CLUSTAL W (1.7) multiple sequence alignment B_Saccharomyces ------------------------------------------------------------ B_Homo -----------------------------------------------------------M B_Cyanidium ------------------------------------------------------------ B_Arabidopsis ------------------------------------------------------------ BCryptosporidium ------------------------------------------------------------ B_Halobacterium ------------------------------------------------------------ B_Methanosarcina ------------------------------------------------------------ B_Methanocaldococcus ------------------------------------------------------------ BPyrobaculum ------------------------------------------------------------ BGiardia ------------------------------------------------------------ alphaChlorobium ------------------------------------------------------------ alphaGeobacter ------------------------------------------------------------ alphaAquifex ------------------------------------------------------------ alpha_Thermoto ------------------------------------------------------------ alphaEnterococcus_hirae ------------------------------------------------------------ alpha_Sacchar ---------------------------------MLARTAAIRSLSRTLINSTKAARPAAA alpha_acetiv ------------------------------------------------------------ APyrobaculum ------------------------------------------------------------ ASulfolobu ------------------------------------------------------------ A_Maceti ------------------------------------------------------------ AHalobacte ------------------------------------------------------------ AjMethanoc ------------------------------------------------------------ AEnterococ ------------------------------------------------------------ AArabidops ------------------------------------------------------------ ACyanidium ------------------------------------------------------------ A1Homo1_Ho ------------------------------------------------------------ ASaccharomy ------------------------------------------------------------ AGiardia ------------------------------------------------------------ beta_ArabidopsisM MTMITPSSNTTHYRESWYACRYRSGIPGSTHASVASRRVLSSLLRSSSGRSAAKLGNRNP AArabidopsis ------------------------------------------------------------ AMus ------------------------------------------------------------ AHalobacterium ------------------------------------------------------------ ANeurospora ------------------------------------------------------------ APlasmodium ------------------------------------------------------------ ATrypanosoma ------------------------------------------------------------ ASulfolobus ------------------------------------------------------------ AMethanosarcina ------------------------------------------------------------ AjMethanoccus ------------------------------------------------------------ betE.coli ------------------------------------------------------------ beta_human --------------------------------------MLGFVGRVAAAPASGALRRLTP beta_Sacchar ------------------------------------------------------------ beta_Thermoto ------------------------------------------------------------ beta_Enteroc ------------------------------------------------------------ beta_aquifex ------------------------------------------------------------ beta_Cyanidium ------------------------------------------------------------ beta_Macetiv ------------------------------------------------------------ BMus ---------------------------------------------------MALRAMRGI BNeurospora ------------------------------------------------------------ BbMethanosarcina ------------------------------------------------------------ BSulfolobus ------------------------------------------------------------ alpE.coli ------------------------------------------------------------ alpAquifex ------------------------------------------------------------ flEcoli ------------------------------------------------------------ flAquifex ------------------------------------------------------------ B_Saccharomyces ----------MVLSDKELFAINKKAVEQGFNVKPRL------------------NYNTVS B_Homo EIDSRPGGLPGSSCNLGAAREHMQAVTRNYITHPRV------------------TYRTVC B_Cyanidium ---------------MEAFNLHKKAVSRDYIVKPRL------------------EYRTVS B_Arabidopsis -------------MSLSVNMGTNDLDIEEGTLEIGM------------------EYRTVS BCryptosporidium -----------MVTSGQAYEANVAAVTRNYNIAPRM------------------EYRTVS B_Halobacterium ----------------------------------MK------------------EYQTIT B_Methanosarcina ---------------------------------MVK------------------EYKTIT B_Methanocaldococcus ----------------------------MATAASAI------------------EYSSVK BPyrobaculum ------------------------------MLTPVV------------------SYTTVR BGiardia -------------------MSLATNITPTPKIHPLP------------------CYSSIS alphaChlorobium --------MSTAVRPDEVSSILRKQLAGFESEADVY------------------DVGTVL alphaGeobacter ----------MEIRAEEISEIIRKQIKEYGKEVEVA------------------ETGTII alphaAquifex ---------MATLTYEEALEILRQQIKDFEPEAKME------------------EVGVVY alpha_Thermoto ----------------------------------------------------------VI alphaEnterococcus_hirae ----------MAIKAEEISALIKEQIENYQNVLSVE------------------EIGTVT alpha_Sacchar ALASTRRLASTKAQPTEVSSILEERIKGVSDEANLN------------------ETGRVL alpha_acetiv ----MEPERLKDVFNNAFNEINQVRKSSTPTLTPR-------------------EVGTIL APyrobaculum ------------------------------------------------------MSGKIE ASulfolobu ----------------------------------MV------------------SEGRVV A_Maceti ----------------------------------ME------------------VKGEIY AHalobacte ----------------------------MSQAEAIT------------------DTGEIE AjMethanoc ---------------------------MKREVENMP------------------VVGKII AEnterococ -----------------------------------L------------------QIGKII AArabidops -----------------MPAFYGGKLTTFEDDEKES------------------EYGYVR ACyanidium ---------------------------MTTVRVNGM------------------KNGIIK A1Homo1_Ho --------------------MDFSKLPKILDEDKES------------------TFGYVH ASaccharomy -------------MAGAIENARKEIKRISLEDHAES------------------EYGAIY AGiardia -----------------------------MVTSETT------------------SNGLIQ beta_ArabidopsisM RLPSPSPARHAAPCSYLLGRVAEYATSSPASSAAPSSAPAKDEGKKTYDYGGKGAIGRVC AArabidopsis -----------------MPAFYGGKLTTFEDDEKES------------------EYGYVR AMus --------------------mdfsklpkirdedkes------------------tfgyvh AHalobacterium ----------------------------MSQAEAIT------------------DTGEIE ANeurospora -----------------------MAPQQNGAEVDGI------------------HTGKIY APlasmodium ---------------------------MTKVAVEKE------------------EPGVVY ATrypanosoma ----------------------MTSDKNPYKTEQRM--------------------GAVK ASulfolobus ----------------------------------MV------------------SEGRVV AMethanosarcina ----------------------------------ME------------------VKGEIY AjMethanoccus ---------------------------MKREVENMP------------------VVGKII betE.coli -----------------------------------M------------------ATGKIV beta_human SASLPPAQLLLRAAPTAVHPVRDYAAQTSPSPKAGA------------------ATGRIV beta_Sacchar -----------MVLPRLYTATSRAAFKAAKQSAPLL--STSWKRCMASAAQSTPITGKVT beta_Thermoto --------------------------------MVKG------------------SKGFIV beta_Enteroc -----------------------------------M------------------SSGKIV beta_aquifex --------------------------------MAEV------------------IKGKVV beta_Cyanidium -----------------MKPCQLKQKQKTLAIAKVN------------------NKGKVI beta_Macetiv -------------MKRCDAIMRGVVKEQIENKNNYS------------------NLGSVV BMus VNGAAPELPVPTGGPMAGAREQALAVSRNYLSQPRL------------------TYKTVS BNeurospora --------------------MADPRVPSSYNVTPRI------------------RYNTVG BbMethanosarcina -------------------------------VNMVK------------------EYKTIT BSulfolobus -----------------------------MSLLNVR------------------EYSNIS alpE.coli ----------MQLNSTEISELIKQRIAQFNVVSEAH------------------NEGTIV alpAquifex ---------MATLTYEEALEILRQQIKDFEPEAKME------------------EVGVVY flEcoli ----------MTTRLTRWLTTLDNFEAKMAQLPAVR------------------RYGRLT flAquifex ----------MKGIRRNLQKSYLKRCSEMYLRGLKV-------------------SGEIV B_Saccharomyces GVNGPLVILEK---VKFPRYNEIVNLTLP--D--GTV----RQGQVLEIRGD-RAIVQLF B_Homo SVNGPLVVLDR---VKFAQYAEIVHFTLP--D--GTQ----RSGQVLEVAGT-KAIVQVF B_Cyanidium AVNGPLIILQN---VKSPRFAEIVNVTLG--D--GSV----RRGQVLEINQD-KAVVQIF B_Arabidopsis GVAGPLVILDK---VKGPKYQEIVNIRLG--D--GST----RRGQVLEVDGE-KAVVQVF BCryptosporidium GVQGPLVILDN---VKFPKYNEIVRITLG--D--GSV----REGQVLEVKGS-RAVVQVF B_Halobacterium EVSGPLVYVET---DEPIGYDEIVEIETP--N--GDV----KRGQVLESSDG-FVAIQVF B_Methanosarcina QIAGPLIFVEK---TEPVGYNEIVNIKMT--D--GTV----RRGQVLDSSSD-IVVVQVF B_Methanocaldococcus SIAGPLLIVEG---VEGAAYGEIVEVICP--D--GEK----RMGQVLEAREG-LAVVQVF BPyrobaculum EVKGPLIVIEK---TRGVSYGEVGEVIGP--D--GEP----RRVQVIEVGTD-YAVAQVL BGiardia SINGPIVVVDK---VQRQCYGEIVTLRLG--N--GEI----RTGKVLECHGS-QAVLQVF alphaChlorobium QVGDGIARIYG---LSKVAAGELLEFPHN------------VMGMALNLEED-NVGAVLF alphaGeobacter SVGDGIARIHG---LDKAMAGELLEFPGG------------VSGMVLNLEED-NVGAAIL alphaAquifex YVGDGVARAYG---LENVMAMEIVEFQGG------------QQGIAFNLEED-NVGIIIL alpha_Thermoto QVGDGIARAYG---LNKVMVSELVEFVET-------G----VKGVAFNLEED-NVGIIIL alphaEnterococcus_hirae YVGDGIARAHG---LENAMSGELLEFSNG------------SYGMAQNLESN-DVGIIIL alpha_Sacchar AVGDGIARVFG---LNNIQAEELVEFSSG------------VKGMALNLEPG-QVGIVLF alpha_acetiv TVSTDIANVSG---LPGVGYEEIVKFPGD------------VFGIAFNVDEK-EVGVILL APyrobaculum YISGPVVKAE----LPGARLYELVFVGEI-------K----LFGEVVRIQGE-KAFIQVY ASulfolobu RVNGPLVIADG---MREAQMFEVVYVSDL-------K----LVGEITRIEGD-RAFIQVY A_Maceti RVAGPVVTAIG---LD-AKMYDLCKVGNE-------G----LMGEVIQIVGG-KTIIQVY AHalobacte SVSGPVVTATG---LD-AQMNDVVYVGDE-------G----LMGEVIEIEGD-VTTIQVY AjMethanoc KIAGPVVVAEG---MKGAQMYEVVKVGEE-------K----LTGEIIQLHDD-KAVIQVY AEnterococ KVSGPLVMAEN---MSEASIQDMCLVGDL-------G----VIGEIIEMRQD-VASIQVY AArabidops KVSGPVVVADG---MAGAAMYELVRVGHD-------N----LIGEIIRLEGD-SATIQVY ACyanidium KVSGPVVSAEN---MDGAAMYELVRVGNE-------Q----LVGEIIRLEGS-VATIQVY A1Homo1_Ho GVSGPVVTACD---MAGAAMYELVRVGHS-------E----LVGEIIRLEGD-MATIQVY ASaccharomy SVSGPVVIAEN---MIGCAMYELVKVGHD-------N----LVGEVIRIDGD-KATIQVY AGiardia SIAGPVVTATN---MTGCFMFEVCYVGKA-------R----LIGEIIQLKGD-SAVIQVY beta_ArabidopsisM QVIGAIVDVRFEDQEGLPPIMTSLEVQDH-----PTR----LVLEVSHHLGQNVVRTIAM AArabidopsis KVSGPVVVADG---MAGAAMYELVRVGHD-------N----LIGEIIRLEGD-SATIQVY AMus gvsgpvvtacd---magaamyelvrvghs-------e----lvgeiirlegd-matiqvy AHalobacterium SVSGPVVTATG---LD-AQMNDVVYVGDE-------G----LMGEVIEIEGD-VTTIQVY ANeurospora SVSGPVVVAED---MIGVAMYELVKVGHD-------Q----LVGEVIRINGD-QATIQVY APlasmodium KVAGSLVIAEN---MSGTRMYELAKVGWN-------K----LVGEIIRLEGN-YAYIQVY ATrypanosoma AVSGPVVIAEN---MGGSAMYELVQVGSF-------R----LVGEIIRLEGD-TATIQVY ASulfolobus RVNGPLVIADG---MREAQMFEVVYVSDL-------K----LVGEITRIEGD-RAFIQVY AMethanosarcina RVSGPVVTAIG---LQ-AKMYDLVKVGNE-------G----LMGEVIQILGP-KTIIQVY AjMethanoccus KIAGPVVVAEG---MKGAQMYEVVKVGEE-------K----LTGEIIQLHDD-KAVIQVY betE.coli QVIGAVVDVEF-PQDAVPRVYDALEVQNG-----NER----LVLEVQQQLGGGIVRTIAM beta_human AVIGAVVDVQF--DEGLPPILNALEVQGR-----ETR----LVLEVAQHLGESTVRTIAM beta_Sacchar AVIGAIVDVHF-EQSELPAILNALEIKTP-----QGK----LVLEVAQHLGENTVRTIAM beta_Thermoto SIMGPVVDVKF-PEEELPDIYNALEVVNP---QTGQK----VVLEVEQLIGDGVVRTVAM beta_Enteroc QVIGPVVDVEFSLDQSLPDINNALVVYKNDEK--KSK----VVLETALELGDGVIRTIAM beta_aquifex QVIGPVVDVEFEGVKELPKIKDGLKTIRRAIDDRGNWFEEVLFMEVAQHIGEHRVRAIAM beta_Cyanidium QIIGPVLDIVF-PDGQLPKVFNAIKINNS--N--NNW----ITCEVQQLLGDNKVRAVAM beta_Macetiv SVRGSIVDIRF--EKYLPPIYSLLRAGKG------GR----IAIEVLTQLDSHRVRGIAL BMus GVNGPLVILDH---VKFPRYAEIVHLTLP--D--GTK----RSGQVLEVSGS-KAVVQVF BNeurospora GVNGPLVILDN---VKFPRYNEIVTLTLP--D--GTQ----RSGQVLEARGN-RAVVQVF BbMethanosarcina QIAGPLVFVEK---TEPVGYKEIVTINLP--D--GTT----RRGEVLDSSSD-IVVIQIF BSulfolobus MIKGPLIAVQG---VSDAAYNELVEIEMP--D--GSK----RRGLVVDSQMG-VTFVQVF alpE.coli SVSDGVIRIHG---LADCMQGEMISLPGN------------RYAIALNLERD-SVGAVVM alpAquifex YVGDGVARAYG---LENVMAMEIVEFQGG------------QQGIAFNLEED-NVGIIIL flEcoli RATGLVLEATG---LQLPLGATCVIERQNGSE--THE----VESEVVGFNGQ-RLFLMPL flAquifex SAKGIYLEAI----LPFANIGNEVEIQSN-----SRR----IRGEVIGFSGD-KVLVMPY B_Saccharomyces E-GTSGIDVKKTTVEFTGESLR-------IPVSEDMLGRIFDGSGRPID----------- B_Homo E-GTSGIDARKTTCEFTGDILR-------TPVSEDMLGRVFNGSGKPID----------- B_Cyanidium E-GTTGIDNKKTVCQFTGEILK-------TPVSLDMLGRVFNGSGKPID----------- B_Arabidopsis E-GTSGIDNKFTTVQFTGEVLK-------TPVSLDMLGRIFNGSGKPID----------- BCryptosporidium E-GTTGIDNQSCRVEFTGDVLC-------MPITEDMLGRTFNGSGKPID----------- B_Halobacterium E-GTEGVG-KDASVRFLGETLK-------MPVTEDLLGRVLDGSGNPID----------- B_Methanosarcina E-GTGGLD-KDCGVIFTGETLK-------LPASIDLLGRILSGSGDPRD----------- B_Methanocaldococcus E-GTTGLSTKDTRVRFTGRTAK-------IGVSMEMLGRIFNGAGKPID----------- BPyrobaculum G-GTLGLPAKGSTVRFYGKTLK-------IPVSEQLIGRILDGKGQPRD----------- BGiardia E-GTEGLDIKQTSAKFTGEVMK-------VGVSRALLGRTLSGSGEIID----------- alphaChlorobium G-ESNAVK-EGDTVKRTNILAS-------IPVGEAMLGRVINPLGEPID----------- alphaGeobacter GEDNENIK-EGTTVKRTGRIVE-------VPVGEALIGRVVNAIGQPID----------- alphaAquifex G-SETGIE-EGHIVKRTGRILD-------APVGEGLVGRVIDPLGNPLD----------- alpha_Thermoto G-EYKDIK-EGHTVRRLKRIIE-------VPVGEELLGRVVNPLGEPLD----------- alphaEnterococcus_hirae G-DFESIR-EGDKVKRTGKIME-------VPVGDALIGRVVNPLGQPID----------- alpha_Sacchar G-SDRLVK-EGELVKRTGNIVD-------VPVGPGLLGRVVDALGNPID----------- alpha_acetiv G-EYSHLH-AGDEVERTGRVMD-------VSVGESLLGRVIDPLGRPLD----------- APyrobaculum E-DTTGLK-PGEPVERTGEPLS-------AWLGPTIIGKIYDGVQRPLRNIEEISKNPFI ASulfolobu E-STDGVK-PGDKVYRSGAPLS-------VELGPGLIGKIYDGLQRPLDSIAKVSNSPFV A_Maceti E-ETGGVK-PGEPCVTTGMSLA-------VELGPGLLSSIYDGVQRPLHVLLEKTGG-FI AHalobacte E-ETSGIG-PGQPVDNTGEPLT-------VDLGPGMLDSIYDGVQRPLDVLEDEMGA-FL AjMethanoc E-ETSGIK-PGEPVVGTGAPLS-------VELGPGMLRAMYDGIQRPLTAIEEKTGSIFI AEnterococ E-ETSGIG-PGEPVRSTGEALS-------VELGPGIISQMFDGIQRPLDTFMEVTQSNFL AArabidops E-ETAGLT-VNDPVLRTHKPLS-------VELGPGILGNIFDGIQRPLKTIARISGDVYI ACyanidium E-ETSGLT-IGDPVLCTGSPLS-------VELGPGLMGNIFDGIQRPLEKIAERSNSVFI A1Homo1_Ho E-ETCGVS-VGDPVLRTGKPLS-------VDVGPGIMGAIFDGIQRPLSDISSQTQSIYI ASaccharomy E-ETAGLT-VGDPVLRTGKPLS-------VELGPGLMETIYDGIQRPLKAIKEESQSIYI AGiardia E-DTSGLE-VNDCVYKSGRLLS-------VHLGPGLLSSIYDGIQRPLEKIAQITNSHFI beta_ArabidopsisM D-GTEGLV-RGRKVLNTGAPIT-------VPVGRATLGRIMNVLGEPID----------- AArabidopsis E-ETAGLT-VNDPVLRTHKPLS-------VELGPGILGNIFDGIQRPLKTIARISGDVYI AMus e-etsgvs-vgdpvlrtgkprs-------velgpgimgaifdgiqrplsdissqtqsiyi AHalobacterium E-ETSGIG-PGQPVDNTGEPLT-------VDLGPGMLDSIYDGVQRPLDVLEDEMGA-FL ANeurospora E-ETAGVM-VGDPVLRTGKPLS-------VELGPGLLNNIYDGIQRPLEKIAEASNSIYI APlasmodium E-DTSGLS-VGDPVIKTGNALS-------VELGPGILDNIYDGIQRPLERIANVCGDVYI ATrypanosoma E-ETGGLT-VGDPVYCTGKPLS-------LELGPGIMSEIFDGIQRPLDTIYRMVENVFI ASulfolobus E-STDGVK-PGDKVYRSGAPLS-------VELGPGLIGKIYDGLQRPLDSIAKVSNSPFV AMethanosarcina E-ETAGIK-PGEPCVSTGSSLS-------VELGPGLLSSIYDGVQRPLHVLLEKMGS-FI AjMethanoccus E-ETSGIK-PGEPVVGTGAPLS-------VELGPGMLRAMYDGIQRPLTAIEEKTGSIFI betE.coli G-SSDGLR-RGLDVKDLEHPIE-------VPVGKATLGRIMNVLGEPVD----------- beta_human D-GTEGLV-RGQKVLDSGAPIK-------IPVGPETLGRIMNVIGEPID----------- beta_Sacchar D-GTEGLV-RGEKVLDTGGPIS-------VPVGRETLGRIINVIGEPID----------- beta_Thermoto D-STDGLT-KGLEVVDTGAPIT-------APVGKEVLGRILNVIGEPVD----------- beta_Enteroc E-STDGLQ-RGMEVIDTGKAIS-------VPVGKDTLGRVFNVLGDTIDL---------- beta_aquifex G-PTDGLV-RGQEVEYLGGPIK-------IPVGKEVLGRIFNVAGQPID----------- beta_Cyanidium S-TTEGLK-RGASAIDTGEPIS-------IPVGKETLGRIFNVLGEPID----------- beta_Macetiv T-PTEGLS-RGTLVEDTGGPLK-------APVGRGILSRMFDVFGNPID----------- BMus E-GTSGIDAKKTSCEFTGDILR-------TPVSEDMLGRVFNGSGKPID----------- BNeurospora E-GTSGIDVKKTKVEFTGESLK-------LGVSEDMLGRIFDGSGRAID----------- BbMethanosarcina E-GTTGLD-KECGVVFTGETLK-------LPASIDLLGRILSGSGEPLD----------- BSulfolobus E-GTTGISPTGSKVRFLGRGLE-------VKISEEMLGRIFNPLGEPLD----------- alpE.coli G-PYADLA-EGMKVKCTGRILE-------VPVGRGLLGRVVNTLGAPID----------- alpAquifex G-SETGIE-EGHIVKRTGRILD-------APVGEGLVGRVIDPLGNPLD----------- flEcoli E-EVEGVL-PGARVYAKNISAEGLQSGKQLPLGPALLGRVLDGSGKPLD----------- flAquifex E-PVFGLR-KGDKVLLKNELVS-------TKTGNGVVGKVVDPFGNPLD----------- B_Saccharomyces -------NGPKVFAEDYLDING-------------------------------------- B_Homo -------KGPVVMAEDFLDING-------------------------------------- B_Cyanidium -------GGPPILPEAYLDIQG-------------------------------------- B_Arabidopsis -------NGPPILPEAYLDISG-------------------------------------- BCryptosporidium -------NGPPIFAEDYIDING-------------------------------------- B_Halobacterium -------GGPDIVPDDRVDIVG-------------------------------------- B_Methanosarcina -------GGPRIVPDQLLDING-------------------------------------- B_Methanocaldococcus -------GGPEIVPEKELDING-------------------------------------- BPyrobaculum -------HMPLPPPEDFRDVNG-------------------------------------- BGiardia -------GGAPVLAEEIRDIEG-------------------------------------- alphaChlorobium -------GKGPINTDIRLPLER-------------------------------------- alphaGeobacter -------GKGPINTTTFGKVEV-------------------------------------- alphaAquifex -------GKGPIQFEYRSPVEK-------------------------------------- alpha_Thermoto -------GKGPINAKNFRPIEI-------------------------------------- alphaEnterococcus_hirae -------GLGEIVTDKVRPVEA-------------------------------------- alpha_Sacchar -------GKGPIDAAGRSRAQV-------------------------------------- alpha_acetiv -------GKGPVISGKRLPIER-------------------------------------- APyrobaculum ARGIGYDKAPPLDLKAEFDFKP--AVKPGEEVYPGDVLGSVKETEPM-THYILYPPLPEH ASulfolobu ARGV---SIPALDRQTKWHFVP--KVKSGDKVGPGDIIGVVQETDLI-EHRILIPP-N-- A_Maceti QRGV---TADGLDHEKLWEFKP--VAKKGDFVKGGEVLGVVQETVNL-EHKVMMPP-D-- AHalobacte DRGV---DAPGIDLDTDWEFEP--TVEAGDEVAAGDVVGTVDETVSI-EHKVLVPPRS-- AjMethanoc PRGV---DVPALPRDIKWEFKP--VVNEGDYVEEGDIIGTVDETPSI-VHKILVPI-G-- AEnterococ GRGV---QLPALDHEKQWWFEA--TIEEGTEVSAGDIIGYVDETKII-QHKIMVPN-G-- AArabidops PRGV---SVPALDKDCLWEFQP-NKFVEGDTITGGDLYATVFENTLM-NHLVALPP-D-- ACyanidium PRGV---NVPALDRKKVWEFRPADNLKVGDPITAGDIYGIVPETPLI-DHKIMLPP-N-- A1Homo1_Ho PRGV---NVSALSRDIKWDFTPCKNLRVGSHITGGDIYGIVSENSLI-KHKIMLPP-R-- ASaccharomy PRGI---DTPALDRTIKWQFTP-GKFQVGDHISGGDIYGSVFENSLISSHKILLPP-R-- AGiardia PRGI---SAPALDLERRWTFRP--LVKLGDLLSVGDIFGIVPENDLL-ECKIMLQSMDST beta_ArabidopsisM -------ERGEIKTEHYLPIHR-------------------------------------- AArabidopsis PRGV---SVPALDKDCLWEFQP-NKFVEGDTITGGDLYATVFENTLM-NHLVALPP-D-- AMus prgv---nvsalsrdikwefipsknlrvgshitggdiygivnensli-khkimlpp-r-- AHalobacterium DRGV---DAPGIDLDTDWEFEP--TVEAGDEVAAGDVVGTVDETVSI-EHKVLVPPRS-- ANeurospora PRGI---ATPALDRKKKWEFTP--TMKVGDHIAGGDVWGTVYENSFISVHKILLPP-R-- APlasmodium YKGI---DMTSLDHDKQWQFYADKKLKLNDIVTGGDIFGFVDENKLFKEHKIMAPP-N-- ATrypanosoma PRGV---QVKSLNDQKQWDFKPC--LKVGDLVSGGDIIGSVVENSLMYNHSIMIPP-N-- ASulfolobus ARGV---SIPALDRQTKWHFVP--KVKSGDKVGPGDIIGVVQETDLI-EHRILIPP-N-- AMethanosarcina QRGV---SADGLDHKKLWDFKP--IVKKGDSVKGGDVIGVVQETVNI-EHKIMVPP-D-- AjMethanoccus PRGV---DVPALPRDIKWEFKP--VVNEGDYVEEGDIIGTVDETPSI-VHKILVPI-G-- betE.coli -------MKGEIGEEERWAIHR-------------------------------------- beta_human -------ERGPIKTKQFAPIHA-------------------------------------- beta_Sacchar -------ERGPIKSKLRKPIHA-------------------------------------- beta_Thermoto -------EAGEIKAKERWPIHR-------------------------------------- beta_Enteroc -------GSSFPEDAERSEIHK-------------------------------------- beta_aquifex -------EQGPVEAKEYWPMFR-------------------------------------- beta_Cyanidium -------EKGPVISNDKLPIHR-------------------------------------- beta_Macetiv -------HRAPPSNVRWRTIHQ-------------------------------------- BMus -------RGPVVLAEDFLDIMG-------------------------------------- BNeurospora -------KGPKVLAEEYLDING-------------------------------------- BbMethanosarcina -------GGPRIVPDQLLDING-------------------------------------- BSulfolobus -------NGPPVIGGEKRNING-------------------------------------- alpE.coli -------GKGPLDHDGFSAVEA-------------------------------------- alpAquifex -------GKGPIQFEYRSPVEK-------------------------------------- flEcoli -------GLPSPDTTETGALIT-------------------------------------- flAquifex --------GGFIGFVEEKGLEL-------------------------------------- B_Saccharomyces ------------------------------------------------------SPINPY B_Homo ------------------------------------------------------QPINPH B_Cyanidium ------------------------------------------------------QPINPQ B_Arabidopsis ------------------------------------------------------SSINPS BCryptosporidium ------------------------------------------------------SPINPY B_Halobacterium ------------------------------------------------------EAINPH B_Methanosarcina ------------------------------------------------------AAMNPY B_Methanocaldococcus ------------------------------------------------------YPLNPV BPyrobaculum ------------------------------------------------------EPLNPY BGiardia ------------------------------------------------------SSLNPV alphaChlorobium ------------------------------------------------------RAPGVI alphaGeobacter ------------------------------------------------------KAPGIV alphaAquifex ------------------------------------------------------IAPGVV alpha_Thermoto ------------------------------------------------------KAPGVI alphaEnterococcus_hirae ------------------------------------------------------MAPGVM alpha_Sacchar ------------------------------------------------------KAPGIL alpha_acetiv ------------------------------------------------------SSAPIM APyrobaculum ----------APGVVEWI-ADGKYKVDD--VIARVKTKRGVV-EVKMWHKWPVRRPRPFK ASulfolobu ----------VHGTLKELAREGDYTVED--VVAVVDMNGDEI-PVKMYQKWPVRIPRPYK A_Maceti ----------KSGTVADI-KSGNFTVLE--TVCTLTDGT----ELQMMHRWPVRRPRPVK AHalobacte ----------DGGEVVAV-ESGTFTVDD--TVVELDTGE----EIQMHQEWPVRRQRPTV AjMethanoc ----------VKGKIVEI-KEGKFTVEE--TVAVVETENGERKEITMMQKWPVRKPRPYK AEnterococ ----------IKGTVQKI-ESGSFTIDD--PICVIETEQGLK-ELTMMQKWPVRRGRPIK AArabidops ----------AMGKITYIAPAGQYSLKD--TVIELEFQGIKK-SYTMLQSWPVRTPRPVA ACyanidium ----------QMGKIVFLAPPGDYTLED--TVLEIDFNGQKK-KFSMVHQWPVRLPRPVT A1Homo1_Ho ----------NRGTVTYIAPPGNYDTSD--VVLELEFEGVKE-KFTMVQVWPARQVRPVT ASaccharomy ----------SRGTITWIAPAGEYTLDE--KILEVEFDGKKS-DFTLYHTWPVRVPRPVT AGiardia RLQMRKRTFQAERLLKYVRPTDAYTVKDEEKILVLEYAGQRY-YYGLAHYHPVRSPKKVF beta_ArabidopsisM ------------------------------------------------------DAPALV AArabidopsis ----------AMGKITYIAPAGQYSLKD--TVIELEFQGIKK-SYTMLQSWPVRTPRPVA AMus ----------nrgsvtyiappgnydasn--vvlelefegvke-kfsmvqvwpvrqvrpvt AHalobacterium ----------DGGEVVAV-ESGTFTVDD--TVVELDTGE----EIQMHQEWPVRRQRPTV ANeurospora ----------ARGTITRIAEKGEYTVEE--KILEVEFDGKKT-EYPMMQTWPVRVPRPAA APlasmodium ----------AKGRLTYIAPDGSYTLKD--KIFELEYQGKKY-TYGLSHLWPVRDPRPVL ATrypanosoma ----------VRGRVTSIVPSGNYTLQD--DIIELEYNGTVK-SLKLMHRWPVRTPRPVA ASulfolobus ----------VHGTLKELAREGDYTVED--VVAVVDMNGDEI-PVKMYQKWPVRIPRPYK AMethanosarcina ----------ISGTISDI-KSGNFTVVD--TICTLTDGT----ELQMMQRWPVRRPRPVK AjMethanoccus ----------VKGKIVEI-KEGKFTVEE--TVAVVETENGERKEITMMQKWPVRKPRPYK betE.coli ------------------------------------------------------AAPSYE beta_human ------------------------------------------------------EAPEFM beta_Sacchar ------------------------------------------------------DPPSFA beta_Thermoto ------------------------------------------------------PAPELV beta_Enteroc ------------------------------------------------------KAPSFD beta_aquifex ------------------------------------------------------NPPELV beta_Cyanidium ------------------------------------------------------PAPKFT beta_Macetiv ------------------------------------------------------APPPLI BMus ------------------------------------------------------QPINPQ BNeurospora ------------------------------------------------------SPINPY BbMethanosarcina ------------------------------------------------------AAMNPY BSulfolobus ------------------------------------------------------DPINPA alpE.coli ------------------------------------------------------IAPGVI alpAquifex ------------------------------------------------------IAPGVV flEcoli ------------------------------------------------------PPFNPL flAquifex ------------------------------------------------------PQINPL B_Saccharomyces ARIYPEEMISTGVSAIDTMNSIARGQKIPIFSASGLPHNEIAAQICRQAGLVR------P B_Homo SRIYPEEMIQTGISPIDVMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVK------K B_Cyanidium SRTYPEEMFETGISSIDVMNSIARGQKIPLFSGAGLPHNEVAAQICRQVCLVST--CTLV B_Arabidopsis ERTYPEEMIQTGISTIDVMNSIARGQKIPLFSAAGLPHNEIAAQICRQAGLVKR--LEKT BCryptosporidium CRVHPREMIQTGISAIDVMNSVVRGQKIPLFSAAGLPHNDIGAQICRQASLV-------S B_Halobacterium AREYPEEFIQTGVSGIDGMNTLVRGQKLPIFSGSGLPHSDLALQIARQASVPE------E B_Methanosarcina ARLPPKDFIQTGISTIDGTNTLVRGQKLPIFSASGLPHNEIALQIARQASVP-------- B_Methanocaldococcus SRKVPSDFIQTGISTIDGMNTLVRGQKLPIFSGSGLPHNQLAAQIARQAKVR-------- BPyrobaculum SREYPEEPIETGISAIDGLYTLVRGQKLPIFSGTGLPHNLMAAQVVRQATVR-------- BGiardia SREYPKNCLETGISTIDILTSICQGQKILLLSGSGLPYNPLLAQIARNARVCVSWEKAVT alphaChlorobium FRKSVHEPLQTGLKAIDAMIPIGRGQRELIIGDRQTGKTAVALDTIINQK---------- alphaGeobacter KRKSVHQPMQTGLKAIDSMVPIGRGQRELIIGDRQTGKTAVAIDTIINQK---------- alphaAquifex KRKPVHEPLQTGIKAIDAMIPIGRGQRELIIGDRATGKTTVAIDTILAQK---------- alpha_Thermoto YRKPVDTPLQTGIKAIDSMIPIGRGQRELIIGDRQTGKTAIAIDTIINQK---------- alphaEnterococcus_hirae QRKSVNEPMQTGLKAIDALVPIGRGQRELVIGDRKTGKTSIAIDTILNQK---------- alpha_Sacchar PRRSVHEPVQTGLKAVDALVPIGRGQRELIIGDRQTGKTAVALDTILNQKRWNN--GSDE alpha_acetiv DRAPVTVPLQTGIKVIDALIPIGRGQRELILGDRQTGKTAIAIDTILNQR---------- APyrobaculum EKLPPVEPLITGVRTVDTMFPIAKGGTAAVPGPFGSGKTVMIRTLSMF------------ ASulfolobu EKLEPVEPLLTGIRVLDTVFPIAKGGTAAIPGPFGSGKTVTLQSLAKW------------ A_Maceti RKLTPEKPLVTGQRILDGLFPVAKGGTAAIPGPFGSGKTVTQQQLSKW------------ AHalobacte DKQTPTEPLVSGQRILDGLFPIAKGGTAAIPGPFGSGKTVTQQSLAKF------------ AjMethanoc EKLPPEIPLITGQRVEDTFFTLAKGGTAAIPGPFGSGKTVTQHQLAKW------------ AEnterococ QKLNPDVPMITGQRVIDTFFPVTKGGAAAVPGPFGAGKTVVQHQIAKW------------ AArabidops SKLAADTPLLTGQRVLDALFPSVLGGTCAIPGAFGCGKTVISQALSKY------------ ACyanidium EKLRADKPLLTGQRVLDALFPSVQGGTCAIPGAFGCGKTVISQALSKF------------ A1Homo1_Ho EKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSLSKY------------ ASaccharomy EKLSADYPLLTGQRVLDALFPCVQGGTTCIPGAFGCGKTVISQSLSKY------------ AGiardia KKLPCINPLITGQRTLDGLFPLAIGATAAIPGGFGCGKTVVSQSISKY------------ beta_ArabidopsisM DLATGQEILATGIKVVDLLAPYQRGGKIGLFGGAGVGKTVLIMELINNVAK--------- AArabidopsis SKLAADTPLLTGQRVLDALFPSVLGGTCAIPGAFGCGKTVISQALSKY------------ AMus eklpanhplltgqrvldalfpcvqggttaipgafgcgktvisqslsky------------ AHalobacterium DKQTPTEPLVSGQRILDGLFPIAKGGTAAIPGPFGSGKTVTQQSLAKF------------ ANeurospora EKHSANQPFLVGQRVLDALFPSVQGGTVAIPGAFGCGKTVISQSVSKF------------ APlasmodium EKVTGDTLLLTGQRVLDSLFPTVQGGTCAIPGAFGCGKTCVSQALSKY------------ ATrypanosoma SKESGNHPLLTGQRVLDALFPSVQGGTCAIPGAFGCGKTVISQALSKF------------ ASulfolobus EKLEPVEPLLTGIRVLDTVFPIAKGGTAAIPGPFGSGKTVTLQSLAKW------------ AMethanosarcina AKLTPTRPLVTGMRILDGLFPVAKGGTAAIPGPFGSGKTVTQQSLAKW------------ AjMethanoccus EKLPPEIPLITGQRVEDTFFTLAKGGTAAIPGPFGSGKTVTQHQLAKW------------ betE.coli ELSNSQELLETGIKVIDLMCPFAKGGKVGLFGGAGVGKTVNMMELIRNIAI--------- beta_human EMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAK--------- beta_Sacchar EQSTSAEILETGIKVVDLLAPYARGGKIGLFGGAGVGKTVFIQELINNIAK--------- beta_Thermoto EQSTEIEILETGIKVIDLLAPFPKGGKIGFFGGAGVGKTVLVMELIRNIAI--------- beta_Enteroc ELSTSTEILETGIKVIDLLAPYLKGGKVGLFGGAGVGKTVLIQELIHNIAQ--------- beta_aquifex EQSTKVEILETGIKVIDLLQPIIKGGKVGLFGGAGVGKTVLMQELIHNIAR--------- beta_Cyanidium QLETKPSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNVAK--------- beta_Macetiv RRSTRSEIFETGIKVIDVLVPLERGGKAGLFGGAGVGKTVLLTEMIHNVVR--------- BMus CRIYPEEMIQTGISAIDGMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVK------K BNeurospora AREYPQEMISTGISAIDTMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVQR--QGIT BbMethanosarcina ARLPPKDFIQTGISTIDGTNTLVRGQKLPIFSASGLPHNEIALQIARQAAVP-------- BSulfolobus TREYPEEFIQTGISAIDGLNSLLRGSKITDLSGSGLPANTLAAQIAKQATVR-------- alpE.coli ERQSVDQPVQTGYKAVDSMIPIGRGQRELIIGDRQTGKTALAIDAIINQR---------- alpAquifex KRKPVHEPLQTGIKAIDAMIPIGRGQRELIIGDRATGKTTVAIDTILAQK---------- flEcoli QRTPIEHVLDTGVRPINALLTVGRGQRMGLFAGSGVGKSVLLGMMARY------------ flAquifex YRERIREVFDTGVRSVNALFTLGKGQKIGIFAGAGVGKSTLLGMITRH------------ B_Saccharomyces TKDVHDGHEENFSIVFAAMGVNLETARFFKQDFEENG----------------------S B_Homo SKAVLDYHDDNFAIVFAAMGVNMETARFFKSDFEQNG----------------------T B_Cyanidium KRSGKD--EEDFAIVFAAMGVNMETARFFRQDFEENG----------------------A B_Arabidopsis VDLLEDHGEDNFAIVFAAMGVNMETAQFFKRDFEENG----------------------S BCryptosporidium GKDVMDHSDDNFAVVFAAMGVNMETARFFRRDFEENG----------------------S B_Halobacterium EAETDDDEGSEFAVVFGAMGITAEEANEFMDDFERTG----------------------A B_Methanosarcina ------GSESAFAVVFAAMGITNEEAQYFMSDFEKTG----------------------A B_Methanocaldococcus ------GEGEKFAVVFAAMGITSEEANFFMEEFRKTG----------------------A BPyrobaculum ------GSEEEFAVVFVGVGIKTEEALFFMDEFRKTG----------------------A BGiardia GEEIKTSEDDKFMIVFAGIGLSHEQAMFFKTQFEQTG----------------------A alphaChlorobium --------GKGVQCIYVAIGLKGSTVAQVVNTLEKYG----------------------A alphaGeobacter --------GGDLICIYVAIGQKRSTVAQVVSKLQEYG----------------------A alphaAquifex --------NSDVYCIYVAVGQKRAAIARLIELLEREG----------------------A alpha_Thermoto --------GQGVYCIYVAIGQKKSAIARIIDKLRQYG----------------------A alphaEnterococcus_hirae --------GQDMICIYVAIGQKDSTVRTQVETLKKYG----------------------A alpha_Sacchar --------SKKLYCVYVAVGQKRSTVAQLVQTLEQHD----------------------A alpha_acetiv --------DYNVLCVYCAIGQRASAVARAVATLREKG----------------------A APyrobaculum --------AQSRFIIPVLCGERGNEAADALQGLLKLKD---PSTGRP------------L ASulfolobu --------SAAKVVIYVGCGERGNEMTDELRSFPKLKD---PWTGKP------------L A_Maceti --------SDTEIVVYVGCGERGNEMADVLWDFPELED---PQTGRP------------L AHalobacte --------ADADIVVYIGCGERGNEMTEVIEDFPELPD---PQTGNP------------L AjMethanoc --------SDADVVVYIGCGERGNEMTEVIEEFPHLED---IRTGNK------------L AEnterococ --------SDVDLVVYVGCGERGNEMTDVVNEFPELID---PNTGES------------L AArabidops --------SNSDAVVYVGCGERGNEMAEVLMDFPQLTMTLPDGREES------------V ACyanidium --------SNSDGIVYVGCGERGNEMAEVLKDFPELTMTVGD-REES------------I A1Homo1_Ho --------SNSDVIIYVGCGERGNEMSEVLRDFPELTMEV-DGKVES------------I ASaccharomy --------SNSDAIIYVGCGERGNEMAEVLMEFPELYTEM-SGTKEP------------I AGiardia --------GNTDVIVYIGCGERGNEMAEILTDFPEMTFEAKKRVIGPSGQQEIKTVVSDI beta_ArabidopsisM --------AHGGFSVFAGVGERTREGNDLYREMIESG----------------------V AArabidopsis --------SNSDAVVYVGCGERGNEMAEVLMDFPQLTMTLPDGREES------------V AMus --------snsdviiyvgcgergnemsevlrdfpeltmev-dgkaes------------i AHalobacterium --------ADADIVVYIGCGERGNEMTEVIEDFPELPD---PQTGNP------------L ANeurospora --------SNSDVIVYVGCGERGNEMAEVLKDFPELSIEV-DGRKEP------------I APlasmodium --------SNSEVIIYVGCGERGNEMAEILSDFPELTTKV-DNEDVG------------I ATrypanosoma --------SNSDAVIYVGCGERGNEMAEVLMDFPTLTTVI-DGREES------------I ASulfolobus --------SAAKVVIYVGCGERGNEMTDELRSFPKLKD---PWTGKP------------L AMethanosarcina --------SDTEIVVYIGCGERGNEMADVLSEFPELED---PQTGRP------------L AjMethanoccus --------SDADVVVYIGCGERGNEMTEVIEEFPHLED---IRTGNK------------L betE.coli --------EHSGYSVFAGVGERTREGNDFYHEMTDSN----------------------V beta_human --------AHGGYSVFAGVGERTREGNDLYHEMIESG----------------------V beta_Sacchar --------AHGGFSVFAGVGERTREGNDLYREMKETG----------------------V beta_Thermoto --------EHKGFSVFAGVGERTREGNELWLEMQESG----------------------V beta_Enteroc --------EHGGISVFTGVGERTREGNDLYYEMKDSG----------------------V beta_aquifex --------FHEGYSVVVGVGERTREGNDLWLEMKESG----------------------V beta_Cyanidium --------AHGGVSVFGGVGERTREGNDLYQEMKESGV---INEKDL------------N beta_Macetiv --------QQKGVSIFCGIGERCREGEELYRDMKEAG----------------------V BMus SKDVVDYSEENFAIVFAAMGVNMETARFFKSDFEENG----------------------S BNeurospora NKGVHDGHEENFSIVFGAMGVNLETARFFTRDFEENG----------------------S BbMethanosarcina ------GSESAFAVVFAAMGITNEEAQYFMSDFEKTG----------------------A BSulfolobus ------GEESNFAVVFAAIGVRYDEALFFRKFFEETG----------------------A alpE.coli --------DSGIKCIYVAIGQKASTISNVVRKLEEHG----------------------A alpAquifex --------NSDVYCIYVAVGQKRAAIARLIELLEREG----------------------A flEcoli --------TRADVIVVGLIGERGREVKDFIENILGAE----------------------G flAquifex --------SKADVVVLALIGERGREVKEFLEEVLGEE----------------------G B_Saccharomyces LE--------RTSLFLNLANDPTIERIITPRLALTTAEYLAYQTERHVLTILTDMSSYAD B_Homo MG--------NVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAE B_Cyanidium ME--------RVTLFLNLANDPTIERIITPRLALTFAEYLAYEKGKHVLVILTDMSAYAD B_Arabidopsis ME--------RVTLFLNLANDPTIERIITPRIALTTAEYLAYECGKHVLVILTDMSSYAD BCryptosporidium ME--------RVCLFLNLANDPTIERILTPKLALTTAEYLAYEKDLHVFVVMTDMSSYAD B_Halobacterium LE--------RSVVFMNLADDPAVERTVTPRMALTTAEYLAFEKDYHVLVILTDMTNYCE B_Methanosarcina LE--------RAVVFLNLADDPAVERIVTPRMALTAAEYLAYEHGMHVLVILTDITNYAE B_Methanocaldococcus LE--------RAVVFINLADDPAIERILTPRIALTVAEYLAYEKDMHVLVILTDMTNYCE BPyrobaculum LR--------RAVAVLNLASDPVAERILAPRVGLTIGEYLAWQLGYHVLVVITDMTNYCE BGiardia LN--------RSVILLNLASDPVVQRISTPRIAVTIAEYFAYTLGYHVLVLLSDIFNYAD alphaChlorobium ME--------YTTVVSATASDPAPLQFIAPFAGATIGEFFRD-TGRHALVVYDDLSKQAV alphaGeobacter MD--------YTIVVSASASEPAPLQFIAPYTGVTMGEYFRD-NGKHALIIYDDLSKQAV alphaAquifex ME--------YTTVVVASASDPASLQYLAPFVGCTIGEYFRD-NGKHALIIYDDLSKHAE alpha_Thermoto ME--------YTTVVVASASDPASLQYIAPYAGCAMGEYFAY-SGRDALVVYDDLSKHAV alphaEnterococcus_hirae MD--------YTIVVNAGASQPAPLLYIAPYAGTAMGEEFMY-NGKHVLIIFDDLSKQAV alpha_Sacchar MK--------YSIIVAATASEAAPLQYLAPFTAASIGEWFRD-NGKHALIVYDDLSKASL alpha_acetiv MD--------YTVVVVTEGNDPSGLTYIAPYAATSIAEYFME-AGRDVLIVYDDLTNHAR APyrobaculum LE--------RTTIIVNTSNMPVAAREASVYMGTTLGEYFRD-QGYDVLVLADSTSRWAE ASulfolobu LL--------RTILVANTSNMPVAARESSIYVGVTMAEYFRD-QGYDVLLVADSTSRWAE A_Maceti ME--------RTILVANTSNMPVAAREASVYTGMTLAEYFRD-MGYNVSLMADSTSRWAE AHalobacte MA--------RTTLIANTSNMPVAGRESCIYTGITIAEYYRD-MGYDVALMADSTSRWAE AjMethanoc MD--------RTVLIANTSNMPVAAREASVYTGITIAEYFRD-MGYGVLLTADSTSRWAE AEnterococ ME--------RTVLIANTSNMPVAAREASIYTGITIAEYFRD-MGYDVAIMADSTSRWAE AArabidops MK--------RTTLVANTSNMPVAAREASIYTGITIAEYFRD-MGYNVSMMADSTSRWAE ACyanidium MK--------RTLLVANTSNMPVAAREASIYTGITVSEYYRD-MGLNISMMADSTSRWAE A1Homo1_Ho MK--------RTALVANTSNMPVAAREASIYTGITLSEYFRD-MGYHVSMMADSTSRWAE ASaccharomy MK--------RTTLVANTSNMPVAAREASIYTGITLAEYFRD-QGKNVSMIADSSSRWAE AGiardia FS--------RTVLVANTSNMPVAAREASIYTGITISEFFRD-QGYNVTLLADSTSRWAE beta_ArabidopsisM IKLGEKQSESKCALVYGQMNEPPGARARVGLTGLTVAEYFRDAEGQDVLLFIDNIFRFTQ AArabidopsis MK--------RTTLVANTSNMPVAAREASIYTGITIAEYFRD-MGYNVSMMADSTSRWAE AMus mk--------rtalvantsnmpvaareasiytgitlseyfrd-mgyhvsmmadstsrwae AHalobacterium MA--------RTTLIANTSNMPVAGRESCIYTGITIAEYYRD-MGYDVALMADSTSRWAE ANeurospora MK--------RTTLIANTSNMPVAAREASIYTGITVAEYFRD-QGMNVAMMADSSSRWAE APlasmodium MQ--------RTCLVANTSNMPVAAREASIYTGITLCEYFRD-MGYNATMMADSTSRWAE ATrypanosoma MK--------RTCLVANTSNMPVAAREASIYTGITLAEYYRD-MGKHIAMMADSTSRWAE ASulfolobus LL--------RTILVANTSNMPVAARESSIYVGVTMAEYFRD-QGYDVLLVADSTSRWAE AMethanosarcina ME--------RTVLIANTSNMPVAAREASVYTGITIAEYYRD-MGLDVSLMADSTSRWAE AjMethanoccus MD--------RTVLIANTSNMPVAAREASVYTGITIAEYFRD-MGYGVLLTADSTSRWAE betE.coli ID--------KVSLVYGQMNEPPGNRLRVALTGLTMAEKFRD-EGRDVLLFVDNIYRYTL beta_human INL--KDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQ beta_Sacchar INL---EGESKVALVFGQMNEPPGARARVALTGLTIAEYFRDEEGQDVLLFIDNIFRFTQ beta_Thermoto LG--------NTVLVFGQMNEPPGARFRVALTALTIAEYFRDIEGRDVLLFIDNIFRFGQ beta_Enteroc IE--------KTAMVFGQMNEPPGARMRVALTGLTIAEYFRDVEGQDVLLFIDNIFRFTQ beta_aquifex LP--------YTVMVYGQMNEPPGVRFRVAHTGLTMAEYFRDVEGQDVLIFIDNIFRFVQ beta_Cyanidium LS--------KVALCYGQMNEPPGARMRVGLTALTMAEYFRDVNKQNVLLFIDNIFRFVQ beta_Macetiv LP--------NTVMVFGQMNEPPGARFRVGHVALTMAEYFRDDEHRDVLLLIDNIFRFIQ BMus MD--------NVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAE BNeurospora LG--------RTTLFLNLANDPTIERIITPRLALTTAEYYAYQLEKHVLVILTDLSSYCD BbMethanosarcina LE--------RAVVFLNLADDPAVERIVTPRMALTAAEYLAYEHGMHVLVILTDITNYAE BSulfolobus IN--------RVAMFVTLANDPPSLKILTPKTALTLAEYLAFEKDMHVLAILIDMTNYCE alpE.coli LA--------NTIVVVATASESAALQYLARMPVALMGEYFRD-RGEDALIIYDDLSKQAV alpAquifex ME--------YTTVVVASASDPASLQYLAPFVGCTIGEYFRD-NGKHALIIYDDLSKHAE flEcoli RA--------RSVVIAAPADVSPLLRMQGAAYATRIAEDFRD-RGQHVLLIMDSLTRYAM flAquifex LK--------KSVVVVSTADQSPILKVKGAISAVVHAHHFAS-QGKDVLLLMDSITRLAL B_Saccharomyces ALREVSAAREEVPGRRGYPGYMYTDLSTIYERAGRVEG---------------------- B_Homo ALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEG---------------------- B_Cyanidium ALREVSAAREEVPGRRGYPGYMYTDLATIYERAGRVEG---------------------- B_Arabidopsis ALREVSAAREEVPGRRGYPGYMYTDLATIYERAGRIEG---------------------- BCryptosporidium ALREVSAAREEVPGRRGYPGYMYTDLSTIYERAGRIEG---------------------- B_Halobacterium ALRQIGAAREEVPGRRGYPGYMYTDLAQLYERAGRIEG---------------------- B_Methanosarcina ALRQMGAARNEVPGRRGYPGYMYTDLATLYERAGIVKG---------------------- B_Methanocaldococcus ALREISAARNEVPGRRGYPGYMYTDLATIYERAGRVKG---------------------- BPyrobaculum GLRELSSGRGELPGRRGYPGYMYTDLATIYERAGRARG---------------------- BGiardia ALRQISSARNEVPGRKGYPPYLYSDLSTIYERAGRVHG---------------------- alphaChlorobium AYRQLSLLLRRPPGREAYPGDVFYLHSRLLERAAKITDDIEVA-------------KKMN alphaGeobacter AYRQLSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDDC-------------------- alphaAquifex AYRQLSLLMRRPPGREAYPGDVFYLHSRLLERAAKLNDDL-------------------- alpha_Thermoto AYRQLSLLMRRPPGREAYPGDIFYLHSRLLERAVRLNDKL-------------------- alphaEnterococcus_hirae AYRELSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDDL-------------------- alpha_Sacchar AYRQLSLMLRRPPGREAYPGDVFYLHSRLLERAAKLSEKE-------------------- alpha_acetiv AYRELSLLLRRPPGREAYPGDIFYIHSRLLERATHLLGEL-------------------- APyrobaculum AMREVALRIGEMPSEEGYPAYLPTRLAEFYERAGRVVLYGSKE----------------- ASulfolobu ALRDLGGRMEEMPAEEGFPSYLPSRLAEYYERAGRVIALGNPE----------------- A_Maceti AMREISSRLEEMPGEEGYPAYLSARLAEFYERAGVAETLCG------------------- AHalobacte AMREISSRLEEMPGEEGYPAYLAARLSEFYERAGYFENFNG------------------- AjMethanoc AMREISGRLEEMPGEEGYPAYLASRLAQFYERAGRVITLGKDN----------------- AEnterococ ALREMSGRLEEMPGDEGYPAYLGSRLAEYYERSGRVIALGSDQ----------------- AArabidops ALREISGRLAEMPADSGYPAYLAARLASFYERAGKVKCLGGPE----------------- ACyanidium ALREISGRLAEMPADSGYPAYLAARLASFYERAGKVSCLGSPN----------------- A1Homo1_Ho ALREISGRLAEMPADSGYPAYLGARLASFYERAGRVKCLGNPE----------------- ASaccharomy ALREISGRLGEMPADQGFPAYLGAKLASFYERAGKAVALGSPD----------------- AGiardia ALREISGRLGGIPGEGGYPADLTSKLSHFYERAGRVICLGNSNGAWSPENILDPTSGAIS beta_ArabidopsisM ANSEVSALLGRIPSAVGYQPTLASDLGALQERITTT------------------------ AArabidopsis ALREISGRLAEMPADSGYPAYLAARLASFYERAGKVKCLGGPE----------------- AMus alreisgrlaempadsgypaylgarlasfyeragrvkclgnpe----------------- AHalobacterium AMREISSRLEEMPGEEGYPAYLAARLSEFYERAGYFENFNG------------------- ANeurospora ALREISGRLGEMPADQGFPAYLGAKLASFYERAGKVQALGSPP----------------- APlasmodium ALREISGRLAEMPADSGYPAYLGARLASFYERAGKVKCIGSPS----------------- ATrypanosoma ALREISGRLAEMPADGGYPAYLSARLASFYERAGRVTCIGGPK----------------- ASulfolobus ALRDLGGRMEEMPAEEGFPSYLPSRLAEYYERAGRVIALGNPE----------------- AMethanosarcina AMREISSRLEEMPGEEGYPAYLSARLAEFYERAGVAESLCG------------------- AjMethanoccus AMREISGRLEEMPGEEGYPAYLASRLAQFYERAGRVITLGKDN----------------- betE.coli AGTEVSALLGRMPSAVGYQPTLAEEMGVLQERITST------------------------ beta_human AGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTT------------------------ beta_Sacchar AGSEVSALLGRIPSAVGYQPTLATDMGLLQERITTT------------------------ beta_Thermoto AGSEVSALLGRMPSAVGYQPTSATIWENLQERITST------------------------ beta_Enteroc AGSEVSALLGRMPSAVGYQPTLATEMGQLQERITST------------------------ beta_aquifex AGAEVSTLLGRLPSAVGYQPTLNTDVGEVQERITST------------------------ beta_Cyanidium AGSEVSALLGRMPSAVGYQPTLGTEMGALQERITST------------------------ beta_Macetiv AGSEVSGLMGQMPSRLGYQPTMGTELSELEERISNT------------------------ BMus ALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEG---------------------- BNeurospora ALREVSAAREEVPGRRGFPGYMYTDLSTIYERAGRVAG---------------------- BbMethanosarcina ALRQMGAARNEIPGRRGYPGYMYTDLATLYERAGIVKG---------------------- BSulfolobus ALRELSASREEVPGRGGYPGYMYTDLATIYERAGKVIG---------------------- alpE.coli AYRQISLLLRRPPGREAFPGDVFYLHSRLLERAARVNAEYVEA-------------FTKG alpAquifex AYRQLSLLMRRPPGREAYPGDVFYLHSRLLERAAKLNDDL-------------------- flEcoli AQREIALAIGEPPATKGYPPSVFAKLPALVERAGNGIS---------------------- flAquifex AQREIGLAAGEPPTLKGFTPSVFQLLTRIAESCGAF------------------------ B_Saccharomyces -----------RNGSITQIPILTMPNDDIT-HPIPDLTGYITEGQIFVDRQLHNKGIYPP B_Homo -----------RGGSITQIPILTMPNDDIT-HPIPDLTGFITEGQIYVDRQLHNRQIYPP B_Cyanidium -----------RPGSITQLPILTMPNDDIT-HPIPDLTGYITEEQIYLDRQLHNRQIYPP B_Arabidopsis -----------RKGSITQIPILTMPNDDIT-HPTPDLTGYITEGQIYIDRQLHNRQIYPP BCryptosporidium -----------RNGSITQFPILTMPNDDIT-HPIPDLTGYITEGQIFVDRALYNRQIYPP B_Halobacterium -----------KEGSVTQIPILTMPGDDDT-HPIPDLTGYITEGQIMMNRDLNSQGVTPP B_Methanosarcina -----------AKGSVTQIPILSMPGDDIT-HPIPDLSGYITEGQIVVARELHRKGIYPP B_Methanocaldococcus -----------RTGTITQIPILTMPDDDIT-HPIPDLTGYITEGQIVLSRELHRKGIYPP BPyrobaculum -----------RRGSVTQFPILTMPHDDIT-HPIPDLTGYITEGQLVLSRAMWGKGIYPP BGiardia -----------IKGSITQIPLITLPNDDIT-HIIADLSAFITEGQIFQDRKLFNKNIIPA alphaChlorobium DLPEPLKPLVKGGGSLTALPVIETQAGDVS-AYIPTNVISITDGQIFLESNLFNAGQRPA alphaGeobacter -----------GAGSLTALPIIETQAGDVS-AYIPTNVISITDGQIYLESDLFYSGVRPA alphaAquifex -----------GAGSLTALPIIETKAGDVA-AYIPTNVISITDGQIYLEADLFNKGIRPA alpha_Thermoto -----------GGGSLTALPIVETQANDIS-AYIPTNVISITDGQIYLEPGLFYAGQRPA alphaEnterococcus_hirae -----------GGGSMTALPFVETQAGDIS-AYIPTNVISITDGQIFLESDLFYAGTRPA alpha_Sacchar -----------GSGSLTALPVIETQGGDVS-AYIPTNVISITDAQIFLEAELFYKGIRPA alpha_acetiv -----------GGGSLTALPIIETEAQNIS-AYIPTNLISITDGQIYLSPSLFELGVLPA APyrobaculum -----------RVGSLTIAASVSPPGGDFT-EPVTSNTLRFIGAFWPLSPRLAYSRHYPA ASulfolobu -----------RYGSVTIASAVSPPGGDFT-EPVTSNTLRFVRVFWPLDVSLAQARHYPA A_Maceti -----------EKGSITAIGAVSPPGGDFS-EPVTQNTLRIVKVFWALDAKLSQRRHFPA AHalobacte -----------TEGSISVIGAVSPPGGDFS-EPVTQNTLRIVKTFWALDSDLAERRHFPA AjMethanoc -----------RQGFVCIVGAVSPPGGDFS-EPVTSNTLRIVKVFWALDANLARRRHFPA AEnterococ -----------REGSITAISAVSPSGGDIS-EPVTQNTLRVVKVFWGLDSSLAQKRHFPS AArabidops -----------RNGSVTIVGAVSPPGGDFS-DPVTSATLSIVQVFWGLDKKLAQRKHFPS ACyanidium -----------RQGSITIVGAVSPPGGDFS-DPVTSATLGIVQVFWGLDKKLAQRKHFPS A1Homo1_Ho -----------REGSVSIVGAVSPPGGDFS-DPVTSATLGIVQVFWGLDKKLAQRKHFPS ASaccharomy -----------RTGSVSIVAAVSPAGGDFS-DPVTTATLGITQVFWGLDKKLAQRKHFPS AGiardia STEQGLLQPGQRIGSVSVIGAVSPAAGDLS-DAVAVSTLAIVQVFWGLSKNLANGKHFPS beta_ArabidopsisM -----------KKGSITSVQAIYVPADDLT-DPAPATTFAHLDATTVLSRQISELGIYPA AArabidopsis -----------RNGSVTIVGAVSPPGGDFS-DPVTSATLSIVQVFWGLDKKLAQRKHFPS AMus -----------regsvsivgavsppggdfs-dpvtsatlgivqvfwgldkklaqrkhfps AHalobacterium -----------TEGSISVIGAVSPPGGDFS-EPVTQNTLRIVKTFWALDSDLAERRHFPA ANeurospora -----------REGSVSIVGAVSPPGGDFS-DPVTSATLGIVQVFWGLDKKLAQRKHFPS APlasmodium -----------RIGSITIVGAVSPPGGDFS-DPVTTATMSIVQAFWGLDKKLAQRKHFPS ATrypanosoma -----------REGSVTIVGAVSPPGGDFS-DPVTSATLGIVQVFWGLEKRLAQRKHFPS ASulfolobus -----------RYGSVTIASAVSPPGGDFT-EPVTSNTLRFVRVFWPLDVSLAQARHYPA AMethanosarcina -----------ETGSITVIGAVSPPGGDFS-EPVTQNTLRIVKVFWALDAKLSQRRHFPA AjMethanoccus -----------RQGFVCIVGAVSPPGGDFS-EPVTSNTLRIVKVFWALDANLARRRHFPA betE.coli -----------KTGSITSVQAVYVPADDLT-DPSPATTFAHLDATVVLSRQIASLGIYPA beta_human -----------KKGSITSVQAIYVPADDLT-DPAPATTFAHLDATTVLSRAIAELGIYPA beta_Sacchar -----------KKGSVTSVQAVYVPADDLT-DPSPSTSFAHLDASSVLSRGISELGIYPA beta_Thermoto -----------RRGSITSVQAIYVPADDIT-DPAPATTFAHLDATVVLSRRIAELGLYPA beta_Enteroc -----------KKGSITSIQAIYVPADDYT-DPAPATAFAHLDATTNLERKLTEQGIYPA beta_aquifex -----------KKGSITAIQAVYVPADDIT-DPAPWSIFAHLDATTVLTRRLAELGIYPA beta_Cyanidium -----------LDGSITSIQAVYVPADDLT-DPAPATTFAHLDATTVLSRALAAKGIYPA beta_Macetiv -----------DAGAIMSIQAVYVPADDFT-DPAAVHTFSHLSASIVLSRKRASEGLYPA BMus -----------RNGSITQIPILTMPNDDIT-HPIPDLTGYITEGQIYVDRQLHNRQIYPP BNeurospora -----------RNGSITQIPILTMPNDDIT-HPIPDLTGYITEGQIFVDRGLHNRGIYPP BbMethanosarcina -----------AKGSVTQIPILSMPGDDIT-HPIPDLSGYITEGQIVVSRELHRKGIYPP BSulfolobus -----------KKGSITQMPILTMPNDDMT-HPIPDLTGYITEGQIVLDRSLFNKGIYPP alpE.coli EVKG-------KTGSLTALPIIETQAGDVS-AFVPTNVISITDGQIFLETNLFNAGIRPA alpAquifex -----------GAGSLTALPIIETKAGDVA-AYIPTNVISITDGQIYLEADLFNKGIRPA flEcoli -----------GGGSITAFYTVLTEGDDQQ-DPIADSARAILDGHIVLSRRLAEAGHYPA flAquifex -----------KKGSITGIFTVLVEGDDISLDPIADSLMGVLDGHIILSRKRAVRGLFPA B_Saccharomyces INVLPSLSRLMKSAIGE--GMTRKDHGDVSNQLYAKYAIGKDAAAMKAV----VGEEALS B_Homo INVLPSLSRLMKSAIGE--GMTRKDHGDVSNQLYACYAIGKDVQAMKAV----VGEEALT B_Cyanidium INVLPSLSRLMKSAIGE--GMTRKDHSDVSNQLYAAYAMGKDALAMRAV----VGVEALS B_Arabidopsis INVLPSLSRLMKSAIGE--GMTRKDHSDVSNQLYANYAIGKDVQAMKAV----VGEEALS BCryptosporidium INVLPSLSRLMKSGIGT--GLTREDHPSVSDQLYANYAIGQDTRAMVAV----VGEEALS B_Halobacterium VNVLPSLSRLMDDGIGE--GLTRADHGDVSDQLYAAYAEGEELRDLVNI----VGREALS B_Methanosarcina INVLPSLSRLMNSGIGP--GKTREDHKAVSDQMYAGYAEGRDLRGLVAI----VGKEALS B_Methanocaldococcus VDVLPSLSRLAGNGQGP--GKTREDHKKVVNQAYAAYAEGRSLRDLVAV----VGEEALT BPyrobaculum FDVIMSLSRLAKDAIGE--GKTREDHKDVANTLIAAYSKALEIRNLATL----VGERNLG BGiardia VDPLPSLSRLQKSAIGK--GRTREDHPDVANQLYASYAIAVEVLSLKSI----VGSEGLS alphaChlorobium INVGISVSRVGGA-------AQIKAMKKVAGTLRLDLAQFRELEAFSKF------GSDLD alphaGeobacter INVGLSVSRVGGS-------AQVKAMKQVAGTLRLNLAQYREMAAFAQF------GSDLD alphaAquifex INVGLSVSRVGGA-------AQIKAMKQVAGTLRLELAQFRELEAFVQF------ASELD alpha_Thermoto INVGLSVSRVGGS-------AQIKAMKQVAGMLRIDLAQYRELETFAQF------ATELD alphaEnterococcus_hirae VDAGLSVSRVGGS-------AQIKAMKKVAGTLRLDLASYRELEAFTQF------GSDLD alpha_Sacchar INVGLSVSRVGSA-------AQVKALKQVAGSLKLFLAQYREVAAFAQF------GSDLD alpha_acetiv VDVGKSVSRVGGK-------AQLAVYREVAGALKLAYSQFEELEAFTRF------GARLD APyrobaculum IDWLVAFSRYVDTVEVWWSKNVSPEWRRIRDALQSILVKEAELQEIVRI----LGTEALS ASulfolobu INWIQGFSAYVDLVAQWWHKNVDPNWKEMRDTMMKVLIREDELRQIVRL----VGPEELA A_Maceti INWLNSYSLYKEDLNDWFTENVAPDYVAMREKAMDMLQTESELQEIVQL----VGSDALP AHalobacte INWDESYSLYKDQLDPWFTDNVVDDWAEQRQSAVDILDEESELEEIVQL----VGKDALP AjMethanoc INWLQSYSLYIDDVTEWWNTNTGPDWRQLRDEAMSLLQKEAELQEIVQL----VGPDALP AEnterococ INWIQSYSLYSTEVGRYMDQILQQDWSDMVTEGMRILQEEEQLNEIVRL----VGIDSLS AArabidops VNWLISYSKYSTALESFY-EKFDPDFINIRTKAREVLQREDDLNEIVQL----VGKDALA ACyanidium VNWLISYSKYMKALEPYY-EERFPEFLNYQQKAREILQTEDDLMEIVQL----VGKDSLA A1Homo1_Ho VNWLISYSKYMRALDEYY-DKHFTEFVPLRTKAKEILQEEEDLAEIVQL----VGKASLA ASaccharomy INTSVSYSKYTNVLNKFY-DSNYPEFPVLRDRMKEILSNAEELEQVVQL----VGKSALS AGiardia VDWLISYSRCTETLAPWY-NARDISFLTNKEKAKTLLQNEVAIQETAQL----VGYDSLD beta_ArabidopsisM VDPLDSTSRMLSP------HILGEEHYNTARGVQKVLQNYKNLQDIIAI----LGMDELS AArabidopsis VNWLISYSKYSTALESFY-EKFDPDFINIRTKAREVLQREDDLNEIVQL----VGKDALA AMus vnwlisyskymraldeyy-dkhftefvplrtkakeilqeegdlaeivql----vgkasla AHalobacterium INWDESYSLYKDQLDPWFTDNVVDDWAEQRQSAVDILDEESELEEIVQL----VGKDALP ANeurospora INTSVSYSKYLTILDKWY-EREYPDFPRLRDRIRQLLSDSEELDQVVQL----VGKSALS APlasmodium VNWSTSFSKYVRQLEQYF-DNFDQDFLSLRQKISDILQQESDLNDIVQL----VGKDSLS ATrypanosoma VNWLISYSKYLNALEPFF-NTLDPDYMRLRSVAAEILQREEELQEIVQL----VGKDSLS ASulfolobus INWIQGFSAYVDLVAQWWHKNVDPNWKEMRDTMMKVLIREDELRQIVRL----VGPEELA AMethanosarcina INWLNSYSLYKDSLNDWFADNVAPDYVPLRERAMEMLQTESELQEIVQL----VGSDALP AjMethanoccus INWLQSYSLYIDDVTEWWNTNTGPDWRQLRDEAMSLLQKEAELQEIVQL----VGPDALP betE.coli VDPLDSTSRQLDP------LVVGQEHYDTARGVQSILQRYQELKDIIAI----LGMDELS beta_human VDPLDSTSRIMDP------NIVGSEHYDVARGVQKILQDYKSLQDIIAI----LGMDELS beta_Sacchar VDPLDSKSRLLDA------AVVGQEHYDVASKVQETLQTYKSLQDIIAI----LGMDELS beta_Thermoto VDPLDSSSKILDP------AIVGREHYEVARGVQEVLQRYKDLQDIIAI----LGVEELS beta_Enteroc VDPLASSSSALAP------EIVGEEHYKVATEVQHVLQRYRELQDIIAI----LGMDELS beta_aquifex IDPLESTSKYLAP------EYVGEEHYEVAMEVKRILQRYKELQEIIAI----LGMEELS beta_Cyanidium VDPLDSTSTMLQP------GIVSDEHYTTARKVKETLQRYKELQDIIAI----LGLDELS beta_Macetiv IDPLQSNSKMSTP------GIIGERHYRLAQEIRQTLAQYAELKDIISM----LGLEQLS BMus INVLPSLSRLMKSAIGE--GMTRKDHADVSNQLYACYAIGKDVQAMKAV----VGEEALT BNeurospora INVLPSLSRLMKSAIGE--GMTRKDHGDVSNQLYAKYAIGRDAAAMKAV----VGEEALS BbMethanosarcina INVLPSLSRLMNSGIGA--GKTREDHKAVSDQMYAGYAEGRDLRGLVAI----VGKEALS BSulfolobus INVLMSLSRLMKDGIGE--GKTRDDHKDLSNQLFAAYARAQDIRGLAAI----IGEDSLS alpE.coli VNPGISVSRVGGA-------AQTKIMKKLSGGIRTALAQYRELAAFSQF------ASDLD alpAquifex INVGLSVSRVGGA-------AQIKAMKQVAGTLRLELAQFRELEAFVQF------ASELD flEcoli IDIEASISRAMTA-------LISEQHYARVRTFKQLLSSFQRNRDLVSVGAYAKGSDPML flAquifex VDPVRSLSRLMPK-------LVSEEHFMKANFFKEVLSKFEDVEELVRIGLYKGGSNPLV B_Saccharomyces IEDKLSLEFLEKFEKTFITQGAYEDRTVFESLDQAWSLLRIY------------------ B_Homo SEDLLYLEFLQKFEKNFINQGPYENRSMFESLDLSWKLLRIF------------------ B_Cyanidium QEDLLYLEFHDKFERRFVNQGAYERRDIYTSLDMAWDLLRIF------------------ B_Arabidopsis SEDLLYLEFLDKFERKFVMQGAYDTRNIFQSLDLAWTLLRIF------------------ BCryptosporidium ADDLLYLEFTSKFESKFLSQGPYEKRDIFESLDLAWELLRTF------------------ B_Halobacterium ERDNRYLDFADRFEAEFIDQGFKTNRDIEETLDLGWELLSMF------------------ B_Methanosarcina ERDTKFLEFADLFEDKFVRQGRNENRTIEDTLEIGWQILTHL------------------ B_Methanocaldococcus DRDRAYLKFADEFEDKFVRQGKDEDRSIEETLDLLWELLAIL------------------ BPyrobaculum WRERRYLRFADAFEQRFIKQGYYERRSFEETLDIGWDVLSIL------------------ BGiardia DNDHKYLKFLEVFEEQFLKQDFNTRRSIYESLDLAWKCLRVL------------------ alphaChlorobium KSTKAQLDRGARLVE-ILKQGQYIPMPVEKQVAIIFIGTQGLLDSVDLKQVRRF------ alphaGeobacter KATQMQLARGERLVE-ILKQPQYRPIPNEKQVLVIFAANNGFVDEYPVSSLRRY------ alphaAquifex KATQQQINRGLRLVE-LLKQEPYNPIPVEKQIVLIYAGTHGYLDDIPVESVRKF------ alpha_Thermoto PATRAQIIRGQRLME-LLKQEQYSPMPVEEQVVVLFAGVRGYLDDLPVEEVRRF------ alphaEnterococcus_hirae AATQAKLNRGRRTVE-ILKQKLHAPLAVEKQVVILYALTHGFLDSIPVDSILDF------ alpha_Sacchar ASTKQTLVRGQRLTQ-LLKQNQYSPLATEEQ-SMIIAGVNGHSGWYELSRIGEF------ alpha_acetiv ENTRKIIEHGRRIRA-LLKQPEFSPVPVPEQIVILLALDAKLFDSVPLDRIIDA------ APyrobaculum EYEKHILNVAFMIREGFLKQDAYNPVDTPSAPIKQFLLMKAIYTYYEEGLKAIE------ ASulfolobu EKDKLVLEAAKLIKDAFLKENAYDDIDAFSSPQKQVRIMRLIYIFYNQSQDLIS------ A_Maceti EEQQLLLEITRMIREIYLQQNAFHPIDTYSPFAKQYKIMQAIMKYGDAAMDALK------ AHalobacte EDQQLTLEVARYIREAWLQQNALHDVDRYCPPEKTYAILSGIKTLHEESFEALD------ AjMethanoc DRERVILEVARMLREDFLQQDAFDEVDTYCPPMKQYLMLKIIMTFYQEALKAVERGVEP- AEnterococ DNDRLTLEVAKSIREDYLQQNAFDDVDTFTSREKQFNMLKVILTFGKEARKALS------ AArabidops EGDKITLETAKLLREDYLAQNAFTPYDKFCPFYKSVWMMRNIIHFYNLANQAVERAAGMD ACyanidium ENDKITLEVAKMIREDFLAQNSFTEYDRFCPFYKSVLMLRNMIHFYELANKAVE--GSGE A1Homo1_Ho ETDKITLEVAKLIKDDFLQQNGYTPYDRFCPFYKTVGMLSNMIAFYDMARRAVETTAQSD ASaccharomy DSDKITLDVATLIKEDFLQQNGYSTYDAFCPIWKTFDMMRAFISYHDEAQKAVA------ AGiardia DSEKLILDVCNLIQEGFLQQNSYTVYDKFCPFIKTDLMLRNIVHYYESCKTALG------ beta_ArabidopsisM EDDKLTVARARKIQR-FLSQ-PFHVAEIFTGAPGKYVDLKENINSF-------------- AArabidopsis EGDKITLETAKLLREDYLAQNAFTPYDKFCPFYKSVWMMRNIIHFYNLANQAVERAAGMD AMus etdkitlevaklikddflqqngytpydrfcpfyktvgmlsnmisfydmarravettaqsd AHalobacterium EDQQLTLEVARYIREAWLQQNALHDVDRYCPPEKTYAILSGIKTLHEESFEALD------ ANeurospora DPDKITLDMATLIKEDFLQQNGYSDYDQFCPIWKTEWMMKLMMGFHDEAQKAIA------ APlasmodium EDQKVVMEVAKIIREDFLQQNAFSDYDYMCPLQKTVGMMRIICHFYAQCLRTLQEYDSRE ATrypanosoma ESDKIILETAKVIREEFLQQNAFTPYDKYCPPYKTCWMLRNIVAFYEESQRVVAESAGE- ASulfolobus EKDKLVLEAAKLIKDAFLKENAYDDIDAFSSPQKQVRIMRLIYIFYNQSQDLIS------ AMethanosarcina DDQQLLLEITRMLREIFLQQNAFHPVDAYSPFDQQYKILKAIMKWGDAAMDALK------ AjMethanoccus DRERVILEVARMLREDFLQQDAFDEVDTYCPPMKQYLMLKIIMTFYQEALKAVERGVEP- betE.coli EEDKLVVARARKIQR-FLSQ-PFFVAEVFTGSPGKYVSLKDTIRGF-------------- beta_human EEDKLTVSRARKIQR-FLSQ-PFQVAEVFTGHMGKLVPLKETIKGF-------------- beta_Sacchar EQDKLTVERARKIQR-FLSQ-PFAVAEVFTGIPGKLVRLKDTVASF-------------- beta_Thermoto PEDKLVVHRARRIQR-FLSQ-PFHVAERFTGRPGRYVPIEETIRGF-------------- beta_Enteroc DQEKVLVSRARRVQF-FLSQ-NFNVAEQFTGLPGSYVPVEETVKGF-------------- beta_aquifex DEDKAIVNRARRIQK-FLSQ-PFHVAEQFTGMPGKYVKLEDTIRSF-------------- beta_Cyanidium EEDRLIVSRARKIEK-FLSQ-PFFVAEVFTGISGKYVSLSDSIKGF-------------- beta_Macetiv QEDRNVVARARRLER-FLTQ-PFFTTEQFTGFKGKFVTLSDALDGC-------------- BMus SDDLLYLEFLQKFEKNFITQGPYENRTVYETLDIGWQLLRIF------------------ BNeurospora NEDKLSLEFLDKFERSFIAQGPYESRTIFESLDLAWSLLRIY------------------ BbMethanosarcina ERDVKFLEFADLFEQQFVTQGRNENRTIADTLDIGWKILAHL------------------ BSulfolobus EVDRKYLLFAEAFERRFVAQGVNENRSIETTVDIGWEVLSIL------------------ alpE.coli DATRKQLDHGQKVTE-LLKQKQYAPMSVAQQSLVLFAAERGYLADVELSKIGSF------ alpAquifex KATQQQINRGLRLVE-LLKQEPYNPIPVEKQIVLIYAGTHGYLDDIPVESVRKF------ flEcoli DKAIALWPQLEG----YLQQGIFERADWEASLQ---GLERIF------------------ flAquifex DKVINNLEKVES----FFKQKPEEKVNFEESLKA-------------------------- B_Saccharomyces -PKEMLNRISQRFLMNFTI------------EPETMPTKMKKIRHKKLR----------- B_Homo -PKEMLKRIPQAVIDEFYSR----------EGRLQDLAPDTAL----------------- B_Cyanidium -PVQMLRRIPEKILQEYYHR----------TSNYEHKENKPHSSRS-------------- B_Arabidopsis -PRELLHRIPAKTLDQFYSR----------DSTS-------------------------- BCryptosporidium -PEDMLKKIKHDLLQKYYP-------------RDNYIQHSK------------------- B_Halobacterium -PKTELNRVDEDLIEDHYV--------------EDVADEATAD----------------- B_Methanosarcina -PENQLGRIDNKYIQKYHP--------------AHRKAK--------------------- B_Methanocaldococcus -PEEELKRVDRELIEKYHP-------------------KYRKK----------------- BPyrobaculum -PEDELTNARPQITQKFYR---------------------RHIFESVQL----------- BGiardia -PINLLSRISDSILEKYYYVQT--------DAAEQPGAKTK------------------- alphaChlorobium -EEEFLAMLEQKHPEILSSIAEKG------TLESDIASKLKELGEKYVASFKEKSKA--- alphaGeobacter -ESELYSFFDSRKADILAELRDKK------AIDDDLKAKMIAALEELKKEFTA------- alphaAquifex -EKELYAYLDNERPDILKEISEKK------KLDEELEKKIKEALDAFKQKFVP------- alpha_Thermoto -EKEFLRFMHEKHQDILDDIKTKK------ELTSETEEKLKKAIEEFKTTFRV------- alphaEnterococcus_hirae -EHELFEYLDTNHADIFETIRTTKDLPEE-ERLNQAIQEYKDIFLATKGNTSSTEDKLKS alpha_Sacchar -ESSFLSYLKSNHNELLTEIREKG------ELSKELLASLKSATESFVATF--------- alpha_acetiv -EHSLRAAVADIPAEVRERFNADA------ELSDRDREIILEIARKALERFRPESKPVTI APyrobaculum -SGVPASVLRELETVKRLPRLRME------VTNDVAKEELTKFIESLVAEIRATTNRRG- ASulfolobu -KGVPLKKILDKVGPIEPEIIRIKY-----TIKNDELNKIDEIENKLKATFDSLLKEVS- A_Maceti -SGVPASEIIKMESKDELPKV---------KFEEDFDGSLSAVLAKMDKEFAALGGR--- AHalobacte -AGVPVEEITSIDAAPRLNRLGT-------TPDDEHEAEVAEIKQQITEQLRELY----- AjMethanoc -AKILGVSVKQDIARMKYI-----------PHDEFINVKSKEIMEKIKNELGSLN----- AEnterococ -LGAYFNEIMEGTVAVRERISRSK------YIPEEELAKISSINEEIKETIQLIVSEGGM AArabidops GQKITYTLIKHRLGDLFYRLVSQKFEDPA-EGEDTLVEKFKKLYDDLNAGFRALEDETR- ACyanidium -QHLTLAQIKEQMGETIYKISGMKFLDPA-QGWSLF------------------------ A1Homo1_Ho -NKITWSIIREHMGDILYKLSSMKFKDPLKDGEAKIKSDYAQLLEDMQNAFRSLED---- ASaccharomy -NGANWSKLADSTGDVKHAVSSSKFFEPS-RGEKEVHGEFEKLLSTMQERFAESTD---- AGiardia -QGHSYQELKNSLEKLITALYRMKFIDTNTNGIEYGVTELDKLHAQITAAFDAL------ beta_ArabidopsisM -QGLLDGKYDDLSEQSFYMV----------GGIDEVVAKAEKIAKESAA----------- AArabidopsis GQKITYTLIKHRLGDLFYRLVSQKFEDPA-EGEDTLVEKFKKLYDDLNAGFRALEDETR- AMus -nkitwsiirehmgeilyklssmkfkdpvkdgeakikadyaqlledmqnafrsled---- AHalobacterium -AGVPVEEITSIDAAPRLNRLGT-------TPDDEHEAEVAEIKQQITEQLRELY----- ANeurospora -QGQNWNKVREATQDLQAQLKSLKFEVPS-EGQEKICKKYEAIQQQMLDKFASVIDE*-- APlasmodium -RKIGWGSIYNTLRPTINKITHMKFENPK-NSDEYFKKYFKALEEEITVGLRNLMEK*-- ATrypanosoma -LKITWNYIREMIPHIYTGLTEMKFRDPQ-EGEEANVEFYRKQNEEIVSAFASLLQ*--- ASulfolobus -KGVPLKKILDKVGPIEPEIIRIKY-----TIKNDELNKIDEIENKLKATFDSLLKEVS* AMethanosarcina -SGVPVTEIIKLESKNVLAKV---------KYEEKFDESMNAVLAQMDKEFASLRGR*-- AjMethanoccus -AKILGVSVKQDIARMKYI-----------PHDEFINVKSKEIMEKIKNELGSLN----- betE.coli -KGIMEGEYDHLPEQAFYMV----------GSIEEAVEKAKKL*---------------- beta_human -QQILAGEYDHLPEQAFYMV----------GPIEEAVAKADKLAEEHSS----------- beta_Sacchar -KAVLEGKYDNIPEHAFYMV----------GGIEDVVRKAEKLAREAN------------ beta_Thermoto -KEILDGKLDDVPEQAFLMA----------GNIEEVKERAKEIEELKM------------ beta_Enteroc -REILEGKYDDLPEEAFRSV----------GRIEDVVEKAKKLGY--------------- beta_aquifex -KEVLTGKYDHLPENAFYMV----------GTIEDVIEKAKQMGAKV------------- beta_Cyanidium -NMILSGEVDNIPEQAFYLV----------GRIEEAIDKAKQVEKS-------------- beta_Macetiv -ERILLDEFKDYPESDLYMI----------GTIDEAIAKKSSRDQT-------------- BMus -PKEMLKRIPQSTLSEFYPR----------DSAKH------------------------- BNeurospora -RKDMLNRIPKKIIDEFYSRSAADR-----KGKGKDKPTTKDTRDTAAPEEENLIDA*-- BbMethanosarcina -PENQLGRIDNKYIQKYHP--------------AHRKGQ*-------------------- BSulfolobus -PESELSLIRSEYIKKYHP---------------NYRGKK*------------------- alpE.coli -EAALLAYVDRDHAPLMQEINQTG------GYNDEIEGKLKGILDSFKATQSW*------ alpAquifex -EKELYAYLDNERPDILKEISEKK------KLDEELEKKIKEALDAFKQKFVP------- flEcoli -PTVS------------------------------------------------------- flAquifex -LDEIYSLLK-------------------------------------------------- B_Saccharomyces ------------------- B_Homo ------------------- B_Cyanidium ------------------- B_Arabidopsis ------------------- BCryptosporidium ------------------- B_Halobacterium ------------------- B_Methanosarcina ------------------- B_Methanocaldococcus ------------------- BPyrobaculum ------------------- BGiardia ------------------- alphaChlorobium ------------------- alphaGeobacter ------------------- alphaAquifex ------------------- alpha_Thermoto ------------------- alphaEnterococcus_hirae IQNA--------------- alpha_Sacchar ------------------- alpha_acetiv TKPEVKTEAKSMQETKENV APyrobaculum ------------------- ASulfolobu ------------------- A_Maceti ------------------- AHalobacte ------------------- AjMethanoc ------------------- AEnterococ TDD---------------- AArabidops ------------------- ACyanidium ------------------- A1Homo1_Ho ------------------- ASaccharomy ------------------- AGiardia ------------------- beta_ArabidopsisM ------------------- AArabidopsis ------------------- AMus ------------------- AHalobacterium ------------------- ANeurospora ------------------- APlasmodium ------------------- ATrypanosoma ------------------- ASulfolobus ------------------- AMethanosarcina ------------------- AjMethanoccus ------------------- betE.coli ------------------- beta_human ------------------- beta_Sacchar ------------------- beta_Thermoto ------------------- beta_Enteroc ------------------- beta_aquifex ------------------- beta_Cyanidium ------------------- beta_Macetiv ------------------- BMus ------------------- BNeurospora ------------------- BbMethanosarcina ------------------- BSulfolobus ------------------- alpE.coli ------------------- alpAquifex ------------------- flEcoli ------------------- flAquifex -------------------