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Question #1:

You performed a BLAST search with an unknown sequence as a query. Your results are depicted in the graph below. The hits are ordered by their BLAST scores, the best hits are on the top.

What can you infer about the unknown sequence? Type your answers in the textbox below:



Question #2:

The tree below depicts a Neighbor-Joining tree of the homologs of ATPases and the extein portion of an unknown protein (marked as extein). The clusters of proteins have different functions, which are marked by different colors: A/V-ATPase catalytic subunits in red, F-ATPase catalytic subunits in blue, Rho termination factors in cyan, flagellar ATPase in green, F-ATPase non-catalytic subunits in yellow, and A/V-ATPase non-catalytic subunits in purple.


What can you infer about the function of extein portion of the unknown protein? Type your answers in the textbox below:



Based on this tree, how confident are you in your answer?:

Very Confident
Not confident at all
Cannot decide


Explain your answer:



Question #3

You ran PSI-BLAST search for 5 generations with putative "ribosomal protein S6 modification protein" as a query. The results of the 5th iteration are below:


Results from round 5
                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value
Sequences used in model and found again:

ref|NP_064551.2| (NM_020166) methylcrotonoyl-Coenzyme A carboxyl...   195  5e-49
gb|AAK67986.1|AF297332_1 (AF297332) 3-methylcrotonyl-CoA carboxy...   195  5e-49
dbj|BAA99407.1| (AB029826) 3-methylcrotonyl-CoA carboxylase biot...   195  5e-49
ref|NP_484982.1| (NC_003272) biotin carboxylase [Nostoc sp. PCC ...   191  7e-48
ref|NP_308959.1| (NC_002695) ribosomal protein S6 modification p...   190  2e-47
ref|NP_455402.1| (NC_003198) ribosomal protein S6 modification p...   188  5e-47
ref|NP_286618.1| (NC_002655) ribosomal protein S6 modification p...   185  3e-46
gb|AAG45427.1|AF317651_4 (AF317651) pyruvate carboxylase ATP-bin...   184  9e-46
gb|AAB88214.1| (U59234) biotin carboxylase [Synechococcus sp. PC...   182  5e-45
ref|NP_371638.1| (NC_002758) pyruvate carboxylase [Staphylococcu...   181  8e-45
ref|NP_439680.1| (NC_000907) ribosomal protein S6 modification p...   180  1e-44
ref|NP_389369.1| (NC_000964) pyruvate carboxylase [Bacillus subt...   180  2e-44
ref|NP_243491.1| (NC_002570) pyruvate carboxylase [Bacillus halo...   179  2e-44
ref|NP_442228.1| (NC_000911) biotin carboxylase [Synechocystis s...   178  4e-44
dbj|BAA12072.1| (D83706) pyruvate carboxylase [Geobacillus stear...   177  1e-43
ref|NP_253884.1| (NC_002516) ribosomal protein S6 modification p...   177  1e-43
ref|NP_539980.1| (NC_003317) BIOTIN CARBOXYLASE [Brucella melite...   177  2e-43
ref|NP_231912.1| (NC_002505) ribosomal protein S6 modification p...   177  2e-43
gb|AAH21382.1|AAH21382 (BC021382) methylcrotonoyl-Coenzyme A car...   177  2e-43
ref|NP_248224.1| (NC_000909) biotin carboxylase (accC) [Methanoc...   177  2e-43
ref|NP_076133.1| (NM_023644) methylcrotonoyl-Coenzyme A carboxyl...   176  2e-43
dbj|BAB25253.1| (AK007782) data source:MGD, source key:MGI:19192...   176  3e-43
ref|NP_564338.1| (NM_102730) carbamoylphosphate synthetase, puta...   176  3e-43
ref|NP_561990.1| (NC_003366) acetyl-CoA carboxylase [Clostridium...   175  4e-43
sp|P46537|CARB_BACCL CARBAMOYL-PHOSPHATE SYNTHASE, PYRIMIDINE-SP...   174  8e-43
pir||T44813 biotin carboxylase (EC 6.3.4.14) yngH [imported] - B...   174  8e-43
ref|NP_214014.1| (NC_000918) biotin carboxylase [Aquifex aeolicu...   174  9e-43
gb|AAF57199.1| (AE003779) CG2118 gene product [Drosophila melano...   174  1e-42
emb|CAB07850.1| (Z93780) carbamoyl phosphate synthetase III [Tak...   173  2e-42
ref|NP_389435.1| (NC_000964) carbamoyl-phosphate synthetase (cat...   173  2e-42
pir||T43735 pyruvate carboxylase (EC 6.4.1.1) [validated] - yell...   173  2e-42
gb|AAD43968.1|AF119250_1 (AF119250) carbamoyl-phosphate syntheta...   173  3e-42
pir||T44419 carbamoyl-phosphate synthase (glutamine-hydrolyzing)...   172  3e-42
gb|AAD34740.1| (AF132152) unknown [Drosophila melanogaster] >gi|...   172  3e-42
ref|XP_080533.1| (XM_080533) BcDNA:GH06348 [Drosophila melanogas...   172  5e-42
gb|AAG22289.1| (AE003831) BcDNA:GH06348 gene product [alt 1] [Dr...   172  5e-42
gb|AAL50065.1| (AY070723) At1g03090/F10O3_8 [Arabidopsis thaliana]    172  5e-42
gb|AAD51318.2| (AF169248) acetylglutamate-activated carbamoyl ph...   171  7e-42
gb|AAB62566.1| (AF006491) carbamoyl-phosphate synthetase III; CP...   171  9e-42
gb|AAD09129.1| (AF112473) PyrABCN [Emericella nidulans]               170  1e-41
ref|NP_465360.1| (NC_003210) highly similar to carbamoyl-phospha...   170  1e-41
ref|NP_004332.2| (NM_004341) carbamoylphosphate synthetase 2/asp...   170  1e-41
ref|NP_277017.1| (NC_000916) biotin carboxylase [Methanothermoba...   170  1e-41
pir||S53602 carbamoyl-phosphate synthase (glutamine-hydrolyzing)...   170  2e-41
gb|AAG34685.1|AF310955_1 (AF310955) ligase VanB2 [Enterococcus f...   170  2e-41
gb|AAA96435.1| (L31362) carbamyl phosphate synthetase III [Squal...   170  2e-41
ref|NP_283408.1| (NC_003116) putative acetyl-CoA carboxylase bio...   170  2e-41
ref|NP_505977.1| (NM_073576) pyruvate carboxylase [Caenorhabditi...   169  3e-41
ref|NP_245763.1| (NC_002663) RimK [Pasteurella multocida] >gi|12...   169  3e-41
ref|NP_471283.1| (NC_003212) highly similar to carbamoyl-phospha...   168  4e-41
sp|P08955|PYR1_MESAU CAD PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT ...   168  5e-41
pir||S04775 rimK protein - Escherichia coli >gi|42747|emb|CAA338...   168  5e-41
ref|NP_241998.1| (NC_002570) biotin carboxylase [Bacillus halodu...   168  5e-41
sp|Q91293|CPSM_RANCA CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MIT...   168  6e-41
gb|AAF32338.1|AF218939_6 (AF218939) acetyl-CoA carboxylase [Baci...   168  7e-41
gb|AAA37062.1| (J05503) carbamoyl-phosphate synthetase (E.C.6.3....   168  7e-41
ref|NP_274857.1| (NC_003112) acetyl-CoA carboxylase, biotin carb...   168  7e-41
gb|AAF72363.1|AF192329_24 (AF192329) VanB [Enterococcus faecalis]     168  8e-41
ref|NP_058768.1| (NM_017072) carboamyl-phosphate synthetase 1 [R...   168  9e-41
sp|Q06893|VANB_ENTFC VANCOMYCIN B-TYPE RESISTANCE PROTEIN VANB (...   167  9e-41
ref|NP_214438.1| (NC_000918) carbamoyl-phosphate synthase large ...   167  1e-40
ref|NP_539717.1| (NC_003317) PROPIONYL-COA CARBOXYLASE ALPHA CHA...   167  1e-40
pir||T06565 acetyl-CoA carboxylase (EC 6.4.1.2) biotin carboxyla...   167  1e-40
sp|P27708|PYR1_HUMAN CAD protein [Includes: Glutamine-dependent ...   167  2e-40
ref|NP_102052.1| (NC_002678) biotin carboxylase [Mesorhizobium l...   167  2e-40
emb|CAB09721.1| (Z97025) pyruvate carboxylase [Bacillus subtilis]     166  2e-40
pir||T07093 acetyl-CoA carboxylase (EC 6.4.1.2) biotin carboxyla...   166  3e-40
gb|AAF80469.1|AF163150_1 (AF163150) acetyl-CoA carboxylase [Glyc...   166  3e-40
ref|NP_253535.1| (NC_002516) biotin carboxylase [Pseudomonas aer...   165  3e-40
ref|NP_243402.1| (NC_002570) carbamoyl-phosphate synthetase (cat...   165  4e-40
sp|P77886|CARB_LACPL CARBAMOYL-PHOSPHATE SYNTHASE, PYRIMIDINE-SP...   165  4e-40
emb|CAB05883.1| (Z83305) D-alanine:D-alanine ligase-related prot...   165  5e-40
pir||T06279 acetyl-CoA carboxylase (EC 6.4.1.2), biotin carboxyl...   165  5e-40
gb|AAG34684.1|AF310954_1 (AF310954) ligase VanB2 [Enterococcus f...   165  5e-40
gb|AAC60207.1| (U65893) carbamoyl-phosphate synthetase III [Onco...   165  5e-40
ref|NP_520908.1| (NC_003295) PROBABLE BIOTIN CARBOXYLASE PROTEIN...   165  5e-40
gb|AAF09095.1|AF068759_1 (AF068759) pyruvate carboxylase [Lactoc...   165  5e-40
gb|AAK25989.1|AF360279_1 (AF360279) putative biotin carboxylase ...   165  5e-40
ref|XP_040883.1| (XM_040883) carbamoyl-phosphate synthetase 1, m...   165  6e-40
ref|NP_104954.1| (NC_002678) pyruvate carboxylase [Mesorhizobium...   165  6e-40
ref|NP_198386.1| (NM_122927) acetyl-CoA carboxylase [Arabidopsis...   165  6e-40
ref|NP_534077.1| (NC_003305) propionyl-coenzyme A carboxylase, a...   165  6e-40
sp|P20054|PYR1_DICDI Protein PYR1-3 [Includes: Glutamine-depende...   165  7e-40
ref|NP_350153.1| (NC_003030) Biotin carboxylase [Clostridium ace...   165  7e-40
gb|AAG34683.1|AF310953_1 (AF310953) ligase VanB2 [Enterococcus f...   165  7e-40
ref|NP_069058.1| (NC_000917) biotin carboxylase (acc) [Archaeogl...   165  7e-40
ref|NP_387384.1| (NC_003047) PROBABLE PYRUVATE CARBOXYLASE PROTE...   164  9e-40
ref|NP_032823.1| (NM_008797) pyruvate decarboxylase [Mus musculu...   164  9e-40
ref|NP_371727.1| (NC_002758) carbamoyl-phosphate synthase large ...   164  9e-40
ref|NP_357031.1| (NC_003063) AGR_L_580GMp [Agrobacterium tumefac...   164  1e-39
pir||S68252 pyruvate carboxylase (EC 6.4.1.1) precursor - rat >g...   164  1e-39
ref|NP_349267.1| (NC_003030) Pyruvate carboxylase, PYKA [Clostri...   164  1e-39
ref|NP_001866.1| (NM_001875) carbamoyl-phosphate synthetase 1, m...   164  1e-39
ref|NP_269044.1| (NC_002737) putative carbamoylphosphate synthet...   164  1e-39
ref|NP_437988.1| (NC_003078) putative propionyl-CoA carboxylase ...   163  2e-39
ref|NP_563488.1| (NC_003366) carbamoyl-phosphate synthetase cata...   163  2e-39
ref|NP_442333.1| (NC_000911) carbamoyl-phosphate synthase, pyrim...   163  2e-39
ref|NP_345739.1| (NC_003028) carbamoyl-phosphate synthase, large...   163  2e-39
pir||T06360 methylcrotonoyl-CoA carboxylase (EC 6.4.1.4) biotin ...   163  2e-39
ref|NP_243761.1| (NC_002570) arginine specific carbamoyl-phospha...   163  2e-39
ref|NP_036876.1| (NM_012744) pyruvate carboxylase [Rattus norveg...   163  2e-39
ref|NP_000911.1| (NM_000920) pyruvate carboxylase precursor [Hom...   163  2e-39
pir||T02431 acetyl-CoA carboxylase (EC 6.4.1.2), biotin carboxyl...   163  3e-39
ref|NP_009767.1| (NC_001134) Urea amidolyase (contains urea carb...   163  3e-39
pir||S23738 pyr1-3 protein - slime mold (Dictyostelium discoideu...   163  3e-39
sp|P11498|PYC_HUMAN Pyruvate carboxylase, mitochondrial precurso...   162  3e-39
ref|NP_385425.1| (NC_003047) PROBABLE BIOTIN CARBOXYLASE PROTEIN...   162  3e-39
ref|NP_354336.1| (NC_003062) AGR_C_2451p [Agrobacterium tumefaci...   162  3e-39
gb|AAF16526.1|AF191301_2 (AF191301) ADP-forming, carbamate-phosp...   162  4e-39
ref|NP_487849.1| (NC_003272) carbamoyl phosphate synthetase larg...   162  4e-39
gb|AAB92588.1| (AF038548) pyruvate carboxylase [Corynebacterium ...   162  4e-39
gb|AAH06915.1|AAH06915 (BC006915) Similar to Propionyl Coenzyme ...   162  5e-39
ref|NP_239976.1| (NC_002528) carbamoyl-phosphate synthase large ...   162  5e-39
ref|NP_358746.1| (NC_003098) Carbamoylphosphate synthase (ammoni...   162  5e-39
ref|NP_454677.1| (NC_003198) carbamoyl-phosphate synthase large ...   161  7e-39
ref|NP_300241.1| (NC_002491) biotin carboxylase [Chlamydophila p...   161  7e-39
gb|AAB31500.1| (S72370) pyruvate carboxylase; pyruvate:carbon di...   161  8e-39
ref|NP_459072.1| (NC_003197) carbamoyl-phosphate synthase, large...   161  9e-39
ref|NP_246444.1| (NC_002663) CarB [Pasteurella multocida] >gi|12...   161  9e-39
pir||S65074 pyrimidine synthesis protein URA1 - fission yeast  (...   161  9e-39
gb|AAL02364.1| (AY046947) propionyl CoA-carboxylase alpha-subuni...   161  1e-38
sp|Q09794|PYR1_SCHPO URA1 protein [Includes: Glutamine-dependent...   160  1e-38
ref|NP_389706.1| (NC_000964) similar to biotin carboxylase [Baci...   160  1e-38
sp|Q47827|DDL_ENTHR D-alanine--D-alanine ligase (D-alanylalanine...   160  1e-38
gb|AAG37026.1|AF277571_3 (AF277571) D-alanine:D-lactate ligase [...   160  2e-38
gb|AAF48639.2| (AE003503) CG18572 gene product [Drosophila melan...   160  2e-38
ref|NP_224391.1| (NC_000922) Biotin Carboxylase [Chlamydophila p...   160  2e-38
ref|NP_009777.1| (NC_001134) converts pyruvate to oxaloacetate; ...   160  2e-38
ref|NP_495838.1| (NM_063437) glutamine-dependent carbamoyl-phosp...   160  2e-38
ref|NP_283414.1| (NC_003116) carbamoyl phosphate synthase large ...   160  2e-38
ref|NP_070102.1| (NC_000917) carbamoyl-phosphate synthase, large...   160  2e-38
sp|Q91437|PYR1_SQUAC CAD protein [Includes: Glutamine-dependent ...   160  2e-38
ref|NP_246028.1| (NC_002663) AccC [Pasteurella multocida] >gi|12...   160  2e-38
gb|AAC41643.1| (M64926) urea amidolyase [Saccharomyces cerevisiae]    159  2e-38
ref|NP_012405.1| (NC_001142) First and second steps of pyrimidin...   159  3e-38
gb|AAA68280.1| (M27174) carbamyl phosphate synthetase [Saccharom...   159  3e-38
ref|NP_228367.1| (NC_000853) carbamoyl-phosphate synthase, large...   159  3e-38
gb|AAD42184.1|AF130997_5 (AF130997) D-alanine:D-lactate ligase [...   159  3e-38
ref|NP_407114.1| (NC_003143) biotin carboxylase [Yersinia pestis...   159  3e-38
emb|CAA42544.1| (X59890) pyruvate carboxylase [Saccharomyces cer...   159  3e-38
dbj|BAA94293.1| (AB029444) Carbamoyl-phosphate Synthetase [Leish...   159  3e-38
ref|NP_390314.1| (NC_000964) acetyl-CoA carboxylase subunit (bio...   159  3e-38
gb|AAA34843.1| (J03889) pyruvate carboxylase (EC 6.4.1.1) [Sacch...   159  3e-38
ref|NP_107983.1| (NC_002678) 3-methylcrotonyl-CoA carboxylase bi...   159  3e-38
emb|CAA60825.1| (X87371) carbamyl phosphate synthetase [Saccharo...   159  3e-38
ref|NP_342159.1| (NC_002754) Carbamoyl-phosphate synthase large ...   159  4e-38
ref|NP_011453.1| (NC_001139) converts pyruvate to oxaloacetate; ...   158  4e-38
ref|NP_274851.1| (NC_003112) carbamoyl-phosphate synthase, large...   158  4e-38
ref|NP_293843.1| (NC_001263) acetyl-CoA carboxylase, biotin carb...   158  5e-38
ref|NP_439133.1| (NC_000907) acetyl-CoA carboxylase, biotin carb...   158  5e-38
pir||T30820 carbamoyl-phosphate synthase (ammonia) (EC 6.3.4.16)...   158  5e-38
ref|NP_355659.1| (NC_003062) AGR_C_4940p [Agrobacterium tumefaci...   158  6e-38
ref|NP_102581.1| (NC_002678) propionyl-CoA carboxylase alpha cha...   158  6e-38
ref|NP_539184.1| (NC_003317) PYRUVATE CARBOXYLASE [Brucella meli...   158  6e-38
gb|AAL66189.1|AF385926_1 (AF385926) propionyl-CoA carboxylase al...   158  7e-38
ref|NP_404125.1| (NC_003143) carbamoyl-phosphate synthase large ...   158  7e-38
ref|NP_571625.1| (NM_131550) pyruvate carboxylase [Danio rerio] ...   158  7e-38
prf||1613430B rimK gene [Escherichia coli]                            158  8e-38
ref|NP_414574.1| (NC_000913) carbamoyl-phosphate synthase large ...   158  8e-38
sp|P14846|CARB_SALTY CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN (C...   158  9e-38
gb|AAK60339.1| (AY034410) biotin carboxylase [Brassica napus]         158  9e-38
ref|NP_285727.1| (NC_002655) carbamoyl-phosphate synthase large ...   158  9e-38
gb|AAC44388.1| (U51439) pyruvate carboxylase [Rhizobium etli]         157  1e-37
ref|NP_000273.1| (NM_000282) Propionyl-Coenzyme A carboxylase, a...   157  1e-37
ref|NP_251581.1| (NC_002516) probable biotin carboxylase/biotin ...   157  1e-37
ref|NP_254123.1| (NC_002516) probable biotin carboxylase subunit...   157  1e-37
ref|NP_294391.1| (NC_001263) carbamoyl-phosphate synthase, large...   157  1e-37
gb|AAA53140.1| (U08469) 3-methylcrotonyl-CoA carboxylase, biotin...   157  2e-37
ref|NP_297342.1| (NC_002488) biotin carboxylase subunit of acety...   157  2e-37
ref|NP_372050.1| (NC_002758) acetyl-CoA carboxylase [Staphylococ...   157  2e-37
ref|NP_266497.1| (NC_002662) D-alanine-D-alanine ligase (EC 6.3....   157  2e-37
ref|NP_457756.1| (NC_003198) biotin carboxylase [Salmonella ente...   157  2e-37
pir||A34337 propionyl-CoA carboxylase (EC 6.4.1.3) alpha chain p...   157  2e-37
gb|AAD41882.1|AF153050_3 (AF153050) D-alanine:D-lactate ligase [...   157  2e-37
pir||S71006 biotin carboxylase protein A1 - Saccharopolyspora er...   156  2e-37
pir||T18410 carbamoyl-phosphate synthase (glutamine-hydrolyzing)...   156  3e-37
ref|NP_012643.1| (NC_001142) carbamyl phosphate synthetase; Cpa2...   156  3e-37
sp|P49787|ACCC_BACSU Biotin carboxylase (A subunit of acetyl-CoA...   156  3e-37
pir||T30518 carbamoyl-phosphate synthase (ammonia) (EC 6.3.4.16)...   156  3e-37
pir||S71009 biotin carboxylase protein A2 - Saccharopolyspora er...   156  3e-37
pdb|1CE8|A Chain A, Carbamoyl Phosphate Synthetase From Escheric...   156  3e-37
gb|AAG49141.1|AF215736_1 (AF215736) D-alanine:D-alanine ligase [...   156  3e-37
gb|AAB17902.2| (U39790) D-alanine:D-alanine ligase [Enterococcus...   155  4e-37
gb|AAG10785.1| (AF286897) carbamoyl phosphate synthetase II [Pla...   155  4e-37
gb|AAD51060.1|AF175293_5 (AF175293) D-alanine:D-lactate ligase [...   155  4e-37
ref|NP_470397.1| (NC_003212) highly similar to pyruvate carboxyl...   155  4e-37
pdb|1A9X|A Chain A, Carbamoyl Phosphate Synthetase: Caught In Th...   155  4e-37
ref|NP_540842.1| (NC_003317) acetyl-CoA carboxylase alpha chain ...   155  4e-37
ref|NP_464597.1| (NC_003210) highly similar to pyruvate carboxyl...   155  5e-37
ref|NP_282436.1| (NC_002163) biotin carboxylase [Campylobacter j...   155  6e-37
gb|AAC69197.1| (AF097728) pyruvate carboxylase [Aspergillus terr...   155  6e-37
emb|CAB64471.1| (AJ243055) D-ala,D-ala ligase [Streptococcus pne...   155  6e-37
pir||T39734 pyruvate carboxylase (EC 6.4.1.1) [similarity] - fis...   155  7e-37
ref|NP_509293.1| (NM_076892) Propionyl-coA carboxylase alpha cha...   155  7e-37
ref|NP_253444.1| (NC_002516) carbamoylphosphate synthetase large...   155  7e-37
dbj|BAA11239.1| (D78170) pyruvate carboxylase [Schizosaccharomyc...   155  8e-37
pir||T39898 carbamoyl-phosphate synthase (glutamine-hydrolyzing)...   155  8e-37
gb|AAG10786.1| (AF286898) carbamoyl phosphate synthetase II [Pla...   154  8e-37
ref|NP_229950.1| (NC_002505) acetyl-CoA carboxylase, biotin carb...   154  9e-37
ref|NP_389006.1| (NC_000964) carbamoyl-phosphate transferase-arg...   154  9e-37
ref|NP_243653.1| (NC_002570) acetyl-CoA carboxylase biotin carbo...   154  1e-36
ref|NP_501777.1| (NM_069376) carbomoyl-phosphate carboxylase [Ca...   154  1e-36
ref|NP_219627.1| (NC_000117) Biotin Carboxylase [Chlamydia trach...   153  2e-36
ref|NP_417722.1| (NC_000913) acetyl CoA carboxylase, biotin carb...   153  2e-36
emb|CAB64483.1| (AJ243058) D-ala,D-ala ligase [Streptococcus pne...   153  2e-36
ref|NP_232019.1| (NC_002505) carbamoyl-phosphate synthase, large...   153  2e-36
gb|AAA23748.1| (M79446) biotin carboxylase [Escherichia coli]         153  2e-36
ref|NP_312155.1| (NC_002695) acetyl CoA carboxylase biotin carbo...   153  2e-36
emb|CAB64463.1| (AJ243053) D-ala,D-ala ligase [Streptococcus pne...   153  2e-36
emb|CAC19838.1| (AJ009972) pyruvate carboxylase [Aspergillus niger]   153  3e-36
emb|CAB56843.1| (X99978) carbamoyl-phosphate synthase large subu...   153  3e-36
ref|NP_563674.1| (NM_100191) putative 3-methylcrotonyl-CoA carbo...   153  3e-36
ref|NP_359108.1| (NC_003098) D-alanine-D-alanine ligase [Strepto...   152  3e-36
ref|NP_289824.1| (NC_002655) acetyl CoA carboxylase, biotin carb...   152  3e-36
gb|AAC95435.1| (AF068901) D-Ala-D-Ala ligase [Streptococcus pneu...   152  4e-36
gb|AAA88512.1| (M22631) alpha-propionyl-CoA carboxylase (EC 6.4....   152  4e-36
emb|CAB64475.1| (AJ243056) D-ala,D-ala ligase [Streptococcus pne...   152  4e-36
pdb|1DV2|A Chain A, The Structure Of Biotin Carboxylase, Mutant ...   152  4e-36
emb|CAB64459.1| (AJ243052) D-ala,D-ala ligase [Streptococcus pne...   152  4e-36
gb|AAA67356.1| (U12536) 3-methylcrotonyl-CoA carboxylase precurs...   152  4e-36
pir||T35363 D-alanine--D-alanine ligase (EC 6.3.2.4) A SC66T3.06...   152  5e-36
gb|AAD37851.1|AF126429_1 (AF126429) JadJ [Streptomyces venezuelae]    152  5e-36
sp|O54631|DDL_STRPN D-alanine--D-alanine ligase (D-alanylalanine...   152  5e-36
emb|CAC22142.1| (AL512902) putative acyl-CoA carboxylase complex...   152  5e-36
sp|P14882|PCCA_RAT Propionyl-CoA carboxylase alpha chain, mitoch...   152  6e-36
sp|P25051|VANA_ENTFC VANCOMYCIN/TEICOPLANIN A-TYPE RESISTANCE PR...   152  6e-36
emb|CAB64487.1| (AJ243059) D-ala,D-ala ligase [Streptococcus pne...   152  6e-36
ref|NP_346110.1| (NC_003028) D-alanine--D-alanine ligase [Strept...   152  6e-36
emb|CAC21629.1| (AL512667) putative acyl-CoA carboxylase complex...   151  8e-36
pir||T42202 probable acyl-CoA carboxylase complex A chain - Stre...   151  1e-35
pir||A64472 carbamoyl-phosphate synthase, large chain (EC 6.3.-....   151  1e-35
ref|NP_282187.1| (NC_002163) putative pyruvate carboxylase A sub...   150  1e-35
ref|NP_214048.1| (NC_000918) pyruvate carboxylase n-terminal dom...   150  1e-35
pdb|1E4E|A Chain A, D-Alanyl-D-Lacate Ligase                          150  1e-35
ref|NP_421694.1| (NC_002696) carbamoyl-phosphate synthase, large...   150  1e-35
pir||T33717 carbamoyl-phosphate synthase (glutamine-hydrolyzing)...   150  2e-35
ref|NP_281472.1| (NC_002163) carbamoyl-phosphate synthase large ...   150  2e-35
ref|NP_360596.1| (NC_003103) propionyl-CoA carboxylase alpha cha...   150  2e-35
dbj|BAB16297.1| (AB039884) acetyl-CoA carboxylase biotin carboxy...   150  2e-35
ref|NP_248381.1| (NC_000909) carbamoyl-phosphate synthase, mediu...   150  2e-35
emb|CAA72256.1| (Y11467) carbamoyl-phosphate synthase (glutamine...   150  2e-35
ref|NP_377467.1| (NC_003106) 1049aa long hypothetical carbamoyl-...   150  2e-35
ref|NP_296778.1| (NC_002620) acetyl-coenzyme A carboxylase, biot...   150  2e-35
ref|NP_269512.1| (NC_002737) putative D-ala,D-ala ligase [Strept...   150  2e-35
ref|NP_106581.1| (NC_002678) 3-methylcrotonyl-CoA carboxylase bi...   150  2e-35
ref|NP_349251.1| (NC_003030) Carbamoylphosphate synthase large s...   150  2e-35
pir||T42206 probable acyl-CoA carboxylase complex A chain - Stre...   149  3e-35
gb|AAL69566.1|AF221670_1 (AF221670) pyruvate carboxylase [Pichia...   149  3e-35
emb|CAB63849.1| (AJ243051) D-ala,D-ala ligase [Streptococcus pne...   149  3e-35
ref|NP_420982.1| (NC_002696) propionyl-CoA carboxylase, alpha su...   149  3e-35
ref|NP_420691.1| (NC_002696) acetyl-CoA carboxylase, biotin carb...   149  4e-35
ref|NP_344948.1| (NC_003028) acetyl-CoA carboxylase, biotin carb...   149  4e-35
pdb|1E4E|B Chain B, D-Alanyl-D-Lacate Ligase                          149  4e-35
ref|NP_519642.1| (NC_003295) PROBABLE CARBAMOYL-PHOSPHATE SYNTHA...   149  4e-35
ref|NP_357979.1| (NC_003098) Biotin carboxylase (a subunit of ac...   148  4e-35
ref|NP_357130.1| (NC_003063) AGR_L_2704p [Agrobacterium tumefaci...   148  5e-35
ref|NP_518386.1| (NC_003295) PROBABLE ACYL-COA CARBOXYLASE ALPHA...   148  5e-35
emb|CAA70282.1| (Y09061) acetyl-CoA carboxylase, biotin carboxyl...   148  6e-35
gb|AAB62175.1| (U94527) vancomycin resistance protein B [Enteroc...   148  7e-35
emb|CAB61227.1| (Y15704) vana protein [Bacillus circulans]            148  7e-35
gb|AAB62176.1| (U94528) vancomycin resistance protein B [Enteroc...   148  8e-35
ref|NP_111322.1| (NC_002689) Carbamoylphosphate synthase large s...   148  8e-35
gb|AAB62174.1| (U94526) vancomycin resistance protein B [Enteroc...   148  1e-34
gb|AAC78719.1| (U43091) carbamoylphosphate synthetase heavy subu...   147  1e-34
prf||2009329A urea amidolyase [Pichia jadinii]                        147  1e-34
ref|NP_267519.1| (NC_002662) carbamoylphosphate synthetase [Lact...   147  1e-34
ref|NP_266825.1| (NC_002662) pyruvate carboxylase (6.4.1.1) [Lac...   147  1e-34
sp|P46056|CARB_TRICU CARBAMOYL-PHOSPHATE SYNTHASE, ARGININE-SPEC...   147  1e-34
ref|NP_437243.1| (NC_003078) putative methylcrotonoyl-CoA carbox...   147  1e-34
ref|NP_223571.1| (NC_000921) CARBAMOYL-PHOSPHATE SYNTHASE LARGE ...   147  1e-34
sp|P78992|PYC_PICPA PYRUVATE CARBOXYLASE (PYRUVIC CARBOXYLASE) (...   147  2e-34
ref|NP_372130.1| (NC_002758) acetyl-CoA carboxylase [Staphylococ...   147  2e-34
ref|NP_464882.1| (NC_003210) acetyl-CoA carboxylase subunit (bio...   146  2e-34
gb|AAA74996.1| (U11295) carbamoyl phosphate synthetase (glutamin...   146  3e-34
ref|NP_533976.1| (NC_003305) 3-methylcrotonyl-CoA carboxylase al...   146  3e-34
ref|NP_217017.1| (NC_000962) accA1 [Mycobacterium tuberculosis H...   146  3e-34
ref|NP_220985.1| (NC_000963) PROPIONYL-COA CARBOXYLASE ALPHA CHA...   146  3e-34
emb|CAB87214.1| (AL163641) acetyl/propionyl CoA carboxylase alph...   146  3e-34
ref|NP_207168.1| (NC_000915) biotin carboxylase (accC) [Helicoba...   146  3e-34
ref|NP_558966.1| (NC_003364) carbamoyl-phosphate synthase large ...   145  4e-34
ref|NP_298397.1| (NC_002488) carbamoyl-phosphate synthase large ...   145  4e-34
ref|NP_394253.1| (NC_002578) probable carbamoyl-phosphate syntha...   145  4e-34
emb|CAB93363.1| (AL357523) carbamoylphosphate synthetase large c...   145  4e-34
ref|NP_470730.1| (NC_003212) acetyl-CoA carboxylase subunit (bio...   145  4e-34
ref|NP_454975.1| (NC_003198) D-alanine:D-alanine ligase A [Salmo...   145  5e-34
gb|AAD25800.1|AC006550_8 (AC006550) Identical to gb|U12536 3-met...   145  5e-34
ref|NP_286119.1| (NC_002655) Z0477 gene product [Escherichia col...   145  5e-34
gb|AAB40890.1| (U35023) acyl coenzyme A carboxylase [Corynebacte...   145  7e-34
ref|NP_207711.1| (NC_000915) carbamoyl-phosphate synthase (gluta...   145  7e-34
sp|Q9TTS3|COA1_BOVIN Acetyl-CoA carboxylase 1 (ACC-alpha) [Inclu...   145  8e-34
sp|Q28559|COA1_SHEEP Acetyl-CoA carboxylase 1 (ACC-alpha) [Inclu...   145  8e-34
ref|NP_223728.1| (NC_000921) BIOTIN CARBOXYLASE [Helicobacter py...   144  9e-34
ref|NP_341715.1| (NC_002754) Ribosomal protein S6 modification p...   144  1e-33
ref|NP_143562.1| (NC_000961) ribosomal protein S6 modification p...   144  1e-33
sp|P11029|COAC_CHICK Acetyl-CoA carboxylase (ACC) [Includes: Bio...   143  2e-33
gb|AAL81838.1| (AE010269) carbamoyl-phosphate synthase large cha...   143  2e-33
ref|XP_037617.3| (XM_037617) acetyl-Coenzyme A carboxylase alpha...   143  2e-33
gb|AAF36803.1|AF155139_2 (AF155139) putative D-alanyl-D-alanine ...   143  2e-33
ref|NP_047031.1| (NC_001905) PCACA; L549.5 [Leishmania major] >g...   143  2e-33
ref|NP_344600.1| (NC_003028) phosphoribosylamine--glycine ligase...   143  2e-33
ref|NP_522501.1| (NC_003296) PUTATIVE BIOTIN CARBOXYLASE PROTEIN...   143  3e-33
ref|NP_269768.1| (NC_002737) putative acetyl-CoA carboxylase bio...   143  3e-33
gb|AAA60990.1| (L29638) ligase [Enterococcus casseliflavus]           142  3e-33
gb|AAK58489.1| (AY033764) D-alanine-D-serine ligase VanC3 [Enter...   142  3e-33
gb|AAC43218.1| (U00457) D-alanine:D-alanine ligase-related prote...   141  5e-33
sp|P29753|VANC_ENTGA Vancomycin C-type resistance protein vanC (...   141  5e-33
ref|NP_388337.1| (NC_000964) D-alanyl-D-alanine ligase A [Bacill...   141  6e-33
ref|NP_356380.1| (NC_003063) AGR_L_1177p [Agrobacterium tumefaci...   141  7e-33
sp|Q47758|DDL_ENTFA D-alanine--D-alanine ligase (D-alanylalanine...   141  7e-33
gb|AAL27442.1|AF430807_7 (AF430807) VanE [Enterococcus faecalis]      141  7e-33
emb|CAA03928.1| (AJ000109) carbamoylphosphate synthetase [Lactoc...   141  8e-33
ref|NP_376481.1| (NC_003106) 513aa long hypothetical biotin carb...   141  9e-33
ref|NP_242487.1| (NC_002570) D-alanyl-D-alanine ligase A [Bacill...   141  1e-32
ref|NP_420636.1| (NC_002696) urea amidolyase-related protein [Ca...   141  1e-32
pir||S41121 acetyl-CoA carboxylase (EC 6.4.1.2) - human >gi|4523...   141  1e-32
ref|NP_388535.1| (NC_000964) phosphoribosylglycinamide synthetas...   141  1e-32
ref|NP_280547.1| (NC_002607) carbamoyl-phosphate synthase large ...   141  1e-32
gb|AAL81806.1| (AE010266) ribosomal protein s6 modification prot...   141  1e-32
ref|NP_266934.1| (NC_002662) biotin carboxylase (EC 6.3.4.14) [L...   140  1e-32
gb|AAB49636.1| (U72704) vancomycin resistance protein [Enterococ...   140  2e-32
ref|NP_357646.1| (NC_003098) Phosphoribosylglycinamide synthetas...   140  2e-32
gb|AAG10491.1|AF279106_53 (AF279106) predicted acetyl-CoA carbox...   140  2e-32
gb|AAK28428.1|AF251259_1 (AF251259) D-alanine-D-X ligase VanD4 [...   140  2e-32
gb|AAF59156.1| (AE003839) CG8723 gene product [Drosophila melano...   139  3e-32
emb|CAA89922.1| (Z49809) unknown [Saccharomyces cerevisiae]           139  3e-32
emb|CAB48407.1| (AJ243652) urea amidolyase homologue [Pseudomona...   139  3e-32
pir||S49991 acetyl-CoA carboxylase (EC 6.4.1.2) - smut fungus (U...   139  4e-32
ref|NP_250702.1| (NC_002516) probable acyl-CoA carboxylase alpha...   139  4e-32
ref|NP_485023.1| (NC_003272) D-alanyl-D-alanine ligase [Nostoc s...   139  4e-32
ref|NP_214146.1| (NC_000918) biotin carboxylase [Aquifex aeolicu...   139  4e-32
dbj|BAB20832.1| (AB045609) phosphoribosylamine-glycine ligase [S...   138  5e-32
emb|CAA80280.1| (Z22558) HFA1 [Saccharomyces cerevisiae]              138  7e-32
sp|P32874|HFA1_YEAST HFA1 PROTEIN                                     138  8e-32
dbj|BAA24410.1| (D78165) acetyl-coenzyme A carboxylase like carb...   138  9e-32
sp|Q47823|DDL_ENTGA D-alanine--D-alanine ligase (D-alanylalanine...   137  1e-31
dbj|BAB63438.1| (AB058945) phosphoribosylamine-glycine ligase [S...   137  1e-31
gb|AAA24785.1| (L15304) vanB2 ORF [Enterococcus faecalis]             137  1e-31
ref|NP_372607.1| (NC_002758) D-alanine-D-alanine ligase [Staphyl...   137  1e-31
ref|NP_356721.1| (NC_003063) AGR_L_1864p [Agrobacterium tumefaci...   137  2e-31
gb|AAG40564.1|AF062308_2 (AF062308) acetyl-CoA carboxylase 2 [Ar...   136  2e-31
ref|NP_385682.1| (NC_003047) PROBABLE CARBAMOYL-PHOSPHATE SYNTHA...   136  2e-31
pir||T44290 biotin carboxylase (EC 6.3.4.14) [imported] - Sulfol...   136  2e-31
ref|NP_108021.1| (NC_002678) similar to ribosomal protein S6-glu...   136  2e-31
gb|AAF71281.1|AF253562_5 (AF253562) ligase [Enterococcus faecalis]    136  2e-31
ref|NP_071529.1| (NM_022193) acetyl-coenzyme A carboxylase [Ratt...   136  3e-31
ref|NP_174850.1| (NM_103314) acetyl-CoA carboxylase, putative [A...   136  3e-31
ref|NP_283078.1| (NC_003116) phosphoribosylamine--glycine ligase...   136  3e-31
ref|NP_355138.1| (NC_003062) AGR_C_3955p [Agrobacterium tumefaci...   136  3e-31
gb|AAD19835.1| (AF060799) D-alanyl-D-alanine ligase [Amycolatops...   136  3e-31
ref|NP_539439.1| (NC_003317) CARBAMOYL-PHOSPHATE SYNTHASE LARGE ...   136  3e-31
ref|NP_249185.1| (NC_002516) probable acyl-CoA carboxylase subun...   136  3e-31
ref|NP_376039.1| (NC_003106) 285aa long conserved hypothetical p...   136  4e-31
ref|NP_275136.1| (NC_003112) phosphoribosylamine--glycine ligase...   135  4e-31
ref|NP_532851.1| (NC_003304) carbamoylphosphate synthase large s...   135  4e-31
ref|NP_420971.1| (NC_002696) acetyl/propionyl-CoA carboxylase, a...   135  5e-31
ref|NP_220281.1| (NC_000117) UDP-N-acetylmuramate-alanine ligase...   135  5e-31
ref|NP_337574.1| (NC_002755) D-alanine--D-alanine ligase [Mycoba...   135  5e-31
dbj|BAA93643.1| (AB025973) biotin carboxylase [Lactobacillus pla...   135  6e-31
ref|NP_457899.1| (NC_003198) phosphoribosylglycineamide syntheta...   135  6e-31
ref|NP_253542.1| (NC_002516) phosphoribosylamine--glycine ligase...   135  6e-31
ref|NP_107762.1| (NC_002678) phosphoribosylamine-glycine ligase ...   135  7e-31
gb|AAG30411.1|AF262949_2 (AF262949) pyruvate carboxylase [Mycoba...   135  7e-31
ref|NP_384964.1| (NC_003047) PROBABLE PHOSPHORIBOSYLAMINE--GLYCI...   135  7e-31
ref|NP_463044.1| (NC_003197) phosphoribosylglycinamide synthetas...   135  8e-31
ref|NP_013934.1| (NC_001145) Similar to acetyl-coenzyme A carbox...   135  8e-31
ref|NP_000655.1| (NM_000664) acetyl-Coenzyme A carboxylase alpha...   134  9e-31
ref|NP_268447.1| (NC_002737) phosphoribosylamine-glycine ligase ...   134  1e-30
ref|NP_299258.1| (NC_002488) glycinamide ribonucleotide syntheta...   134  1e-30
ref|NP_174849.1| (NM_103313) acetyl-CoA carboxylase, putative [A...   134  1e-30
dbj|BAA07012.1| (D34630) acetyl-CoA carboxylase [Arabidopsis tha...   134  1e-30
gb|AAF18638.2|AC006228_9 (AC006228) F5J5.19 [Arabidopsis thaliana]    134  1e-30
ref|NP_126131.1| (NC_000868) RIBOSOMAL PROTEIN S6 MODIFICATION P...   134  1e-30
ref|NP_241500.1| (NC_002570) phosphoribosylglycinamide synthetas...   134  1e-30
ref|NP_294085.1| (NC_001263) D-alanine--D-alanine ligase [Deinoc...   134  1e-30
gb|AAC41645.1| (L27074) acetyl-CoA carboxylase [Arabidopsis thal...   134  1e-30
ref|NP_559164.1| (NC_003364) ribosomal protein S6 modification p...   133  1e-30
ref|NP_217497.1| (NC_000962) ddlA [Mycobacterium tuberculosis H3...   133  2e-30
ref|NP_247604.1| (NC_000909) ribosomal protein S6 modification p...   133  2e-30
gb|AAC23582.1| (U82965) D-alanine:D-alanine ligase-related prote...   133  2e-30
ref|NP_464381.1| (NC_003210) D-alanine--D-alanine ligase [Lister...   133  2e-30
pir||S73055 pyc protein - Mycobacterium tuberculosis >gi|560527|...   133  2e-30
ref|NP_290637.1| (NC_002655) phosphoribosylglycinamide synthetas...   133  3e-30
gb|AAL80333.1| (AE010147) ribosomal protein s6 modification prot...   133  3e-30
pir||T06161 acetyl-CoA carboxylase (EC 6.4.1.2) - wheat >gi|2827...   132  3e-30
pir||T07920 probable acetyl-CoA carboxylase (EC 6.4.1.2) - rape ...   132  3e-30
gb|AAG30191.1| (AF293442) biotin carboxylase [Streptomyces sp. R...   132  4e-30
ref|NP_103843.1| (NC_002678) carbamoyl-phosphate synthase large ...   132  4e-30
ref|NP_470190.1| (NC_003212) D-alanine--D-alanine ligase [Lister...   132  4e-30
emb|CAA55651.1| (X79049) vanA2 [Oerskovia turbata]                    132  4e-30
ref|NP_301567.1| (NC_002677) acetyl/propionyl CoA carboxylase [a...   132  4e-30
sp|Q99148|PUR2_YARLI BIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN AD...   132  4e-30
emb|CAC84690.1| (AJ306727) D-Ala:D-Lac ligase [Enterococcus faec...   132  4e-30
ref|NP_342160.1| (NC_002754) Ribosomal protein S6 modification p...   132  4e-30
pir||I67805 purine synthesis multifunctional protein - mouse >gi...   132  4e-30
ref|NP_280339.1| (NC_002607) biotin carboxylase; Acc [Halobacter...   132  5e-30
ref|NP_034386.1| (NM_010256) phosphoribosylglycinamide formyltra...   132  5e-30
pir||T31339 carbamoyl-phosphate synthase (glutamine-hydrolyzing)...   132  5e-30
ref|NP_407179.1| (NC_003143) phosphoribosylamine--glycine ligase...   132  5e-30
ref|NP_217483.1| (NC_000962) pca [Mycobacterium tuberculosis H37...   131  6e-30
pir||T43945 ribosomal protein S6 modification protein [imported]...   131  6e-30
ref|NP_540436.1| (NC_003317) PHOSPHORIBOSYLAMINE-GLYCINE LIGASE ...   131  6e-30
ref|NP_520312.1| (NC_003295) PROBABLE PHOSPHORIBOSYLAMINE--GLYCI...   131  6e-30
ref|NP_439298.1| (NC_000907) D-alanine--D-alanine ligase (ddlB) ...   131  6e-30
ref|NP_213510.1| (NC_000918) phosphoribosylamine-glycine ligase ...   131  6e-30
ref|NP_245161.1| (NC_002663) PurD [Pasteurella multocida] >gi|13...   131  7e-30
emb|CAC19876.1| (AJ131866) acetyl-CoA carboxylase [Brassica napus]    131  7e-30
sp|Q9ZGN0|DDL_MYCSM D-alanine--D-alanine ligase (D-alanylalanine...   131  7e-30
pir||A55579 biotin carboxyl carrier protein - Mycobacterium lepr...   131  8e-30
ref|NP_217802.1| (NC_000962) accA3 [Mycobacterium tuberculosis H...   131  9e-30
ref|NP_302152.1| (NC_002677) D-alanine-D-alanine ligase A [Mycob...   131  9e-30
pir||T09538 acetyl-CoA carboxylase (EC 6.4.1.2) - alfalfa >gi|49...   131  9e-30
gb|AAF04493.2|AF157612_1 (AF157612) acetyl-CoA carboxylase 1 pre...   131  1e-29
ref|NP_459135.1| (NC_003197) D-alanine-D-alanine ligase B, affec...   131  1e-29
ref|NP_418433.1| (NC_000913) phosphoribosylglycinamide synthetas...   131  1e-29
pdb|1GSO|A Chain A, Glycinamide Ribonucleotide Synthetase (Gar-S...   131  1e-29
ref|NP_229931.1| (NC_002505) phosphoribosylamine--glycine ligase...   131  1e-29
ref|NP_000810.1| (NM_000819) phosphoribosylglycinamide formyltra...   131  1e-29
pir||T46882 phosphoribosylamine--glycine ligase (EC 6.3.4.13) [i...   130  1e-29
gb|AAC53250.1| (U20892) glycinamide ribonucleotide synthetase [M...   130  1e-29
pir||T06162 acetyl-CoA carboxylase (EC 6.4.1.2) - wheat (fragmen...   130  1e-29
gb|AAC39331.1| (AF029896) acetyl-coenzyme A carboxylase [Triticu...   130  2e-29
ref|NP_349497.1| (NC_003030) D-alanine-D-alanine ligase [Clostri...   130  2e-29
emb|CAC84688.1| (AJ306726) D-Ala:D-Lac ligase [Enterococcus faec...   130  2e-29
gb|AAL02056.1|AF294805_1 (AF294805) acetyl-coenzyme A carboxylas...   130  2e-29
ref|NP_404198.1| (NC_003143) D-alanine--D-alanine ligase B [Yers...   130  2e-29
ref|NP_215900.1| (NC_000962) Carbamoylphosphate synthase large s...   130  2e-29
ref|NP_454742.1| (NC_003198) D-alanine:D-alanine ligase B [Salmo...   130  2e-29
emb|CAC19875.1| (AJ131865) acetyl-CoA carboxylase [Brassica napus]    130  2e-29
ref|NP_213366.1| (NC_000918) D-alanine:D-alanine ligase [Aquifex...   130  2e-29
pir||PN0478 vancomycin resistance-conferring protein - Enterococ...   130  2e-29
ref|NP_285788.1| (NC_002655) D-alanine-D-alanine ligase B, affec...   130  2e-29
pir||A57710 acetyl-CoA carboxylase (EC 6.4.1.2) - wheat >gi|5143...   130  2e-29
ref|NP_439049.1| (NC_000907) phosphoribosylamine--glycine ligase...   130  2e-29
gb|AAA24455.1| (J05126) purD (EC 6.3.4.13) [Escherichia coli]         130  3e-29
gb|AAC49275.1| (U39321) acetyl-CoA carboxylase [Triticum aestivu...   130  3e-29
ref|NP_248492.1| (NC_000909) phosphoribosylglycinamide formyltra...   130  3e-29
ref|NP_414634.1| (NC_000913) D-alanine-D-alanine ligase B, affec...   129  3e-29
dbj|BAA06809.1| (D32051) GARS protein [Homo sapiens]                  129  3e-29
ref|NP_343814.1| (NC_002754) Biotin carboxylase a subunit of pro...   129  4e-29
ref|NP_245081.1| (NC_002663) DdlB [Pasteurella multocida] >gi|13...   129  4e-29
ref|NP_103309.1| (NC_002678) D-alanine-D-alanine ligase A [Mesor...   128  5e-29
ref|NP_276131.1| (NC_000916) carbamoyl-phosphate synthase, large...   128  5e-29
ref|NP_440997.1| (NC_000911) D-alanine:D-alanine ligase-related ...   128  6e-29
pir||T02235 acetyl-CoA carboxylase (EC 6.4.1.2) - maize >gi|8547...   128  6e-29
ref|NP_106624.1| (NC_002678) hypothetical protein [Mesorhizobium...   128  6e-29
pir||T07923 acetyl-CoA carboxylase (EC 6.4.1.2) A - rape (fragme...   128  6e-29
gb|AAA20073.1| (M92156) acetyl-CoA carboxylase [Saccharomyces ce...   128  8e-29
pdb|1IOW|   Complex Of Y216f D-Ala:d-Ala Ligase With Adp And A P...   128  9e-29
ref|NP_014413.1| (NC_001146) acetyl-CoA carboxylase; Acc1p [Sacc...   128  9e-29
gb|AAL80554.1| (AE010165) phosphoribosylglycinamide formyltransf...   128  1e-28
dbj|BAA35563.1| (D90723) RimK protein [Escherichia coli]              127  1e-28
ref|NP_172454.1| (NM_100857) putative phosphoribosylglycinamide ...   127  1e-28
emb|CAB95026.1| (AJ237851) D-alanine-D-alanine ligase [Prochloro...   127  1e-28
pir||T07081 acetyl-CoA carboxylase (EC 6.4.1.2) B - soybean (fra...   127  1e-28
ref|NP_388105.1| (NC_000964) phosphoribosylglycinamide formyltra...   127  1e-28
ref|NP_247995.1| (NC_000909) ribosomal protein S6 modification p...   127  2e-28
ref|NP_127315.1| (NC_000868) PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRA...   127  2e-28
ref|NP_253100.1| (NC_002516) D-alanine--D-alanine ligase [Pseudo...   126  2e-28
pir||S47267 5'-phosphoribosyl-1-glycinamide transformylase T - B...   126  3e-28
ref|NP_571692.1| (NM_131617) phosphoribosylglycinamide formyltra...   126  3e-28
pir||T07084 acetyl-CoA carboxylase (EC 6.4.1.2) A - soybean >gi|...   126  3e-28
ref|NP_503072.1| (NM_070671) Carbamoyl-phosphate synthase (CPSas...   126  3e-28
ref|NP_301455.1| (NC_002677) putative carbamoyl-phosphate syntha...   126  3e-28
sp|P78820|COAC_SCHPO ACETYL-COA CARBOXYLASE (ACC) [INCLUDES: BIO...   125  5e-28
ref|NP_353670.1| (NC_003062) AGR_C_1152p [Agrobacterium tumefaci...   125  6e-28
ref|NP_376372.1| (NC_003106) 301aa long conserved hypothetical p...   124  1e-27
pir||T30568 acetyl-CoA carboxylase (EC 6.4.1.2) - Emericella nid...   124  1e-27
ref|NP_252890.1| (NC_002516) D-alanine-D-alanine ligase A [Pseud...   124  1e-27
ref|NP_444046.1| (NC_000914) Y4rH [Rhizobium sp. NGR234] >gi|249...   124  1e-27
ref|NP_558736.1| (NC_003364) ribosomal protein S6 modification p...   124  1e-27
gb|AAL38923.1| (AF325676) acetyl-CoA carboxylase [Lolium multifl...   124  1e-27
sp|Q9ZF44|PUR2_LACLA Phosphoribosylamine--glycine ligase (GARS) ...   124  1e-27
ref|NP_142302.1| (NC_000961) phosphoribosylglycinamide formyl tr...   124  1e-27
ref|NP_267669.1| (NC_002662) phosphoribosylamine-glycine ligase ...   124  1e-27
emb|CAB59603.1| (AL132662) pyruvate carboxylase [Streptomyces co...   123  2e-27
ref|NP_001084.1| (NM_001093) acetyl-Coenzyme A carboxylase beta ...   123  3e-27
ref|NP_562231.1| (NC_003366) D-alanine-D-alanine ligase [Clostri...   123  3e-27
ref|NP_465289.1| (NC_003210) phosphoribosylglycinamide synthetas...   122  4e-27
ref|NP_520963.1| (NC_003295) PROBABLE D-ALANINE--D-ALANINE LIGAS...   122  4e-27
ref|NP_212334.1| (NC_001318) D-alanine--D-alanine ligase (ddlA) ...   122  4e-27
ref|NP_296522.1| (NC_002620) UDP-N-acetylmuramate--alanine ligas...   122  4e-27
gb|AAF37343.1|AF170804_1 (AF170804) D-alanine:D-alanine ligase [...   121  6e-27
ref|NP_181305.1| (NM_129325) putative phosphoribosylaminoimidazo...   121  6e-27
ref|NP_219107.1| (NC_000919) D-alanine--D-alanine ligase (ddlA) ...   121  6e-27
sp|Q48745|DDL_LEUME D-alanine--D-alanine ligase (D-alanylalanine...   121  7e-27
gb|AAF37342.1|AF170803_1 (AF170803) D-alanine:D-alanine ligase [...   121  7e-27
ref|NP_386277.1| (NC_003047) PROBABLE D-ALANINE--D-ALANINE LIGAS...   121  7e-27
pir||T51694 D-alanine--D-alanine ligase (EC 6.3.2.4) [imported] ...   121  7e-27
pdb|1EHI|A Chain A, D-Alanine:d-Lactate Ligase (Lmddl2) Of Vanco...   121  7e-27
emb|CAA04374.1| (AJ000883) purD [Lactococcus lactis]                  121  8e-27
gb|AAB18338.1| (U75444) D-Ala-D-Ala ligase2 [Leuconostoc mesente...   121  9e-27
sp|Q9PLG1|MUDD_CHLMU MurC/ddl bifunctional enzyme [Includes: UDP...   121  9e-27
ref|NP_493922.1| (NM_061521) acetyl-CoA carboxylase [Caenorhabdi...   121  1e-26
ref|NP_441646.1| (NC_000911) glycinamide ribonucleotide syntheta...   121  1e-26
emb|CAB44435.1| (AJ242913) carbamoylphosphate synthase (large su...   121  1e-26
ref|NP_230122.1| (NC_002505) glutathione synthetase [Vibrio chol...   121  1e-26
ref|NP_539644.1| (NC_003317) D-ALANINE--D-ALANINE LIGASE A [Bruc...   120  1e-26
gb|AAA60988.1| (L29640) D-alanine-D-alanine ligase-related enzym...   120  1e-26
gb|AAA60989.1| (L29641) D-alanine-D-alanine ligase-related enzym...   120  1e-26


What is a common feature among retrieved sequences?

Question #4

You calculated the log-likelihoods of two trees:

Tree #1 (Null hypothesis): -27733.86
Tree #2 (Alternative hypothesis): -27775.17

The chi-square statistic (d) is :
Given that you know that there are 3 degrees of freedom, can you REJECT null hypothesis?
Yes
No

Briefly explain how you obtained the answer:

Question #5

In which part of the protein would you expect INTEINs to occur:

The most conserved portion that forms catalytic site
The least conserved part of proteins, usually loops on the surface of the structure
Randomly distributed

Question #6

In which part of the protein would you expect SMALL INSERTIONs/DELETIONs to occur:

The most conserved portion that forms catalytic site
The least conserved part of proteins, usually loops on the surface of the structure
Randomly distributed

Question #7

Which residues in a protein structure that is involved in host-pathogen interaction would you expect to be under POSITIVE selection? NEUTRAL selection? PURIFYING selection?

Question #8

How many different UNROOTED trees are possible for four sequences?

Question #9

Define HOMOLOGOUS:

Define ORTHOLOGOUS:

Define PARALOGOUS:


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