEKVL---GTDNFRLATD------------EEVQELLGTKKGFIG Thermotoga VMVLIRGDLELNEAKLKAHL---KDQSLRMATP------------EEILKDFGVPVGFIG Bacillus VLVLVRGDHEVNDIKVKNLL---HAEVVELATH------------EEVIQQLGTEPGFVG Treponema VAVCIRGDLELNESKLEALL---RVPSVVLATE------------QEVYALSGTPVGFIG Chlamydia FAICIRGDRQINLTKVASFL---QVDDCELASE------------EEILKHLHVEKGFIG Helicobacter ACFFVRGDDNLEEVKALNALNIIGANALELREAS-----------QKDLDNVGLIAGFIG 2Saccharomyces ICFYYPKDRQLNWNLALNAMDK--DIDLTLRNK------------------PN--DHVLQ Candida ICAYYPSNRVLEPKFIQNEIP---DIDLDSIN-----------------------D--LS Drosophila VLPPHVACIQAIVVPCGITVN--------------------------------TKDDERA Homo VLPPRVACVQVVIIPCGITNA--------------------------------LSEEDKE Caenorhabditis VLPPRVAAVQVIVVPVGFK----------------------------------T--ENKQ Saccharomyces VIPPRVSQFQSVVIPVGITKK--------------------------------TSEEQRK Borellia VLPPRIAPIEIIVIPIFKK-----------------------------------EDEINK Deinococcus MMPPRIAPIQVVVIPVGRK-------------------------------------DNFD lMycobacterium VLPPQVAPYQVVIVPITTG-------------------------------------NKAS pMycoplasma VLPWKVAPIQVKLYLFDKK-------------------------------------GD-T gMycoplasma VLPWYLASKQVKLYLFDKN-------------------------------------NN-P Methanococcus ILPPIVAPIQVVIVPLIFK-----------------------------------GKED-- Methanobacterium CLPPDVAAHQVVIVPIIFK-----------------------------------KAAE-- Archaeoglobus VLPFEVAPVQIVIIPILYK-----------------------------------GKEE-- Pyrococcus VLPPTIAPIQVVIVPIPKK-----------------------------------EKQE-- Sulfolobus VLPPSVAPIKVVVIPIPAK-----------------------------------NEEETQ Aeropyrum VIPPSVAPIQVVVIPITPG-----------------------------------DEEKRG Escherichia LGPVNMPIPV----------------------------VIDRTVAAMSDFAAGANIDGKH Haemophilus LGAVNLNIPA----------------------------IIDRTVALMSDFSCGANIDGKH Rickettsia ------------------------------------------------WYAAAE------ Zymomonas --IVNDHI---------------------------------------SDYAATD------ Synechocystis PGISDDYIATNKQVAD------------------KFLRLVDQTAVDLTNFATGADAVDYH tMycobacterium PKALRENNVR---------------------------YLVDPRIVDGTSWITGADQPGRH Aquifex IFNLPE----------------------------NIKVLWDNSLYGVKNLVVALNEPDWH Thermotoga PIGV------------------------------DVKKVADHSVRGLKNFVVGGMEEDTH Bacillus PVGIHQ----------------------------DVEVYADQAVKAMVNAVAGANEGDHH Treponema PVGLAQRAAAAYAARTPAFFPSAAEPASVTSDIPFFSLVADQSVMAMHNAITGALKVDTH Chlamydia PLYCPIP------------------------------CYADETTRLMTNFICANNQKDVH Helicobacter PYGLKKHVS---------------------------YIIFDEDLKEGDCLIAGANEKDFH 2Saccharomyces VYEKDNED-----------------------------IMFSKILRVMDCRLNSKSNFPDF Candida EFNHD---------------------------------ISTRIVRIMDSRLSSRSKFPDF Drosophila --------------------------------------QLLDACKALEKRLVGGG----- Homo --------------------------------------ALIAKCNDYRRRLLSVN----- Caenorhabditis --------------------------------------SLFDAVDKVTKDLVADG----- Saccharomyces --------------------------------------HIHETARSVESRLKKVG----- Borellia --------------------------------------KILDYSDCVVDALKKAE----- Deinococcus --------------------------------------QMVQEGEKLAAELRAQG----- lMycobacterium --------------------------------------EVGHAAADLARRLQAAG----- pMycoplasma --------------------------------------KTVELAQKVQTLLEQLA----- gMycoplasma --------------------------------------KTRALAFLVKDFLEKLK----- Methanococcus --------------------------------------IVMEKAKEIYEKLKGK------ Methanobacterium --------------------------------------EVMEACRELRSRLEAAG----- Archaeoglobus --------------------------------------AVMEACRKLAEKLKA------- Pyrococcus --------------------------------------IVYEYAREIEEELRTAG----- Sulfolobus --------------------------------------QVMKYSIEICEMFNKNN----- Aeropyrum --------------------------------------KVLTYTAKAAEALEKAG----- Escherichia YFGINWDRDVAT-PEVADIRNVVAGD-PSPDGQGRLLIKRGIEVGHIFQLGTKYSEALKA Haemophilus YFNVNWERDVAI-PKVFDLRNVVEGD-PSPDGKGTLQIKRGIEVGHIFQLGKKYSEAMKA Rickettsia -----------------EKHDVNKLS-SFPEG---ITRSKGIEVGHIFYIGSKYSVNMNA Zymomonas -----------------EKRDPLREA-QAGDK---LRQSRGIEVGHIFFFGTKYSKPMGF Synechocystis VTGANWSTDFTLPKLVVDVRKALAGDRPVHDPTGELKTARGIEVGHIFQLGTKYSQAMGA tMycobacterium VVGLVAGRDFTADG-TIEAAEVREGD-PSPDGAGPLVMARGIEIGHIFQLGSKYTDAFTA Aquifex YINVNPGRDFQYG-EFVDVAEVREGD-PCPKCGSPLKVRRGLELGHIFLLGTRYSEPMKA Thermotoga YVNANHPRDFKVD-EWYDLRTVVEGD-PCPVCGEPLKATKGIELGHIFKLGTKYSEAMKA Bacillus YKNVNVNRDAQIK-EFADLRFIKEGD-PSPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNA Treponema LVQVEPGRDFVPD-AVADLMLVRAGD-RCIHCGAPLYEKKGNELGHLFKLGDKYTRSMHL Chlamydia CKHVNWGRDIPLP-AFGDFLLAEAGDLCPQNGGAPYEIFQGVEVAHIFNLGTRYTESFSV Helicobacter AVGVDLKG-FEN-LVYADIVQVKESD-RCPNCQGALKYHKSLEVGHIFKLGQGYAKSLKA 2Saccharomyces PLKKYLKNNFG-QISDVSIVDAQENEICGKCEEGRLEPLKSIEVGHIFLLGNKYSKPLNV Candida PISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDL Drosophila ---------------VRCEGDYRDNY----SPGWKFNHWELKGVPLRLEVGPKDLKAQQL Homo ---------------IRVRADLRDNY----SPGWKFNHWELKGVPIRLEVGPRDMKSCQF Caenorhabditis ---------------VKAEHDLRENY----NAGWKFNHWELKGVPIRFEVGPNDLAKNQV Saccharomyces ---------------IRAFGDYNDNY----TPGWKFSQYELKGIPIRIELGPKDIEKNQV Borellia ---------------FRVEIDKDVRS----SPGFRFSSAEFKGIPIRLEVGINDVLLNSV Deinococcus ---------------LRVKVDGRDGV----TNGFKYNDWELKGVPVRIELGPRDLESGVL lMycobacterium ---------------VRTHVDARPQL----TPGWKYNEWELRGVPIRLELGPRDLEAGTT pMycoplasma ---------------IRFQFIKVEN-----QLGKQLGQGEVNGIPFQLIVD----NPQTV gMycoplasma ---------------IRFSFIEINN-----QLGKQLLKGEIEGIPLQMIVD----NEKTI Methanococcus ---------------FRVHIDDRDI-----RPGRKFNDWEIKGVPLRIEVGPKDIENKKI Methanobacterium ---------------FRVHLDDRDI-----RAGRKYYEWEMRGVPLRVEIGPRDLEKGAA Archaeoglobus ---------------FRVVLDEGED-----RPGAKYYKWELKGVPIRFEIGPRDAEKGVA Pyrococcus ---------------IRVHLDMREK-----RPGWKFYDWELKGVPVRIEVGPRDVENSTV Sulfolobus ---------------ITCLTDQDTEK----TPGEKFYIWEIKGVPIRLEIGPRELISGTV Aeropyrum ---------------LRVHVDDREWE----RPGAKFYYWEAKGVPIRVEIGLREAEQDTL : . .. Escherichia SVQGEDGRN----QILTMGCYGIGVTRVVAAAIEQNYDERGIVWP----DAIAPFQVAIL Haemophilus TVQGEDGKP----LVMTMGCYGIGVTRVVASAIEQHHDERGIIWPS---DEIAPFTVAIV Rickettsia LINDEYGKL----IPVEMSSYGIGISRLAAAIIEANCDKKGIIWP----CSVAPFKVSLI Zymomonas TLPGPDGKP----IPIQMGSYGIGISRLLGAIIEASHDDNGIIWP----EAVAPYHVGLI Synechocystis TFTNEQGEE----KPLVMGCYGIGVSRLAQAAVEQSYDKDGIIWP----TAIAPYEVVIV tMycobacterium DVLGEDGKP----VRLTMGSYGIGVSRLVAVVAEQHHDELGLRWP----STVAPFDVHLV Aquifex YFTDRDGKE----KPIIMGCYGIGVSRILAALVEQYHDDKGIKWP----TPVAPFELDII Thermotoga YFMDENGEM----KPFIMGCYGWGVSRTMAAVVEHFHDENGMIWP----LSIAPYTVVVD Bacillus TYLDENGRA----QPMLMGCYGIGVSRTLSAIAEQHHDEKGLIWP----KSVAPYDLHIL Treponema TFTDEQGVR----QFPLMGCYGIGLDRTLASVVENHHDTRGISWP----LAISPYAVVLI Chlamydia GFQDKNGDK----QLCWMGTYGIGVGRTLAACIEQLADNKGLVWP----LAVAPFSITIL Helicobacter SFLDKNGKE----QFFEMGCYGIGISRLLSAILEQKSDDLGCVWT----KNTAPFDVVIV 2Saccharomyces KFVDKENKN---ETFVHMGCYGIGVSRLVGAIAELGRDSNGFRWP----AIMAPYKVSIC Candida EVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWP----RSIAPWEVTVV Drosophila VAVRRDTGE-----KITIPLADVEKK-IPALLETIHESMLNKAQED-----MTSHTKKVT Homo VAVRRDTGE-----KLTVAENEAETK-LQAILEDIQVTLFTRASED-----LKTHMVVAN Caenorhabditis TAVIRHNGE-----KKQLSLEGLSKT-VKSLLDEIHTAMYNKVLAQ-----RDSHLKSTT Saccharomyces VVVRRNDSK-----KYVVSFDELEAR-IPEILEEMQGDLFKKAKEL-----FDTHRVIVN Borellia TISRRDKDRK---FKYQISLDSLISK-VKVELDLMQKDLFQRALNFRILNTKEIFRSSKD Deinococcus VVKNRHSE-----DKETLPRAEAVSG-MSARLDTIHDFLMKRATDF-----LLANTAEVD lMycobacterium VMVRRIGEK----AKQPIAIAAAPTE-LPGILEEFQRTLLERATQF-----RDDHTTLVD pMycoplasma NIFNRLTR-----VKTAYSFEQLASR-FVELVQQYHQAMYDKAKAV-----VQQKVVQAT gMycoplasma NIFNRLTR-----LKTSLTFANLQTE-FVNLVNNYHTEMYRKANDL-----VEQKLARVQ Methanococcus TLFRRDTME-----KFQVDETQLMEV-VEKTLNNIMENIKNRAWEK-----FENFITILE Methanobacterium VISRRDTGE-----KVTADLQGIEET-LRELMKDILENLRTRAWER-----MESEIREAE Archaeoglobus VVSFRDEKR-----KFEVPLDEVDEGKVLEWARELKQRLRNAAAER-----MAEKVKFVE Pyrococcus VLARRDKLE-----KITIKREELVDK-VRELFDDIMKYLYERANEW-----LNSHIKRVE Sulfolobus FIKRRDNFK-----SYTVRKEEAINK-IKELLNEIQEDLRRKAWED-----LKSRIEYSN Aeropyrum TIARRDTLE-----KTEVPLGEAGNR-IRELMAQIESSMRERAKSF-----FGERLLRTE Escherichia PMNMHKS--FRVQELAEKLYSELRAQGIEV---LLDDRKERP----------GVMFADME Haemophilus PMNMHKS--EAVQKYAEELYRTLQSQGVDV---IFDDRKERP----------GVMFADME Rickettsia NLNIHD---NKCVELAAKTDKELSHQNIEV---LYDDTDARP----------GSKFATHD Zymomonas NLRIDD---ENCRAIADSLYQRLEAAGIDT---LYDDRNERG----------GAKFATMD Synechocystis VPNVGD---EEQMQVAEQIYTEFQAAEVDV---LLDDRNERA----------GVKFKDSE tMycobacterium IANKDA----QARAGATALAADLDRLGVEV---LLDDRQASP----------GVKFKDAE Aquifex LLNTKD---EEMKNVAEKLYLEAEEKGIDV---IFDDREESP----------GFKFADAD Thermotoga ILNMND---AEQKQVGEKIYQVLSEKGEEV---VLDDREVSP----------GFKFKDAD Bacillus ALNMKN---DGQRELAEKLYADLKAEGYEV---LYDDRAERA----------GVKFADSD Treponema PIPHTQ---AP-YAAAEALYVQLRTRGVEV---LFDDRAERP----------GVKFADAD Chlamydia YNGGDT----EGEATALQLYQSLNTEGFEP---LLDDRNERL----------GFKLKDSD Helicobacter VSNWKD---EAQKKLAFEVYERLLQKGVDA---LLDDRDARF----------GAKMRDFE 2Saccharomyces TGPNNPENSQRLQDVKSELLNDPTMQNLQN--DILDQFNEKL--------GIGARIKLSH Candida EVSKQ----KQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSD-SMGKKLKQSD Drosophila NW--TD---FCGFLEQKN-ILLAPFCGEISCEDKIKADSARGEEAEPG-----APAMGAK Homo TM--ED---FQKILDSGK-IVQIPFCGEIDCEDWIKKTTARDQDLEPG-----APSMGAK Caenorhabditis CI--EE---FKKLLDEKC-IILSPFCGRPDCEEEIKKASTR-EDGE-------GAQMGAK Saccharomyces EW--SG---FVPALNKKN-VILAPWCGVMECEEDIKESSAKKDDGEEFEEDDKAPSMGAK Borellia SY--ET---FKAYVNDYSGFVLSCWCGSLNCENIIKNETK------------------AT Deinococcus SY--DA---FQREIEAGH-WVRAYHCGEPACEKSIKEDTK------------------AT lMycobacterium NW--DA---FATTVATG--WALAIHCGNPECEEDIKAETA------------------AT pMycoplasma TL--KQ---IEQAFNDKK-AVLCAVRLTDTLEQQLKERYQ------------------VT gMycoplasma TL--KE---IEQAFKNKK-AVLCTVKLTGELEQHLKTKYQ------------------VS Methanococcus DINPDE---IKNILSEKRGVILVPFK-EEIYNEELEEKVEAT----------------IL Methanobacterium TL--EE---ASRIVDEKRGIISFMWCGEEECGMDVEEKVRVD----------------IL Archaeoglobus NT---------GEIEEWGGVVAVYLCSDEDCGHSVEEHGKS-----------------LL Pyrococcus TL--EE---AKKAFEDRRGIVEIPWCGEESCGLKMEEELDAK----------------ML Sulfolobus DI--EK---AKKILGNNSGIVEVPWCGSNECGLKIEELTNAR----------------VL Aeropyrum SL--EE---ARDWVEGRRGIAEIPWCGRESCGLEMEERVNGK----------------VL . Escherichia LIGIPHTIVLGDRNLDNDDIEYKYRRNGEKQLIKTGDIVEYLVKQIKG------------ Haemophilus LIGVPHMVVIGEKNLDNGEIEYKNRRTGEKEMISKDKLLSVLNEKLGNL----------- Rickettsia LIGSPYQIIIGPKKAANNIVELKDRKTGVLEDIEVENIINYIKNIDSI------------ Zymomonas LIGLPWQVVIGPKGAEKGVIELKNRASGEKQTISVEDAFNLLTAGHQQR----------- Synechocystis LIGIPYRVVTG-KSLKQGQLEVVKRADKSVQNLAIAAVVPTLTAWIKAEKKTS------- tMycobacterium LLGMPWIVVVG-RGWADGVVELRDRFSGQTRELVAGASLATDIAAAVTG----------- Aquifex LVGFPYRIVVG-KKVKEGKVEVQSRHTGEKWDVEIEKAIDFVKEKIEEDKK--------- Thermotoga LIGFPIRINVG-RSLKEGVVELKKRYSKELVKVNIKNGFGALLETLEKMKREYDPKEAVR Bacillus LIGLPIRITVG-KRADEGIVEVKIRQTGESTEISVDELSAFISKQ--------------- Treponema LIGIPLRVVLS-AKTLP-RVECTTRCGAHTYFFTQEEASEHIARLLEQLASPESS----- Chlamydia LLGIPYKLIIGKSFQSTGLLEIESR-SGEKCNVSPENLLDWCSKNLPCHTRKIPPLREQN Helicobacter LIGERLALIIGKQTLESKEFECIKRANLEKQTIKDIELEEKILEMLESE----------- 2Saccharomyces AMGIPLCVIVGSKSWPNVEIEVRG-IRWGEKDLWRKQFEKRCSELQWKCTKNEHG-IEKH Candida LLGIPLSIILGN-QYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKH Drosophila SLCIPFDQPA--PIAASDKCINPSCTNKPKFYTLFGRSY--------------------- Homo SLCIPFKPLC--ELQPGAKCVCG--KNPAKYYTLFGRSY--------------------- Caenorhabditis TLCIPLDQPK--QELP-SKCLFPSCTYNAKAFALFGRSY--------------------- Saccharomyces SLCIPFDQPV--LNEG-QKCIK--CERIAVNYCMFGRSY--------------------- Borellia IRCIPDDFKA--RDLTGMTCIY--CSSKAKYFVLFAKSY--------------------- Deinococcus ARNVPFDDAEFFAERGEGQCVKCGQPSAYGKRVLFGRQY--------------------- lMycobacterium PRCVPRQGAP-----ATGRCIRCDAPSAYDKRVIFARAY--------------------- pMycoplasma VRCCLEQLQK-----P-QICPFS--GESAQDYVLIARAY--------------------- gMycoplasma VRCVFKKSDV-----T-QNCPFT--NQPCFDSVLIARAY--------------------- Methanococcus GET--EYK--------GNKYIAIA--KTY------------------------------- Methanobacterium GIQ--EEG--------SGTCINCG--REAPTGLTLPEHIS-------------------- Archaeoglobus GWF--EEVPDWLDLEPEGKCVVCG--REGRLAALAKTY---------------------- Pyrococcus GIPYPEEKAKAPE---GSRCPVCG--RDAKFIARFARTY--------------------- Sulfolobus G--YPIEKRE--V---NDKCVICK--MNAKTVLRIAKTY--------------------- Aeropyrum GTPWPEEPVE--E---GKRCPLCG--RPAVAWIRLAKTY--------------------- Escherichia ------------------ Haemophilus ------------------ Rickettsia ------------------ Zymomonas ------------------ Synechocystis ------------------ tMycobacterium ------------------ Aquifex ------------------ Thermotoga ------------------ Bacillus ------------------ Treponema ------------------ Chlamydia ------------------ Helicobacter ------------------ 2Saccharomyces TVPIQHLAEVIGVLLKDM Candida YIHKDGLVTVVNSLLNDM Drosophila ------------------ Homo ------------------ Caenorhabditis ------------------ Saccharomyces ------------------ Borellia ------------------ Deinococcus ------------------ lMycobacterium ------------------ pMycoplasma ------------------ gMycoplasma ------------------ Methanococcus ------------------ Methanobacterium ------------------ Archaeoglobus ------------------ Pyrococcus ------------------ Sulfolobus ------------------ Aeropyrum ------------------