CLUSTAL X (1.64b) multiple sequence alignment Caenorhabditis_elegans IQRVLVANRGEIAIRVQNTARKMGIETVAVFSDADRNSLFVKKADKAYHI Mycobacterium_tuberculosis FDTVLVANRGEIAVRVIRTLRRLGIRSVAVYSDPDVDARHVLEADAAVRL 2Homo_sapiens FDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCV 2Caenorhabditis_elegans FDKILIANRGEIACRVIKTARAMGIKTVAVHSDVDSNSLHVKMADEAVCV Leishmania_major FDKVLVANRGEIACRVMATCQRLGIKTVAVYSTADEQAKHVKVADEGVCI 2Bacillus_subtilis FTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKAATEAYLI Chlamydia_trachomatis MKKVLIANRGEIAIRIIRACHDLGLATVAVYSMADQEALHVLLADEAVCI Helicobacter_pylori LSRILIANRGEIALRAIQTIQEMGKESIAIYSIADKDAHYLNTANAKVCI Escherichia_coli LDKIVIANRGEIALRILRACKELGIKTVAVHSSADRDLKHVLLADETVCI Haemophilus_influenzae LEKVVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETICI Pseudomonas_aeruginosa LEKVLIANRGEIALRILRACKELGIKTVAVHSTADRELMHLSLADESVCI Synechocystis_sp. FAKILIANRGEIALRIIHSCEELGIPTVAVHSTIDRHALHVQLANESVCI Synechococcus_PCC7942 FNKILIANRGEIALRILRTCEELGIGTIAVHSTVDRNALHVQLADEAVCI Synechocystis_sp2 FDKILIANRGEIALRILRACEEMGIATIAVHSTVDRNALHVQLADEAVCI Glycine_max -DKILIANRGEIAVRVIRTAHELGIPCVAVYSTIDKDALHVKLADEAVCI Arabidopsis_thaliana GDKILVANRGEIAVRVIRTAHEMGIPCVAVYSTIDKDALHVKLADEAVCI Deinococcus --KILIANRGEIALRVIRTAREMGIQTVVVYSTADEKSLPVLLADESVCV Bacillus_subtilis IKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQMADEAFCI Archaeoglobus_fulgidus FSKILVANRGEIAVRVMRACRELGIKTVGVYSSADKRAFHRVYADECYYI Methanobacterium_thermoautotro FSKILVANRGEIAIRVMRACRELGIKSVAVYSEADKNALFTRYADEAYEI Methanococcus_jannaschii FNKVLIANRGEIAIRIIRACWELGIKTVAVYSEADKRSLHATLADEAYCI Aquifex_aeolicus FKRVLIANRGEIAVRAIRACRELGLKTVAIYSEADKNSLHVELADEAICI 2Aquifex_aeolicusgi|2983860 FRKVLVANRGEVAVRIIRACKELGIKTVAIYSEADVRSLHVKKADEAYLI 3Aquifex_aeolicus FNKVLVANRGEIAVRIIRACKELGIPTVAIYNEVESTARHVKLADEAYMI Sulfolobus_metallicus FGKVLVSNRGEIAVSVMKRIKEMGMKAVAVYSEADKYALHVKYADEAYYI Homo_sapiens IKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLI Aedes_aegypti IRSVLVANRGEIAIRVFRACNELGIRSVAVYSEQDKMHMHRQKADESYMV Saccharomyces_cerevisiae KNKILVANRGEIPIRIFRSAHELSMRTIAIYSHEDRLSMHRLKADEAYVI Bacillus_stearothermophilus IRKVLVANRGEIAIRVFRACTELGIRTVAIYSKEDVGSYHRYKADEAYLV Rhizobium_etli ISKILVANRSEIAIRVFRAANELGIKTVAIWAEEDKLALHRFKADESYQV 2Mycobacterium_tuberculosis ISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFAL ::::**.*:. . : : : * : Caenorhabditis_elegans GPP-------LAAESYLNMDKIINSALRSGAQAIHPGYGFLSENAGFAEK Mycobacterium_tuberculosis GPA-------PARESYLDIGKVLDAAARTGAQAIHPGYGFLAENADFAAA 2Homo_sapiens GPA-------PTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARC 2Caenorhabditis_elegans GEA-------PTAKSYLRADRILQAVEDTGAQAVHPGYGFLSENTKFAAE Leishmania_major GPP-------ASVESYLCIDKIVDACKKTGAQAVHPGYGFLSENGEFQAA 2Bacillus_subtilis GES-------RVSESYLNIERIIKTAKKAKADAIHPGYGLLSENSRFAER Chlamydia_trachomatis GEA-------QAAKSYLKIANILAACEITGVDAVHPGYGFLSENANFASI Helicobacter_pylori GGA-------KSSESYLNIPAIISAAELFEADAIFPGYGFLSENQNFVEI Escherichia_coli GPA-------PSVKSYLNIPAIISAAEITGAVAIHPGYGFLSENANFAEQ Haemophilus_influenzae GPA-------PSAKSYLNIPAIIAAAEVTGADAIHPGYGFLSENADFAEQ Pseudomonas_aeruginosa GPA-------PATQSYLQIPAIIAAAEVTGATAIHPGYGFLAENADFAEQ Synechocystis_sp. GPP-------PSNKSYLNIPNIIAAALTRNATAIHPGYGFLAENARFAEI Synechococcus_PCC7942 GEA-------ASSKSYLNIPNIIAAALTRNASAIHPGYGFLAENARFAEI Synechocystis_sp2 GEP-------ASAKSYLNIPNIIAAALTRNASAIHPGYGFLSENAKFAEI Glycine_max GEA-------PSSQSYLLIPNVLSAAISRRCTMLHPGYGFLAENAVFVEM Arabidopsis_thaliana GEA-------PSNQSYLVIPNVLSAAISRGCTMLHPGYGFLSENALFVEM Deinococcus GPP-------ASNQSYLNIPNILSAALMTGAEAIHPGYGFMAENPDFAEM Bacillus_subtilis GPK-------ASKDSYLNVTNIVSVAKLTGTDAIHPGYGFLAENADFAEL Archaeoglobus_fulgidus GKA-------DPRDSYLNIDRIIEVAKKSGAEAIHPGYGFLAENAEFAER Methanobacterium_thermoautotro GKP-------APSQSYLRIDRILEVAEKAGAEAIHPGYGFLAENPRLGEE Methanococcus_jannaschii GPA-------PAAKSYLNIDAILNVAEKAKVDAIHPGYGFLAENAEFARA Aquifex_aeolicus GPP-------DPSKSYLDIPRIMSALEVSKADAVYPGYGFLSENPKFAEI 2Aquifex_aeolicusgi|2983860 T-G-------DPIRAYLDYVRIVDLAKQVGADAIHPGYGFLAENADFARY 3Aquifex_aeolicus G-T-------DPLDTYLNKQRIINLALEVGADAIHPGYGFLAENAEFAKM Sulfolobus_metallicus GPA-------PSIESYLNIERIIDAAEKAHADAVHPGYGFLSERADFAEA Homo_sapiens GRG------LAPVQAYLHIPDIIKVAKENNVDAVHPGYGFLSERADFAQA Aedes_aegypti GKG------LAPVEAYLSIPEIIRVCKENDVDAVHPGYGFLSERSDFAQA Saccharomyces_cerevisiae GEEG----QYTPVGAYLAMDEIIEIAKKHKVDFIHPGYGFLSENSEFADK Bacillus_stearothermophilus GEG------KKPIEAYLDIEGIIEIAKAHDVDAIHPGYGFFSENIQFAKR Rhizobium_etli GRGPHLARDLGPIESYLSIDEVIRVAKLSGADAIHPGYGLLSESPEFVDA 2Mycobacterium_tuberculosis GGQ-------TSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQA :** :: :.****:::* : Caenorhabditis_elegans CAQAGLVFIGPPAQAIRDMGAKNVSKQIMEDAKVPVVKGFH-GEDQSDAN Mycobacterium_tuberculosis CERARVVFLGPPARAIEVMGDKIAAKNAVAAFDVPVVPGVA-RAGLTDDA 2Homo_sapiens LAAEDVVFIGPDTHAIQAMGDKIESKLLAKKAEVNTIPGFD-GVVKDAEE 2Caenorhabditis_elegans LEKAGAKFIGPNSKAILDMGDKIHSKKIATAARVSMIPGYD-GEIADEDM Leishmania_major LHKNNIIFVGPDAHSIEAMGDKIESKRLAHSAGVTCIPGFI-GEVKTHED 2Bacillus_subtilis CKQENIVFIGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVS-ESLGDIEA Chlamydia_trachomatis CESCGLTFIGPSAESIATMGDKVAAKQLAKKIKCPVIPGSE-GVVKDEVE Helicobacter_pylori CSHHSLEFIGPSAKVMALMSDKAKAKIVMKEAGMPVIEGSD-GLLKSYQE Escherichia_coli VERSGFIFIGPKAETIRLMGDKVSAIAAMKKAGVPCVPGSDGPLGDDMDK Haemophilus_influenzae VERSGFTFIGPTADVIRLMGDKVSAIKAMKKAGVPCVPGSDGPVSNDIAK Pseudomonas_aeruginosa IERSGFTFVGPTAEVIRLMGDKVSAKDAMKRAGVPTVPGSDGPLPEDEET Synechocystis_sp. CADHQITFIGPSPEAITAMGDKSTAKKTMQKSGVPCVPGSP-GLIESEAT Synechococcus_PCC7942 CADHHLTFIGPSPDSIRAMGDKSTAKETMQRVGVPTIPGSD-GLLTDVDS Synechocystis_sp2 CADHHIAFIGPTPEAIRLMGDKSTAKETMQKAGVPTVPGSE-GLVETEQE Glycine_max CREHGINFIGPNPDSIRVMGDKATARETMKKAGVPTVPGSD-GLLQSTEE Arabidopsis_thaliana CRDHGINFIGPNPDSIRVMGDKATARETMKNAGVPTVPGSD-GLLQSTEE Deinococcus CREHGIVFIGPTPESMRALGSKAGGREIAAQSNVPTVPGT--GVLESVDA Bacillus_subtilis CEEVNVTFVGPSPDAISKMGTKDVARETMKQAGVPIVPGSQ-GIIENVEE Archaeoglobus_fulgidus CEEEGIVFIGPSPEVIRIAGSKVRSRESMQRAGVPVIPGSP-K-IDTVDE Methanobacterium_thermoautotro CEKQGIKLIGPKGSVIEAMGDKITSKKLMKKAGVPVIPGTD-QGVSDPDE Methanococcus_jannaschii VKKAGFEFIGPNPDAIEAMGSKINAKKIMKKAGVPLIPGSE-GAIEDIDE Aquifex_aeolicus VEKSGAKFIGPRSEVLAKIGDKVLAKKVAKEVGLPLVPGSD--EPLEFSE 2Aquifex_aeolicusgi|2983860 CRRRGITFIGPTPEQIEMFGDKVKAKKVMKEVGLPTIPGTE-EPVRTLED 3Aquifex_aeolicus CEEAGITFIGPHWKVIELMGDKARSKEVMKKAGVPVVPGSD-GVLKSLEE Sulfolobus_metallicus VEKAGMTFIGPSSEVMNRVKSKLDGKRIAKEAGTPIAPGSD-GPVGSLDE Homo_sapiens CQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTD-APITSLHE Aedes_aegypti VIDAGLRFIGPSPKVVQQMGDKVAARKAAIEAGVPIVPGTD-GPVTTKEE Saccharomyces_cerevisiae VVKAGITWIGPPAEVIESVGDKVSARHLAARANVPTVPGTP-GPIETVQE Bacillus_stearothermophilus CREEGIIFFGPNENHLDMFGDKVKARHAAVNAGIPVIPGSD-GPVDGLED Rhizobium_etli CNKAGIIFIGPKADTMRQLGNKVAARNLAISVGVPVVPATE-PLPDDMAE 2Mycobacterium_tuberculosis VIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTP-DPVKGADE .** : * . . Caenorhabditis_elegans LKKKSAEIGYPVMLKAVYGGGGKGMRIAWNEAEFEEKLASARNEAKKSFG Mycobacterium_tuberculosis LVTAAAEVGYPVLIKPSAGGGGKGMRLVQDPARLPEALVSARREAMSSFG 2Homo_sapiens AVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFG 2Caenorhabditis_elegans CVKVSRDIGYPVMIKASAGGGGKGMRVAWNDKQAREGYRLSKQEAASSFG Leishmania_major VLKFAREVGYPVMIKASGGGGGKGMRVAYNDSQCVEYYDMCREEAKAAFN 2Bacillus_subtilis ACRTASQIGYPVMLKASAGGGGIGMQRVENEEALKKAYEGNKKRAADFFG Chlamydia_trachomatis GIRIAEKIGFPIVIKAVAGGGGRGIRIVREKDEFYRAFTAARAEAEAGFN Helicobacter_pylori AEEIADKIGYPVIIKAAAGGGGRGMRVVGDKSKLKNLYLAAETEALSAFG Escherichia_coli NRAIAKRIGYPVIIKASGGGGGRGMRVVRGDAELAQSISMTRAEAKAAFS Haemophilus_influenzae NKEIAKRIGYPIIIKASGGGGGRGMRVVRSEDALEESIAMTKAEAKAAFN Pseudomonas_aeruginosa ALAIAREVGYPVIIKAAGGGGGRGMRVVYDESELIKSAKLTRTEAGAAFG Synechocystis_sp. ALKIAAEIGYPVIIKATAGGGGRGMRLVQEEKDFLKLFHAAQGEAGAAFG Synechococcus_PCC7942 AAKVAAEIGYPVMIKATAGGGGRGMRLVREPADLEKLFLAAQGEAEAAFG Synechocystis_sp2 GLELAKDIGYPVMIKATAGGGGRGMRLVRSPDEFVKLFLAAQGEAGAAFG Glycine_max AIRLANEIGFPVMIKATAGGGGRGMRLAKEPDEFVKLLQQAKSEAAAAFG Arabidopsis_thaliana AVRVANEIGFPVMIKATAGGGGRGMRLAKEPGEFVKLLQQAKSEAAAAFG Deinococcus ALLAAKQIGYPVLLKASAGGGGRGQKVIRTQEELQKGFNQAQEEARLYFG Bacillus_subtilis AVSLANEIGYPVIIKATAGGGGKGIRVARTEEELINGIKITQQEAATAFR Archaeoglobus_fulgidus AKEWAEKIGYPVAVKASGGGGGIGIVVVNSQEELEEAFRKSKKLGESYFK Methanobacterium_thermoautotro AARIADSIGYPVIIKASAGGGGIGMRAVYEEDELIRAMESTQSVAASAFG Methanococcus_jannaschii AIEIAEAIGFPVVVKASAGGGGMGMSVAYSKEELKEVIESARNIAKSAFG Aquifex_aeolicus AVKLASKIGYPVVIKAAAGGGGRGIRIIRDEKELREKFPLAKKEAESAFG 2Aquifex_aeolicusgi|2983860 AKHAVKEIGFPVMLKAAYGGGGRGMRVIRNEEELEKNFESAFREAETFFG 3Aquifex_aeolicus AKALAREIGYPVLLKATAGGGGRGIRICRNEEELVKNYEQASREAEKAFG Sulfolobus_metallicus ALKLTEKIGYPVMVKAAYGGGGIGITRADNPDQLMDIWGRNQRLAKEAFG Homo_sapiens AHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFG Aedes_aegypti ALDFCKKHGLPVIFKAAYGGGGRGMRVVRKMEEVEDNFQRASSEAKAAFG Saccharomyces_cerevisiae ALDFVNEYGYPVIIKAAFGGGGRGMRVVREGDDVADAFQRATSEARTAFG Bacillus_stearothermophilus VVAFAEAHGYPIIIKAALGGGGRGMRFVRSKSEVKEAFERAKSEAKAAFG Rhizobium_etli VAKMAAAIGYPVMLKASWGGGGRGMRVIRSEADLAKEVTEAKREAMAAFG 2Mycobacterium_tuberculosis VVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFG * *: .*. **** * . * Caenorhabditis_elegans NDEMLVEKFVEKPRHVEVQVFGDHHGNYVHLWERDCSVQRRHQKIIEEAP Mycobacterium_tuberculosis DDTLFLERFVLRPRHIEVQVLADAHGNVVHLGERECSLQRRHQKVIEEAP 2Homo_sapiens DDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAP 2Caenorhabditis_elegans DDRMLVEKFIDNPRHIEMQVLCDKHGNALWLNERECSIQRRNQKVIEEAP Leishmania_major SDKMLVEKFIENPRHIEIQVIADRRGNTLYLPERECSIQRRNQKVIEEAP 2Bacillus_subtilis DGSMYIEKVIEHARHIEVQLLADQHGHTVHLFERDCSVQRRHQKVIEEAP Chlamydia_trachomatis NPDVYIEKFIENPRHLEVQVIGDKHGNYVYLGERDCTVQRRRQKLIEETP Helicobacter_pylori DGSVYLEKFINKPKHIEVQILADKHGNVIHVGERDCSVQRRQQKLIEETP Escherichia_coli NDMVYMEKYLENPRHVEIQVLADGQGNAIYLAERDCSMQRRHQKVVEEAP Haemophilus_influenzae NDMVYMEKYLENPRHVEIQVLADTHGNAVYLAERDCSMQRRHQKVVEEAP Pseudomonas_aeruginosa NPMVYLEKFLTNPRHVEVQVLSDGQGNAIHLGDRDCSLQRRHQKVIEEAP Synechocystis_sp. NPGVYLEKFIEKPRHIEFQILADSHGNVVHLGERDCSIQRRHQKLLEEAP Synechococcus_PCC7942 NPGLYLEKFIDRPRHVEFQILADAYGNVVHLGERDCSIQRRHQKLLEEAP Synechocystis_sp2 NAGVYIEKFIERPRHIEFQILADNYGNVIHLGERDCSIQRRNQKLLEEAP Glycine_max NDGVYLEKYIQNPRHIEFQVLADKYGNVVHFGERDCSIQRRNQKLLEEAP Arabidopsis_thaliana NDGCYLEKFVQNPRHIEFQVLADKFGNVVHFGERDCSIQRRNQKLLEEAP Deinococcus DPAIIMEKFLEEFRHIEVQVMGDGQGHVIHIGERDCSIQRRNQKLIEEAP Bacillus_subtilis NPGVYIEKYIEDFRHVEIQVLADNYGNTIHLGERDCSIQRRLQKLLEESP Archaeoglobus_fulgidus DSTVYLEKYLARPRHIEVQILADQHGNVIHLGERECSIQRRHQKLIEEAP Methanobacterium_thermoautotro DPTVYIEKYLERPRHIEFQVMADESGNVIHLADRECSIQRRHQKLIEEAP Methanococcus_jannaschii DPTVFIEKYLENPRHIEIQLLGDKHGNIIHLGDRECSIQRRHQKLIEEAP Aquifex_aeolicus DGRLYIEKYVINPKHIEFQVIADEHGNVYVLGERECSIQRRHQKLIEEAP 2Aquifex_aeolicusgi|2983860 KGDLFIEKYVENPKHIEVQILGDKYGNIIHLGERDCSIQRRHQKLIEIAP 3Aquifex_aeolicus RGDLLLEKFIENPKHIEYQVLGDKHGNVIHLGERDCSIQRRNQKLVEIAP Sulfolobus_metallicus RPDLYIEKAAVRPRHIETQLIGDKYGTYVVAFERECTIQRRNQKLIEEAP Homo_sapiens NGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAP Aedes_aegypti NGAMFIEKFIERPRHIEVQLLGDKAGNVVHLYERDCSVQRRHQKVVEIAP Saccharomyces_cerevisiae NGTCFVERFLDKPKHIEVQLLADKHGNVVHLFERDCSVQRRHQKVVEVAP Bacillus_stearothermophilus SDEVYVEKLIENPKHIEVQILGDYEGNIVHLYERDCSVQRRHQKVVEVAP Rhizobium_etli KDEVYLEKLVERARHVESQILGDTHGNVVHLFERDCSVQRRNQKVVERAP 2Mycobacterium_tuberculosis RGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEEAP :*: :*:* *:: * * *:*::*** **::* :* Caenorhabditis_elegans APNMEHDTRVKLGESAVRAAAAVGYVGAGTVEFIMDPR--GEFYFMEMNT Mycobacterium_tuberculosis SPLLDPQTRERIGVAACNTARCVDYVGAGTVEFIVSAQRPDEFFFMEMNT 2Homo_sapiens SIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSK--KNFYFLEMNT 2Caenorhabditis_elegans SSFVPPEMRRKMGEQAVQLAKAVGYDSAGTVEFLVDSQ--RNFYFLEMNT Leishmania_major SVLLDAKTRKAMGEEAVAMARAVQYVSAGTVENVVNPQ--KQFYFLEMNT 2Bacillus_subtilis SPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEFIVDQK--QNFYFLEMNT Chlamydia_trachomatis SPILTPEMRAKVGKVAVDLARSAGYFSVGTVEFLLDK-E-KRFYFMEMNT Helicobacter_pylori AVVLEESVRKRLLETAIKAAKYIGYVGAGTFEFLLDSNM-KDFYFMEMNT Escherichia_coli APGITPELRRYIGERCAKACVDIGYRGAGTFEFLFE-NG-E-FYFIEMNT Haemophilus_influenzae APGITEEVRRDIGSRCANACVEIGYRGAGTFEFLYE-NG-E-FYFIEMNT Pseudomonas_aeruginosa APGIDEKARQEVFARCVQACIEIGYRGAGTFEFLYE-NG-R-FYFIEMNT Synechocystis_sp. SPFLTPHLRKKMGEAAVKAAKSINYVGAGTVEFLVDGNG-N-FYFMEMNT Synechococcus_PCC7942 SPALSADLRQKMGDAAVKVAQAIGYIGAGTVEFLVDATG-N-FYFMEMNT Synechocystis_sp2 SPALDSDLREKMGQAAVKAAQFINYTGAGTIEFLLDRSG-Q-FYFMEMNT Glycine_max SPALTPELRKAMGDAAVAAAASIGYIGVGTIEFLLDERG-S-FYFMEMNT Arabidopsis_thaliana SPALTAELRKAMGDAAVAAAASIGYIGVGTVEFLLDERG-S-FYFMEMNT Deinococcus S-TLPESLRQEILAAGVRLAQFVNYAGAGTLEFIMDRDG-N-YYFMEMNT Bacillus_subtilis SPALDSEIREQMGDAAVKAAKAVGYTGAGTVEFIYDYNE-QRYYFMEMNT Archaeoglobus_fulgidus SPALNEEMREELGKLAVKGAREIGYTNAGTFEFLYE-NG-N-FYFLEINS Methanobacterium_thermoautotro SPIMTPELRERMGSAAVKAAEYIGYENAGTVEFLYS-NG-D-FYFLEMNT Methanococcus_jannaschii SPIMTEELRERMGEAAIKAGKAINYDSAGTVEFLYE-NG-N-FYFLEMNT Aquifex_aeolicus SVSVSEEKRKEISEKVAEFCKRLGYTSAGTVEFLMDEEG-N-FYFMEMNG 2Aquifex_aeolicusgi|2983860 SPKLPQDLRMKILGNAVRAMTRVGYENAGTLEFLVDLKT-GEYYFIEMNT 3Aquifex_aeolicus SLILTPEKREYYGNIVTKAAKEIGYYNAGTMEFIADQE--GNLYFIEMNT Sulfolobus_metallicus SPALTWEKREEFIDASVKFGKKIGYFALGTMEFAYSDTT-KDLYFLELNK Homo_sapiens AAHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDRH--GKHYFIEVNS Aedes_aegypti APRLPREVRDKMTEYAVKLAKHVGYENAGTVEFLCDES--GNFYFIEVNA Saccharomyces_cerevisiae AKTFPREVRDAILTDAVKLAKVCGYRNAGTAEFLVDNQ--NRHYFIEINP Bacillus_stearothermophilus SVSLSDELRQRICEAAVQLMRSVGYVNAGTVEFLVSG---DEFYFIEVNP Rhizobium_etli APYLSEAQRQELAAYSLKIAGATNYIGAGTVEYLMDADT-GKFYFIEVNP 2Mycobacterium_tuberculosis APFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQD--GLISFLEVNT : . * * ** * *:*:* Caenorhabditis_elegans RLQVEHPVSEAITGIDFIMGDWKLSNNLISGTDLVEWQLRVAQGEKLPL- Mycobacterium_tuberculosis RLQVEHPVTEAIT-----------------GLDLVEWQLRVGAGEKLGF- 2Homo_sapiens RLQVEHPVTECIH-----------------WPGPSPGKT-VLQEHLSGT- 2Caenorhabditis_elegans RLQVEHPITECIT-----------------GIDIVQQMLRVSYGHPLPI- Leishmania_major RLQVEHPITEEIT-----------------GIDLVEQMLRAAADLPLSI- 2Bacillus_subtilis RLQVEHPVTEEIT-----------------GLDLVEQQLRIAAGHTLTF- Chlamydia_trachomatis RIQVEHTITEEVT-----------------GIDLLKAQISVAKGEKLPW- Helicobacter_pylori RLQVEHTISEMVS-----------------GLNLIEWMIKIAQGEELP-- Escherichia_coli RIQVEHPVTEMIT-----------------GVDLIKEQMRIAAGQPLSI- Haemophilus_influenzae RIQVEHPVTEMIT-----------------GVDLVKEQLRIAAGLPISF- Pseudomonas_aeruginosa RVQVEHPVSEMVT-----------------GVDIVKEMLRIASGEKLSI- Synechocystis_sp. RIQVEHPVTEMIT-----------------GYDLISEQIRIAMGEKLRF- Synechococcus_PCC7942 RIQVEHPVTEMIT-----------------GLDLIAEQIRIAQGEALRF- Synechocystis_sp2 RIQVEHPVTEMVT-----------------GVDLLVEQIRIAQGERLRL- Glycine_max RIQVEHPVTEMIS-----------------STDLIEEQIRVAMGEKLRY- Arabidopsis_thaliana RIQVEHPVTEMIY-----------------SVDLIEEQIRVAMGEKLRY- Deinococcus RIQVEHCVSEMIS-----------------SLDLVRLQIEIAAGLGLNI- Bacillus_subtilis RIQVEHPVTEMVT-----------------GTDLIKEQIKVASGMELSL- Archaeoglobus_fulgidus RLQVEHTITEVVT-----------------GIDIVKYQIRIAYGEELRH- Methanobacterium_thermoautotro RIQVEHPITEVIT-----------------GVDLVKEQIRVASGEELRF- Methanococcus_jannaschii RIQVEHTVTEQVT-----------------GIDLVKAMIKIAAGEELTL- Aquifex_aeolicus RIQVEHPVTEMVT-----------------GVDIVKLQLIAAMGEEIK-- 2Aquifex_aeolicusgi|2983860 RLQVEHTITEAIT-----------------GVDIVEAMIRIAAGEPLPY- 3Aquifex_aeolicus RIQVEHPVSEMVT-----------------GIDIVKWQIKIAAGEPLTI- Sulfolobus_metallicus RLQVEHGITELVT-----------------GIDLVKLQIRLVAGEHMPF- Homo_sapiens RLQVEHTVTEEIT-----------------DVDLVHAQIHVSEGRSLP-- Aedes_aegypti RLQVEHTVTEEIT-----------------GIDLVQSQIRVAEGMTLP-- Saccharomyces_cerevisiae RIQVEHTITEEIT-----------------GIDIVSAQIQIAAGATLT-- Bacillus_stearothermophilus RIQVEHTITEMIT-----------------GIDIVQSQILIADGCSLHSH Rhizobium_etli RIQVEHTVTEVVT-----------------GIDIVKAQIHILDGAAIGTP 2Mycobacterium_tuberculosis RLQVEHPVTEETA-----------------GIDLVLQQFRIANGEKLDI- *:**** ::* . Caenorhabditis_elegans ---K--QSEIPLNGHAFECRVYAEDTRKGAFMPTAGRLNYVDFPED---A Mycobacterium_tuberculosis ---A--QNDIELRGHAIEARVYAEDPAR-EFLPTGGRVLAVFEPAG-PGV 2Homo_sapiens ---N--KLIFAFNGWAVECRVYAEDPYKSFGLPSIGRLSQYQEPLHLPGV 2Caenorhabditis_elegans ---T--QEQVPLNGWAFESRVYAEDPYKGFGLPSVGRLSRYVEPKHVDGV Leishmania_major ---T--QDDIKINGHATECRVYAEDPMKNY-FPSIGRLTMYQEPTG-PGV 2Bacillus_subtilis ---S--QKDIQRNGHAIEVRIYAEDPKT--FFPSPGTITAFSLPDQ-KGV Chlamydia_trachomatis -----KQKNIKFKGHVIQCRINAEDPINN-FTPSPGRLDYYLPPAG-PAV Helicobacter_pylori -----KQESFSLKGHAIECRITAEDPKK--FYPSPGKITEWIAPGG-VNV Escherichia_coli -----KQEEVHVRGHAVECRINAEDP-NT-FLPSPGKITRFHAPGG-FGV Haemophilus_influenzae -----KQEDIKVKGHAMECRINAEDP-KT-FLPSPGKVNHLHSPGG-LGV Pseudomonas_aeruginosa -----RQEDVVIRGHALECRINAEDP-KT-FMPSPGKVKHFHAPGG-NGV Synechocystis_sp. -----RQSDVEIRGHAIECRINAEDPKQN-FRPHPGKISAYLPPGG-PGV Synechococcus_PCC7942 -----RQADIQLRGHAIECRINAEDPEYN-FRPNPGRITGYLPPGG-PGV Synechocystis_sp2 -----TQDQVVLRGHAIECRINAEDPDHD-FRPAPGRISGYLPPGG-PGV Glycine_max -----KQEDIVLRGHSIECRINAEDAFKG-FRPGPGRITAYLPSGG-PFV Arabidopsis_thaliana -----KQEDIVLRGHSIECRINAEDPFKG-FRPGPGRITSYLPSGG-PFV Deinococcus -----QQDDVKLHGHAIECRINAEDPDKD-FRPAAGKIDDAHFAGG-AGV Bacillus_subtilis -----KQEDVEFEGWAIECRINAENPSKN-FMPSPGEIKMYLPPGG-LGV Archaeoglobus_fulgidus -----GQEDVAIRGHAIECRINAEDP-VN-FYPRSGRILHYRSPGG-IGI Methanobacterium_thermoautotro -----TQKDINIRGHAIECRINAENPLAD-FAPNPGKITGYRSPGG-IGV Methanococcus_jannaschii -----KQEDVKIRGHAIECRINAEDPLND-FVPCPGKIKLYRSPGG-PGV Aquifex_aeolicus ------LEKVETNGFAIEFRINAEDP-VT-FIPSPGQVEKLILPGG-PGV 2Aquifex_aeolicusgi|2983860 -----LQSDITFRGYAIEFRINAEDPKKN-FAPAPGKITSYYSPGG-PGV 3Aquifex_aeolicus -----KQEDVKFNGYAIECRINAEDPKKN-FAPSTGVIERYYVPGG-FGI Sulfolobus_metallicus ---TQEELKKRLRGHAIEYRINAEDPLNN-FTGSSGFVTYYKEPSG-PGV Homo_sapiens DLGLR-QENIRINGCAIQCRVTTEDPARS-FQPDTGRIEVFRSGEG-MGI Aedes_aegypti ELGYN-QENIKTQGYAIQCRVTTEDPAND-FQPSTGRLEVFRSGEG-MGI Saccharomyces_cerevisiae QLGLL-QDKITTRGFSIQCRITTEDPSKN-FQPDTGRLEVYRSAGG-NGV Bacillus_stearothermophilus EVGIPKQEDIRINGYAIQSRVTTEDPLNN-FMPDTGKIMAYRSGGG-FGV Rhizobium_etli QSGVPNQEDIRLNGHALQCRVTTEDPEHN-FIPDYGRITAYRSASG-FGI 2Mycobacterium_tuberculosis ------TEDPTPRGHAIEFRINGEDAGRN-FLPAPGPVTKFHPPSG-PGV .* : *: *:. * : Caenorhabditis_elegans RIDTGVVS-GDEVSIHYDPMIAKVVVWGQDRAVAAAKLESALARTRISG- Mycobacterium_tuberculosis RVDSSLLG-GTVVGSDYDPLLTKVIAHGADREEALDRLDQALARTAVLG- 2Homo_sapiens RVDSGIQP-GSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRG- 2Caenorhabditis_elegans RCDSGIRE-GSEISIYYDPLICKLVTHGDNREQALNRMQEALDNYVIRG- Leishmania_major RCDSGIIE-GSQISVYYDPLICKLSTWGKDRAACIERMEKALDEYVIRG- 2Bacillus_subtilis RHECAVAK-DSTVTPFYDPMIAKMIVKGQTRTEAIEKLETALRDYRVEG- Chlamydia_trachomatis RVDGACYS-GYAIPPYYDSMIAKVITKGKNREEAIAIMKRALKEFHIGG- Helicobacter_pylori RLDSHAHA-NYVVPTNYDSMIGKLIVWGENRERAIAKMKRALKEFKVEG- Escherichia_coli RWESHIYA-GYTVPPYYDSMIGKLICYGENRDVAIARMKNALQELIIDG- Haemophilus_influenzae RWDSHVYG-GYTVPPHYDSMIAKLITYGDTREVAIRRMQNALSETIIDG- Pseudomonas_aeruginosa RVDSHLYS-GYSVPPNYDSLVGKVITYGADRDEALARMRNALDELIVDG- Synechocystis_sp. RIDSHVYT-DYEIPPYYDSLIGKLIVWAGDRPSAIKRMQRALRECAITG- Synechococcus_PCC7942 RVDSHVYT-DYEIPPYYDSLIGKLIVWGATREEAIARMQRALRECAITG- Synechocystis_sp2 RIDSHVYT-DYQIPPYYDSLIGKLIVWGPDRATAINRMKRALRECAITG- Glycine_max RMDSHVYP-DYVVPPSYDSLLGKLIVWAPTREKAIERMKRALDDTIITG- Arabidopsis_thaliana RMDSHVYS-DYVVPPSYDSLLGKLIVWAPTREKAIERMKRALNDTIITG- Deinococcus RVDTHVYS-GYSIPPHYDSLIGKLIVWHEDRDKAVSRMKRALEETVIQG- Bacillus_subtilis RVDSAAYP-GYSIPPYYDSMIAKVITYGKTRDEAIARMKRALSEFVIEG- Archaeoglobus_fulgidus RVDSGIHM-GYRIPEEYDSMISKLIAYGETREEAIARMKRALYEYIIEG- Methanobacterium_thermoautotro RVDSGVYM-NYEIPPFYDSMISKLIVWGMDRQEAINRMKRALSEYIILG- Methanococcus_jannaschii RIDSGVYG-GAEIPPYYDSMIAKLITYGNSREEAIARMKRALREYVIIG- Aquifex_aeolicus RVDTHLYQ-GYTVPPYYDSLLAKIIVWGNTRQEAIARGKRALGELKIEGK 2Aquifex_aeolicusgi|2983860 RIDASVYK-DYIIPPYYDSMIAKMTVWALTWEKAVARARRALDEFVVRG- 3Aquifex_aeolicus RVEHAAAR-GFEVTPYYDSMIAKLITWAPTWDEAVERMRAVLETYEITG- Sulfolobus_metallicus RLDTGIME-GSYVPPFYDSLVAKLMVYGENRARAIEVGRRALRDLQIGG- Homo_sapiens RLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRG- Aedes_aegypti RLDSASAYAGAIISPYYDSLLVKVISHASDLQSSAAKMNRALREFRIRG- Saccharomyces_cerevisiae RLDGGNAYAGATISPHYDSMLVKCSCSGSTYEIVRRKMIRALIEFRIRG- Bacillus_stearothermophilus RLDAGNGFQGAVITPYYDSLLVKLSTWALTFEQAARKMLRNLRTFRIRV- Rhizobium_etli RLDGGTSYSGAIITRYYDPLLVKVTAWAPNPLEAISRMDRALREFRIRG- 2Mycobacterium_tuberculosis RVDSGVET-GSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGVEG- * : . : :*.:: * * : Caenorhabditis_elegans -LPTNIDFVRRVLAHPEFA----AGNVYTDFIPDHQKELFAESETPAEIY Mycobacterium_tuberculosis -VQTNVEFLRFLLADERVR----VGDLDTAVLDERSADFTAR-PAPDDVL 2Homo_sapiens -VTHNIALLREVIINSRFV----KGDISTKFLSDVYPDGFKGHMLTKSEK 2Caenorhabditis_elegans -VTHNIPLLRDIVQEKRFR----TGDITTKYLPEVYPEGFQGTSLSPKEQ Leishmania_major -LRHNICLLRDVVTEPRYQ----SGNLTTNYLPEQYPNGFKKAELTAEE- 2Bacillus_subtilis -IKTNLPLLIQAAATKAFK----EGDVTTDFLKQHL-------------- Chlamydia_trachomatis -VHSTIPFHQFMLDNPKFL----LSDYDINYVDQLLASGSTFLNLADGS- Helicobacter_pylori -IKTTIPFHIEMLENADFR----QAKIHTKYLEENF-------------- Escherichia_coli -IKTNVDLQIRIMNDENFQ----HGGTNIHYLEKKLGLQEK--------- Haemophilus_influenzae -IKTNIPLHELILEDENFQ----KGGTNIHYLEKKLGMNE---------- Pseudomonas_aeruginosa -IKTNTELHKDLVRDAAFC----KGGVNIHYLEKKLGMDKH--------- Synechocystis_sp. -VPTTLEFHQRILQTPAFL----AGDVYTNFI----EEHLTP-------- Synechococcus_PCC7942 -LPTTLSFHQLMLQMPEFL----RGELYTNFV----EQVMLP--RILKS- Synechocystis_sp2 -LPTTIGFHQRIMENPQFL----QGNVSTSFV----QEMNK--------- Glycine_max -VPTTIDYHKLILDIEDFR----NGKVDTAFIPKHEEELAMPPQKMVLAN Arabidopsis_thaliana -VPTTINYHKLILDVEDFK----NGKVDTAFIVKHEEELAEP-QEIVA-- Deinococcus -PKTTIPLYIKIMDNPFYK----RGAVMTNFLK----------------- Bacillus_subtilis -IETTIPFHLKLLEHETFV----SGEFNTKFLETYDVMGS---------- Archaeoglobus_fulgidus -VETNIPFHFAVLNDEEFV----RGNIHTKFVEE--RNIAEKVKEYLRIF Methanobacterium_thermoautotro -VKTTIPFHKAIMRNEAFR----RGELHTHFVDEYRRGIDAEMRKIVKED Methanococcus_jannaschii -VKTNIPFHRAVLEEENFL----KGNISTHYVEQNMHKLREKMVKYALES Aquifex_aeolicus GLKVNTEFHLRVLDQKEFI----EGKHDITFVERIMV------------- 2Aquifex_aeolicusgi|2983860 -VPTNIPLYREIVRDPDFL----KGDFGTRFLEEKIAKGEYDFEIEGEKP 3Aquifex_aeolicus -VKTTIPLLINIMKEKDFK----AGKFTTKYLEEHPEVFEYEEHKD---- Sulfolobus_metallicus -IKTTIPLYKLIMDDEDYQ----NGNFTTAYIADKSEIFTKKLREKEML- Homo_sapiens -VKTNIAFLQNVLNNQQFL----AGTVDTQFIDENPELFQLRPAQNRAQK Aedes_aegypti -VKTNIPFLLNVLENQKFL----NGVLDTYFIDEHPQLFRFAKSKNRAQK Saccharomyces_cerevisiae -VKTNIPFLLTLLTNPVFI----EGTYWTTFIDDTPQLFQMVSSQNRAQK Bacillus_stearothermophilus -FKTNIPFLENVVQHPKFL----SGEYDTSFIDTTPELFVFPRRKDRGTK Rhizobium_etli -VATNLTFLEAIIGHPKFR----DNSYTTRFIDTTPELFQQVKRQDRATK 2Mycobacterium_tuberculosis -LATVIPFHRAVVSDPAFIGDANGFSVHTRWIETEWNNTIEPFT------ : Caenorhabditis_elegans - Mycobacterium_tuberculosis A 2Homo_sapiens - 2Caenorhabditis_elegans - Leishmania_major - 2Bacillus_subtilis - Chlamydia_trachomatis - Helicobacter_pylori - Escherichia_coli - Haemophilus_influenzae - Pseudomonas_aeruginosa - Synechocystis_sp. - Synechococcus_PCC7942 - Synechocystis_sp2 - Glycine_max - Arabidopsis_thaliana - Deinococcus - Bacillus_subtilis - Archaeoglobus_fulgidus - Methanobacterium_thermoautotro - Methanococcus_jannaschii - Aquifex_aeolicus - 2Aquifex_aeolicusgi|2983860 - 3Aquifex_aeolicus - Sulfolobus_metallicus - Homo_sapiens - Aedes_aegypti - Saccharomyces_cerevisiae - Bacillus_stearothermophilus - Rhizobium_etli - 2Mycobacterium_tuberculosis -